AChR
Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.
Products of "AChR"
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Terodiline hydrochloride
CAS:Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2),Formula:C20H28ClNPurity:98%Color and Shape:SolidMolecular weight:317.9Nitenpyram
CAS:Nitenpyram (Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.Formula:C11H15ClN4O2Purity:98.42%Color and Shape:Light-Yellow CrystalMolecular weight:270.72nAChR agonist 1
CAS:nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.Formula:C20H18ClNO3S2Purity:97.59%Color and Shape:SolidMolecular weight:419.94Ref: TM-T12165
1mg94.00€5mg170.00€10mg259.00€25mg424.00€50mg562.00€100mg775.00€200mg1,026.00€1mL*10mM (DMSO)192.00€Pancuronium dibromide
CAS:Pancuronium dibromide (Pavulon), a competitive AChR antagonist, acts as a skeletal muscle relaxant. Pancuronium dibromide blocks neuromuscular transmission.Formula:C35H60Br2N2O4Purity:99.86%Color and Shape:solidMolecular weight:732.67Ref: TM-T0166
5mg38.00€10mg55.00€25mg82.00€50mg115.00€100mg188.00€200mg235.00€500mg394.00€1mL*10mM (DMSO)63.00€Darifenacin hydrobromide
CAS:Darifenacin hydrobromide (UK-88525) is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.Formula:C28H31BrN2O2Purity:100% - 99.75%Color and Shape:SolidMolecular weight:505.45VU 0255035
CAS:VU 0255035 is a highly selective, competitive and brain penetrant muscarinic M1 receptor antagonist with an IC50 of 130 nM.Formula:C18H20N6O3S2Purity:96.53% - 98.26%Color and Shape:SolidMolecular weight:432.52Adiphenine hydrochloride
CAS:Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.Formula:C20H25NO2·HClPurity:97.76% - 99.13%Color and Shape:White Or Almost White PowderMolecular weight:347.88Methacholine Chloride
CAS:Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of acetylcholine.Formula:C8H18ClNO2Purity:99.37% - 99.74%Color and Shape:White Hygroscopic Crystals With Slight Odor Of Dead FishMolecular weight:195.69Ispronicline
CAS:Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitiveFormula:C14H22N2OPurity:96.49% - 99.16%Color and Shape:SolidMolecular weight:234.348-Aminoadenine
CAS:8-Aminoadenine (7H-purine-6,8-diamine) is a ligand for Adenine Receptor with Ki of 0.0341 μM.Formula:C5H6N6Purity:98.34%Color and Shape:SolidMolecular weight:150.14PNU-120596
CAS:PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.Formula:C13H14ClN3O4Purity:98.34%Color and Shape:SolidMolecular weight:311.72suvn-911
CAS:suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.Formula:C11H14Cl2N2OPurity:98.88%Color and Shape:SolidMolecular weight:261.15Ref: TM-T9787
1mg71.00€5mg140.00€10mg215.00€25mg359.00€50mg510.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)182.00€MHP 133
CAS:MHP 133 is a drug with multiple CNS targets(AChE with Ki of 69 μM).Formula:C17H20ClN5O3Purity:98%Color and Shape:SolidMolecular weight:377.83Ipratropium Bromide
CAS:Ipratropium Bromide (Sch 1000) is an antagonist of muscarinic receptors and is used in COPD and asthma studies.Formula:C20H30BrNO3Purity:99.91%Color and Shape:SolidMolecular weight:412.37Varenicline Tartrate
CAS:Varenicline Tartrate (CP 526555-18) is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist.Formula:C13H13N3·C4H6O6Purity:98.23% - 98.32%Color and Shape:Tan SolidMolecular weight:361.35GSK233705
