MEK
MEK is a dual-specificity kinase that plays a central role in the MAPK/ERK signaling pathway by activating ERK through phosphorylation. MEK signaling is crucial for regulating cell growth, survival, and differentiation. Aberrant MEK activity has been implicated in various cancers and developmental disorders, making it an important therapeutic target. At CymitQuimica, we provide a variety of MEK inhibitors and modulators to support your research in oncology, cell signaling, and therapeutic development.
Products of "MEK"
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EBI-1051
CAS:EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).Formula:C18H15F2IN2O5Purity:98%Color and Shape:SolidMolecular weight:504.22APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Formula:C23H21N3O3·HClPurity:97.08% - 98.64%Color and Shape:SolidMolecular weight:423.89Ref: TM-T6760
1mg44.00€2mg55.00€5mg71.00€10mg106.00€25mg250.00€50mg401.00€100mg563.00€500mg1,225.00€1mL*10mM (DMSO)71.00€Selumetinib
CAS:Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrClFN4O3Purity:98.1% - 99.46%Color and Shape:White Or Pale White SolidMolecular weight:457.68BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purity:97.13% - 97.54%Color and Shape:SolidMolecular weight:464.56Ref: TM-T6785
1mg49.00€5mg97.00€10mg153.00€25mg296.00€50mg445.00€100mg660.00€200mg917.00€1mL*10mM (DMSO)97.00€GDC-0623
CAS:GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.Formula:C16H14FIN4O3Purity:98.27% - 98.95%Color and Shape:SolidMolecular weight:456.21Ref: TM-T6843
1mg52.00€2mg73.00€5mg119.00€10mg187.00€25mg280.00€50mg369.00€100mg612.00€1mL*10mM (DMSO)119.00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:97.29% - 99.91%Color and Shape:SolidMolecular weight:545.63Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurity:98.35% - 99.95%Color and Shape:Needles From Benzene Or Alcohol SolidMolecular weight:234.34PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purity:100% - 99.66%Color and Shape:Yellow SolidMolecular weight:267.28Ref: TM-T2623
5mg40.00€10mg52.00€25mg82.00€50mg106.00€100mg177.00€200mg264.00€500mg444.00€1mL*10mM (DMSO)58.00€MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Formula:C24H20N4O4Purity:98%Color and Shape:SolidMolecular weight:428.44Refametinib R enantiomer
CAS:Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be usedFormula:C19H20F3IN2O5SPurity:99.43%Color and Shape:SolidMolecular weight:572.34MS934
CAS:MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.Formula:C52H69F3IN7O6SPurity:98%Color and Shape:SolidMolecular weight:1104.11Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.Formula:C16H12O7Purity:92.82% - 99.20%Color and Shape:SolidMolecular weight:316.26Ref: TM-T2836
1mg40.00€5mg82.00€10mg119.00€25mg235.00€50mg393.00€100mg560.00€500mg1,206.00€1mL*10mM (DMSO)86.00€Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurity:98.13% - 98.3%Color and Shape:SolidMolecular weight:471.46Ref: TM-T6971
1mg57.00€2mg82.00€5mg115.00€10mg172.00€25mg329.00€50mg527.00€100mg758.00€1mL*10mM (DMSO)118.00€Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Formula:C26H23FIN5O4Purity:98% - 99.88%Color and Shape:SolidMolecular weight:615.39GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Formula:C23H21ClN2O3Purity:99.73%Color and Shape:SolidMolecular weight:408.87MEK ligand-2
CAS:MEK ligand-2, a ligand for the target protein for PROTAC (Ligand for Target Protein for PROTAC), functions as an inhibitor for both MEK1 and MEK2. This compound plays a crucial role in MS934, which is a VHL-recruiting MEK1/2 PROTAC degrader.Formula:C13H8F3IN2O2Color and Shape:SolidMolecular weight:408.12MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Color and Shape:SolidMolecular weight:649.4Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82U0126-EtOH
CAS:U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).Formula:C18H16N6S2·C2H6OPurity:98.65% - 99.82%Color and Shape:SolidMolecular weight:426.6Luvometinib
CAS:Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.Formula:C26H22F2IN5O4SColor and Shape:SolidMolecular weight:665.45
