GPR
G protein-coupled receptors (GPRs) are a large family of cell surface receptors that play a crucial role in transmitting signals from hormones, neurotransmitters, and other extracellular ligands into the cell. GPRs are involved in a wide range of physiological processes, including hormone regulation, immune response, and sensory perception. Modulating GPR activity is a key strategy in the development of therapeutics for various diseases, including endocrine disorders, cardiovascular diseases, and neurological conditions. At CymitQuimica, we offer a selection of high-quality GPR modulators to support your research in cell signaling, endocrinology, and drug discovery.
Products of "GPR"
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Latanoprost acid
CAS:Latanoprost acid is a prostanoid receptor agonist that blocks RANKL and can be used to reduce intraocular pressure.Formula:C23H34O5Purity:96.97%Color and Shape:Pale Yellow OilMolecular weight:390.51Ref: TM-T15718
1mg57.00€5mg145.00€10mg226.00€25mg454.00€50mg672.00€100mg924.00€200mg1,225.00€1mL*10mM (DMSO)160.00€GSK1292263
CAS:GSK1292263 is a GPR119 agonist and has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.Formula:C23H28N4O4SPurity:98.34% - 99.46%Color and Shape:SolidMolecular weight:456.56NCRW0005-F05
CAS:NCRW0005-F05 is a potent agonist of orphan G-protein coupled receptor GPR139 with an IC 50 value of 0.21 μM.Formula:C16H13F2NO2Purity:99.48%Color and Shape:SolidMolecular weight:289.28P2Y2R/GPR17 antagonist 1
CAS:P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R (IC50: 3.17 μM) and GPR17 (IC50: 1.67 μM) antagonist.Formula:C19H13ClN2O6SPurity:98.21%Color and Shape:SolidMolecular weight:432.83YL-365
YL-365 is a highly potent and selective GPR34 antagonist that exhibits excellent activity in neuropathic pain models for the study of neurologic diseases.Purity:98.51%Color and Shape:Odour Solid7-FluorotryptaMine HCl
CAS:7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used toFormula:C10H12ClFN2Purity:98.06%Color and Shape:SolidMolecular weight:214.67GW9508
CAS:GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.Formula:C22H21NO3Purity:97.89% - 99.19%Color and Shape:SolidMolecular weight:347.41GPR40 Agonist 2
CAS:GPR40 Agonist 2 is a GPR40 agonist. It can be used in the research of diabetes.Formula:C24H30O3Purity:98%Color and Shape:SolidMolecular weight:366.49Myristyl nicotinate
CAS:Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinicFormula:C20H33NO2Purity:99.50%Color and Shape:SolidMolecular weight:319.48LY2922470
CAS:LY2922470: Selective GPR40 agonist; EC50=7nM (human), 1nM (mouse), 3nM (rat); lowers glucose, boosts insulin/GLP-1.Formula:C28H29NO4SPurity:93.34% - 96%Color and Shape:SolidMolecular weight:475.6Ref: TM-T15810
1mg115.00€5mg236.00€10mg355.00€25mg617.00€50mg879.00€100mg1,198.00€1mL*10mM (DMSO)248.00€CAY10786
CAS:CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).Formula:C15H14OSPurity:99.84%Color and Shape:SolidMolecular weight:242.34IBC 293
CAS:IBC 293: Selective GPR109B agonist, favoring it over GPR109A; targets receptor in fat cells.Formula:C10H11N3O2Purity:99.63%Color and Shape:SolidMolecular weight:205.21MK-6892
CAS:MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).Formula:C19H22N4O5Purity:99.01% - 99.03%Color and Shape:SolidMolecular weight:386.4Ref: TM-TQ0108
1mg97.00€5mg188.00€10mg283.00€25mg472.00€50mg655.00€100mg944.00€500mg1,882.00€1mL*10mM (DMSO)230.00€MK-7246
CAS:MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).Formula:C21H21FN2O4SColor and Shape:SolidMolecular weight:416.47GW-1100
CAS:GW-1100 is a selective GPR40 and FFAR1 antagonist for the study of diabetes and metabolic diseases.Formula:C27H25FN4O4SPurity:97.01%Color and Shape:SolidMolecular weight:520.58MBX-2982
CAS:MBX-2982 is a selective, orally-available GPR119 agonist, used for the treatment of diabetes.Formula:C22H24N8OSPurity:98% - 99.96%Color and Shape:SolidMolecular weight:448.54Ref: TM-T1793
