PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFormula:C27H26N4O5SPurity:99.52% - 99.66%Color and Shape:SolidMolecular weight:518.58PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Formula:C17H23FN6O2Purity:100%Color and Shape:SolidMolecular weight:362.4Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C22H21N9O2Purity:98%Color and Shape:SolidMolecular weight:443.46PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Formula:C18H20ClN5OPurity:98.75%Color and Shape:SolidMolecular weight:357.84Ref: TM-T28352
1mg39.00€5mg73.00€10mg94.00€25mg153.00€50mg219.00€100mg325.00€200mg465.00€1mL*10mM (DMSO)84.00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Formula:C16H14N4OPurity:100% - 99.61%Color and Shape:SolidMolecular weight:278.31Ref: TM-T23638
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€500mgTo inquire1mL*10mM (DMSO)240.00€PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Formula:C19H17ClN2O2Purity:100%Color and Shape:SolidMolecular weight:340.8Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Formula:C26H24N4O5Purity:97.03% - 99.29%Color and Shape:SolidMolecular weight:472.49Ref: TM-T3987
1mg34.00€2mg47.00€5mg70.00€10mg96.00€25mg170.00€50mg298.00€100mg430.00€200mg607.00€1mL*10mM (DMSO)71.00€HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Formula:C24H19BFNO5SPurity:100% - ≥95%Color and Shape:SolidMolecular weight:463.29Ref: TM-T2646
2mg39.00€5mg57.00€10mg93.00€25mg145.00€50mg235.00€100mg351.00€200mg528.00€1mL*10mM (DMSO)58.00€ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Formula:C9H13N5OPurity:99.02%Color and Shape:White SolidMolecular weight:207.23PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Formula:C19H18ClN3O2SPurity:99.37%Color and Shape:SolidMolecular weight:387.88Ref: TM-T36832
1mg37.00€5mg79.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)87.00€HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurity:98.92%Color and Shape:SolidMolecular weight:463.29PF-04447943
CAS:PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.Formula:C20H25N7O2Purity:99.11% - 99.11%Color and Shape:SolidMolecular weight:395.46Naproxen etemesil
CAS:Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.Formula:C17H20O5SPurity:98%Color and Shape:SolidMolecular weight:336.4CRT0273750
CAS:CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.Formula:C25H22ClF3N4O2Purity:99.49%Color and Shape:SolidMolecular weight:502.92Dazonone
CAS:Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.Formula:C11H10ClN3OPurity:99.21% - 99.67%Color and Shape:SolidMolecular weight:235.67Ref: TM-T9871
1mg77.00€5mg158.00€10mg225.00€25mg338.00€50mg475.00€100mg638.00€200mg845.00€1mL*10mM (DMSO)138.00€BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Formula:C28H31F6NO3Purity:98.03%Color and Shape:SolidMolecular weight:543.54Ref: TM-T10545
1mg221.00€5mg550.00€10mg905.00€25mg1,890.00€50mg3,030.00€100mg4,874.00€1mL*10mM (DMSO)35.00€Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Formula:C12H9N3OPurity:99.22% - 99.92%Color and Shape:SolidMolecular weight:211.22
