Potassium Channel
Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.
Products of "Potassium Channel"
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NS6180
CAS:NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.Formula:C16H12F3NOSPurity:99.83% - ≥95%Color and Shape:SolidMolecular weight:323.33Ref: TM-T1752
1mg35.00€2mg49.00€5mg70.00€10mg106.00€25mg225.00€50mg365.00€100mg545.00€1mL*10mM (DMSO)70.00€ML133 hydrochloride
CAS:ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1, has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.Formula:C19H19NO·HClPurity:99.48%Color and Shape:SolidMolecular weight:313.82Ref: TM-T6592
5mg50.00€10mg66.00€25mg106.00€50mg170.00€100mg274.00€200mg354.00€500mg597.00€1mL*10mM (DMSO)52.00€Quinine dihydrochloride
CAS:Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae).Formula:C20H26Cl2N2O2Purity:99.45% - 99.97%Color and Shape:White SolidMolecular weight:397.34Linaprazan
CAS:Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.Formula:C21H26N4O2Purity:99.63%Color and Shape:SolidMolecular weight:366.46Dendrotoxin K TFA
Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].Formula:C294H462N84O75S6·XC2HF3OC2Purity:98%Color and Shape:SolidMolecular weight:6559.66 (free base)Dronedarone hydrochloride
CAS:Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5S·HClPurity:99.61%Color and Shape:SolidMolecular weight:593.22Ref: TM-T1073
5mg38.00€10mg52.00€25mg87.00€50mg117.00€100mg170.00€200mg250.00€500mg424.00€1mL*10mM (DMSO)55.00€Dimethindene
CAS:Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.Formula:C20H24N2Purity:99% - 99.44%Color and Shape:SolidMolecular weight:292.42C 101248
CAS:C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Formula:C15H12N6OPurity:99.25% - 99.31%Color and Shape:SolidMolecular weight:292.3Flupirtine maleate
CAS:Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. Flupirtine is an NMDA receptor antagonist.Formula:C15H17FN4O2·C4H4O4Purity:99.50% - 99.9%Color and Shape:Off-White Crystalline PowderMolecular weight:420.39Reserpine hydrochloride
CAS:Reserpine hydrochloride inhibits the uptake of norepinephrine, depletion of catecholamines and serotonin in axon terminals, antihypertensive and antipsychotic.Formula:C33H41ClN2O9Purity:99.96%Color and Shape:SolidMolecular weight:645.14KS176
CAS:KS176: selective BCRP inhibitor, potent against breast cancer drug resistance; ineffective on P-gp, MRP1.Formula:C22H19N3O5Purity:99.55% - 99.78%Color and Shape:SolidMolecular weight:405.4Ref: TM-T3581
2mg34.00€5mg51.00€10mg86.00€25mg167.00€50mg305.00€100mg439.00€200mg615.00€1mL*10mM (DMSO)51.00€ML213
CAS:ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM,Formula:C17H23NOPurity:99.74%Color and Shape:SolidMolecular weight:257.37Cesium chloride
CAS:Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.Formula:ClCsPurity:98%Color and Shape:White Solid CrystallineMolecular weight:168.36Doxapram
CAS:Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels.Formula:C24H30N2O2Purity:99.42%Color and Shape:SolidMolecular weight:378.51Quinidine
CAS:Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.Formula:C20H24N2O2Purity:97.03% - 99.99%Color and Shape:Crystals With 2 5 Mol Water Of Crystallization; Crystals From Dilute Alcohol Physical Description Crystals Or White Powder (Ntp 1992)Molecular weight:324.42Iptakalim Hydrochloride
CAS:Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholineFormula:C9H22ClNPurity:95%Color and Shape:SolidMolecular weight:179.731Nateglinide
