STAT
STAT proteins are critical components of the JAK/STAT signaling pathway, which transmits extracellular signals from cytokines and growth factors to the cell nucleus, influencing gene expression. STAT proteins are involved in regulating immune responses, cell growth, differentiation, and survival. Dysregulation of STAT signaling is implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammation. At CymitQuimica, we provide a comprehensive range of STAT pathway modulators to support your research in signal transduction, immunology, and therapeutic development.
Products of "STAT"
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Eupalinolide K
CAS:Eupalinolide K is a natural productFormula:C20H26O6Purity:98%Color and Shape:SolidMolecular weight:362.42Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Formula:C40H52O4Purity:95.1% - 99.79%Color and Shape:Needles From Acetone/Light Petroleum SolidMolecular weight:596.84STAT3 HiBiT degrader 1
CAS:STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.Formula:C58H63F4N10O14PSColor and Shape:SolidMolecular weight:1263.21Niclosamide olamine
CAS:Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.Formula:C15H15Cl2N3O5Purity:99.89%Color and Shape:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Molecular weight:388.2Ref: TM-T4S0145
1mg51.00€5mg96.00€10mg153.00€25mg249.00€50mg369.00€100mg545.00€500mg1,130.00€1mL*10mM (DMSO)145.00€2-(1,8-naphthyridin-2-yl)phenol
CAS:2-NP is a STAT1 enhancer.Formula:C14H10N2OPurity:99.33% - 99.82%Color and Shape:SolidMolecular weight:222.24Ref: TM-T2168
5mg60.00€10mg96.00€25mg187.00€50mg298.00€100mg469.00€200mg682.00€500mg1,035.00€1mL*10mM (DMSO)66.00€Atranorin
CAS:Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Formula:C19H18O8Purity:98% - 99.57%Color and Shape:SolidMolecular weight:374.34Casticin
CAS:Casticin combats vascular inflammation by blocking ROS-NF-κB and could lead in prostate cancer treatment.Formula:C19H18O8Purity:99.37% - ≥95%Color and Shape:SolidMolecular weight:374.34STAT3-IN-36
CAS:STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.Formula:C30H24F2N2O9S2Color and Shape:SolidMolecular weight:658.65Balsalazide disodium dihydrate
CAS:Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.Formula:C17H17N3Na2O8Purity:98.95% - 99.46%Color and Shape:Yellow To Orange Crystalline PowderMolecular weight:437.31STAT5-IN-1
CAS:STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Formula:C16H11N3O3Purity:99.44% - ≥95%Color and Shape:SolidMolecular weight:293.28Antitumor agent-195
Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.Formula:C22H22N2O4Color and Shape:SolidMolecular weight:378.42Anticancer agent 259
Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.Formula:C30H26N2O2Color and Shape:SolidMolecular weight:446.54Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purity:98.21% - 99.85%Color and Shape:SolidMolecular weight:476.73Ref: TM-TN2346
1mg37.00€5mg74.00€10mg111.00€25mg180.00€50mg269.00€100mg399.00€500mg905.00€1mL*10mM (DMSO)79.00€SH-4-54
CAS:SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.Formula:C29H27F5N2O5SPurity:98% - 99.12%Color and Shape:SolidMolecular weight:610.59Ref: TM-T6669
1mg50.00€2mg66.00€5mg96.00€10mg160.00€25mg311.00€50mg502.00€100mg730.00€1mL*10mM (DMSO)135.00€Compound SC-1
CAS:SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.Formula:C21H13ClF3N3O2Purity:99.41%Color and Shape:SolidMolecular weight:431.8Ref: TM-T22424
1mg90.00€5mg160.00€10mg245.00€25mg444.00€50mg638.00€100mg848.00€200mg1,121.00€1mL*10mM (DMSO)178.00€Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formula:C26H24N2O11P2Purity:97.18%Color and Shape:SolidMolecular weight:602.42Napabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Formula:C14H8O4Purity:98.43% - 99.61%Color and Shape:SolidMolecular weight:240.21Angoline
CAS:Angoline hydrochloride: IL6/STAT3 inhibitor, IC50: 11.56 μM, blocks STAT3 phosphorylation and cancer cell growth.Formula:C22H21NO5Purity:99.43% - 99.96%Color and Shape:SolidMolecular weight:379.41Ref: TM-TN6739
1mg66.00€5mg144.00€10mg207.00€25mg344.00€50mg512.00€100mg740.00€1mL*10mM (DMSO)158.00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.39%Color and Shape:Yellow SolidMolecular weight:294.3HODHBt
CAS:HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Formula:C7H5N3O2Purity:99.45% - 99.95%Color and Shape:Off-White To Yellow SolidMolecular weight:163.13Ascochlorin
CAS:Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.Formula:C23H29ClO4Purity:98%Color and Shape:SolidMolecular weight:404.93Diosgenin
CAS:Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Formula:C27H42O3Purity:98.87% - 99.87%Color and Shape:Flaky Or Needle CrystalMolecular weight:414.62ML115
