
Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase
- Cysteine Protease
- DPP-4
- Glutaminase
- HCV Protease
- HIV Protease
- p97
- PAI-1
- Protease-activated Receptor
- Protease Inhibitors
- Proteasome
- Serine Protease
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Products of "Proteases/Proteasome"
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PR 39 (porcine) acetate
PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor.Purity:98%Color and Shape:LiquidMolecular weight:N/ADolutegravir sodium
CAS:Dolutegravir sodium (GSK-1349572A) salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signatureFormula:C20H18F2N3NaO5Purity:98% - 99.74%Color and Shape:SolidMolecular weight:441.36EDTA, Disodium Salt, Dihydrate
CAS:EDTA disodium dihydrate chelates metals, inhibits proteases, and aids in protein purification; doesn't affect cellulase.Formula:C10H18N2Na2O10Purity:99.97%Color and Shape:SolidMolecular weight:372.24Beclabuvir
CAS:Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.Formula:C36H45N5O5SPurity:99.87% - 99.93%Color and Shape:SolidMolecular weight:659.84Sulochrin
CAS:Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparentFormula:C17H16O7Purity:98%Color and Shape:SolidMolecular weight:332.3ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Formula:C32H22O10Purity:98% - 99.72%Color and Shape:SolidMolecular weight:566.51Davelizomib
CAS:Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].Formula:C21H26BF2N3O7Purity:98%Color and Shape:SolidMolecular weight:481.25Notoginsenoside T5
CAS:TPNS from San-Chi root (Araliaceae) treats atherosclerosis by lowering lipids and modifying vascular CD40/MMP-9, suggesting clinical use.Formula:C41H68O12Purity:98%Color and Shape:SolidMolecular weight:752.983Viscumneoside III
CAS:Viscumneoside III, a dihydroflavone O-glycoside, is a potent Tyrosinase inhibitor with an IC50 of 0.5 mM. Viscumneoside III has anti-angina pectoris.Formula:C27H32O15Purity:98%Color and Shape:SolidMolecular weight:596.53Aloin
CAS:Aloin (Aloin-A)(mixture of A&B), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.Formula:C21H22O9Purity:98.28%Color and Shape:Yellow PowderMolecular weight:418.39Mizoribine
CAS:Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.Formula:C9H13N3O6Purity:98.38% - 99.95%Color and Shape:White To Off-White Crystalline PowderMolecular weight:259.22Isatoribine
CAS:Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.Formula:C10H12N4O6SPurity:100% - 99.73%Color and Shape:SolidMolecular weight:316.29CIL62
CAS:CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].Formula:C23H26O5Purity:97.07%Color and Shape:SolidMolecular weight:382.45Ref: TM-T8468
1mg52.00€5mg116.00€10mg170.00€25mg335.00€50mg562.00€100mg758.00€200mg1,017.00€1mL*10mM (DMSO)128.00€HIV-1 Inhibitor 18A
CAS:HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) specifically inhibits the entry of multiple HIV-1 isolates.Formula:C14H11N5O2SPurity:91.64%Color and Shape:SolidMolecular weight:313.33Ref: TM-T24141
1mg115.00€5mg227.00€10mg313.00€25mg535.00€50mg752.00€100mg1,064.00€1mL*10mM (DMSO)217.00€Sirpiglenastat
CAS:Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.Formula:C22H27N5O5Purity:98.01% - 98.37%Color and Shape:SolidMolecular weight:441.48Atazanavir Sulfate
CAS:Formula:C38H52N6O7·H2SO4Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:802.94Melagatran
CAS:Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.Formula:C22H31N5O4Purity:100% - 98.37%Color and Shape:SolidMolecular weight:429.51Ref: TM-T11994
1mg513.00€5mg1,198.00€10mg1,549.00€25mg2,337.00€50mg3,125.00€100mg4,246.00€1mL*10mM (DMSO)1,130.00€BMS-561392 Formic acid
BMS-561392 Formic acid is a selective inhibitor of TACE and reduces TNFalpha levels.Formula:C28H34N4O6Purity:97.25%Color and Shape:SoildMolecular weight:522.59Ref: TM-T30531L
1mg185.00€5mg424.00€10mg627.00€25mg938.00€50mg1,311.00€100mg1,795.00€500mg3,600.00€1mL*10mM (DMSO)520.00€Pseudane IX
CAS:Pseudane IX (2-nonyl-1H-quinolin-4-one) reduces infection of Huh 7.5 cells by hepatitis C virus (HCV) with an IC50 of 1.4 μg/ml.Formula:C18H25NOPurity:99.71%Color and Shape:SolidMolecular weight:271.4TG2-IN-3h
CAS:TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitorFormula:C21H26N4O4SPurity:99.34% - 99.76%Color and Shape:SolidMolecular weight:430.52MEGA-9
CAS:MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.Formula:C16H33NO6Purity:99.59%Color and Shape:SolidMolecular weight:335.44Emtricitabine S-oxide
CAS:Emtricitabine treats HIV; its degradation byproduct is Emtricitabine S-oxide.Formula:C8H10FN3O4SPurity:98%Color and Shape:SolidMolecular weight:263.25PSI
