JNK
JNKs are a subgroup of the MAPK family that respond to stress stimuli, such as cytokines, ultraviolet irradiation, and heat shock, and are involved in controlling apoptosis, inflammation, and immune responses. JNK signaling is crucial for the regulation of cellular stress responses and has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. At CymitQuimica, we provide a range of JNK pathway modulators to support your research in stress signaling, apoptosis, and disease pathology.
Products of "JNK"
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JNK-1-IN-3
JNK-1-IN-3 (Compound 9e) acts as a JNK1 inhibitor, both reducing JNK1 gene expression and lowering the protein levels of its phosphorylated form. It concurrently diminishes the expression of downstream targets c-Jun and c-Fos in tumors, while also restoring p53 activity. Exhibiting broad-spectrum antiproliferative effects, JNK-1-IN-3 is particularly effective against renal and breast cancer cell lines, showing significant anticancer activity both in vivo and in vitro.Formula:C19H17FN4O3Color and Shape:SolidMolecular weight:368.36JNK1 Protein, Human, Recombinant (GST)
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.Color and Shape:Lyophilized PowderMolecular weight:75 kDa (predicted); 65 kDa (reducing conditions)JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purity:98%Color and Shape:SolidMolecular weight:467.52WHI-P258
CAS:WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formula:C16H15N3O2Purity:99.64% - 99.95%Color and Shape:SolidMolecular weight:281.31Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Formula:C11H12Cl2N2O5Purity:99.6% - 99.84%Color and Shape:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMolecular weight:323.13JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formula:C12H11NO3S2Purity:98.82%Color and Shape:SolidMolecular weight:281.35Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37Epieriocalyxin A
CAS:Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formula:C20H24O5Purity:97.00%Color and Shape:SolidMolecular weight:344.4JNK-IN-13
CAS:JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formula:C13H7ClN4SPurity:98.74%Color and Shape:SolidMolecular weight:286.74SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurity:99.50% - 99.81%Color and Shape:SolidMolecular weight:490.56Ref: TM-T16927
1mg52.00€5mg103.00€10mg160.00€25mg304.00€50mg550.00€100mg882.00€500mg1,768.00€1mL*10mM (DMSO)114.00€Juglanin
CAS:Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.Formula:C20H18O10Purity:98.8% - 99.33%Color and Shape:SolidMolecular weight:418.35NBDHEX
CAS:NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).Formula:C12H15N3O4SPurity:97.38%Color and Shape:SolidMolecular weight:297.33BI-78D3
CAS:BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Formula:C13H9N5O5S2Purity:100% - 97.89%Color and Shape:SolidMolecular weight:379.37SP600125
CAS:SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFormula:C14H8N2OPurity:97.63% - 99.58%Color and Shape:SolidMolecular weight:220.23JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Formula:C28H27N7O2Purity:99.53% - 99.58%Color and Shape:SolidMolecular weight:493.56Ref: TM-T3598
1mg87.00€2mg158.00€5mg226.00€10mg290.00€25mg522.00€50mg752.00€100mg1,026.00€1mL*10mM (DMSO)245.00€Ezatiostat hydrochloride
CAS:Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.Formula:C27H36ClN3O6SPurity:98%Color and Shape:SolidMolecular weight:566.11Ref: TM-T22776
2mg58.00€5mg82.00€10mg120.00€25mg200.00€50mg306.00€100mg517.00€200mg777.00€500mg1,165.00€1mL*10mM (DMSO)118.00€IQ-1S free acid
CAS:IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formula:C15H9N3OPurity:97.92% - 99.05%Color and Shape:SolidMolecular weight:247.25Ref: TM-T3627
5mg47.00€10mg52.00€25mg96.00€50mg169.00€100mg304.00€200mg454.00€500mg733.00€1mL*10mM (DMSO)50.00€TC ASK 10
CAS:TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Formula:C21H23Cl2N5OPurity:99.71%Color and Shape:SolidMolecular weight:432.35Ref: TM-T13099
1mg34.00€5mg90.00€10mg131.00€25mg250.00€50mg393.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)90.00€CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Formula:C16H27N5O2Purity:99.87%Color and Shape:SolidMolecular weight:321.42Ref: TM-T9688
1mg157.00€5mg323.00€10mg510.00€25mg825.00€50mg1,130.00€100mg1,510.00€1mL*10mM (DMSO)354.00€TCS JNK 5a
CAS:TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).Formula:C20H16N2OSPurity:97.88% - 99.5%Color and Shape:SolidMolecular weight:332.42
