Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Products of "Sirtuin"
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SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purity:98.96% - 99.75%Color and Shape:SolidMolecular weight:420.55Ref: TM-T6984
1mg39.00€2mg50.00€5mg79.00€10mg107.00€25mg197.00€50mg311.00€100mg505.00€1mL*10mM (DMSO)90.00€Splitomicin
CAS:Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in aFormula:C13H10O2Purity:98.64% - 99.11%Color and Shape:SolidMolecular weight:198.22Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurity:98.53% - 99.79%Color and Shape:SolidMolecular weight:248.71Ref: TM-T6111
5mg50.00€10mg57.00€25mg93.00€50mg140.00€100mg235.00€200mg349.00€500mg565.00€1mL*10mM (DMSO)52.00€WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formula:C20H23ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:406.93YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.Formula:C44H70O16Purity:99.13%Color and Shape:SolidMolecular weight:855.02MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Formula:C22H19N3OSPurity:99.9%Color and Shape:SolidMolecular weight:373.47SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formula:C40H54N8O6SPurity:98%Color and Shape:SolidMolecular weight:774.97YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Ref: TM-T9320
2mg40.00€5mg60.00€10mg87.00€25mg180.00€50mg305.00€100mg535.00€200mg690.00€500mg1,074.00€1mL*10mM (DMSO)66.00€SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purity:98%Color and Shape:SolidMolecular weight:401.35SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Color and Shape:Odour SolidJGB1741
CAS:JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.Formula:C27H24N2O2SPurity:97.24%Color and Shape:SolidMolecular weight:440.56SIRT5 inhibitor 6
CAS:SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential forFormula:C21H28N6O4SPurity:99.82%Color and Shape:SolidMolecular weight:460.55SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formula:C14H16N2OPurity:99.31%Color and Shape:SolidMolecular weight:228.29Ref: TM-T9648
1mg96.00€5mg202.00€10mg311.00€25mg533.00€50mg747.00€100mg1,017.00€200mg1,359.00€1mL*10mM (DMSO)207.00€Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.47%Color and Shape:SolidMolecular weight:349.41Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurity:98.47% - 99.83%Color and Shape:SolidMolecular weight:360.43Ref: TM-T4019
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)66.00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurity:100% - 97.71%Color and Shape:SolidMolecular weight:454.63Ref: TM-T1818
1mg43.00€2mg56.00€5mg77.00€10mg87.00€25mg157.00€50mg230.00€100mg393.00€500mg930.00€1mL*10mM (DMSO)79.00€Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Purity:98%Color and Shape:Odour SolidSRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Formula:C25H24ClN7OSPurity:98% - 99.93%Color and Shape:SolidMolecular weight:506.22Ref: TM-T2412
1mg69.00€2mg89.00€5mg139.00€10mg250.00€25mg394.00€50mg562.00€100mg800.00€200mg1,103.00€500mg1,634.00€1mL*10mM (DMSO)221.00€Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Formula:C14H12O3Purity:99.53% - 99.9%Color and Shape:Off-White To Tan PowderMolecular weight:228.24Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formula:C37H46O12Purity:99.06% - ≥95%Color and Shape:SolidMolecular weight:682.753-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Formula:C7H6N4Purity:100% - 99.16%Color and Shape:SolidMolecular weight:146.15Ref: TM-T4108
5mg57.00€10mg87.00€25mg170.00€50mg261.00€100mg470.00€500mg1,064.00€1mL*10mM (DMSO)57.00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formula:C19H14N2O6Purity:97.47% - 99.25%Color and Shape:SolidMolecular weight:366.32Ref: TM-T4328
1mg46.00€2mg59.00€5mg93.00€10mg117.00€25mg235.00€50mg432.00€100mg638.00€500mg1,359.00€1mL*10mM (DMSO)93.00€MC2184