CAS:Nateglinide is an oral drug for type 2 diabetes, stimulating insulin release; may cause rare acute liver injury.Formula:C19H27NO3Purity:99.93% - 99.94%Color and Shape:White Crystalline PowderMolecular weight:317.42Paederosidic acid methyl ester
CAS:Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.Formula:C19H26O12SPurity:99.67% - 99.91%Color and Shape:SolidMolecular weight:478.47Gliquidone
CAS:Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity.Formula:C27H33N3O6SPurity:98.92% - 99.93%Color and Shape:SolidMolecular weight:527.63VU0134992
CAS:VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μMFormula:C20H31BrN2O2Purity:99.86%Color and Shape:SolidMolecular weight:411.38Ref: TM-T8372
1mg74.00€5mg138.00€10mg202.00€25mg340.00€50mg484.00€100mg667.00€200mg899.00€1mL*10mM (DMSO)164.00€ML 297
CAS:ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively).Formula:C17H14F2N4OPurity:97.85%Color and Shape:SolidMolecular weight:328.32TASK-1-IN-1
CAS:TASK-1-IN-1: Potent, selective TASK-1 blocker (IC50: 148 nM), weaker on TASK-3 (IC50: 1750 nM), anticancer properties.Formula:C22H20N2O2Purity:100%Color and Shape:SoildMolecular weight:344.41APD668
CAS:APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.Formula:C21H24FN5O5SPurity:99.45% - 99.97%Color and Shape:SolidMolecular weight:477.51CLP257
CAS:CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.Formula:C14H14FN3O2SPurity:98.13%Color and Shape:SolidMolecular weight:307.34BMS-191095
CAS:BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.Formula:C22H21ClN4O2Purity:100%Color and Shape:SolidMolecular weight:408.88Ref: TM-T10566
1mg96.00€5mg202.00€10mg305.00€25mg550.00€50mg747.00€100mg1,008.00€1mL*10mM (DMSO)224.00€Butamben
CAS:Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.Formula:C11H15NO2Purity:99.43%Color and Shape:Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Molecular weight:193.24(±)8(9)-EpETE
CAS:(±)8(9)-EpETE ((±)8,9-EEQ) is an epoxide of arachidonic acid biosynthesized by CYP450 epoxygenase.1.2 In rat and rabbit liver microsomes.Formula:C20H30O3Color and Shape:SolidMolecular weight:318.45DCPIB
CAS:DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFormula:C22H28Cl2O4Purity:99.79% - 99.87%Color and Shape:SolidMolecular weight:427.36Ref: TM-T10979
1mg35.00€5mg74.00€10mg114.00€25mg235.00€50mg465.00€100mg605.00€200mg852.00€1mL*10mM (DMSO)84.00€Yoda 1
CAS:Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.Formula:C13H8Cl2N4S2Purity:98% - 99.98%Color and Shape:SolidMolecular weight:355.27Ref: TM-T7506
1mg47.00€2mg60.00€5mg95.00€10mg115.00€25mg230.00€50mg447.00€100mg655.00€500mg1,388.00€1mL*10mM (DMSO)94.00€N-Acetylprocainamide
CAS:N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmicFormula:C15H23N3O2Purity:99.68% - 99.85%Color and Shape:SolidMolecular weight:277.36JNJ 303
CAS:JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).Formula:C21H29ClN2O4SPurity:99.28%Color and Shape:SolidMolecular weight:440.98Ref: TM-T7653
1mg48.00€2mg65.00€5mg89.00€10mg147.00€25mg325.00€50mg472.00€100mg705.00€1mL*10mM (DMSO)92.00€GAL-021 sulfate
CAS:GAL-021 sulfate is a BKCa channel blocker that inhibits the analgesic effects of opioids and is used in the study of respiratory control diseases.Formula:C11H24N6O5SPurity:99.68%Color and Shape:SolidMolecular weight:352.41OR-1896
CAS:OR-1896 is a PDE III inhibitor, a vasodilator with partial anti-inflammatory properties, and can be used to study heart failure and vascular dysfunction.Formula:C13H15N3O2Purity:99.51%Color and Shape:SolidMolecular weight:245.28Ref: TM-T12315
