NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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SZM679
SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.Formula:C27H18F5N3O5SPurity:98%Color and Shape:SolidMolecular weight:591.51IRAK4-IN-26
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%.Formula:C22H23N5O3Purity:98%Color and Shape:SolidMolecular weight:405.45Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formula:C17H13N3O3Purity:99.20% - 99.30%Color and Shape:SolidMolecular weight:307.31-Caffeoylquinic acid
CAS:1-Caffeoylquinic acid: a lignin precursor with anti-influenza, antioxidant properties, and moderates post-meal glucose release.Formula:C16H18O9Purity:98.77% - 99.16%Color and Shape:SolidMolecular weight:354.31Ref: TM-TN1051
1mg90.00€5mg243.00€10mg351.00€25mg548.00€50mg735.00€100mgTo inquire1mL*10mM (DMSO)225.00€ETHYL CAFFEATE
CAS:Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.Formula:C11H12O4Purity:97.79%Color and Shape:SolidMolecular weight:208.21AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Formula:C21H31N5O2Purity:98.81%Color and Shape:SolidMolecular weight:385.5Ref: TM-T14367
1mg87.00€5mg164.00€10mg259.00€25mg369.00€50mg520.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)178.00€(E/Z)-IT-603
CAS:(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor. IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding activity.Formula:C11H9BrN2O3SPurity:99.35%Color and Shape:SolidMolecular weight:329.17Ref: TM-T8799
1mg59.00€5mg126.00€10mg202.00€25mg406.00€50mg607.00€100mg845.00€500mg1,738.00€1mL*10mM (DMSO)140.00€Myrislignan
CAS:Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.Formula:C21H26O6Purity:98.77% - 99.41%Color and Shape:SolidMolecular weight:374.43Ref: TM-T4S1540
1mg47.00€5mg93.00€10mg144.00€25mg250.00€50mg406.00€100mg592.00€1mL*10mM (DMSO)107.00€CBL0137
CAS:CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM).Formula:C21H24N2O2Purity:99.57%Color and Shape:SolidMolecular weight:336.434-Aminosalicylic acid
CAS:4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.Formula:C7H7NO3Purity:97.07%Color and Shape:Minute Crystals From Alc SolidMolecular weight:153.14IRAK-4 protein kinase inhibitor 2
CAS:IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Formula:C14H10N4O3Purity:99.67%Color and Shape:SolidMolecular weight:282.25BMS986299
CAS:BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.Formula:C18H19N7OPurity:99.93% - 99.93%Color and Shape:SolidMolecular weight:349.39Esculentoside A
CAS:Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.Formula:C42H66O16Purity:98% - 99.85%Color and Shape:SolidMolecular weight:826.96Dendrophenol
CAS:Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Formula:C17H20O5Purity:98.2% - 98.96%Color and Shape:SolidMolecular weight:304.34Ref: TM-T3S1707
1mg104.00€2mg145.00€5mg227.00€10mg338.00€25mg558.00€50mg797.00€100mg1,074.00€1mL*10mM (DMSO)246.00€NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFormula:C26H30N2O4Purity:98%Color and Shape:SolidMolecular weight:434.53DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formula:C13H11NO5Purity:98%Color and Shape:SolidMolecular weight:261.23NLRP3-IN-13
CAS:NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.Formula:C19H15N3O3SPurity:98.82%Color and Shape:SolidMolecular weight:365.41E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:98.83%Color and Shape:SolidMolecular weight:378.46Ref: TM-T6823
1mg50.00€2mg72.00€5mg107.00€10mg167.00€25mg304.00€50mg500.00€100mg725.00€200mg1,017.00€500mg1,510.00€1mL*10mM (DMSO)88.00€Ginsenoside Rk3
CAS:Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Formula:C36H60O8Purity:99.33% - 99.88%Color and Shape:SolidMolecular weight:620.86Ref: TM-T6S1495
1mg85.00€5mg172.00€10mg255.00€25mg426.00€50mg630.00€100mg898.00€1mL*10mM (DMSO)283.00€