1mg50.00€5mg106.00€10mg177.00€25mg321.00€50mg487.00€100mg730.00€200mg998.00€1mL*10mM (DMSO)117.00€FL104
CAS:FL104 is a potent agonist of small-molecule urotensin II receptor, pEC50= 7.11.Formula:C24H25ClN2OPurity:99.46%Color and Shape:SolidMolecular weight:392.92Ref: TM-T27328
1mg116.00€5mg273.00€10mg373.00€25mg563.00€50mg758.00€100mg998.00€200mg1,320.00€1mL*10mM (DMSO)333.00€GSK256073
CAS:GSK256073 is an orally active GPR109A agonist.Formula:C10H13ClN4O2Purity:98.03%Color and Shape:SolidMolecular weight:256.69Ref: TM-T15432
1mg73.00€2mg97.00€5mg160.00€10mg250.00€25mg439.00€50mg647.00€100mg920.00€1mL*10mM (DMSO)170.00€AS1269574
CAS:AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.Formula:C13H14BrN3OPurity:99.99%Color and Shape:SolidMolecular weight:308.17Ref: TM-T21623
2mg39.00€5mg57.00€10mg96.00€25mg168.00€50mg270.00€100mg406.00€200mg592.00€1mL*10mM (DMSO)66.00€3-Hydroxyoctanoic Acid
CAS:3-Hydroxyoctanoic Acid, an energy metabolism intermediate, activates orphan receptor GPR109B.Formula:C8H16O3Purity:97.82% - ≥98%Color and Shape:SolidMolecular weight:160.21TC-O 9311
CAS:TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139).Formula:C20H19N3O4Purity:99.24% - 99.84%Color and Shape:SolidMolecular weight:365.38Ref: TM-T4626L
5mg49.00€10mg77.00€25mg134.00€50mg207.00€100mg339.00€200mg480.00€1mL*10mM (DMSO)50.00€Pamoic acid
CAS:Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.Formula:C23H16O6Purity:99.99%Color and Shape:Fine Yellow PowderMolecular weight:388.37CVN424
CAS:CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.Formula:C24H29F2N5O3Purity:99.02%Color and Shape:SolidMolecular weight:473.52Ref: TM-T9346
1mg96.00€5mg243.00€10mg376.00€25mg630.00€50mg898.00€100mg1,216.00€1mL*10mM (DMSO)253.00€GLPG1205
CAS:GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity.Formula:C22H22N2O4Purity:95.97% - 99.34%Color and Shape:SolidMolecular weight:378.42Ref: TM-T11411
1mg96.00€5mg207.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€1mL*10mM (DMSO)226.00€TUG-891
CAS:TUG-891 is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.Formula:C23H21FO3Purity:98.28% - 99.21%Color and Shape:SolidMolecular weight:364.41Ref: TM-T3433
1mg40.00€2mg51.00€5mg85.00€10mg115.00€25mg225.00€50mg378.00€100mg552.00€500mg1,169.00€1mL*10mM (DMSO)93.00€SNAP 94847
CAS:SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM).Formula:C29H32F2N2O2Purity:98%Color and Shape:SolidMolecular weight:478.57CAY10471 Racemate
CAS:CAY10471 Racemate is a potent CRTH2/DP2 antagonist with Ki of 0.6 nM; less active on DP1 and TP.Formula:C21H21FN2O4SPurity:99.08%Color and Shape:SolidMolecular weight:416.47BMS-903452
CAS:BMS-903452: potent GPR119 agonist, EC50 = 14 nM, treats rodent diabetes, no P450 inhibition, safe for liver cells.Formula:C21H19Cl2FN4O4SPurity:100% - 100%Color and Shape:SolidMolecular weight:513.37Ref: TM-T67791
1mg90.00€5mg220.00€10mg311.00€25mg469.00€50mg632.00€100mg855.00€200mg1,121.00€1mL*10mM (DMSO)258.00€Vincamine
CAS:Vincamine, from Vinca minor, is an alkaloid used as a vasodilator and antihypertensive for brain circulation issues.Formula:C21H26N2O3Purity:98.96%Color and Shape:White To Almost White Fine Crystalline PowderMolecular weight:354.44GPR4 antagonist 1
CAS:GPR4 antagonist 1 is a GPR4 antagonist (IC50: 189 nM).Formula:C27H37N5Purity:98%Color and Shape:SolidMolecular weight:431.62Fezagepras
CAS:Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-Formula:C13H18O2Purity:96.73% - 99.38%Color and Shape:SolidMolecular weight:206.28Ref: TM-T12883
1mg52.00€2mg74.00€5mg96.00€10mg140.00€25mg245.00€50mg350.00€100mgTo inquire1mL*10mM (DMSO)93.00€PU-WS13 hydrobromide
PU-WS13 hydrobromide is a GRP94 inhibitor with anti-inflammatory activity and inhibits the proliferation of M2-like macrophages in mouse TNBC tumors.Formula:C17H21BrCl2N6SPurity:98.63%Color and Shape:SoildMolecular weight:492.26MS21570
