PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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N-Ethyl tadalafil
CAS:N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.Formula:C23H21N3O4Purity:99.58%Color and Shape:SolidMolecular weight:403.43BI 1015550
CAS:Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Formula:C20H25ClN6O2SPurity:100% - 99.71%Color and Shape:SoildMolecular weight:448.97Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C32H40ClF3N6O6S2Purity:98%Color and Shape:SolidMolecular weight:761.28Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Formula:C24H32N6O3Purity:98.96%Color and Shape:SolidMolecular weight:452.55Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C30H29N9O2Purity:98%Color and Shape:SolidMolecular weight:547.61Enpp/Carbonic anhydrase-IN-1
CAS:Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.Formula:C23H25NO4SPurity:100%Color and Shape:SoildMolecular weight:411.51GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Formula:C21H25N7O2SPurity:99.43% - 99.79%Color and Shape:SolidMolecular weight:439.53CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Formula:C23H19FN2O7Purity:99.39%Color and Shape:SolidMolecular weight:454.42,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Formula:C9H9Cl2F2NO3SPurity:98.60%Color and Shape:SolidMolecular weight:320.14Ref: TM-T50062
1mg84.00€2mg111.00€5mg172.00€10mg249.00€25mg426.00€50mg627.00€100mg893.00€1mL*10mM (DMSO)172.00€ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Formula:C22H19N3O4Purity:98%Color and Shape:SolidMolecular weight:389.4Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Formula:C15H22N2O3Purity:98% - 99.14%Color and Shape:SolidMolecular weight:278.35Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Formula:C40H37N5OPurity:99.06%Color and Shape:SolidMolecular weight:603.75SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Formula:C21H19N7Purity:99.29%Color and Shape:SolidMolecular weight:369.42BC 11-38
CAS:BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).Formula:C15H16N2OS2Purity:97.71% - 98.72%Color and Shape:SolidMolecular weight:304.43Ref: TM-T21865
1mg35.00€5mg70.00€10mg97.00€25mg202.00€50mg329.00€100mg527.00€200mg747.00€1mL*10mM (DMSO)81.00€Zardaverine
CAS:Zardaverine (BY 290) is a PDE3/4 inhibitor with anti-hepatocarcinogenic activity and is used in the study of acute renal failure and chronic airflow obstructionFormula:C12H10F2N2O3Purity:99.11%Color and Shape:SolidMolecular weight:268.22WAY-313170
CAS:WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Formula:C19H17ClN2O2S2Purity:99.3%Color and Shape:SolidMolecular weight:404.93RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFormula:C19H14ClN5O4Purity:99.25%Color and Shape:SolidMolecular weight:411.8Ref: TM-T23256
2mg34.00€5mg52.00€10mg85.00€25mg170.00€50mg259.00€100mg374.00€200mg545.00€1mL*10mM (DMSO)65.00€ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Formula:C29H29FN7O5PPurity:98.21%Color and Shape:SolidMolecular weight:605.56Ref: TM-T11689
1mg74.00€2mg97.00€5mg166.00€10mg303.00€25mg533.00€50mg750.00€100mg1,064.00€1mL*10mM (DMSO)217.00€PF-05180999
CAS:α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.Formula:C19H17F3N8Purity:99.43%Color and Shape:SolidMolecular weight:414.39Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Formula:C30H33FN8O2SPurity:97% - 99.85%Color and Shape:SolidMolecular weight:588.7UK 227786
CAS:UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.Formula:C22H22Cl2N4O4Purity:100%Color and Shape:SoildMolecular weight:477.34Ref: TM-T11220L
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€500mg2,147.00€1mL*10mM (DMSO)304.00€Arofylline
CAS:Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Formula:C14H13ClN4O2Purity:97.98%Color and Shape:SolidMolecular weight:304.73Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFormula:C12H18N4O2Purity:97.97% - 99.55%Color and Shape:SolidMolecular weight:250.3Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Formula:C14H16N6OPurity:99.63% - 99.77%Color and Shape:SolidMolecular weight:284.32Ref: TM-T12913
