Androgen Receptor
The androgen receptor (AR) is a nuclear hormone receptor that is activated by binding to androgens, such as testosterone and dihydrotestosterone. This receptor plays a crucial role in the development and maintenance of male characteristics, as well as in the regulation of several physiological processes, including muscle growth, libido, and bone density. Androgen receptor inhibitors are widely studied in the context of prostate cancer, where AR signaling is often upregulated. At CymitQuimica, we offer a range of high-quality androgen receptor modulators to support your research in endocrinology, cancer biology, and hormone regulation.
Products of "Androgen Receptor"
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AR antagonist 10
CAS:AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.Formula:C18H17ClN4O3SColor and Shape:SolidMolecular weight:404.871Dehydroisoandrosterone 3-acetate
CAS:Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.Formula:C21H30O3Purity:100% - 99.81%Color and Shape:SolidMolecular weight:330.46ONC1-13B
CAS:ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.Formula:C22H16F4N4O3SPurity:99.45% - 99.85%Color and Shape:SolidMolecular weight:492.45ARD-2585
CAS:ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Formula:C41H43ClN8O5Color and Shape:SolidMolecular weight:763.28LY2452473
CAS:LY2452473 (OPK 88004) is an orally available and selective androgen receptor modulator with potential anticancer activity for the study of prostate cancer.Formula:C22H22N4O2Purity:99.72%Color and Shape:SolidMolecular weight:374.44Ref: TM-T15804
1mg35.00€5mg74.00€10mg97.00€25mg149.00€50mg188.00€100mg281.00€200mg429.00€1mL*10mM (DMSO)81.00€p,p'-DDE
CAS:p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDTFormula:C14H8Cl4Purity:99.68%Color and Shape:White Crystalline Solid Physical Description White Crystalline Solid Or White Powder (Ntp 1992)Molecular weight:318.03Androgen receptor antagonist 12
CAS:Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.Formula:C12H8F3N3O2Color and Shape:SolidMolecular weight:283.21LX1
CAS:LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Formula:C22H15F6NO2Color and Shape:SolidMolecular weight:439.35CTK8A3536
CAS:CTK8A3536 ((2-MORPHOLIN-4-YL-4-PHENYL-1,3-THIAZOL-5-YL)METHANOL) is an inhibitor of Androgen receptor.Formula:C14H16N2O2SPurity:99.62%Color and Shape:SolidMolecular weight:276.35Ref: TM-T8592
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)169.00€Pentomone
CAS:Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Formula:C24H26O5Color and Shape:SolidMolecular weight:394.46Zanoterone
CAS:Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders andFormula:C23H32N2O3SPurity:99.85% - 99.96%Color and Shape:SoildMolecular weight:416.58Bavdegalutamide
CAS:Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR).Formula:C41H43ClFN9O6Purity:97.17% - 99.04%Color and Shape:SolidMolecular weight:812.29ARD-2128
CAS:ARD-2128: potent oral PROTAC that degrades AR, curbing prostate cancer growth with no toxicity.Formula:C45H50ClN7O6Purity:98.80%Color and Shape:SolidMolecular weight:820.37Bifluranol
CAS:Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostaticFormula:C17H18F2O2Purity:99.77%Color and Shape:SolidMolecular weight:292.32Gridegalutamide
CAS:Gridegalutamide exhibits anti-androgen and anti-tumor activities.Formula:C41H45F3N8O5SColor and Shape:SolidMolecular weight:818.91Vosilasarm
CAS:RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.Formula:C20H16ClN5O2Purity:99.01% - 99.6%Color and Shape:A Crystalline SolidMolecular weight:393.82(+)-JJ-74-138
CAS:(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).Formula:C22H22F8N2OSColor and Shape:SolidMolecular weight:514.48YXG-158
CAS:YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1Formula:C30H36FN3OPurity:98%Color and Shape:SolidMolecular weight:473.62ACP-105
CAS:ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgenFormula:C16H19ClN2OPurity:99.53%Color and Shape:SolidMolecular weight:290.79Ref: TM-T14116
2mg38.00€5mg58.00€10mg90.00€25mg164.00€50mg226.00€100mg325.00€200mg455.00€1mL*10mM (DMSO)65.00€MI-136
CAS:MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.Formula:C23H21F3N6SPurity:97.08% - 98.63%Color and Shape:SolidMolecular weight:470.51Ref: TM-T6889
1mg47.00€5mg87.00€10mg147.00€25mg279.00€50mg472.00€100mg730.00€200mg1,017.00€1mL*10mM (DMSO)97.00€
