PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Formula:C15H22N4O3Purity:99.11% - 99.42%Color and Shape:Off-White SolidMolecular weight:306.36Ref: TM-T19812
1mg69.00€5mg145.00€10mg212.00€25mg358.00€50mg527.00€100mg750.00€1mL*10mM (DMSO)157.00€cis-Tadalafil
CAS:Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.Formula:C22H19N3O4Purity:≥98%Color and Shape:SolidMolecular weight:389.4Anti-ALDH7A1 Antibody (3P955)
Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.Color and Shape:Odour LiquidThioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Formula:C24H29ClN6OSPurity:98.73%Color and Shape:SolidMolecular weight:485.05Ref: TM-T9773
1mg84.00€5mg178.00€10mg266.00€25mg434.00€50mg562.00€100mg787.00€200mg1,035.00€1mL*10mM (DMSO)205.00€Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Formula:C23H32N6O4SPurity:99.88%Color and Shape:White SolidMolecular weight:488.6Ref: TM-T8919
2mg42.00€5mg64.00€10mg92.00€25mg187.00€50mg281.00€100mg393.00€200mg552.00€1mL*10mM (DMSO)78.00€Ketotifen fumarate
CAS:Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.Formula:C23H23NO5SPurity:99.25% - 99.73%Color and Shape:SolidMolecular weight:425.5Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Formula:C25H20N4OPurity:98.82% - 99.81%Color and Shape:SolidMolecular weight:392.45Ref: TM-T16499
1mg43.00€2mg55.00€5mg92.00€10mg150.00€25mg245.00€50mg365.00€100mg547.00€1mL*10mM (DMSO)92.00€Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Formula:C17H12Cl2N2O6SPurity:98%Color and Shape:SolidMolecular weight:443.26PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Formula:C21H19N7Purity:99.65%Color and Shape:SolidMolecular weight:369.42N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Formula:C8H9NOPurity:99.83%Color and Shape:Physical Description Off-White Crystalline Solid (Ntp 1992)Molecular weight:135.16Anti-ALDH7A1 Antibody (5P692)
Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.Color and Shape:Odour LiquidBAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Formula:C15H12ClF3N4OColor and Shape:SolidMolecular weight:356.73Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Formula:C22H28BrN5O5Purity:98.64% - 99.16%Color and Shape:SolidMolecular weight:522.39Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Formula:C21H18N4O4Purity:99.45%Color and Shape:White PowderMolecular weight:390.39TyK2-IN-2
CAS:TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).Formula:C16H18N6OPurity:98%Color and Shape:SolidMolecular weight:310.35ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Formula:C21H23Cl2N2O6PPurity:99.52%Color and Shape:SolidMolecular weight:501.3PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Formula:C22H21Cl2N3O5Purity:98.70% - 99.25%Color and Shape:SolidMolecular weight:478.33Vardenafil
CAS:Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction.Formula:C23H32N6O4SPurity:99.88%Color and Shape:SolidMolecular weight:488.6Nauclefine
CAS:Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.Formula:C18H13N3OPurity:99.92%Color and Shape:SolidMolecular weight:287.32BAY 73-6691 racemate
CAS:BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.Formula:C15H12ClF3N4OColor and Shape:SolidMolecular weight:356.73Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Formula:C21H23N7O2Purity:98%Color and Shape:SolidMolecular weight:405.45NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Formula:C17H19N3O2Purity:99.10%Color and Shape:SolidMolecular weight:297.35Ref: TM-T12267
1mg52.00€5mg116.00€10mg187.00€25mg325.00€50mg467.00€100mg645.00€200mg872.00€1mL*10mM (DMSO)128.00€MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Formula:C19H22N6OSPurity:100% - 99.67%Color and Shape:SolidMolecular weight:382.48Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Formula:C21H26N6O2Purity:98.14%Color and Shape:SolidMolecular weight:394.47FCPR03
CAS:FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Formula:C15H19F2NO3Purity:100.00%Color and Shape:SolidMolecular weight:299.31Ref: TM-T39341
1mg52.00€2mg75.00€5mg116.00€10mg183.00€25mg311.00€50mg444.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)128.00€T-0156
