GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Products of "GluR"
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LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFormula:C9H13NO4Purity:98%Color and Shape:SolidMolecular weight:199.2GYKI 53655 hydrochloride
CAS:GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.Formula:C19H21ClN4O3Purity:98.02%Color and Shape:SolidMolecular weight:388.85Foliglurax
CAS:Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).Formula:C23H23N3O3SPurity:98%Color and Shape:SolidMolecular weight:421.51MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFormula:C15H10ClFN2Purity:98%Color and Shape:SolidMolecular weight:272.71cis-PDA
CAS:cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.Formula:C7H11NO4Purity:≥98%Color and Shape:White SolidMolecular weight:173.17Decoglurant
CAS:Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.Formula:C21H11F6N5Purity:99.77%Color and Shape:SolidMolecular weight:447.34Ref: TM-T15090
1mg55.00€5mg117.00€10mg167.00€25mg309.00€50mg434.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)160.00€VU 0364439
CAS:VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).Formula:C18H13Cl2N3O3SPurity:97.90%Color and Shape:SolidMolecular weight:422.29CPPHA
CAS:CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.Formula:C22H15ClN2O4Purity:99.61%Color and Shape:SolidMolecular weight:406.82VU0155041 sodium
CAS:VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.Formula:C14H14Cl2NNaO3Purity:98%Color and Shape:SolidMolecular weight:338.16SIB-1757
CAS:SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)Formula:C12H11N3OPurity:97.37%Color and Shape:SolidMolecular weight:213.24Ref: TM-T8434
2mg39.00€5mg58.00€10mg94.00€25mg170.00€50mg259.00€100mg363.00€200mg509.00€1mL*10mM (DMSO)77.00€FPTQ
CAS:FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Formula:C17H12FN5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:305.31Ref: TM-T5509
1mg50.00€2mg73.00€5mg111.00€10mg160.00€25mg310.00€50mg419.00€100mg557.00€500mgTo inquire1mL*10mM (DMSO)116.00€VU 0285683
CAS:VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.Formula:C14H7FN4OPurity:99.8%Color and Shape:SolidMolecular weight:266.23Ref: TM-T23509
1mg42.00€5mg90.00€10mg101.00€25mg170.00€50mg235.00€100mg335.00€200mg455.00€1mL*10mM (DMSO)92.00€VU6005649
CAS:VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).Formula:C16H12F5N3OPurity:99.79%Color and Shape:SolidMolecular weight:357.28Ref: TM-T13321
5mg40.00€10mg58.00€25mg105.00€50mg170.00€100mg259.00€200mg369.00€1mL*10mM (DMSO)44.00€VU-29
CAS:VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.Formula:C22H16N4O3Purity:99.63%Color and Shape:SolidMolecular weight:384.39Ref: TM-T23515
2mg34.00€5mg52.00€10mg90.00€25mg170.00€50mg273.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)58.00€CBiPES hydrochloride
CAS:CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.Formula:C21H20ClN3O2SPurity:99.66%Color and Shape:SolidMolecular weight:413.92TCN238
CAS:TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).Formula:C12H11N3Purity:99.90%Color and Shape:SolidMolecular weight:197.24VU0422288
CAS:VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.Formula:C17H11Cl2N3O2Purity:95.48%Color and Shape:SolidMolecular weight:360.19IEM 1754 2HBr
CAS:IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.Formula:C16H30N2·2HBrPurity:99.71% - 99.72%Color and Shape:SolidMolecular weight:412.25NS-102
CAS:NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2) and inhibits specific binding to the glur6 receptor.Formula:C12H11N3O4Purity:98.73% - 98.95%Color and Shape:SolidMolecular weight:261.23TC-N 22A
CAS:TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.Formula:C14H13N5SPurity:99.84%Color and Shape:SolidMolecular weight:283.35ML289
CAS:ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.Formula:C22H23NO3Purity:99.09%Color and Shape:SolidMolecular weight:349.42Ref: TM-T23000
5mg50.00€10mg80.00€25mg145.00€50mg225.00€100mg339.00€200mg470.00€1mL*10mM (DMSO)51.00€AZD6538
CAS:AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.Formula:C15H6FN5OPurity:98.68%Color and Shape:SolidMolecular weight:291.24MMPIP hydrochloride
CAS:MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.Formula:C19H16ClN3O3Purity:99.26%Color and Shape:SolidMolecular weight:369.8CX614
CAS:CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.Formula:C13H13NO4Purity:97.43%Color and Shape:SolidMolecular weight:247.25Ref: TM-T19698
5mg55.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€200mg409.00€1mL*10mM (DMSO)66.00€LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Formula:C16H18N2O6Purity:98.15%Color and Shape:SolidMolecular weight:334.32Ro 67-4853
CAS:Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).Formula:C19H19NO4Purity:98.57%Color and Shape:SolidMolecular weight:325.36Caroverine hydrochloride