CAS:MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice.Formula:C10H11N3S2Purity:97.79%Color and Shape:SolidMolecular weight:237.34BI-671800
CAS:BI-671800 (AP-761) is a DP2/CRTH2 antagonist with IC50 values of 4.5 nM and 3.7 nM, potential for treating asthma.Formula:C25H26F3N5O3Purity:99.19%Color and Shape:SolidMolecular weight:501.5Ref: TM-T14565
1mg58.00€5mg131.00€10mg207.00€25mg373.00€50mg530.00€100mg718.00€200mg938.00€1mL*10mM (DMSO)144.00€(1S,2R)-2-PCCA
(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellularFormula:C30H39Cl2N3OPurity:99.34%Color and Shape:SoildMolecular weight:528.56AZD1981
CAS:AZD1981: selective CRTh2 antagonist, IC50 4 nM, 1000x specificity over 340+ enzymes/receptors, tested in asthma and other trials.Formula:C19H17ClN2O3SPurity:98.59% - 99.54%Color and Shape:SolidMolecular weight:388.872-Oleoylglycerol
CAS:2-Oleoylglycerol is a lipid found in palm kernels that acts as a GPR119 agonist with neuroprotective properties and can be used in steatohepatitis modeling.Formula:C21H40O4Purity:98%Color and Shape:SolidMolecular weight:356.54FTBMT
CAS:FTBMT is a selective GPR52 agonist (EC50: 75 nM) and it also has antipsychotic and procognitive properties.Formula:C19H16F4N4OPurity:99.12%Color and Shape:SolidMolecular weight:392.35Ref: TM-T15352
5mg52.00€10mg85.00€25mg170.00€50mg301.00€100mg469.00€200mg620.00€1mL*10mM (DMSO)52.00€MEDICA16
CAS:MEDICA16: GPR40 agonist, GPR120 partial agonist, ATP-citrate lyase inhibitor, lowers TG, boosts insulin sensitivity in muscle.Formula:C20H38O4Purity:99.13% - 99.85%Color and Shape:White SolidMolecular weight:342.51GLPG0974
CAS:GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.Formula:C25H25ClN2O4SPurity:99.58%Color and Shape:SolidMolecular weight:484.99AM-1638
CAS:AM-1638 is an orally active GPR40/FFA1 agonist, useful for studying type II diabetes.Formula:C33H35FO4Color and Shape:SolidMolecular weight:514.63Timapiprant
CAS:Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).Formula:C21H17FN2O2Purity:98.4% - 99.51%Color and Shape:SolidMolecular weight:348.37Benzyl nicotinate
CAS:Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptorFormula:C13H11NO2Purity:98.22%Color and Shape:Yellow LiquidMolecular weight:213.23SNAP 94847 hydrochloride
CAS:SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)Formula:C29H33ClF2N2O2Purity:100% - 99.85%Color and Shape:SolidMolecular weight:515.03Ref: TM-T8004
2mg42.00€5mg64.00€10mg97.00€25mg187.00€50mg316.00€100mg455.00€200mg635.00€1mL*10mM (DMSO)71.00€Fevipiprant
CAS:Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.Formula:C19H17F3N2O4SPurity:99.32% - 99.59%Color and Shape:SolidMolecular weight:426.41(+/-)-Pinocembrin
CAS:(+/-)-Pinocembrin (NSC-43318), a natural product from axillary pines, is a GPR120 ligand that promotes wound healing in the HaCaT cell line.Formula:C15H12O4Purity:99.79%Color and Shape:SolidMolecular weight:256.25Dihydromunduletone
CAS:Dihydromunduletone (DHM) is an adhesion G protein-coupled receptor (aGPCR) antagonist inhibits GPR56 and GPR114/ADGRG5, which have similar tethered agonists.Formula:C25H28O6Purity:99.96%Color and Shape:SolidMolecular weight:424.49TUG-499
CAS:TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptorsFormula:C16H11Cl2NO2Purity:99.59%Color and Shape:SoildMolecular weight:320.17Ref: TM-T60184
1mg35.00€5mg74.00€10mg97.00€25mg164.00€50mg212.00€100mg279.00€200mg395.00€1mL*10mM (DMSO)78.00€NF-56-EJ40
CAS:NF-56-EJ40 is an effective and highly selective antagonist of human SUCNR1 with an IC50 of 25 nM and a Ki of 33 nM.Formula:C27H29N3O3Purity:99.51%Color and Shape:SolidMolecular weight:443.54Monomethyl fumarate
CAS:Monomethyl fumarate is a potent agonist of GPR109A .Formula:C5H6O4Purity:99.21%Color and Shape:SolidMolecular weight:130.1
