Membrane Transporter/Ion Channel
Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.
Subcategories of "Membrane Transporter/Ion Channel"
- ABC
- Adiponectin receptor
- ATPase
- Calcium Channel
- CFTR
- CGRP Receptor
- Chloride channel
- GABA Receptor
- Monoamine Transporter
- Monocarboxylate transporter
- Na-K-Cl cotransporter
- NKCC
- NPC1L1
- OAT
- OCT
- P-gp
- Potassium Channel
- Proton pump
- SGLT
- Sodium Channel
- TRP/TRPV Channel
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Products of "Membrane Transporter/Ion Channel"
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(R)-Baclofen hydrochloride
CAS:Arbaclofen HCl, a GABA-B agonist, treats spasticity from spinal injury by reducing excitatory transmission.Formula:C10H13Cl2NO2Purity:98%Color and Shape:SolidMolecular weight:250.12PF 04531083
CAS:PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.Formula:C17H16ClN5O2Purity:99.81%Color and Shape:SolidMolecular weight:357.79D-3263 hydrochloride
CAS:D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.Formula:C21H32ClN3O3Purity:99.85%Color and Shape:SolidMolecular weight:409.95Nicorandil
CAS:Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.Formula:C8H9N3O4Purity:98.14% - 99.44%Color and Shape:White Or Off-White PowderMolecular weight:211.17(R)-Elexacaftor
CAS:(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).Formula:C26H34F3N7O4SPurity:98%Color and Shape:SolidMolecular weight:597.65L-655708
CAS:L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.Formula:C18H19N3O4Purity:98.41%Color and Shape:PowderMolecular weight:341.36Suloctidil
CAS:Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders.Formula:C20H35NOSPurity:99.75% - 99.79%Color and Shape:SolidMolecular weight:337.56U 89843A
CAS:U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.Formula:C16H23N5Purity:99.53%Color and Shape:SolidMolecular weight:285.39PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.Formula:C26H38N6O2Purity:98.48%Color and Shape:SolidMolecular weight:466.62A 425619
CAS:A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonistFormula:C18H14F3N3OPurity:99.35%Color and Shape:SolidMolecular weight:345.32Ref: TM-T8562
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)177.00€V-ATPase-IN-1
CAS:V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.Formula:C21H20ClNO2Color and Shape:SolidMolecular weight:353.84L-DABA hydrobromide
CAS:L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) , GABA transaminase inhibitor with antitumor and anticonvulsant activity.Formula:C4H11BrN2O2Purity:99.11%Color and Shape:SolidMolecular weight:199.05KTX-Sp2
KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3Formula:C155H244N58O49S7Purity:98%Color and Shape:SolidMolecular weight:3928.41Phrixotoxin-1
CAS:Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels, originates from the venom of the theraphosid spider Phrixotrichus auratus [1] [2].Formula:C156H246N44O37S7Purity:98%Color and Shape:SolidMolecular weight:3554.35Nav1.7-IN-18
Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).Formula:C30H33Cl2F2NO4Color and Shape:SolidMolecular weight:580.49Mambalgin-2
Mambalgin-2 (Mamb-2), a venom peptide sourced from the African black mamba, acts as an inhibitor of acid-sensitive ion channels (ASICs).Formula:C272H431N85O83S10Purity:98%Color and Shape:SolidMolecular weight:6540.5Fraxin
CAS:Fraxin (Fraxoside) is a glucoside of fraxetin.Formula:C16H18O10Purity:99.19% - 99.87%Color and Shape:Yellow PowderMolecular weight:370.31Ref: TM-T3783
1mg38.00€5mg79.00€10mg119.00€25mg221.00€50mg313.00€100mg470.00€200mg657.00€1mL*10mM (DMSO)87.00€Daurisoline
CAS:Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.Formula:C37H42N2O6Purity:98% - 99.92%Color and Shape:Light Yellow PowderMolecular weight:610.74TGN-073
CAS:TGN-073 is an enhancer of aquaporin 4 (AQP4), a water channel in astrocytes. It shows an increase in lymphatic transport in the rat brain by up to 41%.Formula:C18H16N2O3SColor and Shape:SolidMolecular weight:340.396GeX-2
CAS:GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.Formula:C103H169N43O27Color and Shape:SolidMolecular weight:2441.72GABAA receptor agent 1
CAS:GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.Formula:C13H8ClN3O2Purity:99.31%Color and Shape:SolidMolecular weight:273.67Ref: TM-T11349
1mg38.00€5mg84.00€10mg117.00€25mg226.00€50mg340.00€100mg495.00€200mg682.00€1mL*10mM (DMSO)90.00€DPI 201-106
