Calcium Channel

Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.

(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.

5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE).

Applications Labelled Diltiazem (D460620). A calcium channel blocker with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV). References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),

Levamlodipine besylate, or S-amlodipine (CAS 103129-82-4), is the active enantiomer of amlodipine, used to treat hypertension and angina.

SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)

Impurity Clevidipine Butyrate Impurity A Applications Desethyl Felodipine is an impurity in the synthesis of Felodipine (F232375), a dihydropyridine calcium channel blocker. References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),

FPL64176 is a L-type calcium channels activator.

Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity used in the study of hypertension.

Applications Desacetyl Diltiazem-d4 Hydrochloride is the labeled analogue of Desacetyl Diltiazem Hydrochloride (D289335), a metabolite of Diltiazem Hydrochloride (D460620), a calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV). References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987); Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990); Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991); Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971); Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998); Hansson, L., et al.: Lancet, 356, 359 (2000)

(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.

Fluspirilene is a long-acting antipsychotic for schizophrenia, inhibiting L-type calcium channels (IC50: 0.03 μM).

Nexopamil (LU-49938) is a dual calcium channel and 5-HT2A receptor antagonist that inhibits cell contraction and growth.

Impurity Nimodipine EP Impurity C; Nimodipine USP Related Compound B Applications O-Desisopropyl-O-methoxyethyl Nimodipine (Nimodipine EP Impurity C) is an impurity in the synthesis of Nimodipine (A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Nimodipine USP Related Compound B. References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),

Applications TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel. Clotrimazole impurity. References Wulff, H., et al.: J. of Biological Chemistry, 276, 34, 32040 (2001)

Stability Light Sensitive Applications Ethyl Palmitoleate-d5 is the isotope analog of Ethyl Palmitoleate. Ethyl Palmitoleate is used in biological studies for calcium relase-activated calcium channel blockade as a potential tool in antipancreatitis therapy. References Gerasimenko, J.V., et al.: Proc. Natl. Acad. Sci. U.S.A., 110, 13186 (2013)

D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) is a second messenger produced in cells by phospholipase C-mediated

Ibutilide Fumarate is a class III antiarrhythmic, prolonging action potentials by enhancing sodium influx, and can extend QT interval.

TPC2-A1-N is a TPC2 small molecule agonist that can be used to detect different functions of TPC2 channels in intact cells.

CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis.