Ras
Ras proteins are small GTPases that act as molecular switches in the MAPK signaling pathway, controlling cell growth, differentiation, and survival. Activated Ras initiates a signaling cascade that includes Raf, MEK, and ERK, leading to various cellular responses. Mutations in Ras genes are common in cancers, making Ras an important focus of cancer research. At CymitQuimica, we offer a range of Ras modulators to support your research in cancer biology, signal transduction, and therapeutic development.
Products of "Ras"
Sort by
ARS-1323
CAS:ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Formula:C21H17ClF2N4O2Purity:98.88%Color and Shape:SolidMolecular weight:430.84FTI-277 hydrochloride
CAS:FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.Formula:C22H30ClN3O3S2Purity:97.57% - 97.61%Color and Shape:SolidMolecular weight:484.07Ref: TM-T2700
1mg52.00€2mg73.00€5mg96.00€10mg175.00€25mg320.00€50mg537.00€100mg753.00€1mL*10mM (DMSO)111.00€Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Formula:C14H9F4N5O4SPurity:98.36% - 99.39%Color and Shape:SolidMolecular weight:419.31GGTI298 Trifluoroacetate
CAS:GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Formula:C27H33N3O3S·C2HF3O2Purity:100% - 98.29%Color and Shape:SolidMolecular weight:593.66ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formula:C21H17ClF2N4O2Purity:97.81%Color and Shape:SolidMolecular weight:430.84Ref: TM-T10376
1mg52.00€5mg117.00€10mg170.00€25mg325.00€50mg469.00€100mg615.00€1mL*10mM (DMSO)134.00€SOS2 ligand 1
CAS:SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.Formula:C19H21N5OColor and Shape:SolidMolecular weight:335.403ML141
CAS:ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).Formula:C22H21N3O3SPurity:99.36% - 99.56%Color and Shape:SolidMolecular weight:407.49Ref: TM-T2463
1mg39.00€2mg50.00€5mg72.00€10mg110.00€25mg225.00€50mg406.00€100mg582.00€500mg1,254.00€1mL*10mM (DMSO)74.00€ESI-08
CAS:ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.Formula:C20H23N3OSPurity:99.05%Color and Shape:SolidMolecular weight:353.48NSC 23766 trihydrochloride
CAS:NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.Formula:C24H35N7·3HClPurity:96.48% - 99.54%Color and Shape:SolidMolecular weight:530.96MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formula:C22H18N4Purity:98.07% - 98.74%Color and Shape:SolidMolecular weight:338.41Ref: TM-T16021
1mg37.00€2mg52.00€5mg79.00€10mg111.00€25mg208.00€50mg376.00€100mg567.00€1mL*10mM (DMSO)87.00€SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Formula:C29H34F3N5O2Color and Shape:SolidMolecular weight:541.61Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Formula:C23H24ClN3O3Purity:97.98%Color and Shape:SolidMolecular weight:425.91Ref: TM-T9407
1mg40.00€5mg80.00€10mg116.00€25mg205.00€50mg340.00€100mg485.00€200mg655.00€1mL*10mM (DMSO)88.00€CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFormula:C23H19ClF2N2O3Purity:98.76%Color and Shape:SolidMolecular weight:444.86Ref: TM-T7764
2mg42.00€5mg65.00€10mg99.00€25mg182.00€50mg279.00€100mg414.00€200mg587.00€1mL*10mM (DMSO)70.00€6H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Formula:C20H30ClN3O2S3Purity:98%Color and Shape:SolidMolecular weight:476.12KRAS inhibitor-32
CAS:KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Formula:C29H35FN10OS2Color and Shape:SolidMolecular weight:622.78Adagrasib
CAS:View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Formula:C32H35ClFN7O2Purity:99.10% - 99.9%Color and Shape:SolidMolecular weight:604.12LUNA18
CAS:LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation.Formula:C73H105F5N12O12Purity:98%Color and Shape:SolidMolecular weight:1437.68KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Formula:C33H38ClN7O2Purity:98%Color and Shape:SolidMolecular weight:600.15NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47Atranorin
CAS:Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Formula:C19H18O8Purity:98% - 99.57%Color and Shape:SolidMolecular weight:374.34pan-KRAS degrader 1
CAS:Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.Formula:C22H26N8OSColor and Shape:SolidMolecular weight:450.56BQU57
CAS:BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Formula:C16H13F3N4OPurity:97.45% - 98.72%Color and Shape:SolidMolecular weight:334.3CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formula:C21H17ClF6N2O2Purity:99.58%Color and Shape:SolidMolecular weight:478.82Ref: TM-T22062
5mg38.00€10mg57.00€25mg114.00€50mg188.00€100mg303.00€200mg449.00€1mL*10mM (DMSO)43.00€KRAS inhibitor-31
CAS:KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Formula:C33H30F3N5O4Color and Shape:SolidMolecular weight:617.62CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formula:C23H21ClN2O3Purity:98.82% - 99.35%Color and Shape:SolidMolecular weight:408.88MC 976
