Calcium Channel

Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.

Ticolubant: Oral LTB4 antagonist, Ki=0.78 nM; blocks Ca2+ migration, IC50=6.6 nM; anti-inflammatory in mice.

Applications A dihydropyridine calcium channel blocker. References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),

Amlodipine maleate (Amvaz) is an oral dihydropyridine calcium blocker for hypertension and cancer studies.

VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor.

Caldaret HCl is an intracellular Ca2+ modulator that regulates calcium homeostasis at the sarcoplasmic reticulum and cell membrane, and can be used to study acute myocardial infarction and heart failure.

Efonidipine HCl monoethanolate is a calcium blocker, boosts dehydroepiandrosterone sulfate in NCI-H295R cells.

D-myo-Inositol-1,4,5-triphosphate tripotassium is a second messenger in the intracellular signaling system that induces Ca2+ mobilization.

CaV1.3 antagonist-1 is a selective CaV1.3L-type calcium channel antagonist useful for researching neurological disorders and cardiovascular diseases.

Applications Ethyl 3-Aminocrotonate is used as a reagent to synthesize Nitrendipine (N490150), a calcium channel antagonist that is used to treat patients with hypertension. Ethyl 3-Aminocrotonate is also used as a reagent to synthesize (S)-Felodipine (F232370), a calcium entry blocker that has antihypertensive properties. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bailey, D., et al.: Clin. Invest. Med., 12, 357 (1989); Bean, B.: Proc. Nat. Acad. Sci., 81, 6388 (1984); Kwon, K., et al.: Tetrahedron, 67, 10222 (2011); Leenen, F. & Holiwell, D.: Am. J. Cardio., 69, 639 (1992); Meyer, H., et al.: Arz. Forsch., 33, 1528 (1983); Stoepel, K., et al.: Arz. Forsch., 31, 2056 (1980)

Applications A dihydropyridine calcium channel blocker. Antihypertensive. References Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989), Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002), McCormack, A.J., et al.: Drugs, 63, 2327 (2003),

Z944 is a T-type calcium channel blocker.

γ-Glutamylserine TFA (γ-Glu-Ser TFA) serves as a calcium receptor activator and is utilized in research focused on Parkinson's disease, diabetes, and obesity [1

Tricaine methanesulfonate (TMS/MS-222) is an anesthetic used in hatcheries and studies to immobilize fish for marking, transport, and invasive procedures.

Applications Manidipine Dihydrochloride is a metabolite of Manidipine (M164000), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992); Hosaka, S., et al.: Chem. Pharma. Bulletin., 55, 793 (2007);

Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain.

Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.

OPC 8490 free base is a positive inotropic vasodilator and a cardiotonic agent that can be used to study cardiovascular diseases.

Flunarizine dihydrochloride: a calcium blocker also targeting calmodulin and histamine H1, used for migraine, vertigo, vascular disease, and epilepsy aid.

Applications Calcium channel blocker, used as an oral antihypertensive. References Odenstedt, J., et al.: J. Cardiovas., Pharmacol., 44, 407 (2004), Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006), Obach, R., et al.: Drug Metab. Disposition, 36, 1385 (2008), Varon, J., et al.: Drugs, 68, 283 (2008),