CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Products of "CCR"
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AZD-5672
CAS:AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.Formula:C32H38F2N2O5S2Purity:95.58%Color and Shape:SolidMolecular weight:632.78Ref: TM-T30260
1mg202.00€5mg459.00€10mg643.00€25mg938.00€50mg1,311.00€100mg1,786.00€1mL*10mM (DMSO)560.00€C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Formula:C27H43Cl2N5O2Purity:98.51%Color and Shape:SolidMolecular weight:540.57ZK 756326
CAS:ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Formula:C21H28N2O3Purity:99.43%Color and Shape:SolidMolecular weight:356.46CCR1 antagonist 6
CAS:CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).Formula:C21H23ClN4O3SPurity:98.40% - 99.26%Color and Shape:SolidMolecular weight:446.95Maraviroc
CAS:Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s-MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.Formula:C29H41F2N5OPurity:100% - 99.55%Color and Shape:Brown SolidMolecular weight:513.67Ref: TM-T6016
5mg51.00€10mg95.00€25mg160.00€50mg273.00€100mg492.00€200mg633.00€500mg998.00€1mL*10mM (DMSO)59.00€7,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Formula:C15H10O4Purity:99.39% - 99.6%Color and Shape:SolidMolecular weight:254.24CCR1 antagonist 8
CAS:CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).Formula:C22H18FN5O3SColor and Shape:SolidMolecular weight:451.47J-113863
CAS:J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).Formula:C30H37Cl2IN2O2Purity:98%Color and Shape:SolidMolecular weight:655.44Ref: TM-T11699
1mg59.00€2mg87.00€5mg126.00€10mg169.00€25mg304.00€50mg527.00€100mg758.00€1mL*10mM (DMSO)180.00€AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Formula:C27H32Cl2N2O7Purity:99.01%Color and Shape:SolidMolecular weight:567.46R243
CAS:R243 is CCR8 signaling and chemotaxis inhibitor.Formula:C21H27NO4Purity:97.86%Color and Shape:SolidMolecular weight:357.44Ref: TM-T24700
1mg43.00€2mg56.00€5mg85.00€10mg124.00€25mg220.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)95.00€YM022
CAS:YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Formula:C32H28N4O3Purity:98%Color and Shape:SolidMolecular weight:516.59CCR1 antagonist 7
CAS:CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Formula:C21H24ClN5O3SPurity:98%Color and Shape:SolidMolecular weight:461.96BMS-813160
CAS:BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.Formula:C25H40N8O2Purity:99.66% - 99.78%Color and Shape:SolidMolecular weight:484.64Ref: TM-T4584
1mg63.00€5mg137.00€10mg187.00€25mg341.00€50mg567.00€100mg810.00€500mg1,644.00€1mL*10mM (DMSO)145.00€Cenicriviroc
CAS:Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.Formula:C41H52N4O4SPurity:97.87%Color and Shape:SolidMolecular weight:696.94Ref: TM-TQ0297
1mg69.00€5mg149.00€10mg235.00€25mg470.00€50mg610.00€100mg793.00€200mg1,064.00€1mL*10mM (DMSO)221.00€BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Formula:C28H34F3N5O4SPurity:99.05%Color and Shape:SolidMolecular weight:593.66Ref: TM-T14688
1mg58.00€5mg116.00€10mg183.00€25mg368.00€50mg562.00€100mg758.00€200mg1,017.00€1mL*10mM (DMSO)156.00€CCR4 antagonist 3-1
CAS:CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Formula:C14H12N2SPurity:99.53%Color and Shape:SolidMolecular weight:240.32MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Formula:C30H31ClN2O4Purity:98.62%Color and Shape:SolidMolecular weight:519.03IPG7236
CAS:IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFormula:C23H31N3O3SPurity:98%Color and Shape:SolidMolecular weight:429.58Denikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Color and Shape:Odour LiquidNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour Liquid