CAS:MC 976 is a derivative of Vitamin D3.Formula:C27H42O3Purity:98%Color and Shape:SolidMolecular weight:414.63BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formula:C23H25F3N4O3Purity:99.20% - 99.66%Color and Shape:SolidMolecular weight:462.46Ref: TM-T12979
1mg73.00€5mg160.00€10mg250.00€25mg464.00€50mg663.00€100mg919.00€500mg1,833.00€1mL*10mM (DMSO)170.00€Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formula:C13H11F3N2OSColor and Shape:SolidMolecular weight:300.3Methylophiopogonanone B
CAS:1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.Formula:C19H20O5Purity:99.24%Color and Shape:SolidMolecular weight:328.36ADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formula:C26H24FNO5Purity:97.75%Color and Shape:SoildMolecular weight:449.47Ref: TM-T85316
1mg49.00€5mg92.00€10mg131.00€25mg212.00€50mg373.00€100mg635.00€200mg1,035.00€1mL*10mM (DMSO)110.00€Arglabin
CAS:Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.Formula:C15H18O3Purity:99.62% - 99.62%Color and Shape:SolidMolecular weight:246.3Ref: TM-TQ0165
1mg104.00€5mg240.00€10mg360.00€25mg520.00€50mg692.00€100mg1,035.00€1mL*10mM (DMSO)310.00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Formula:C9H10O2SPurity:99.48%Color and Shape:SolidMolecular weight:182.24Ref: TM-T8870
1mg51.00€5mg153.00€10mg207.00€25mg288.00€50mg404.00€100mg562.00€200mg758.00€1mL*10mM (DMSO)101.00€KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formula:C32H36ClN7O2Purity:98%Color and Shape:SolidMolecular weight:586.13ARS-853
CAS:ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellsFormula:C22H29ClN4O3Purity:96.64% - 97.43%Color and Shape:SolidMolecular weight:432.94Ref: TM-T7414
1mg150.00€5mg373.00€10mg553.00€25mg890.00€50mg1,206.00€100mg1,634.00€500mg3,258.00€1mL*10mM (DMSO)356.00€KRAS inhibitor-35
CAS:KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.Formula:C38H32F4N6O3SColor and Shape:SolidMolecular weight:728.76pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Formula:C33H32F3N5O2Purity:98%Color and Shape:SolidMolecular weight:587.63KRAS G12D inhibitor 26
CAS:KRAS G12D inhibitor 26 serves as a modulator of Kras and specifically targets Kras(G12D) with an IC50 of less than or equal to 100 nM.Formula:C35H44ClFN8O2Color and Shape:SolidMolecular weight:663.228CCG-1423
CAS:CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Formula:C18H13ClF6N2O3Purity:99.80%Color and Shape:SolidMolecular weight:454.75CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Formula:C22H20BrN3O3SPurity:99.66%Color and Shape:SolidMolecular weight:486.38Ref: TM-T8930
2mg35.00€5mg52.00€10mg89.00€25mg167.00€50mg258.00€100mg379.00€200mg540.00€1mL*10mM (DMSO)58.00€HJC0197
CAS:HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Formula:C19H21N3OSPurity:98.05%Color and Shape:SolidMolecular weight:339.45Ref: TM-T15485
2mg38.00€5mg54.00€10mg86.00€25mg135.00€50mg188.00€100mg283.00€200mg426.00€1mL*10mM (DMSO)64.00€KRAS G12C inhibitor 17
CAS:KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.Formula:C24H20ClF2N3O3Purity:98%Color and Shape:SolidMolecular weight:471.88APS6-45
CAS:APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.Formula:C23H16F8N4O3Purity:99.39%Color and Shape:SolidMolecular weight:548.39Ref: TM-T8843
2mg39.00€5mg88.00€10mg127.00€25mg250.00€50mg401.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)97.00€ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Formula:C14H13NO2SPurity:99.48%Color and Shape:SolidMolecular weight:259.32Ref: TM-T22991
1mg48.00€2mg64.00€5mg96.00€10mg153.00€25mg305.00€50mg487.00€100mg710.00€1mL*10mM (DMSO)94.00€KRas G12C inhibitor 2
CAS:KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.Formula:C32H37N7O3Purity:98%Color and Shape:SolidMolecular weight:567.68SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Formula:C24H28N2O9SPurity:95.65%Color and Shape:SolidMolecular weight:520.55pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Formula:C36H34F2N6O3Purity:98%Color and Shape:SolidMolecular weight:636.69KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Formula:C31H38N6O3Purity:98%Color and Shape:SolidMolecular weight:542.67Salirasib
CAS:Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.Formula:C22H30O2SPurity:99.45%Color and Shape:SolidMolecular weight:358.54Ref: TM-T6163
5mg35.00€10mg52.00€25mg96.00€50mg159.00€100mg221.00€200mg364.00€500mg597.00€1mL*10mM (DMSO)59.00€TH-Z827
CAS:TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).Formula:C30H38N6OPurity:98%Color and Shape:SolidMolecular weight:498.66KRAS inhibitor-6
CAS:KRAS inhibitor-6 is a potent KRAS G12C inhibitor.Formula:C27H30ClF2N5O3Purity:98%Color and Shape:SolidMolecular weight:546.01