1mg92.00€2mg135.00€5mg216.00€10mg393.00€25mg847.00€50mg1,159.00€100mg1,568.00€1mL*10mM (DMSO)240.00€Tolazamide
CAS:Tolazamide (U-17835) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.Formula:C14H21N3O3SPurity:100% - 99.7%Color and Shape:SolidMolecular weight:311.4Ref: TM-T1333
2mg35.00€5mg52.00€10mg70.00€25mg97.00€50mg125.00€100mg160.00€200mg230.00€1mL*10mM (DMSO)62.00€Zacopride hydrochloride
CAS:Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.Formula:C15H20ClN3O2·HClPurity:98.32%Color and Shape:SolidMolecular weight:346.26Ref: TM-T5336
1mg46.00€5mg87.00€10mg144.00€25mg283.00€50mg454.00€100mg655.00€200mg930.00€1mL*10mM (DMSO)97.00€RL648_81
CAS:RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.Formula:C17H17F4N3O2Purity:98.85%Color and Shape:SolidMolecular weight:371.33Ref: TM-T28544
2mg44.00€5mg64.00€10mg105.00€25mg226.00€50mg335.00€100mg480.00€200mg652.00€1mL*10mM (DMSO)77.00€Indapamide
CAS:Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.Formula:C16H16ClN3O3SPurity:98.97% - 99.83%Color and Shape:SolidMolecular weight:365.83KCNQ2/3 activator-1
CAS:KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator.Formula:C23H29FN2OPurity:98.99% - 99.16%Color and Shape:SolidMolecular weight:368.49Ref: TM-T9400
2mg40.00€5mg62.00€10mg94.00€25mg153.00€50mg235.00€100mg373.00€500mg938.00€1mL*10mM (DMSO)67.00€Talatisamine
CAS:Talatisamine and TEA mitigate Aβ oligomer effects on I(K), bolstering cell survival and reducing K(+) loss-induced apoptosis; promising for further study.Formula:C24H39NO5Purity:98.62% - 99.44%Color and Shape:SolidMolecular weight:421.57Taurocholic acid sodium salt hydrate
CAS:Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) is the product of conjugation of taurine with cholic acid.Formula:C26H44NNaO7S·xH2OPurity:99.26% - ≥98%Color and Shape:SolidMolecular weight:537.68Glimepiride
CAS:Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.Formula:C24H34N4O5SPurity:97.84% - 98.49%Color and Shape:White Cyrstalline SolidMolecular weight:490.62Maralixibat Chloride
CAS:Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.Formula:C40H56ClN3O4SPurity:100.00% - 98.36%Color and Shape:SolidMolecular weight:710.41Ropivacaine hydrochloride monohydrate
CAS:Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.Formula:C17H29ClN2O2Purity:99.94% - 99.95%Color and Shape:White SolidMolecular weight:328.88NS 11021
CAS:NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channelsFormula:C16H9BrF6N6SPurity:97%Color and Shape:SolidMolecular weight:511.24DMP-543
CAS:DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.Formula:C26H18F2N2OPurity:100%Color and Shape:SolidMolecular weight:412.43ZTZ240
CAS:ZTZ240 is a KCNQ2 channel activator used in the study of epilepsy.Formula:C12H8ClFN2OPurity:99.93%Color and Shape:SolidMolecular weight:250.66Almokalant
CAS:Almokalant: Class III antiarrhythmic, K+ channel blocker, inhibits Ikr current.Formula:C18H28N2O3SPurity:98%Color and Shape:SolidMolecular weight:352.49Ketanserin
CAS:Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Formula:C22H22FN3O3Purity:99.19% - 99.73%Color and Shape:SolidMolecular weight:395.43Bisaramil hydrochloride
CAS:Bisaramil hydrochloride (Bisaramil) is an antiarrhythmic compound that inhibits free radical production.Formula:C17H24Cl2N2O2Purity:98.90% - 99.64%Color and Shape:SolidMolecular weight:359.29ICA-27243
CAS:ICA-27243: Potent KCNQ2/Q3 opener, oral, EC50 0.38 μM; less effective on KCNQ4, KCNQ3/Q5; antiepileptic.Formula:C12H7ClF2N2OPurity:99.54%Color and Shape:SolidMolecular weight:268.65
