TRP/TRPV Channel
TRP (Transient Receptor Potential) channels, including the TRPV subfamily, are a group of ion channels involved in various sensory processes, such as temperature sensation, pain perception, and osmoregulation. TRP channels are widely expressed in different tissues and play a role in physiological responses to environmental stimuli. The TRPV channels, in particular, are involved in detecting temperature changes and are implicated in conditions such as chronic pain, inflammation, and cancer. At CymitQuimica, we offer a comprehensive range of TRP/TRPV channel modulators to support your research in sensory biology, pain management, and signal transduction.
Products of "TRP/TRPV Channel"
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ML204
CAS:ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.Formula:C15H18N2Purity:98.1% - 99.72%Color and Shape:SolidMolecular weight:226.32Ref: TM-T2298
2mg35.00€5mg50.00€10mg74.00€25mg111.00€50mg145.00€100mg220.00€200mg284.00€500mg467.00€1mL*10mM (DMSO)52.00€ASP7663
CAS:ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.Formula:C14H14FNO3Purity:98.61%Color and Shape:SolidMolecular weight:263.26GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Formula:C20H15F4N3O5SPurity:98%Color and Shape:SolidMolecular weight:485.41Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Formula:C18H16ClF3N2OSPurity:98.90%Color and Shape:SolidMolecular weight:400.85Apcin A HCL
CAS:Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].Formula:C10H15Cl4N5O2Purity:99.30%Color and Shape:SolidMolecular weight:379.07Ref: TM-T001
1mgTo inquire2mg63.00€5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire200mgTo inquire500mg2,792.00€Vanilloid receptor antagonist 1
CAS:Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.Formula:C18H15N3O2Purity:98.14%Color and Shape:SolidMolecular weight:305.33Ref: TM-T9247
1mg99.00€5mg235.00€10mg354.00€25mg602.00€50mg847.00€100mg1,206.00€1mL*10mM (DMSO)47.00€TRPA1-IN-2
CAS:TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.Formula:C24H25F3N4OPurity:98.05%Color and Shape:SoildMolecular weight:442.48Ref: TM-T77511
1mg85.00€5mg187.00€10mg284.00€25mg482.00€50mg672.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)207.00€FEMA-4809
CAS:FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Formula:C17H17N3O2SPurity:99.19%Color and Shape:SolidMolecular weight:327.4Ref: TM-T27308
1mg35.00€5mg78.00€10mg116.00€25mg190.00€50mg269.00€100mg383.00€200mg525.00€1mL*10mM (DMSO)88.00€TC-I 2014
CAS:TC-I 2014 shows antiallodynic properties in pain models.Formula:C23H19F6N3OPurity:98.75%Color and Shape:SolidMolecular weight:467.41Ref: TM-T17006
1mg60.00€5mg127.00€10mg202.00€25mg406.00€50mg655.00€100mg1,074.00€200mg1,454.00€1mL*10mM (DMSO)133.00€AMG9810
CAS:AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.Formula:C21H23NO3Purity:99.79% - 99.83%Color and Shape:SolidMolecular weight:337.41JYL 1421
CAS:JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).Formula:C20H26FN3O2S2Purity:98.83%Color and Shape:SolidMolecular weight:423.57Ref: TM-T15634
1mg70.00€5mg187.00€10mg305.00€25mg612.00€50mg938.00€100mg1,491.00€200mg1,985.00€1mL*10mM (DMSO)173.00€RN-1747
CAS:RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).Formula:C17H18ClN3O4SPurity:99.29%Color and Shape:SolidMolecular weight:395.86Ref: TM-T16763
5mg44.00€10mg74.00€25mg126.00€50mg188.00€100mg316.00€200mg452.00€1mL*10mM (DMSO)47.00€HC067047 Hydrochloride(883031-03-6 free base)
CAS:HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.Formula:C26H29ClF3N3O2Purity:99.95%Color and Shape:SolidMolecular weight:507.98Ref: TM-T4680L
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)217.00€RN9893
CAS:RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.Formula:C21H23F3N4O5SPurity:99.89%Color and Shape:SolidMolecular weight:500.49D-3263 hydrochloride
CAS:D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.Formula:C21H32ClN3O3Purity:99.85%Color and Shape:SolidMolecular weight:409.95PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.Formula:C26H38N6O2Purity:98.48%Color and Shape:SolidMolecular weight:466.62A 425619
CAS:A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonistFormula:C18H14F3N3OPurity:99.35%Color and Shape:SolidMolecular weight:345.32Ref: TM-T8562
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)177.00€HC-070
CAS:HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Formula:C22H20Cl2N4O4Purity:97.06%Color and Shape:SolidMolecular weight:475.32Ref: TM-T15465
1mg88.00€5mg170.00€10mg259.00€25mg429.00€50mg605.00€100mg815.00€200mg1,093.00€1mL*10mM (DMSO)168.00€A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectivelyFormula:C12H14FNOPurity:98.34% - 99.75%Color and Shape:SolidMolecular weight:207.24Ononetin
CAS:Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).Formula:C15H14O4Purity:98.15%Color and Shape:SolidMolecular weight:258.27
