IκB/IKK
The IκB/IKK complex is a key regulator of the NF-κB signaling pathway, which controls the expression of genes involved in immune responses, inflammation, and cell survival. IκB proteins inhibit NF-κB activity by sequestering it in the cytoplasm, while IKKs phosphorylate IκB, leading to its degradation and the activation of NF-κB. Dysregulation of the IκB/IKK pathway is linked to chronic inflammation, cancer, and autoimmune diseases. At CymitQuimica, we provide a selection of high-quality IκB/IKK modulators to support your research in signal transduction, inflammation, and therapeutic development.
Products of "IκB/IKK"
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SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Formula:C9H8N2OS2Purity:100% - 99.88%Color and Shape:SolidMolecular weight:224.3Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formula:C22H26N2O2Purity:99.85% - 99.98%Color and Shape:White Crystalline SolidMolecular weight:350.45BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Formula:C14H17N5Purity:98.74% - 99.74%Color and Shape:SolidMolecular weight:255.32INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formula:C15H16N2OPurity:95.41%Color and Shape:SolidMolecular weight:240.3Ref: TM-T5209
2mg38.00€5mg56.00€10mg84.00€25mg120.00€50mg210.00€100mg313.00€200mg452.00€1mL*10mM (DMSO)58.00€MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formula:C26H37ClN6O2Purity:98.19%Color and Shape:SolidMolecular weight:501.07Selinidin
CAS:Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.Formula:C19H20O5Purity:98%Color and Shape:SolidMolecular weight:328.364ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formula:C21H25ClN4O2Purity:100%Color and Shape:SolidMolecular weight:400.9Ref: TM-T10237
1mg66.00€5mg144.00€10mg227.00€25mg375.00€50mg540.00€100mg777.00€500mg1,549.00€1mL*10mM (DMSO)159.00€IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formula:C12H11N3O2SPurity:100%Color and Shape:SolidMolecular weight:261.3Ref: TM-T36524
1mg163.00€5mg395.00€10mg605.00€25mg938.00€50mg1,264.00€100mg1,700.00€200mg2,270.00€500µg111.00€Cudraflavone B
CAS:Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells andFormula:C25H24O6Purity:98%Color and Shape:SolidMolecular weight:420.45BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formula:C27H30F3N9OPurity:99.62%Color and Shape:SolidMolecular weight:553.58Ref: TM-T10477
1mg172.00€5mg354.00€10mg567.00€25mg905.00€50mg1,225.00€100mg1,644.00€1mL*10mM (DMSO)430.00€Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H26ClN3O4Color and Shape:SolidMolecular weight:431.91TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53Dehydrocostus Lactone
CAS:Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Formula:C15H18O2Purity:99.86% - 99.98%Color and Shape:SolidMolecular weight:230.3GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formula:C28H19FN2O4Purity:99.72%Color and Shape:SolidMolecular weight:466.46Ref: TM-T25465
2mg38.00€5mg58.00€10mg92.00€25mg170.00€50mg259.00€100mg378.00€200mg548.00€1mL*10mM (DMSO)60.00€CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formula:C27H37N7O2Purity:99.91%Color and Shape:SolidMolecular weight:491.63MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formula:C19H15ClN4O2Purity:98.92%Color and Shape:SolidMolecular weight:366.8Ref: TM-TQ0306
1mg49.00€2mg70.00€5mg96.00€10mg160.00€25mg329.00€50mg567.00€100mg777.00€1mL*10mM (DMSO)116.00€Armepavine
CAS:Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.Formula:C19H23NO3Purity:95.00%Color and Shape:SolidMolecular weight:313.39IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formula:C15H8ClF6NO2Purity:99.56% - 99.71%Color and Shape:SolidMolecular weight:383.67Ref: TM-T6141
2mg48.00€5mg66.00€10mg92.00€25mg163.00€50mg221.00€100mg310.00€500mg753.00€1mL*10mM (DMSO)69.00€GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53Ref: TM-T15558
1mg73.00€5mg153.00€10mg255.00€25mg535.00€50mg910.00€100mg1,216.00€1mL*10mM (DMSO)340.00€
