Sodium Channel

ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.

Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.

Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.

Mexiletine hydrochloride is a lidocaine-like antiarrhythmic (Class IB) and anesthetic, stabilizing heartbeats by inhibiting sodium in cardiac cells.

Applications Anesthetic (local). References Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 12, 105 (1983), Curto, E., et al.: Biochem. Pharmacol., 57, 663 (1999), Hall, A., et al.: Pigment Cell Res., 18, 122 (2005), Yamaguchi, Y., et al.: J. Biol. Chem., 282, 27557 (2007),

Applications Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. Inhibitory activity of Ralfinamide mesylate is voltage dependent, with higher potency towards inactivated channels. Ralfinamide mesylate is useful in preventing, alleviating and curing a wide range of pathologies, including pain, migraine, peripheral diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinol. systems, gastrointestinal, urogenital, metabolic and seizure disorders. References Bayes, M., et al.: Methods. Find. Exp. Clin. Pharmacol., 27, 411 (2005); Pevarello, P., et al.: J. Med. Chem., 41, 579 (1998); Bauer, M., et al.: Pharmacol., 85, 297 (2010);

DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.

Applications Veratridine is a voltage dependent Na+ channel opening agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.

Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.

Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel.

Stability Hygroscopic Applications N-Despropyl Propafenone Hydrochloride is a metabolite of Propafenone (P757500), a sodium channel blocker. Antiarrhythmic (class IC). References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993); Rae, A. P., et al.: Am. J. Cardiol., 82, 59N (1998)

Applications Nor Lidocaine-d6 Hydrochloride is the labeled analogue of Nor Lidocaine Hydrochloride (N713500), a hydrochloride salt metabolite of Lidocaine (L397800), a local anesthetic; antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fukuda, S., et al.: Anesthesiology, 53, 106 (1980); Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971); Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973); Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985); Davies, P.S., et al.: Drugs, 64, 937 (2004)

Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.

ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.

Benzonatate is an antagonist of sodium channel protein.

R 56865 is a weak potential-operated channel inhibitor that inhibits the late sodium current in human isolated cardiomyocytes.

(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.

Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.

Stability Hygroscopic Applications Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971), Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973), Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),