Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Products of "Sodium Channel"
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Tetracaine Hydrochloride
CAS:Applications A local anesthetic used topically in opthalmology. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),Formula:C15H24N2O2·ClHColor and Shape:Off-WhiteMolecular weight:300.82Nisoxetine hydrochloride
CAS:Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitorFormula:C17H21NO2·HClPurity:98.52%Color and Shape:White SolidMolecular weight:307.82Sodium Channel inhibitor 4
CAS:Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].Formula:C19H18ClN3O4S2Purity:98%Color and Shape:SolidMolecular weight:451.95Rufinamide-d2
CAS:Controlled ProductApplications Labelled Rufinamide (R701552). Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. References Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),Formula:C10H6D2F2N4OColor and Shape:White To Light YellowMolecular weight:240.21Pilsicainide HCl
CAS:Pilsicainide HCl (SUN 1165) is a pure sodium channel blockerFormula:C17H25ClN2OPurity:99.22% - 99.80%Color and Shape:SolidMolecular weight:308.85Mebeverine hydrochloride
CAS:Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gutFormula:C25H35NO5Purity:99.81% - 99.81%Color and Shape:SolidMolecular weight:429.55SLC13A5-IN-1
CAS:SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).Formula:C19H19Cl3N2O3SPurity:99.11%Color and Shape:SolidMolecular weight:461.79Ref: TM-T12931
1mg50.00€5mg97.00€10mg160.00€25mg283.00€50mg472.00€100mg658.00€200mg933.00€500mg1,378.00€1mL*10mM (DMSO)120.00€VX-150
CAS:VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).Formula:C21H17F4N2O7PPurity:95.06%Color and Shape:SolidMolecular weight:516.34Ref: TM-T9683
1mg70.00€5mg153.00€10mg246.00€25mg494.00€50mg793.00€100mg1,216.00€200mg1,634.00€1mL*10mM (DMSO)167.00€Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formula:C10H13NO4S2Purity:99.16%Color and Shape:SolidMolecular weight:275.34PF-06869206
CAS:PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).Formula:C15H14ClF3N4O2Purity:99.37% - 99.79%Color and Shape:SolidMolecular weight:374.754,4'-Dichlorodiphenyldichloroethylene - d8
CAS:Controlled ProductApplications 4,4'-DDE - d8 is a metabolite of DDT - d8 (D434197), a synthetic organochlorine insecticide that functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-DDE - d8 has shown to have endocrine disrupting effects on gonadotropin hormones in pituitary gonadotrope cells. References Saschenbrecker, P.W.: Can. J. Comp. Med., 37, 203 (1973); Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989); Zhou, J., et. al.: Environ. Toxicol. Phar., 37, 1194 (2014)Formula:C142H8Cl4Color and Shape:White SolidMolecular weight:326.07Dyclonine Hydrochloride
CAS:Controlled ProductApplications Used as a local anesthetic. References Chawla, H.P.S., et al.: J. Med. Chem., 13, 3, 480 (1970)Formula:C18H27NO2·ClHColor and Shape:NeatMolecular weight:325.87Dibucaine
CAS:Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.Formula:C20H29N3O2Purity:99.83% - 99.88%Color and Shape:Colorless Or Almost Colorless Powder SolidMolecular weight:343.46Zonisamide
CAS:Applications Sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant. Neuroprotective & Neuroresearch Product. References Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980), Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987), Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993), Sorkin, E.M., et al.: Drugs, 45, 760 (1993),Formula:C8H8N2O3SColor and Shape:White To Off-WhiteMolecular weight:212.233-Hydroxy-4-phenylbenzoic Acid
CAS:Controlled ProductApplications 3-Hydroxy-4-phenylbenzoic Acid is a useful reagent for the preparation of spiro[3,4-dihydro-2H-pyrrolo[1,2-a]pyrazine-1,4'-piperidine] derivatives as modulators of sodium ion channel. References Hadida Ruah, S. S., et al.: U.S. Pat. Appl. Publ. (2012), US 20120196869 A1Formula:C13H10O3Color and Shape:NeatMolecular weight:214.22Tocainide hydrochloride
CAS:Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) is a sodium channel blocker.Formula:C11H17ClN2OPurity:98.85%Color and Shape:SolidMolecular weight:228.72Ref: TM-T9234
2mg38.00€5mg58.00€10mg96.00€25mg170.00€50mg273.00€100mg439.00€200mg617.00€1mL*10mM (DMSO)65.00€Propafenone
CAS:Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.Formula:C21H27NO3Purity:99.02%Color and Shape:SolidMolecular weight:341.44GX 201
CAS:GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.Formula:C25H27ClF4N2O4SPurity:99.46%Color and Shape:SolidMolecular weight:563Clofedanol Hydrochloride
CAS:Controlled ProductStability Hygroscopic Applications A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. References Yuizono, T., et al.: Yakugaku Zasshi, 87, 915 (1967), Nomura, A., et al.: Oyo Yakuri, 8, 119 (1974),Formula:C17H20ClNO·ClHColor and Shape:White To Off-WhiteMolecular weight:326.26Flunarizine dihydrochloride
CAS:Flunarizine dihydrochloride: a calcium blocker also targeting calmodulin and histamine H1, used for migraine, vertigo, vascular disease, and epilepsy aid.Formula:C26H28Cl2F2N2Purity:99.53% - 99.89%Color and Shape:White Crystalline Powder Odorless And TastelessMolecular weight:477.42
