Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
Products of "Raf"
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RMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formula:C22H25ClF3N5O3Purity:99.81%Color and Shape:SolidMolecular weight:499.91Ref: TM-T38170
1mg145.00€2mg210.00€5mg354.00€10mg630.00€25mg1,301.00€50mg2,015.00€100mg3,002.00€1mL*10mM (DMSO)378.00€AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formula:C22H19F4N7OPurity:100% - 99.49%Color and Shape:SolidMolecular weight:473.43Ref: TM-T4301
1mg47.00€5mg92.00€10mg145.00€25mg283.00€50mg464.00€100mg680.00€500mg1,406.00€1mL*10mM (DMSO)96.00€Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8Purity:98.05%Color and Shape:SolidMolecular weight:478.94Regorafénib N-oxyde (M2)
CAS:Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.Formula:C21H15ClF4N4O4Purity:98.03% - 99.48%Color and Shape:SolidMolecular weight:498.81Ref: TM-T10157
1mg44.00€2mg56.00€5mg80.00€10mg103.00€25mg180.00€50mg324.00€100mg472.00€1mL*10mM (DMSO)88.00€NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Formula:C22H18F2N4O5SPurity:98.62%Color and Shape:SolidMolecular weight:488.46PLX8394
CAS:Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.Formula:C25H21F3N6O3SPurity:100% - 98.22%Color and Shape:SolidMolecular weight:542.53Ref: TM-T3579
2mg42.00€5mg59.00€10mg99.00€25mg165.00€50mg265.00€100mg472.00€200mg687.00€1mL*10mM (DMSO)72.00€CCT196969
CAS:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Formula:C27H24FN7O3Purity:98.58% - 98.93%Color and Shape:SolidMolecular weight:513.52BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formula:C25H28N4O2SPurity:96.8%Color and Shape:SolidMolecular weight:448.58TAK-580
CAS:TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.Formula:C17H12Cl2F3N7O2SPurity:99.25% - 99.77%Color and Shape:SolidMolecular weight:506.29Ref: TM-T6895
1mg52.00€2mg74.00€5mg103.00€10mg180.00€25mg303.00€50mg445.00€100mg655.00€1mL*10mM (DMSO)116.00€LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formula:C27H19F3N8OPurity:99.03%Color and Shape:SolidMolecular weight:528.49Ref: TM-T15794
1mg66.00€5mg142.00€10mg188.00€25mg346.00€50mg487.00€100mg682.00€1mL*10mM (DMSO)166.00€K-Ras(G12C) Inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Formula:C17H22Cl2N2O3SPurity:89.07% - 97.09%Color and Shape:SolidMolecular weight:405.33Ref: TM-T3725
1mg63.00€2mg88.00€5mg133.00€10mg230.00€25mg477.00€50mg667.00€100mg932.00€1mL*10mM (DMSO)133.00€Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Formula:C24H24F3N5O5S3Purity:99.45% - 99.62%Color and Shape:SolidMolecular weight:615.67Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormula:C21H17ClF4N4O4Purity:99.69%Color and Shape:SolidMolecular weight:500.83Ref: TM-T1792L
5mg35.00€10mg48.00€25mg69.00€50mg88.00€100mg140.00€200mg207.00€500mg348.00€1mL*10mM (DMSO)58.00€K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurity:97.33% - 97.45%Color and Shape:SolidMolecular weight:513.78Ref: TM-T6556
1mg52.00€2mg74.00€5mg123.00€10mg183.00€25mg378.00€50mg547.00€100mg750.00€1mL*10mM (DMSO)183.00€Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurity:98.27%Color and Shape:SolidMolecular weight:547.99Ref: TM-T22436
1mg97.00€2mg135.00€5mg188.00€10mg283.00€25mg462.00€50mg645.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)255.00€Cyclorasin 9A5 TFA
Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.Formula:C75H108FN25O13·xC2HF3O2Color and Shape:SolidMolecular weight:1586.82 (free base)BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurity:97.33% - 99.07%Color and Shape:SolidMolecular weight:569.67MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formula:C28H29F3N6O5SColor and Shape:SolidMolecular weight:618.63KG5
CAS:KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).Formula:C20H16F3N7OSPurity:98.2%Color and Shape:SolidMolecular weight:459.45Ref: TM-T41003
1mg34.00€2mg47.00€5mg74.00€10mg105.00€25mg205.00€50mg313.00€100mg449.00€200mg628.00€1mL*10mM (DMSO)89.00€LSN3074753
CAS:LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound exhibits inhibitory activity against tumor cells driven by either BRAF monomers or RAF dimers, particularly in the activation of the MAPK pathway, including colorectal cancers with BRAF or KRAS mutations. When combined with Cetuximab, LSN3074753 demonstrates additive and synergistic effects in colorectal cancer PDX models, especially in those harboring KRAS or BRAF mutations.Formula:C24H30FN5O2Color and Shape:SolidMolecular weight:439.53
