Sodium Channel

Applications Deacetamide Acetonitrile-pentisomide is an intermediate in the synthesis of Pentisomide (P275600). Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I). References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992); Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)

Stability Moisture Sensitive Applications Mesaconine is an Aconine (A190245) derivative, which is an Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),

Applications Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.Used in producing heart arrhythmia in experimental animals. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),

Applications Yunnaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes. Yunnaconitine is a deiterpene alkaloid, known to exhibit cytotoxic activity in human leukemic cell. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References He, Y.Q., et al.: J. Pharma. Analysis., 1, 57 (2011); Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010); Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010);

Applications Bupivacaine is a sodium channel blocker, local anesthetic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),

AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM.

EIPA (L593754) is a TRPP3 channel inhibitor and an inhibitor of Na+/H+ exchange (NHE). EIPA inhibits megacytosis, promotes autophagy. Cost-effective and quality-assured.

Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.

Applications Isotope labelled 4,4'-Dichlorodiphenyltrichloroethane a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989);

Sodium Channel inhibitor 2 is a blocker of sodium channel.

Impurity Lidocaine EP impurity I Applications 2-(Diethylamino)-N-(2,4-dimethylphenyl)acetamide is a Lidocaine (L397800) derivative with reduced local anesthetic action. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Costa, J.C.S., et al.: Bioorg. Med. Chem. Lett., 18, 1162 (2008); Magee, P.S., et al.: J. Org. Chem., 19, 168 (1954);

Vormatrigine effectively inhibits sodium channels (sodium channel).

Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and

BIIB 722 Mesylate is a sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia.

Tolperisone hydrochloride (Muscalm) is a muscle relaxant for treating muscle tone disorders from neurological diseases.

Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.

Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests

Applications 4-Hydroxylidocaine, is a metabolite of Lidocaine (L397800), a common local anesthetic and antiarrhythmic drug. References Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971), Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973), Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),

Primidone (NCI-C56360) is a potent anticonvulsant agent.