TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Products of "TLR"
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SM-276001
CAS:SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.Formula:C16H21N7OPurity:99.37%Color and Shape:SolidMolecular weight:327.38Ref: TM-T12933
1mg64.00€5mg139.00€10mg202.00€25mg364.00€50mg547.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)153.00€TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Formula:C22H25N5Purity:99.4%Color and Shape:SolidMolecular weight:359.47CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formula:C17H13F3N4O2Purity:99.84%Color and Shape:SolidMolecular weight:362.31Ref: TM-T15017
1mg106.00€2mg150.00€5mg216.00€10mg283.00€25mg356.00€50mg432.00€100mg625.00€500mg1,293.00€1mL*10mM (DMSO)188.00€TLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Formula:C21H25N5OPurity:98%Color and Shape:SolidMolecular weight:363.46DSR-6434
CAS:DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.Formula:C19H28N8O2Purity:99.12%Color and Shape:SolidMolecular weight:400.48TLR7/8/9 antagonist 2
CAS:TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Formula:C23H31N7Purity:98%Color and Shape:SoildMolecular weight:405.54Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Formula:C15H13F5N2O2Purity:98%Color and Shape:SolidMolecular weight:348.27Semapimod tetrahydrochloride
CAS:Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor.Formula:C34H56Cl4N18O2Purity:99.8%Color and Shape:SolidMolecular weight:890.74M62812
CAS:TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Formula:C13H13Cl2N3OSPurity:96.85%Color and Shape:SolidMolecular weight:330.23AT791
CAS:AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Formula:C23H31N3O3Purity:99.88%Color and Shape:SolidMolecular weight:397.51Ref: TM-T61882
1mg103.00€5mg246.00€10mg395.00€25mg785.00€50mg1,130.00€100mg1,768.00€200mg2,357.00€1mL*10mM (DMSO)271.00€TH1020
CAS:TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.Formula:C23H15N7S2Purity:99.23%Color and Shape:SolidMolecular weight:453.54SM360320
CAS:SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.Formula:C15H17N5O3Purity:98.4%Color and Shape:SolidMolecular weight:315.33Ref: TM-T19675
1mg116.00€5mg244.00€10mg364.00€25mg562.00€50mg780.00€100mg1,035.00€500mg2,100.00€1mL*10mM (DMSO)269.00€CU-CPD107
CAS:CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.Formula:C16H21IN2O2Purity:98.86%Color and Shape:SolidMolecular weight:400.25
