ROR
Retinoic Acid-Related Orphan Receptors (RORs) are nuclear receptors that regulate various physiological processes, including circadian rhythm, immune response, and metabolism. ROR inhibitors are of interest in the study of autoimmune diseases, metabolic disorders, and cancer, as they can modulate gene expression and influence cellular functions. At CymitQuimica, we offer ROR inhibitors to support your research in immunology, endocrinology, and oncology.
Products of "ROR"
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SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Formula:C13H9F6NO3S2Purity:99.77%Color and Shape:SolidMolecular weight:405.34T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Formula:C17H12F9NO3SPurity:98% - 99.58%Color and Shape:SolidMolecular weight:481.33Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Formula:C27H40O4Purity:99.5% - 99.92%Color and Shape:SolidMolecular weight:428.6Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Formula:C27H23F6NO6SPurity:99.92%Color and Shape:SolidMolecular weight:603.53Ref: TM-TQ0007
1mg85.00€5mg147.00€10mg197.00€25mg329.00€50mg490.00€100mg710.00€1mL*10mM (DMSO)187.00€RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.Formula:C27H37NO5SMolecular weight:487.651SR2211
CAS:SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).Formula:C26H24F7N3OPurity:98.2%Color and Shape:SolidMolecular weight:527.48Ref: TM-T16929
1mg52.00€5mg96.00€10mg180.00€25mg274.00€50mg376.00€100mg533.00€500mg1,130.00€1mL*10mM (DMSO)120.00€RORγt inhibitor 4
CAS:RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.Formula:C22H16Cl2F3NO4SColor and Shape:SolidMolecular weight:518.333RORγt inverse agonist 32
CAS:RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Formula:C24H28F3NO5SColor and Shape:SolidMolecular weight:499.54XY101
CAS:XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).Formula:C25H20F7NO4SPurity:98.81%Color and Shape:SolidMolecular weight:563.48Ref: TM-T13362
1mg87.00€5mg170.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€500mg1,691.00€1mL*10mM (DMSO)205.00€RORγt Inverse agonist 8
CAS:RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).Formula:C26H33N7O2Purity:98%Color and Shape:SolidMolecular weight:475.59S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Formula:C26H25F3N2O4SPurity:99.24% - 99.31%Color and Shape:SolidMolecular weight:518.55Ref: TM-T16832
1mg57.00€5mg125.00€10mg188.00€25mg335.00€50mg470.00€100mg662.00€500mg1,320.00€1mL*10mM (DMSO)142.00€AZD-0284
CAS:AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].Formula:C21H18F6N2O5SPurity:99.75%Color and Shape:SolidMolecular weight:524.43Ref: TM-T14369
1mg58.00€5mg135.00€10mg197.00€25mg306.00€50mg444.00€100mg562.00€1mL*10mM (DMSO)158.00€RORγt inverse agonist 14
CAS:RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.Formula:C26H26F8N2O6S2Purity:98%Color and Shape:SolidMolecular weight:678.61A-9758
CAS:A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.Formula:C25H23Cl2F3N2O3Purity:98%Color and Shape:SolidMolecular weight:527.36RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Formula:C23H15Cl2F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:555.36SR0987
CAS:SR0987 is a RORγt agonist,Formula:C16H10ClF6NO2Purity:99.43%Color and Shape:SolidMolecular weight:397.7Ref: TM-T4670
2mg42.00€5mg59.00€10mg92.00€25mg188.00€50mg329.00€100mg490.00€200mg697.00€1mL*10mM (DMSO)66.00€FM26
CAS:FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.Formula:C22H15ClF3N3O3Purity:98%Color and Shape:SolidMolecular weight:461.82
