CFTR
CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.
Products of "CFTR"
Sort by
UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂,可用于研究囊性纤维化。Formula:C14H8ClF3N2OPurity:100%Color and Shape:SolidMolecular weight:312.67CFTR corrector 16
CAS:CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.Formula:C27H26ClN5O2SColor and Shape:SolidMolecular weight:520.05Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Formula:C24H18F2N2O5Purity:99.48% - 99.68%Color and Shape:SolidMolecular weight:452.41PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Formula:C28H29N3O2Purity:99.87%Color and Shape:SolidMolecular weight:439.55Ref: TM-T16516
1mg84.00€5mg215.00€10mg324.00€25mg520.00€50mg702.00€100mg950.00€200mg1,283.00€1mL*10mM (DMSO)210.00€Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Formula:C18H18N4O4Purity:98.64%Color and Shape:SolidMolecular weight:354.36Ref: TM-T16681
1mg96.00€5mg215.00€10mg378.00€25mg650.00€50mg927.00€100mg1,254.00€1mL*10mM (DMSO)236.00€Crinecerfont tosylate
CAS:Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).Formula:C34H36ClFN2O4S2Color and Shape:SolidMolecular weight:655.242CFTR corrector 8
CAS:CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.Formula:C29H27F2NO7Purity:99.58%Color and Shape:SolidMolecular weight:539.52Ref: TM-T63806
1mg52.00€5mg105.00€10mg164.00€25mg320.00€50mg504.00€100mg827.00€200mg1,111.00€1mL*10mM (DMSO)137.00€ARN23765
CAS:ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).Formula:C30H22F5N3O6Color and Shape:SolidMolecular weight:615.504WAY-326766
CAS:WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).Formula:C21H23N3O5Purity:98.76%Color and Shape:SolidMolecular weight:397.42Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formula:C24H28N2O3Purity:99% - 99.98%Color and Shape:SolidMolecular weight:392.49Ref: TM-T2588
1mg38.00€5mg81.00€10mg127.00€25mg205.00€50mg304.00€100mg455.00€500mg998.00€1mL*10mM (DMSO)88.00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Formula:C26H27F3N2O6Purity:100% - 99.69%Color and Shape:SolidMolecular weight:520.5Ref: TM-T2263
1mg40.00€2mg52.00€5mg82.00€10mg123.00€25mg212.00€50mg343.00€100mg505.00€1mL*10mM (DMSO)88.00€CFTR activator 2
CAS:CFTRactivator 2 (WAY-326769) acts as an activator for the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR).Formula:C27H27N3O3Color and Shape:SolidMolecular weight:441.52KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFormula:C19H17Cl2N3O2SPurity:98.86%Color and Shape:SolidMolecular weight:422.33CFTR corrector 4
CAS:Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.Formula:C29H27F2NO7Purity:98.43%Color and Shape:SolidMolecular weight:539.52Ref: TM-T10776
1mg74.00€5mg170.00€10mg264.00€25mg535.00€50mg753.00€100mg1,074.00€500mg2,147.00€1mL*10mM (DMSO)202.00€CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formula:C27H23FN4O4Purity:99.66%Color and Shape:SolidMolecular weight:486.49Ref: TM-T5312
2mg39.00€5mg58.00€10mg85.00€25mg156.00€50mg226.00€100mg335.00€200mg469.00€1mL*10mM (DMSO)63.00€SRI-37240
CAS:SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Formula:C24H23N3O2Purity:98.73%Color and Shape:SolidMolecular weight:385.46Crofelemer
CAS:Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Color and Shape:SolidSRI-41315
CAS:SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.Formula:C22H19N3O2Purity:99.87%Color and Shape:SolidMolecular weight:357.41PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Formula:C26H22N4O3Purity:99.17% - ≥95%Color and Shape:SolidMolecular weight:438.48Ref: TM-T1874
1mg40.00€2mg51.00€5mg85.00€10mg135.00€25mg269.00€50mg520.00€100mg745.00€1mL*10mM (DMSO)93.00€DNDS
CAS:DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Formula:C14H8N2Na2O10S2Purity:99.88%Color and Shape:Physical Description White Powder (Ntp 1992)Molecular weight:474.33