CAS:GSK233705, a muscarinic antagonist, is used to prevent/treat COPD and asthma.Formula:C24H29BrN2Purity:99.67% - 99.76%Color and Shape:SolidMolecular weight:425.4DMAB-anabaseine dihydrochloride
CAS:DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) is an α7-containingFormula:C19H23Cl2N3Purity:99.86%Color and Shape:SolidMolecular weight:364.31A-867744
CAS:A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).Formula:C20H19ClN2O3SPurity:95.66%Color and Shape:SolidMolecular weight:402.89MK-7622
CAS:MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric.Formula:C25H25N3O2Purity:99.77% - 99.8%Color and Shape:SolidMolecular weight:399.48JHU37152
CAS:JHU37152 is a DREADD agonist; Ki: 1.8 nM at hM3Dq, 8.7 nM at hM4Di; EC50: 5 nM (hM3Dq), 0.5 nM (hM4Di) in HEK-293 cell assays.Formula:C19H20ClFN4Purity:99.72%Color and Shape:SolidMolecular weight:358.84Ref: TM-T9019
2mg35.00€5mg52.00€10mg90.00€25mg170.00€50mg255.00€100mg375.00€200mg533.00€1mL*10mM (DMSO)58.00€Oxotremorine M iodide
CAS:Oxotremorine M iodide (Oxotremorine methiodide) is an agonist of mAChR and potentiates NMDA receptors.Formula:C11H19IN2OPurity:98.75%Color and Shape:SolidMolecular weight:322.19LY2119620
CAS:LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.Formula:C19H24ClN5O3SPurity:99.7%Color and Shape:SolidMolecular weight:437.94UP202-56
CAS:UP202-56 is an adenosinergic agonist and is an adenosine analog.Formula:C33H37N7O4Purity:98%Color and Shape:SolidMolecular weight:595.69NBTGR
CAS:NBTGR is a potent nucleoside transport inhibitor(adenosine uptake ,Ki of 70 nM).Formula:C17H18N6O6SPurity:98%Color and Shape:SolidMolecular weight:434.43mAChr-in-1
CAS:mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).Formula:C23H25IN2O2Purity:98%Color and Shape:SolidMolecular weight:488.36VU0467154
CAS:VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor.Formula:C17H15F3N4O3S2Purity:98.05% - 98.28%Color and Shape:SolidMolecular weight:444.45Ref: TM-T17244
1mg52.00€5mg97.00€10mg139.00€25mg263.00€50mg444.00€100mg772.00€200mg1,026.00€1mL*10mM (DMSO)111.00€CHF5407
CAS:CHF5407(SVT-47060) is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors.CHF5407 has an effect onFormula:C27H25BrF4N2O3SPurity:100%Color and Shape:SolidMolecular weight:613.46V-11-0711 HCl
V-11-0711 HCl is a selective and highly effective choline kinase α (ChoKα) inhibitor that inhibits the catalytic activity of Chk.Formula:C27H36ClNO3Purity:100%Color and Shape:SolidMolecular weight:458.03Varenicline
CAS:Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.Formula:C13H13N3Purity:99.76%Color and Shape:SolidMolecular weight:211.26Ref: TM-T4246L
2mg35.00€5mg52.00€10mg80.00€25mg144.00€50mg210.00€100mg329.00€200mg490.00€1mL*10mM (DMSO)58.00€CCMI
CAS:CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric.Formula:C19H15Cl2N3O2Purity:100%Color and Shape:SolidMolecular weight:388.25M4 mAChR agonist-1
CAS:M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).Formula:C14H18N4OSPurity:98.25%Color and Shape:SolidMolecular weight:290.38SIB-1553A hydrochloride
CAS:SIB-1553A hydrochloride is a nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligandFormula:C13H20ClNOSPurity:99.47% - 99.71%Color and Shape:SolidMolecular weight:273.82Tacrine hydrochloride (hydrate)
CAS:Tacrine hydrochloride hydrate (Tetrahydroaminacrine) is a cholinesterase inhibitor that crosses the blood-brain barrier.Formula:C13H14N2·XHCl·XH2OPurity:99.01% - 99.89%Color and Shape:SolidMolecular weight:234.72PNU-282987
