Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Products of "Sodium Channel"
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Halofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Formula:C16H17BrClN3O3Purity:97.67%Color and Shape:Off-White SolidMolecular weight:414.68Bupivacaine N-Oxide Hydrochloride Salt
CAS:Controlled ProductApplications The N-oxide of the local anesthetic Bupivacaine (B689546). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageFormula:C18H29ClN2O2Color and Shape:White To BeigeMolecular weight:340.89Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formula:C11H14ClN3O3S2Color and Shape:SolidMolecular weight:335.83Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formula:C22H26N2O2Purity:99.85% - 99.98%Color and Shape:White Crystalline SolidMolecular weight:350.45Metaflumizone
CAS:Applications Metaflumizone is a semicarbazone insecticide that works by blocking sodium channel in target insects resulting in paralyzation associated with blocking nerve activity. Metaflumizone is useful as a heartworm control treatment. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Zhang, Zhe,, et al.: J. Integrat. Agri. 11, 1145 (2012); Kuhn, D., et al.: Modern. Crop. Protect. Compound., 3, 1273 (2012);Formula:C24H16F6N4O2Color and Shape:WhiteMolecular weight:506.40KR-32568
CAS:KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).Formula:C13H12FN3O2Purity:99.89%Color and Shape:SolidMolecular weight:261.25Ref: TM-T36569
1mg46.00€5mg92.00€10mg145.00€25mg284.00€50mg411.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)95.00€Capsazepine
CAS:Controlled ProductApplications A selective vanilloid receptor antagonist (Ki=3.2uM) References Dickenson and Dray: Br. J. Pharmacol., 104, 1045 (1991), Kwak, et al.: Neuroscience, 86, 619 (1998), Szallasi and Blumberg: Pharmacol. Rev., 51, 159 (999)Formula:C19H21ClN2O2SColor and Shape:NeatMolecular weight:376.90QX-314 chloride
CAS:QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.Formula:C16H27ClN2OPurity:99.73%Color and Shape:SolidMolecular weight:298.85Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Formula:C22H27Cl2F2N3O2SColor and Shape:SolidMolecular weight:506.44Propafenone hydrochloride
CAS:Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.Formula:C21H27NO3·HClPurity:99.67%Color and Shape:White SolidMolecular weight:377.9Prilocaine-D7 Hydrochloride
CAS:Controlled ProductApplications Labelled Prilocaine (P725000). Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003),Formula:C13H14D7ClN2OColor and Shape:NeatMolecular weight:263.81Phenazopyridine hydrochloride
CAS:Phenazopyridine HCl, an oral urinary analgesic, may cause nausea, anemia, and liver/kidney toxicity. Possibly carcinogenic.Formula:C11H12ClN5Purity:99.27%Color and Shape:Brownish-Yellow Crystals Aqueous Solutions Are Yellow To Brick-Red And Slightly Acidic; They May Be Stabilized By The AdditionMolecular weight:249.7Silperisone HCl
CAS:Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.Formula:C15H25ClFNSiPurity:100%Color and Shape:SolidMolecular weight:301.9Bupivacaine-d9 N-Oxide
CAS:Controlled ProductStability Very Hygroscopic Applications The labelled N-oxide of the local anesthetic Bupivacaine (B689546).Formula:C18H19D9N2O2Color and Shape:NeatMolecular weight:313.48ICA-121431
CAS:ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.Formula:C23H19N3O3S2Purity:98%Color and Shape:SolidMolecular weight:449.55Dimethocaine Hydrochloride
CAS:Controlled ProductApplications A local anesthetic with stimulant properties. Studies have shown its potency to be about half that of Cocaine (C633500). References Wppdward, J.J. et al.: Eur. J. Pharmacol., 277, 7 (1995); Rigon, A.R. et al.: Psychopharmacol., 127, 323 (1996); Wilcox, K.M. et al.: Synapse, 58, 220 (2005);Formula:C16H26N2O2·ClHColor and Shape:White To BeigeMolecular weight:314.85Soraprazan
CAS:BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.Formula:C21H25N3O3Purity:97.69% - 99.84%Color and Shape:SolidMolecular weight:367.44Gitoxin
CAS:Controlled ProductStability Hygroscopic Applications Gitoxin acts as in inhibitor of the sodium and potassium ion channels, interfering with ATPase activity and used in cancer treatment as a growth inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Colovic, M. et al.: Russ. J. Phys. Chem. A., 83, 1602 (2009); Banuls, L. et al.: Mol. Canc., 12, 33 (2013);Formula:C41H64O14Color and Shape:NeatMolecular weight:780.94Mepivacaine Hydrochloride
CAS:Controlled ProductApplications An anti-inflammatory and analgesic agent. Anesthetic (local). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Reynolds, et al.: Br. J. Anaesth., 43, 33 (1971), Tullar, et al.: J. Med. Chem., 14, 891 (1971), Aberg, G., et al.: Acta Pharmacol. Toxicol., 31, 273 (1972),Formula:C15H22N2O·ClHColor and Shape:WhiteMolecular weight:282.8120(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purity:100% - 99.93%Color and Shape:SolidMolecular weight:785.01
