Potassium Channel
Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.
Products of "Potassium Channel"
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Glipizide
CAS:Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.Formula:C21H27N5O4SPurity:99.67% - 99.75%Color and Shape:SolidMolecular weight:445.54VU0071063
CAS:VU0071063 is a Kir6.2/SUR1 activator.Formula:C18H22N4O2Purity:99.33%Color and Shape:SolidMolecular weight:326.39Glibornuride
CAS:Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).Formula:C18H26N2O4SPurity:98.51%Color and Shape:SolidMolecular weight:366.48Ref: TM-T15385
1mg74.00€5mg160.00€10mg250.00€25mg432.00€50mg612.00€100mg848.00€1mL*10mM (DMSO)170.00€LY 303511
CAS:LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.Formula:C19H18N2O2Purity:98%Color and Shape:SolidMolecular weight:306.36Tetrandrine
CAS:Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.Formula:C38H42N2O6Purity:98.88% - 99.72%Color and Shape:White SolidMolecular weight:622.75Neosolaniol
CAS:Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.Formula:C19H26O8Purity:98%Color and Shape:SolidMolecular weight:382.4A2793
CAS:A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM.Formula:C13H12ClNO3Purity:98.54%Color and Shape:SolidMolecular weight:265.69Ref: TM-T7774
2mg42.00€5mg65.00€10mg93.00€25mg178.00€50mg284.00€100mg411.00€200mg585.00€1mL*10mM (DMSO)99.00€Terfenadine
CAS:Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.Formula:C32H41NO2Purity:98.76% - 99.75%Color and Shape:SolidMolecular weight:471.67CyPPA
CAS:CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.Formula:C16H23N5Purity:99.72%Color and Shape:SolidMolecular weight:285.39Ref: TM-T20968
2mg44.00€5mg65.00€10mg92.00€25mg170.00€50mg281.00€100mg465.00€500mg1,026.00€1mL*10mM (DMSO)70.00€Quinidine hydrochloride monohydrate
CAS:Quinidine hydrochloride monohydrate is an optical isomer of quinine. Quinidine prolongs cellular action potential and decreases automaticity.Formula:C20H27ClN2O3Purity:94.4% - 94.72%Color and Shape:SolidMolecular weight:378.89CTP-amiodarone
CTP-amiodarone, a cellular-penetrating conjugate of myocardial cell-targeting peptide and Amiodarone, exhibits anti-arrhythmic activity by blocking Na+, K+, and Ca2+ channels as well as β-adrenergic receptors.Formula:C97H131F3I2N20O25S2Color and Shape:SolidMolecular weight:2352.13Clofilium tosylate
CAS:Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.Formula:C28H44ClNO3SPurity:99.68%Color and Shape:SolidMolecular weight:510.172,2,2-Trichloroethanol
CAS:2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.Formula:C2H3Cl3OPurity:97.56%Color and Shape:LiquidMolecular weight:149.4Dequalinium chloride
CAS:Dequalinium chloride: topical bacteriostat, blocks apamin-sensitive K+ channels, used for wounds, oral infections, potential antifungal, risk of skin ulcers.Formula:C30H40Cl2N4Purity:99.58% - 99.79%Color and Shape:SolidMolecular weight:527.59Hydrochlorothiazide
CAS:Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药,可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能,减少纤维化并具有降压作用。Formula:C7H8ClN3O4S2Purity:99.43% - 99.50%Color and Shape:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Molecular weight:297.74DPO-1
CAS:DPO-1 可以高效抑制电压门控钾离子通道Kv1.5,也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。Formula:C22H29OPPurity:97.52%Color and Shape:SolidMolecular weight:340.44Senicapoc
CAS:Senicapoc (ICA-17043) blocks Gardos channel, reduces RBC dehydration, IC50: 11 nM for rubidium flux, 30 nM for dehydration. Used in Sickle Cell therapy.Formula:C20H15F2NOPurity:95.7% - 99.47%Color and Shape:SolidMolecular weight:323.34SCH-23390 maleate