CAS:MC2184 is the inhibitor of human recombinant SIRT1.Formula:C11H6N2O3Purity:98%Color and Shape:SolidMolecular weight:214.18MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formula:C21H16BrCl2FN2O6S2Purity:100%Color and Shape:SolidMolecular weight:626.3BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormula:C24H25NO4Purity:100%Color and Shape:SolidMolecular weight:391.46Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.Formula:C13H13ClN2OPurity:99.69%Color and Shape:SolidMolecular weight:248.71Ref: TM-T7058
1mg150.00€2mg215.00€5mg331.00€10mg472.00€25mg753.00€50mg1,074.00€1mL*10mM (DMSO)379.00€CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurity:98.92%Color and Shape:SolidMolecular weight:418.44SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Formula:C15H21N5O3S2Purity:98.26%Color and Shape:SolidMolecular weight:383.49Ref: TM-T12919
1mg97.00€5mg227.00€10mg364.00€25mg620.00€50mg848.00€100mg1,159.00€200mg1,549.00€1mL*10mM (DMSO)250.00€MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Formula:C33H38N4O8Purity:98% - 99.48%Color and Shape:SoildMolecular weight:618.68Ref: TM-T11962
1mg52.00€2mg74.00€5mg111.00€10mg180.00€25mg283.00€50mg445.00€100mg723.00€500mg1,454.00€SIRT5 inhibitor 5
CAS:SIRT5 Inhibitor 5 is a potent substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 0.21 µM, and does not interact with the NAD+-binding pocket [1].Formula:C21H14ClN3O3SPurity:98%Color and Shape:SolidMolecular weight:423.87UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purity:99.75%Color and Shape:SolidMolecular weight:247.29Ref: TM-T7679
1mg40.00€5mg81.00€10mg116.00€25mg226.00€50mg324.00€100mg452.00€200mg632.00€1mL*10mM (DMSO)100.00€Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Formula:C11H15N2O5Purity:98.61% - 99.58%Color and Shape:SolidMolecular weight:255.25Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Formula:C26H22N2O2Purity:97.09% - 99.55%Color and Shape:SolidMolecular weight:394.47SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formula:C15H12ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:285.73Ref: TM-T39233
1mg96.00€5mg235.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€1mL*10mM (DMSO)259.00€SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formula:C23H23N3O6Color and Shape:SolidMolecular weight:437.45Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purity:98.06% - 99.87%Color and Shape:SolidMolecular weight:514.65AGK2
CAS:AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.Formula:C23H13Cl2N3O2Purity:98.68% - 99.17%Color and Shape:SolidMolecular weight:434.27SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Formula:C21H22N6OS2Purity:99.5%Color and Shape:SolidMolecular weight:438.57Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Formula:C16H18O9Purity:99.09% - ≥95%Color and Shape:SolidMolecular weight:354.31Tenovin-3
CAS:Tenovin-3 acts as a p53 activator.Formula:C18H21N3OSPurity:100% - ≥95%Color and Shape:SolidMolecular weight:327.44Ref: TM-T1873
1mg60.00€5mg126.00€10mg202.00€25mg432.00€50mg638.00€100mg908.00€500mg1,825.00€1mL*10mM (DMSO)140.00€Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Formula:C25H19N5OS2Purity:97.69% - 99.36%Color and Shape:SolidMolecular weight:469.58Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Formula:C20H15N3O2SPurity:99.02%Color and Shape:SolidMolecular weight:361.42SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Formula:C27H24N4O2SPurity:97.86%Color and Shape:SolidMolecular weight:468.57Ref: TM-T16932
1mg50.00€2mg72.00€5mg107.00€10mg165.00€25mg283.00€50mg430.00€100mg622.00€1mL*10mM (DMSO)111.00€SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Color and Shape:Odour SolidB2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purity:99.14%Color and Shape:SolidMolecular weight:396.83AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurity:98.32% - 99.44%Color and Shape:SolidMolecular weight:403.45HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Purity:98%Color and Shape:Odour Solid
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