CAS:PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).Formula:C14H18Cl2N2OPurity:100% - 99.92%Color and Shape:SolidMolecular weight:301.21PF-03635659
CAS:PF-03635659: potent M3 antagonist, Ki=0.2 nM, long half-life, potential COPD treatment.Formula:C28H32N2O3Purity:98.05% - 99.83%Color and Shape:SolidMolecular weight:444.57Xanomeline oxalate
CAS:Xanomeline oxalate (LY246708), a potent SMRA, boosts phosphoinositide hydrolysis; key for Alzheimer's research.Formula:C16H25N3O5SPurity:98.22%Color and Shape:SolidMolecular weight:371.45Ref: TM-T13353
5mg38.00€10mg58.00€25mg105.00€50mg168.00€100mg259.00€200mg373.00€1mL*10mM (DMSO)42.00€SEN12333
CAS:SEN12333 is an α7 nicotinic acetylcholine receptor (nAChR) agonistFormula:C20H25N3O2Purity:99.02%Color and Shape:SolidMolecular weight:339.43Ref: TM-T23348
2mg39.00€5mg57.00€10mg95.00€25mg167.00€50mg269.00€100mg432.00€200mg622.00€1mL*10mM (DMSO)63.00€AChE/BChE-IN-10
CAS:AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.Formula:C26H30N2O2Purity:99.55% - 99.75%Color and Shape:SoildMolecular weight:402.53Ref: TM-T61969
5mg44.00€10mg67.00€25mg126.00€50mg188.00€100mg306.00€200mg454.00€1mL*10mM (DMSO)54.00€N-0861 racemate
CAS:N-0861 racemate is the racemate of N-0861.Formula:C13H17N5Purity:98%Color and Shape:SolidMolecular weight:243.31Trospium chloride
CAS:Trospium chloride treats urinary incontinence without causing liver damage.Formula:C25H30ClNO3Purity:100% - 99.92%Color and Shape:White To Off-White PowderMolecular weight:427.964bPiDDB
CAS:bPiDDB (N,N'-Dodecylbis-Picolinium Bromide) is a nicotinic receptor (nAChR) antagonist.Formula:C24H38Br2N2Purity:98.72%Color and Shape:SolidMolecular weight:514.38Ref: TM-T37818
2mg43.00€5mg60.00€10mg96.00€25mg188.00€50mg278.00€100mg411.00€200mg607.00€1mL*10mM (DMSO)73.00€Ursulcholic acid
CAS:Ursulcholic acid (Ursulcholic) is a water-soluble anticholinergic compound.Formula:C24H40O10S2Purity:98%Color and Shape:SolidMolecular weight:552.7Loxeen
CAS:Loxeen (Pridinol methanesulfonate) is used as an anticholinergic and as an antiparkinsonian agent.Formula:C20H25NO·CH4O3SPurity:99.46%Color and Shape:White To Off-White Crystalline PowderMolecular weight:391.52Otenzepad
CAS:Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.Formula:C24H31N5O2Purity:99.81%Color and Shape:SolidMolecular weight:421.54Cimetropium Bromide
CAS:Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.Formula:C21H28BrNO4Color and Shape:SolidMolecular weight:438.36Nitrobenzylthioinosine
CAS:Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.Formula:C17H17N5O6SPurity:98.83% - 99.69%Color and Shape:Off-White SolidMolecular weight:419.414-DAMP
CAS:4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.Formula:C21H26INO2Purity:98%Color and Shape:SolidMolecular weight:451.34Imidafenacin
CAS:Imidafenacin (KRP-197)(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.Formula:C20H21N3OPurity:99.17%Color and Shape:SolidMolecular weight:319.4Tolterodine
CAS:Tolterodine ((R)-(+)-Tolterodine) is an mACh antagonist used in the treatment of detrusor instability and overactive bladder syndrome.Formula:C22H31NOPurity:99.71%Color and Shape:White Like Or Light Brown Crystalline PowderMolecular weight:325.49Mepenzolate Bromide
CAS:Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions.Formula:C21H26BrNO3Purity:95.73% - 99.21%Color and Shape:SolidMolecular weight:420.34