CAS:SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM,Formula:C21H22ClNO5Purity:98%Color and Shape:SolidMolecular weight:403.86SCH-23390 hydrochloride
CAS:SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).Formula:C17H19Cl2NOPurity:98% - 99.51%Color and Shape:SolidMolecular weight:324.24Ref: TM-T4369
1mg39.00€2mg50.00€5mg78.00€10mg97.00€25mg195.00€50mg369.00€100mg550.00€1mL*10mM (DMSO)78.00€Cloperastine hydrochloride
CAS:Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.Formula:C20H25Cl2NOPurity:97.74% - 99.82%Color and Shape:SolidMolecular weight:366.33AVE1231
CAS:AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.Formula:C20H27N3O4SPurity:98.03%Color and Shape:SolidMolecular weight:405.51Amiodarone
CAS:Amiodarone (Cordarone) is an antiarrhythmic compound that induces pulmonary toxicity and inhibits ATP-sensitive potassium channels.Formula:C25H29I2NO3Purity:98.09%Color and Shape:Crystalline Powder; Crystals From Acetone SolidMolecular weight:645.31ML335
CAS:ML335 is a selective activator of TREK-1 and TREK-2.Formula:C15H14Cl2N2O3SPurity:99.73% - 99.79%Color and Shape:SolidMolecular weight:373.25Ref: TM-T4224
2mg43.00€5mg63.00€10mg95.00€25mg187.00€50mg283.00€100mg424.00€200mg612.00€1mL*10mM (DMSO)63.00€Nifekalant hydrochloride
CAS:Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM.Formula:C19H28ClN5O5Purity:99.58%Color and Shape:SolidMolecular weight:441.91Tetraethylammonium bromide
CAS:Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.Formula:C8H20BrNPurity:98%Color and Shape:White SolidMolecular weight:210.16Guanosine 5'-diphosphate disodium salt
CAS:5'-GDP-Na2: a nucleoside diphosphate, iron mobilizer, blocks hepcidin-ferroportin, affects IL-6/stat-3.Formula:C10H13N5Na2O11P2Purity:99.40%Color and Shape:White PowderMolecular weight:487.16Dofetilide
CAS:Dofetilide (UK 68789), a class III antiarrhythmic sulfonamide, blocks Ikr cardiac channels, prolongs action potential, and treats atrial fibrillation/flutter.Formula:C19H27N3O5S2Purity:97.85% - 99.06%Color and Shape:Off-White Or Yellowish Crystalline PowderMolecular weight:441.56Ref: TM-T6476
5mg55.00€10mg69.00€25mg117.00€50mg177.00€100mg250.00€200mg480.00€500mg782.00€1mL*10mM (DMSO)55.00€Kv7.2/Kv7.3 activator-1
CAS:Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.Formula:C19H22F2N4OColor and Shape:SolidMolecular weight:360.40UK 78282 hydrochloride
CAS:UK-78282 hydrochloride, a Kv1.3 blocker.UK-78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.Formula:C29H36ClNO2Purity:99.68%Color and Shape:SolidMolecular weight:466.05Sematilide hydrochloride
CAS:Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.Formula:C14H24ClN3O3SPurity:99.14%Color and Shape:SolidMolecular weight:349.87Rabeprazole
CAS:Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells and can be used in the study of gastric ulcers.Formula:C18H21N3O3SPurity:97.06%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:359.44TWIK-1/TREK-1-IN-1
CAS:Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers andFormula:C21H24F3NO3Purity:98%Color and Shape:SolidMolecular weight:395.42PD-118057
CAS:PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.Formula:C21H17Cl2NO2Purity:98.97% - 99.16%Color and Shape:SolidMolecular weight:386.27Ref: TM-T16444
1mg96.00€5mg202.00€10mg311.00€25mg597.00€50mg948.00€100mg1,510.00€1mL*10mM (DMSO)224.00€Mitiglinide Calcium
CAS:Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-Formula:(C19H24NO3)2·CaPurity:99.83%Color and Shape:White Crystal PosderMolecular weight:668.88Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Formula:C2HBrClF3Purity:100% - 98.50%Color and Shape:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustibleMolecular weight:197.38Amiodarone hydrochloride