CAS:DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.Formula:C29H30N4O2Purity:97.26%Color and Shape:SolidMolecular weight:466.57Dimethindene
CAS:Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.Formula:C20H24N2Purity:99% - 99.44%Color and Shape:SolidMolecular weight:292.42TWIK-1/TREK-1-IN-3
CAS:TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.Formula:C19H27F3N2O2Purity:99.04%Color and Shape:SolidMolecular weight:372.43N-Depropylpropafenone
CAS:N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.Formula:C18H21NO3Color and Shape:SolidMolecular weight:299.36Indenebart
Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.Color and Shape:Odour LiquidArecaidine hydrochloride
CAS:Arecaidine hydrochloride may have carcinogenesis.Formula:C7H12ClNO2Purity:≥95% - ≥98%Color and Shape:SolidMolecular weight:177.63Ref: TM-T5799
2mg35.00€5mg50.00€10mg71.00€25mg105.00€50mg158.00€100mg225.00€200mg334.00€1mL*10mM (DMSO)51.00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formula:C15H9FN2O3Purity:99.16% - 99.84%Color and Shape:SolidMolecular weight:284.24Ref: TM-T1805
5mg38.00€10mg57.00€25mg93.00€50mg124.00€100mg188.00€200mg225.00€500mg379.00€1mL*10mM (DMSO)48.00€Alismol
CAS:Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used forFormula:C15H24OPurity:98%Color and Shape:SolidMolecular weight:220.35Odoroside H
CAS:Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.Formula:C30H46O8Purity:98%Color and Shape:SolidMolecular weight:534.68Methocarbamol
CAS:Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established.Formula:C11H15NO5Purity:99.96%Color and Shape:Crystals From Benzene SolidMolecular weight:241.24Thevetin B
CAS:Thevetin B is a cardiac glycoside and an inhibitor of Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) from Thevetia peruviana.Formula:C42H66O18Purity:98%Color and Shape:SolidMolecular weight:858.96Valbenazine
CAS:Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia.Formula:C24H38N2O4Purity:97.58%Color and Shape:SolidMolecular weight:418.57Ref: TM-T7147
1mg49.00€5mg114.00€10mg178.00€25mg344.00€50mg537.00€100mg785.00€200mg1,035.00€1mL*10mM (DMSO)124.00€Prilocaine
CAS:Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread ofFormula:C13H20N2OPurity:98.49%Color and Shape:Needles SolidMolecular weight:220.31Nerisopam
CAS:Nerisopam is an agonist of gamma-aminobutyric acid (GABA) receptor.Formula:C18H19N3O2Purity:97.27%Color and Shape:SolidMolecular weight:309.36Ref: TM-T28159
1mg93.00€5mg200.00€10mg303.00€25mg490.00€50mg710.00€100mg998.00€200mg1,349.00€1mL*10mM (DMSO)270.00€Wilfordine
CAS:Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.Formula:C43H49NO19Purity:98%Color and Shape:SolidMolecular weight:883.853Imidazenil
CAS:Imidazenil is an modulator of GABA-A that blocks the sedative effects without lowering the convulsion threshold.Formula:C18H12BrFN4OPurity:98.4%Color and Shape:SolidMolecular weight:399.225,2',6'-Trihydroxy-6,7,8-trimethoxyflavone
CAS:5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell.Formula:C18H16O8Purity:98%Color and Shape:SolidMolecular weight:360.31ETD001
CAS:ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.Formula:C41H57F6N9O16Color and Shape:SolidMolecular weight:1045.93µ-Conotoxin BuIIIA
μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA), a toxin derived from Cone snail venom, functions as a voltage-gated sodium channel (VGSC) blocker.Formula:C106H172N44O31S6Purity:98%Color and Shape:SolidMolecular weight:2751.17SKF89976A hydrochloride
CAS:SKF89976A hydrochloride (d,l-SKF89976A hydrochloride) is a selective inhibitor GABA transporter such as GAT-1 (IC50s = 0.28 μM), GAT-2 (IC50s = 137.34 μM) andFormula:C22H26ClNO2Purity:98.72%Color and Shape:SolidMolecular weight:371.9Ref: TM-T12930
1mg35.00€5mg69.00€10mg95.00€25mg178.00€50mg283.00€100mg454.00€200mg650.00€1mL*10mM (DMSO)74.00€Hemitoxin
Hemitoxin, a scorpion-venom peptide, functions as a K+ channel blocker and selectively inhibits rat Kv1.1, Kv1.2, and Kv1.3 channels expressed in XenopusFormula:C159H259N49O49S8Purity:98%Color and Shape:SolidMolecular weight:3897.58C 101248
CAS:C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Formula:C15H12N6OPurity:99.25% - 99.31%Color and Shape:SolidMolecular weight:292.34-Acetamidobutanoic acid
CAS:4-Acetamidobutanoic acid, a GABA derivative in eukaryotes, found in blood, feces, urine, and human prostate.Formula:C6H11NO3Purity:99.79%Color and Shape:SolidMolecular weight:145.16Co 102862