CAS:T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.Formula:C31H29N5O7Purity:100% - 98.42%Color and Shape:SoildMolecular weight:583.59Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C30H39ClN6O4S2Purity:98%Color and Shape:SolidMolecular weight:647.25Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Formula:C13H12N4OPurity:98.56% - 99.36%Color and Shape:SolidMolecular weight:240.26Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Formula:C13H13ClN4OPurity:99.84%Color and Shape:SolidMolecular weight:276.72Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFormula:C17H14Cl2F2N2O3Purity:100.00% - 99.76%Color and Shape:SolidMolecular weight:403.21BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Formula:C9H12N2O4SPurity:99.66%Color and Shape:SolidMolecular weight:244.27Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Formula:C22H21N9O2Purity:98.49% - 99.21%Color and Shape:SolidMolecular weight:443.46Ref: TM-T10415
2mg46.00€5mg70.00€10mg101.00€25mg183.00€50mg284.00€100mg455.00€200mg625.00€1mL*10mM (DMSO)78.00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Formula:C13H16O3Purity:99.54%Color and Shape:SolidMolecular weight:220.26PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Formula:C25H21N3O6SPurity:98%Color and Shape:SolidMolecular weight:491.52Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Formula:C23H33N7O5SPurity:98.25% - 99.06%Color and Shape:SolidMolecular weight:519.62Ref: TM-T15381
1mg185.00€5mg415.00€10mg613.00€25mg938.00€50mg1,311.00€100mg1,768.00€1mL*10mM (DMSO)520.00€Pumafentrine
CAS:Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Formula:C29H39N3O3Purity:99.79%Color and Shape:SolidMolecular weight:477.64PF-05085727
CAS:PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.Formula:C20H18F3N7Purity:98%Color and Shape:SolidMolecular weight:413.4OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Formula:C20H23ClN2O4Purity:98.92%Color and Shape:SoildMolecular weight:390.86Ref: TM-T83974
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€1mL*10mM (DMSO)47.00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Formula:C25H20N4OPurity:99.87%Color and Shape:SolidMolecular weight:391.45YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Formula:C17H16ClN3OPurity:99.84%Color and Shape:SolidMolecular weight:313.78PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Formula:C20H28N8O4SPurity:100%Color and Shape:SolidMolecular weight:476.55K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Formula:C22H29N3O4Purity:98%Color and Shape:SolidMolecular weight:399.48WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Formula:C23H28N4O4Purity:98.63%Color and Shape:SolidMolecular weight:424.49Ref: TM-T13331
1mg77.00€5mg158.00€10mg225.00€25mg338.00€50mg475.00€100mg638.00€200mg845.00€1mL*10mM (DMSO)170.00€Avanafil
CAS:Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.Formula:C23H26ClN7O3Purity:98% - 99.03%Color and Shape:White SolidMolecular weight:483.95Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Formula:C20H25NO4Purity:97.37% - 99.43%Color and Shape:White SolidMolecular weight:343.42PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Formula:C14H15F3N8OSPurity:99.02%Color and Shape:SolidMolecular weight:400.38Ref: TM-T12422
1mg137.00€5mg235.00€10mg354.00€25mg610.00€50mg885.00€100mg1,320.00€1mL*10mM (DMSO)207.00€MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Formula:C19H16Cl3FN4OPurity:98.09% - 98.94%Color and Shape:SolidMolecular weight:441.71Ref: TM-T12103
1mg145.00€2mg207.00€5mg354.00€10mg528.00€25mg852.00€50mg1,159.00€100mg1,568.00€500mg3,125.00€1mL*10mM (DMSO)378.00€AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Formula:C25H23N5O3Purity:99.35%Color and Shape:SolidMolecular weight:441.48Ref: TM-T14217
1mg35.00€2mg47.00€5mg73.00€10mg105.00€25mgTo inquire50mgTo inquire1mL*10mM (DMSO)82.00€Vardenafil hydrochloride trihydrate
CAS:Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Formula:C23H32N6O4S·HCl·3H2OPurity:99.77%Color and Shape:SolidMolecular weight:579.11Ref: TM-T4097
5mg47.00€10mg70.00€25mg125.00€50mg187.00€100mg298.00€200mg444.00€500mg715.00€1mL*10mM (DMSO)63.00€Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Formula:C17H17N3O3SPurity:97.52%Color and Shape:SolidMolecular weight:343.4Ref: TM-T7888
1mg133.00€5mg274.00€10mg432.00€25mg715.00€50mg1,008.00€100mg1,359.00€1mL*10mM (DMSO)303.00€
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