CAS:Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.Formula:C25H29I2NO3·HClPurity:99.49% - ≥95%Color and Shape:White To Cream Crystalline PowderMolecular weight:681.78Meclofenamic acid
CAS:Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.Formula:C14H11Cl2NO2Purity:98%Color and Shape:SolidMolecular weight:296.15RY796
CAS:RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.Formula:C21H27N3O2Purity:98.59%Color and Shape:SolidMolecular weight:353.46Keto Ziprasidone
CAS:Ziprasidone, an antipsychotic agent, functions as a dual antagonist of 5-HT (serotonin) and dopamine receptors.Formula:C21H19ClN4O2SPurity:98%Color and Shape:SolidMolecular weight:426.92ICA-069673
CAS:ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).Formula:C11H6ClF2N3OPurity:99.04% - 99.66%Color and Shape:SolidMolecular weight:269.63O-Nornuciferine
CAS:O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.Formula:C18H19NO2Purity:99.86%Color and Shape:SolidMolecular weight:281.35Sulcardine sulfate
CAS:Sulcardine sulfate (B-87823) is a multi-ion channel blocker with antiarrhythmic activity that inhibits Na+, K+, and Ca2+ channels.Formula:C24H35N3O8S2Purity:98.74%Color and Shape:SolidMolecular weight:557.68Repaglinide
CAS:Repaglinide, a benzoic acid derivative, stimulates insulin, treats type 2 diabetes, and may rarely cause acute liver injury.Formula:C27H36N2O4Purity:99.6% - 99.80%Color and Shape:White To Off-White SolidMolecular weight:452.59BMS-919373
CAS:BMS-919373 is a potassium channel Kv1.5 (KCNA5) inhibitor for atrial fibrillation and acute coronary syndrome.Formula:C25H20N6O2SPurity:98.51%Color and Shape:SolidMolecular weight:468.53Ref: TM-T30544
1mg246.00€5mg603.00€10mg848.00€25mg1,254.00€50mg1,691.00€100mg2,270.00€1mL*10mM (DMSO)657.00€UK 66914
CAS:UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.Formula:C18H24N4O3SPurity:99.86%Color and Shape:SolidMolecular weight:376.47PAP-1
CAS:PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).Formula:C21H18O5Purity:99.35% - 99.68%Color and Shape:White SolidMolecular weight:350.36Ref: TM-TQ0179
2mg63.00€5mg88.00€10mg136.00€25mg291.00€50mg520.00€100mg550.00€200mg785.00€1mL*10mM (DMSO)90.00€BL-1249
CAS:BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).Formula:C17H17N5Purity:98% - 98.25%Color and Shape:SolidMolecular weight:291.35Ref: TM-T14666
1mg52.00€5mg111.00€10mg170.00€25mg259.00€50mg354.00€100mg620.00€500mg1,283.00€1mL*10mM (DMSO)155.00€GW9508
CAS:GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.Formula:C22H21NO3Purity:97.89% - 99.19%Color and Shape:SolidMolecular weight:347.41A2764 dihydrochloride
CAS:A2764 dihydrochloride is a highly selective inhibitor of TRESK.Formula:C15H21Cl3N2OPurity:99.05%Color and Shape:SolidMolecular weight:351.7Tolbutamide
CAS:Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.Formula:C12H18N2O3SPurity:99.80% - 99.93%Color and Shape:White Crystalline PowderMolecular weight:270.351-EBIO
CAS:1-EBIO (1-EBIO) is a calium channel agonist.Formula:C9H10N2OPurity:99.79%Color and Shape:SolidMolecular weight:162.19Linopirdine
CAS:Linopirdine (DuP 996) is a TRPV1 agonist.Formula:C26H21N3OPurity:99.45% - 99.78%Color and Shape:SolidMolecular weight:391.46Ref: TM-T15758
1mg43.00€2mg56.00€5mg88.00€10mg126.00€25mg227.00€50mg393.00€100mg560.00€200mg810.00€500mg1,206.00€1mL*10mM (DMSO)87.00€Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurity:98.59%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:393.46Amifampridine
CAS:Amifampridine blocks nerve potassium channels, extends action potentials, boosts acetylcholine release, and treats rare muscle diseases.Formula:C5H7N3Purity:99.82%Color and Shape:Slightly Beige PowderMolecular weight:109.13Hydroquinidine