1mg42.00€5mg88.00€10mg127.00€25mg264.00€50mg424.00€100mg655.00€200mg924.00€1mL*10mM (DMSO)87.00€GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Formula:C29H27F3N4O7SColor and Shape:SolidMolecular weight:632.61THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Formula:C23H21ClN6O3Purity:99.46%Color and Shape:SolidMolecular weight:464.9CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Formula:C23H19N5O2Color and Shape:SolidMolecular weight:397.43Anti-ALDH7A1 Antibody-FITC (5P692)
Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.Color and Shape:Odour LiquidML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Formula:C20H20N4O4SPurity:97.93%Color and Shape:SolidMolecular weight:412.46Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Formula:C21H17N3O4Purity:99.42%Color and Shape:SolidMolecular weight:375.38Ref: TM-T6147
1mg37.00€2mg52.00€5mg79.00€10mg111.00€25mg202.00€50mg354.00€100mg567.00€200mg805.00€500mg1,198.00€1mL*10mM (DMSO)87.00€Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFormula:C14H10N4OPurity:99.68%Color and Shape:SolidMolecular weight:250.26Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Formula:C24H28N2O6SPurity:98.75% - 99.74%Color and Shape:SolidMolecular weight:472.55Anagrelide
CAS:Anagrelide (Xagrid) is a Platelet-reducing Agent.Formula:C10H7Cl2N3OPurity:100%Color and Shape:SolidMolecular weight:256.09Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Formula:C23H17FN6O2Purity:98.32% - 98.97%Color and Shape:SolidMolecular weight:428.42Ref: TM-T1745
1mg38.00€2mg49.00€5mg79.00€10mg93.00€25mg156.00€50mg256.00€100mg444.00€1mL*10mM (DMSO)79.00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonaryFormula:C24H35N5O3Purity:100%Color and Shape:SolidMolecular weight:441.57PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.Formula:C22H21N5O3Purity:99.30%Color and Shape:SolidMolecular weight:403.43Ref: TM-T24656
2mg34.00€5mg52.00€10mg85.00€25mg170.00€50mg259.00€100mg374.00€200mg545.00€1mL*10mM (DMSO)57.00€Mirodenafil dihydrochloride
CAS:Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Formula:C26H39Cl2N5O5SPurity:99.64% - 99.78%Color and Shape:SolidMolecular weight:604.59Bay 60-7550
CAS:Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Formula:C27H32N4O4Purity:98.14%Color and Shape:SolidMolecular weight:476.57ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Formula:C15H18N6Color and Shape:SolidMolecular weight:282.34Vardenafil dihydrochloride
CAS:Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Formula:C23H34Cl2N6O4SPurity:98%Color and Shape:SolidMolecular weight:561.52Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Formula:C12H12N2O2SPurity:95.52%Color and Shape:SolidMolecular weight:248.3KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Formula:C25H35N7O6SPurity:99.55%Color and Shape:SolidMolecular weight:561.65MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Formula:C20H14ClN3Purity:99.77%Color and Shape:SolidMolecular weight:331.8BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Formula:C13H12FN5Purity:99.45%Color and Shape:SolidMolecular weight:257.27Ref: TM-T5101
1mg39.00€5mg101.00€10mg153.00€25mg249.00€50mg359.00€100mg507.00€200mg695.00€1mL*10mM (DMSO)44.00€Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Formula:C18H18Cl2N2O3Purity:98.28%Color and Shape:SolidMolecular weight:381.25Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Formula:C15H20N2O4Purity:98.44% - 99.64%Color and Shape:SolidMolecular weight:292.33Ref: TM-T31792
1mg226.00€5mg552.00€10mg735.00€25mg1,111.00€50mg1,491.00€100mg2,005.00€200mg2,707.00€1mL*10mM (DMSO)500.00€Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Formula:C15H15ClN4OPurity:99.93%Color and Shape:SolidMolecular weight:302.76Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFormula:C26H31N5O4Purity:98.45% - 99.94%Color and Shape:SolidMolecular weight:477.56Ref: TM-T25376
1mg35.00€5mg96.00€10mg160.00€25mg329.00€50mg533.00€100mg847.00€200mg1,159.00€1mL*10mM (DMSO)105.00€Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Formula:C23H32N6O5SPurity:99.92%Color and Shape:SolidMolecular weight:504.6Ref: TM-T7346
2mg35.00€5mg50.00€10mg81.00€25mg129.00€50mg187.00€100mg259.00€200mg373.00€1mL*10mM (DMSO)56.00€BAY 2666605
CAS:BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Formula:C17H12F4N2O2Purity:99.98%Color and Shape:SolidMolecular weight:352.28Ref: TM-T9805
1mg97.00€5mg235.00€10mg376.00€25mg828.00€50mg1,320.00€100mg2,118.00€1mL*10mM (DMSO)259.00€
