Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Products of "Cyclooxygenase (COX) Inhibitors"
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Tazofelone
CAS:Tazofelone (LY-213829) is a NSAID used for the treatment of inflammatory bowel disease.Formula:C18H27NO2SPurity:99.46%Color and Shape:SolidMolecular weight:321.48Ref: TM-T22437
1mg81.00€2mg97.00€5mg156.00€10mg226.00€25mg379.00€50mg538.00€100mg730.00€200mg938.00€1mL*10mM (DMSO)170.00€PF-04634817 succinate
CAS:PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.Formula:C29H42F3N5O7Purity:98%Color and Shape:SolidMolecular weight:629.67COX-2-IN-35
COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].Formula:C22H19NO2S2Purity:98%Color and Shape:SolidMolecular weight:393.52Carprofen
CAS:Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.Formula:C15H12ClNO2Purity:98.99% - 99.65%Color and Shape:SolidMolecular weight:273.71DICLOFENAC METHYL ESTER
CAS:Formula:C15H13Cl2NO2Purity:97%Color and Shape:SolidMolecular weight:310.17521999999997Loxoprofen
CAS:Formula:C15H18O3Purity:>97.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:246.31Flurbiprofen Axetil
CAS:Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.Formula:C19H19FO4Purity:96.02% - 98%Color and Shape:SolidMolecular weight:330.35Revaprazan hydrochloride
CAS:Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.Formula:C22H24ClFN4Purity:99.62% - 99.91%Color and Shape:SolidMolecular weight:398.9Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formula:C20H18O11Purity:97.02% - 99.94%Color and Shape:White PowderMolecular weight:434.35Ref: TM-T6S0117
1mg58.00€5mg97.00€10mg160.00€25mg283.00€50mg418.00€100mg615.00€200mg878.00€1mL*10mM (DMSO)111.00€α-Humulene
CAS:α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatoryFormula:C15H24Purity:97.18% - 97.18%Color and Shape:LiquidMolecular weight:204.35COX-2-IN-52
COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.Formula:C16H13IN4O4S2Color and Shape:SolidMolecular weight:516.333Nitroaspirin
CAS:NCX 4016, a NO-donor nitro-derivative of Aspirin, inhibits COX-1 and triggers apoptosis in ovarian cancer cells by modulating EGFR/PI3K/STAT3 and Bcl-2.Formula:C16H13NO7Purity:99.32%Color and Shape:SolidMolecular weight:331.28Ref: TM-T16328
1mg87.00€5mg187.00€10mg259.00€25mg396.00€50mg487.00€100mg658.00€200mg905.00€1mL*10mM (DMSO)172.00€Polmacoxib
CAS:Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.Formula:C18H16FNO4SPurity:97.88%Color and Shape:SolidMolecular weight:361.39Ref: TM-T21294
2mg47.00€5mg70.00€10mg107.00€25mg173.00€50mg259.00€100mg378.00€200mg563.00€1mL*10mM (DMSO)77.00€Ginsenoside Rd
CAS:Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purity:99.13% - 99.8%Color and Shape:SolidMolecular weight:947.15Ref: TM-T2878
1mg39.00€5mg81.00€10mg127.00€25mg205.00€50mg304.00€100mg455.00€500mg998.00€1mL*10mM (DMSO)131.00€hCYP3A4 Fluorogenic substrate 1
CAS:hCYP3A4 Fluorogenic substrate 1 is a phthalimide derivative and shows low activity against COX.Formula:C19H12FNO2Purity:98.59%Color and Shape:SoildMolecular weight:305.3Ref: TM-T77698
1mg57.00€2mg81.00€5mg120.00€10mg187.00€25mg376.00€50mg597.00€100mg938.00€500mg1,882.00€Valdecoxib
CAS:Formula:C16H14N2O3SPurity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:314.362-(6-Methoxynaphthalen-2-yl)acetic Acid
CAS:Formula:C13H12O3Purity:>95.0%(GC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:216.24Phenacetin
CAS:Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from theFormula:C10H13NO2Purity:99.96% - 99.98%Color and Shape:Monoclinic Prisms Analgesic MedicineMolecular weight:179.22Licofelone
CAS:Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.Formula:C23H22ClNO2Purity:99.49%Color and Shape:Yellowish SolidMolecular weight:379.88Ref: TM-T6568
5mg47.00€10mg70.00€25mg126.00€50mg187.00€100mg279.00€200mg415.00€500mg658.00€1mL*10mM (DMSO)50.00€