CAS:ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formula:C15H15ClN2O4Purity:99.35%Color and Shape:SolidMolecular weight:322.74Ref: TM-T35544
1mg95.00€5mg227.00€10mg359.00€25mg630.00€50mg882.00€100mg1,188.00€200mg1,596.00€500mg2,357.00€1mL*10mM (DMSO)251.00€STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.Formula:C22H14N4O3Purity:99.42%Color and Shape:SolidMolecular weight:382.37Ref: TM-T60160
5mg64.00€10mg92.00€25mg177.00€50mg283.00€100mg425.00€500mgTo inquire1mL*10mM (DMSO)64.00€HJC0152 hydrochloride
CAS:HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Formula:C15H14Cl3N3O4Purity:98.33% - 98.62%Color and Shape:SolidMolecular weight:406.64STAT3-IN-35
CAS:STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.Formula:C21H23NO4Color and Shape:SolidMolecular weight:353.41Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formula:C19H28O8Purity:99.53% - 99.91%Color and Shape:White Crystalline PowderMolecular weight:384.42TPCA-1
CAS:TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFormula:C12H10FN3O2SPurity:95.03% - 97.86%Color and Shape:SolidMolecular weight:279.29Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Formula:C28H26N2O12P2Purity:98.97%Color and Shape:SolidMolecular weight:644.46Ref: TM-T9646
1mg208.00€5mg518.00€10mg740.00€25mg1,093.00€50mg1,473.00€100mg2,015.00€1mL*10mM (DMSO)737.00€AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formula:C16H14Cl2N8OPurity:100%Color and Shape:SolidMolecular weight:405.24Ref: TM-T8378
1mg131.00€2mg180.00€5mg274.00€10mg432.00€25mg715.00€50mg1,008.00€100mg1,359.00€1mL*10mM (DMSO)303.00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurity:98.85% - ≥98%Color and Shape:SolidMolecular weight:373.21Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purity:97.55% - 99.83%Color and Shape:SolidMolecular weight:230.3KT-333
CAS:KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Formula:C60H74ClN10O14PSPurity:98.12%Color and Shape:SolidMolecular weight:1257.78Tetramethylcurcumin
CAS:Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it alsoFormula:C25H28O6Purity:99.94% - ≥98%Color and Shape:SolidMolecular weight:424.49PMMB-187
CAS:PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.Formula:C27H23BrN2O6S2Color and Shape:SolidMolecular weight:615.52Stafia-1
CAS:Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.Formula:C24H27O10PPurity:98.08%Color and Shape:SolidMolecular weight:506.44Ref: TM-T9339
1mg86.00€5mg187.00€10mg309.00€25mg525.00€50mg757.00€100mg1,035.00€500mg2,110.00€1mL*10mM (DMSO)217.00€Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formula:C15H12O5Purity:100% - 99.42%Color and Shape:SolidMolecular weight:272.25Ref: TM-TJS1779
1mg87.00€5mg216.00€10mg354.00€25mg582.00€50mg825.00€100mg1,111.00€1mL*10mM (DMSO)197.00€UC-514321
CAS:UC-514321 directly targets STAT3/5 and represses TET1 expression.Formula:C26H35NO5Purity:97%Color and Shape:SolidMolecular weight:441.56Ref: TM-T13950
1mg78.00€5mg169.00€10mg264.00€25mg528.00€50mg810.00€100mg1,169.00€200mg1,568.00€1mL*10mM (DMSO)178.00€Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formula:C25H24O6Purity:98.68% - 99.8%Color and Shape:SolidMolecular weight:420.45Antitumor agent-73
CAS:Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.Formula:C50H82BrO4PPurity:98%Color and Shape:SolidMolecular weight:858.06Picroside I
CAS:Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.Formula:C24H28O11Purity:99.70%Color and Shape:SolidMolecular weight:492.47SC-43
CAS:SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Formula:C21H13ClF3N3O2Purity:98.44%Color and Shape:SolidMolecular weight:431.8S3I-201
CAS:S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.Formula:C16H15NO7SPurity:97.83%Color and Shape:SolidMolecular weight:365.36BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormula:C14H13N3OSPurity:99.02%Color and Shape:SolidMolecular weight:271.34Stattic
CAS:Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.Formula:C8H5NO4SPurity:98.54% - 99.76%Color and Shape:SolidMolecular weight:211.19Ref: TM-T6308
5mg35.00€10mg51.00€25mg85.00€50mg124.00€100mg187.00€200mg279.00€500mg465.00€1mL*10mM (DMSO)55.00€WP1066
CAS:WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formula:C17H14BrN3OPurity:98.92% - 99.73%Color and Shape:SolidMolecular weight:356.22SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurity:99.56%Color and Shape:SolidMolecular weight:336.15Ref: TM-T8719
1mg46.00€5mg93.00€10mg140.00€25mg240.00€50mg363.00€100mg452.00€200mg630.00€1mL*10mM (DMSO)99.00€AS1517499
CAS:AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nMFormula:C20H20ClN5O2Purity:98.27% - 98.7%Color and Shape:SolidMolecular weight:397.86Ref: TM-T4476
1mg40.00€2mg52.00€5mg88.00€10mg119.00€25mg235.00€50mg376.00€100mg469.00€500mg1,064.00€1mL*10mM (DMSO)87.00€