CAS:Hydroquinidine ((+)-Hydroquinidine) is an organic compound, used as an antiarrhythmic agent.Formula:C20H26N2O2Purity:98.61% - 99.68%Color and Shape:SolidMolecular weight:326.43Clobutinol hydrochloride
CAS:Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].Formula:C14H23Cl2NOPurity:98%Color and Shape:SolidMolecular weight:292.25Gut restricted-7
CAS:Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor.Formula:C25H40FNaO6SPurity:98.81% - 99.27%Color and Shape:SolidMolecular weight:510.64Quinine hydrochloride dihydrate
CAS:Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.Formula:C20H24N2O2·HCl·2H2OPurity:99.04%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:396.91TWIK-1/TREK-1-IN-2
CAS:TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 valuesFormula:C20H29F3N2O2Purity:98%Color and Shape:SolidMolecular weight:386.45Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurity:99% - 99.74%Color and Shape:Off-White To Yellow SolidMolecular weight:414.77Mefloquine
CAS:Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.Formula:C17H16F6N2OPurity:99.97%Color and Shape:SolidMolecular weight:378.31Ref: TM-T0860L
1mg70.00€5mg154.00€10mg225.00€25mg376.00€50mg538.00€100mg755.00€200mg1,017.00€1mL*10mM (DMSO)160.00€RU-TRAAK-2
CAS:RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.Formula:C19H17N3OSPurity:99.68%Color and Shape:SolidMolecular weight:335.42Ref: TM-T60061
1mg81.00€5mg170.00€10mg264.00€25mg454.00€50mg620.00€100mg873.00€200mg1,169.00€1mL*10mM (DMSO)180.00€Nigericin sodium salt
CAS:Nigericin sodium salt, an antibiotic and NLRP3 activator from S. hygroscopicus, inhibits Golgi and gram-positive bacteria, blocking viral activation.Formula:C40H67NaO11Purity:98.2% - 99.52%Color and Shape:SolidMolecular weight:746.94AM-92016 hydrochloride
CAS:AM-92016 is a specific blocker of rectifier potassium current.Formula:C19H24Cl2N2O4S·HClPurity:98.68%Color and Shape:SolidMolecular weight:483.84Ref: TM-T5585
2mg35.00€5mg52.00€10mg96.00€25mg164.00€50mg279.00€100mg399.00€200mg567.00€1mL*10mM (DMSO)58.00€Celivarone
CAS:Celivarone is a potassium channel blocker used in the study of arrhythmias, atrial flutter and atrial fibrillation.Formula:C34H47NO4Purity:99.03%Color and Shape:SolidMolecular weight:533.74Azimilide Dihydrochloride
CAS:Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the IKs and IKr with antiarrhythmic activity.Formula:C23H30Cl3N5O3Purity:97.59% - ≥95%Color and Shape:SolidMolecular weight:530.88Hydroxyhexamide
CAS:Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.Formula:C15H22N2O4SPurity:98.91%Color and Shape:SolidMolecular weight:326.41ML365
CAS:ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).Formula:C22H20N2O3Purity:98.78%Color and Shape:SolidMolecular weight:360.41cis-KV1.3-IN-1
CAS:cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Formula:C23H30N2O4SColor and Shape:SolidMolecular weight:430.56Allocryptopine
CAS:Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.Formula:C21H23NO5Purity:99.23% - ≥95%Color and Shape:SolidMolecular weight:369.41ADWX 1 TFA
ADWX 1 TFA is a novel peptide that potently targets and inhibits the Kv1.3 channel, with an IC50 of 1.89 pM. It specifically suppresses the activity of the Kv1.3 channel, in addition to inhibiting initial calcium signaling and NF-κB activation. This compound has been shown to ameliorate symptoms in rats with experimental autoimmune encephalomyelitis (EAE). ADWX 1 TFA is utilized in research focused on T-cell-mediated autoimmune diseases.Formula:C169H281N57O46S7·xC2HF3O2Color and Shape:SolidMolecular weight:4071.85 (free base)Vernakalant
CAS:Vernakalant (RSD-1235) is a mixed ion channel blocker.Formula:C20H31NO4Purity:98%Color and Shape:SolidMolecular weight:349.46