CAS:Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.Formula:C14H12FN3O2Purity:99.54%Color and Shape:SolidMolecular weight:273.26Zilvetrigine
CAS:Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.Formula:C20H20ClN3O2Color and Shape:SolidMolecular weight:369.845HC-070
CAS:HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Formula:C22H20Cl2N4O4Purity:97.06%Color and Shape:SolidMolecular weight:475.32Ref: TM-T15465
1mg88.00€5mg170.00€10mg259.00€25mg429.00€50mg605.00€100mg815.00€200mg1,093.00€1mL*10mM (DMSO)168.00€(S)-PF-03716556
CAS:(S)-PF-03716556 can be used as an acid pump inhibitor for the treatment of disease conditions mediated by acid pump inhibitory activity.Formula:C22H26N4O3Purity:99.49% - 99.66%Color and Shape:SoildMolecular weight:394.47ABCG2-IN-1
CAS:ABCG2-IN-1 (compound K2), an analog of Ko143, constitutes an orally active inhibitor targeting ABCG2 with an inhibitory concentration (IC50) of 0.13 μM.Formula:C26H36N4O4Purity:98%Color and Shape:SolidMolecular weight:468.59U-89843A
CAS:U-89843A is an allosteric modulator of the GABA_A receptor, known to enhance GABA-induced Cl^- currents [1].Formula:C16H24ClN5Purity:98%Color and Shape:SolidMolecular weight:321.85(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purity:95.26%Color and Shape:SolidMolecular weight:304.38Ref: TM-T11137
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€200mg1,454.00€1mL*10mM (DMSO)246.00€Cyproflanilide
CAS:Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.Formula:C28H17BrF12N2O2Color and Shape:SolidMolecular weight:721.33A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectivelyFormula:C12H14FNOPurity:98.34% - 99.75%Color and Shape:SolidMolecular weight:207.24BDS-I
CAS:BDS-I, a marine toxin derived from Anemonia sulcata, functions as a selective inhibitor of the potassium channel, specifically targeting Kv3.4.Formula:C210H297N57O56S6Purity:98%Color and Shape:SolidMolecular weight:4708.34GluN2A Allosteric modulator 1
GluN2A Allosteric modulator 1 (Compound 11) is an orally bioavailable compound that effectively crosses the blood-brain barrier and functions as a highly selective negative allosteric modulator of GluN2A. It exhibits an IC50 of 0.042 μM for GluN2A and 13 μM for GluN2B. This compound is useful for research in neurological disorders.Formula:C20H16ClF2N5O2Molecular weight:431.823DS-1971a
CAS:DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.Formula:C20H21ClFN5O3SPurity:99.66%Color and Shape:SolidMolecular weight:465.93KCC2 Modulator-2
CAS:KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.Formula:C35H45N5O3Color and Shape:SolidMolecular weight:583.76BTS
CAS:BTS (N-Tosylbenzylamine) is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) .Formula:C14H15NO2SPurity:99.45%Color and Shape:White Crystalline SolidMolecular weight:261.34Minoxidil
CAS:Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.Formula:C9H15N5OPurity:99.89% - 99.97%Color and Shape:Crystals From Methanol-Acetonitrile SolidMolecular weight:209.25Tetraethylammonium chloride
CAS:Tetraethylammonium chloride is a quaternary ammonium compound.Formula:C8H20ClNPurity:≥95%Color and Shape:White Solid Solid Particulate/PowderMolecular weight:165.7Azosemide
CAS:Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B).Formula:C12H11ClN6O2S2Purity:99.84%Color and Shape:SolidMolecular weight:370.84KV1.3-IN-1
KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in Ltk cells and 26.12 nM in PHA-activated T-lymphocytes,Formula:C23H30N2O4SPurity:98%Color and Shape:SolidMolecular weight:430.56Cesium chloride
CAS:Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.Formula:ClCsPurity:98%Color and Shape:White Solid CrystallineMolecular weight:168.36Ononetin
CAS:Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).Formula:C15H14O4Purity:98.15%Color and Shape:SolidMolecular weight:258.276-(4-Methoxyphenyl)-3-pyridazinamine
CAS:6-(4-Methoxyphenyl)-3-pyridazinamine is a GABAA receptor antagonistFormula:C11H11N3OPurity:99.03%Color and Shape:SolidMolecular weight:201.22GSK2193874
CAS:GSK2193874 was identified as a selective, orally active TRPV4 blocker.Formula:C37H38BrF3N4OPurity:98.79% - ≥95%Color and Shape:SolidMolecular weight:691.62Ref: TM-T5640
1mg43.00€2mg57.00€5mg81.00€10mg127.00€25mg246.00€50mg404.00€100mg602.00€1mL*10mM (DMSO)111.00€IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Formula:C22H15Br2N3O4Purity:100% - ≥95%Color and Shape:SolidMolecular weight:545.18