CAS:Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.Formula:C22H28ClN3O2Purity:98.37% - 98.75%Color and Shape:SolidMolecular weight:401.9Ref: TM-T9133
5mg47.00€10mg70.00€25mg131.00€50mg216.00€100mg378.00€200mg552.00€500mg868.00€1mL*10mM (DMSO)50.00€FTIDC
CAS:FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.Formula:C18H23FN6OPurity:≥98%Color and Shape:SolidMolecular weight:358.41Ref: TM-T3483
1mg105.00€2mg154.00€5mg227.00€10mg359.00€25mg597.00€50mg842.00€100mg1,130.00€1mL*10mM (DMSO)250.00€ADX-47273
CAS:ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).Formula:C20H17F2N3O2Purity:97% - 99.18%Color and Shape:SolidMolecular weight:369.36Decanoic Acid
CAS:Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.Formula:C10H20O2Purity:98.59%Color and Shape:Crystalline Solid SolidMolecular weight:172.26AZD 9272
CAS:AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.Formula:C14H6F2N4OPurity:97.53%Color and Shape:SolidMolecular weight:284.22CX717
CAS:CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect.Formula:C11H11N3O3Purity:100%Color and Shape:SoildMolecular weight:233.23LY-404187
CAS:LY404187 is a positive allosteric modulator of AMPA receptorsFormula:C19H22N2O2SPurity:99.34%Color and Shape:SolidMolecular weight:342.46Ref: TM-T7706
2mg35.00€5mg52.00€10mg90.00€25mg164.00€50mg239.00€100mg339.00€200mg472.00€1mL*10mM (DMSO)58.00€Cyclothiazide
CAS:Cyclothiazide enhances AMPA receptors, prevents desensitization, and boosts glutamic acid response (EC50 = 3.8µM).Formula:C14H16ClN3O4S2Purity:98.23% - 99.49%Color and Shape:Crystals From Dilute Alcohol SolidMolecular weight:389.88(S)-3-Hydroxyphenylglycine
CAS:(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).Formula:C8H9NO3Purity:99.18%Color and Shape:SolidMolecular weight:167.16JNJ16259685
CAS:JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19Formula:C20H23NO3Purity:98.31%Color and Shape:SolidMolecular weight:325.4Ref: TM-T5512
1mg48.00€2mg65.00€5mg90.00€10mg140.00€25mg293.00€50mg449.00€100mg655.00€1mL*10mM (DMSO)100.00€MPEP
CAS:MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.Formula:C14H11NPurity:99.54%Color and Shape:SolidMolecular weight:193.24LSN2463359
CAS:LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.Formula:C16H15N3OPurity:99.36%Color and Shape:SolidMolecular weight:265.31Ref: TM-T27854
2mg35.00€5mg52.00€10mg85.00€25mg170.00€50mg259.00€100mg383.00€200mg545.00€1mL*10mM (DMSO)58.00€VU0650786
CAS:VU0650786: selective mGlu3 NAM, CNS-penetrant, IC50 392 nM, shows antidepressant/anxiolytic effects in rodents.Formula:C18H15ClFN5O2Purity:99.09%Color and Shape:SolidMolecular weight:387.8Ref: TM-T13318
1mg96.00€5mg235.00€10mg329.00€25mg560.00€50mg800.00€100mg1,103.00€1mL*10mM (DMSO)259.00€FITM
CAS:FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).Formula:C18H18FN5OSPurity:97.25%Color and Shape:SolidMolecular weight:371.43Ref: TM-T7292
1mg35.00€2mg47.00€5mg70.00€10mg97.00€25mg187.00€50mg283.00€100mg416.00€1mL*10mM (DMSO)65.00€VU0364770
CAS:VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGluFormula:C12H9ClN2OPurity:99.65% - 99.92%Color and Shape:SolidMolecular weight:232.67EGLU
CAS:EGLU, an antidepressant and potent mGluR-2 antagonist, binds with a 66 μM Kd to (lS,3S)-ACPD sites.Formula:C7H13NO4Purity:99.98%Color and Shape:SolidMolecular weight:175.18DCB
CAS:DCB is an mGluR5 allosteric ligand that blocks mGluR modulation, countering DMeOB and DFB effects.Formula:C14H10Cl2N2Purity:99.12% - 99.9%Color and Shape:SolidMolecular weight:277.15Ref: TM-T22711
5mg39.00€10mg50.00€25mg105.00€50mg170.00€100mg273.00€200mg378.00€1mL*10mM (DMSO)42.00€(E/Z)-SIB-1893
CAS:(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.Formula:C14H13NPurity:99.92%Color and Shape:SolidMolecular weight:195.26Org-26576
CAS:Org-26576 is a positive allosteric modulator of the AMPA receptor.Formula:C11H12N2O2Purity:99.67%Color and Shape:SolidMolecular weight:204.23Ref: TM-T16402
5mg47.00€10mg70.00€25mg104.00€50mg150.00€100mg256.00€200mg379.00€1mL*10mM (DMSO)50.00€Biphenylindanone A
CAS:Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.Formula:C30H30O4Purity:98%Color and Shape:SolidMolecular weight:454.56Piracetam
CAS:Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.Formula:C6H10N2O2Purity:97.16%Color and Shape:Crystals From Isopropanol SolidMolecular weight:142.16MTEP hydrochloride
CAS:MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)Formula:C11H9ClN2SPurity:99.58%Color and Shape:SolidMolecular weight:236.72AMN082 free base
CAS:AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.Formula:C28H28N2Purity:97.75% - 97.79%Color and Shape:SolidMolecular weight:392.54Ref: TM-T21935L
1mg39.00€5mg78.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€200mg793.00€1mL*10mM (DMSO)89.00€VU-1545
CAS:VU-1545 is mGlu5 positive allosteric modulator.Formula:C22H15FN4O3Purity:98.80%Color and Shape:SolidMolecular weight:402.38
