JNK
JNKs are a subgroup of the MAPK family that respond to stress stimuli, such as cytokines, ultraviolet irradiation, and heat shock, and are involved in controlling apoptosis, inflammation, and immune responses. JNK signaling is crucial for the regulation of cellular stress responses and has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. At CymitQuimica, we provide a range of JNK pathway modulators to support your research in stress signaling, apoptosis, and disease pathology.
Products of "JNK"
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n-Butyl α-D-fructofuranoside
CAS:N-Butyl α-D-fructofuranoside, extracted from the root barks of Ulmus davidiana var.Formula:C10H20O6Purity:98%Color and Shape:SolidMolecular weight:236.26Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formula:C41H68O14Purity:99% - 99.84%Color and Shape:Hydroscopic Brown Or Yellow PowderMolecular weight:784.97IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45Ref: TM-T9010
1mg40.00€5mg96.00€10mg135.00€25mg226.00€50mg320.00€100mg434.00€200mg602.00€1mL*10mM (DMSO)131.00€Vacquinol-1
CAS:Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Formula:C21H21ClN2OPurity:98.67%Color and Shape:SolidMolecular weight:352.86Ezatiostat
CAS:Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.Formula:C27H35N3O6SPurity:97.95%Color and Shape:SolidMolecular weight:529.65Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormula:C13H8O3Purity:99.45%Color and Shape:SolidMolecular weight:212.2IQ-3
CAS:IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.Formula:C20H11N3O3Purity:≥98%Color and Shape:SolidMolecular weight:341.32Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formula:C21H28O2Purity:99.40% - 99.8%Color and Shape:Light Yellow PowderMolecular weight:312.45Ref: TM-T5574
1mg35.00€5mg55.00€10mg93.00€25mg178.00€50mg245.00€100mg360.00€200mg532.00€1mL*10mM (DMSO)60.00€Taurochenodeoxycholic Acid
CAS:Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Formula:C26H45NO6SPurity:99.69% - 99.86%Color and Shape:SolidMolecular weight:499.7JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Formula:C29H29N7O2Purity:100% - 99.59%Color and Shape:SolidMolecular weight:507.59Ref: TM-T2668
2mg47.00€5mg77.00€10mg119.00€25mg207.00€50mg344.00€100mg510.00€200mg722.00€1mL*10mM (DMSO)87.00€p38 Kinase inhibitor 8
CAS:p38 Kinase inhibitor 8 (Compound CCLXXVIII) is an orally active inhibitor targeting p38β and JNK2α2, with IC50 values of 6.3 nM and 53.6 nM, respectively. It has demonstrated anti-inflammatory effects in a rat model of collagen-induced arthritis.Formula:C22H21FN6O2Color and Shape:SolidMolecular weight:420.44Mefloquine
CAS:Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.Formula:C17H16F6N2OPurity:99.97%Color and Shape:SolidMolecular weight:378.31Ref: TM-T0860L
1mg70.00€5mg154.00€10mg225.00€25mg376.00€50mg538.00€100mg755.00€200mg1,017.00€1mL*10mM (DMSO)160.00€(±)-Perillaldehyde
CAS:(±)-Perillaldehyde exhibits antidepressant effects in mice with stress-induced depressive-like behavior by modulating the olfactory nervous system. Additionally, it demonstrates anti-inflammatory activity by activating JNK in RAW264.7 cells and suppressing the expression of TNF-α, with an IC50 value of 171.7 μM.Formula:C10H14OColor and Shape:SolidMolecular weight:150.22PROTAC JNK1-targeted-1
PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]Formula:C35H32BrN9O6Molecular weight:754.589Anisomycin
CAS:Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.Formula:C14H19NO4Purity:98.33% - 99.81%Color and Shape:White Crystalline SolidMolecular weight:265.3Tanzisertib
CAS:Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Formula:C21H23F3N6O2Purity:98.66% - 99.28%Color and Shape:SolidMolecular weight:448.44Ref: TM-T14895
1mg42.00€5mg87.00€10mg145.00€25mg283.00€50mg558.00€100mg743.00€200mg1,026.00€1mL*10mM (DMSO)96.00€JNK-1-IN-2
"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values ofFormula:C16H20BrN5OPurity:98%Color and Shape:SolidMolecular weight:378.27Bentamapimod
CAS:Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Formula:C25H23N5O2SPurity:95.21% - 99.92%Color and Shape:SolidMolecular weight:457.55Ref: TM-T2675
1g2,080.00€2g2,802.00€2mg46.00€5mg66.00€10mg99.00€25mg162.00€50mg197.00€100mg350.00€500mg1,149.00€Ref: TM-T6S1371
1mg52.00€5mg97.00€10mg140.00€25mg274.00€50mg411.00€100mg597.00€500mg1,225.00€1mL*10mM (DMSO)105.00€AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Formula:C20H16N6SPurity:98% - 99.02%Color and Shape:SolidMolecular weight:372.45