CAS:PSI is a proteasome inhibitor.Formula:C32H50N4O8Purity:97% - 98.33%Color and Shape:SolidMolecular weight:618.76Methylchloroisothiazolinone/Methylisothiazolinone Mixture
CAS:Methylchloroisothiazolinone/Methylisothiazolinone Mixture (Kathon 886MW),a preservative, activates MMPs in human bronchial epithelial cells.Formula:C8H9ClN2O2S2Color and Shape:SolidMolecular weight:264.75Sovaprevir
CAS:Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection.Formula:C43H53N5O8SPurity:99.10%Color and Shape:SolidMolecular weight:799.97Ref: TM-T28830
1mg266.00€5mg655.00€10mg934.00€25mg1,388.00€50mg1,872.00€100mg2,517.00€1mL*10mM (DMSO)1,035.00€TS-021
CAS:TS-021 is a selective dipeptidyl peptidase 4 (DPP-4) inhibitor with antidiabetic activity for the study of type 2 diabetes.Formula:C17H24FN3O5SPurity:100% - 100%Color and Shape:SolidMolecular weight:401.45RJF02215
CAS:RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formula:C17H12ClN3OS3Color and Shape:SolidMolecular weight:405.95Salicylanilide
CAS:Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.Formula:C13H11NO2Purity:99.55%Color and Shape:White To Off-White Crystalline PowderMolecular weight:213.23hTYR/AbTYR-IN-1
CAS:hTYR/AbTYR-IN-1 is a dual hTYR/AbTYR inhibitor with inhibitory effects on hTYR and AbTYR, with IC50s of 5.4 μM and 3.52 μM, respectively.Formula:C18H20N2O3Purity:99.59%Color and Shape:SoildMolecular weight:312.36Heparin
CAS:Heparin (Adomiparin) is a mucopolysaccharide sulfate that has shown partial anti-inflammatory activity in in vivo studies.Formula:C26H42N2O37S5Purity:98%Color and Shape:White Or Pale-Colored Amorphous Powder SolidMolecular weight:1134.9Oxindole
CAS:Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.Formula:C8H7NOPurity:99.34%Color and Shape:Off-White Crystalline PowderMolecular weight:133.15TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Formula:C39H37N3O3Purity:98.2% - 98.75%Color and Shape:SolidMolecular weight:595.73Ref: TM-T17011
1mg74.00€5mg160.00€10mg250.00€25mg455.00€50mg682.00€100mg938.00€1mL*10mM (DMSO)265.00€KW-2450 Formate
KW-2450 Formate is an IGF-1R/IR tyrosine kinase inhibitor with antitumor effects that acts through inhibition of Aurora A and B kinases.KW-2450 Formate inhibits the growth of TNBC xenografts and induces tetraploid accumulation.Formula:C29H31N5O5SPurity:99.34%Color and Shape:SolidMolecular weight:561.65Thiamine disulfide
CAS:Thiamine disulfide (Algoneurina) , also known as thiamin or vitamin B1, is a vitamin found in food and manufactured as a dietary supplement and medication.Formula:C24H34N8O4S2Purity:99.18%Color and Shape:CoaMolecular weight:562.71Chlorcyclizine
CAS:CHLORCYCLIZINE is a histamine H1 antagonist and a potent hepatitis C virus (HCV) entry inhibitor.Formula:C18H21ClN2Purity:98% - 98.75%Color and Shape:SolidMolecular weight:300.83UK 356618
CAS:UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).Formula:C34H43N3O4Purity:98%Color and Shape:SolidMolecular weight:557.72Cabotegravir
CAS:Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (Formula:C19H17F2N3O5Purity:98.55% - 99.92%Color and Shape:SolidMolecular weight:405.35Tyrosinase-IN-35
CAS:Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.Formula:C17H15N5OSColor and Shape:SolidMolecular weight:337.40DRB
CAS:DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)Formula:C12H12Cl2N2O4Purity:99.46%Color and Shape:White To Off-White Crystalline SolidMolecular weight:319.14Collagenase Type II
Collagenase Type II, an endopeptidic MMP-8, preferentially degrades type I collagen tissues requiring high digestive efficiency pancreas and liver.Color and Shape:Odour SolidU18666A
CAS:U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor.Formula:C25H42ClNO2Purity:98.99%Color and Shape:SolidMolecular weight:424.06Ref: TM-T17190
1mg35.00€2mg47.00€5mg70.00€10mg97.00€25mg185.00€50mg301.00€100mg454.00€200mg650.00€1mL*10mM (DMSO)77.00€CASP3 Activator 1541
CAS:CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.Formula:C24H17N3O4Purity:98.84%Color and Shape:SolidMolecular weight:411.41L 756423
CAS:L756423 is a potent, selective HIV protease inhibitor (Ki=0.049 nM), effective against HIV spread in MT25 lymphocytes at 0.1-0.5 nM, useful for AIDS research.Formula:C39H48N4O5Purity:100% - 100%Color and Shape:SolidMolecular weight:652.82TAPI1
CAS:TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.Formula:C26H37N5O5Purity:≥95%Color and Shape:SolidMolecular weight:499.6Setrobuvir
CAS:Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension withFormula:C25H25FN4O6S2Purity:100% - 99%Color and Shape:SolidMolecular weight:560.62Ref: TM-T28762
1mg229.00€5mg570.00€10mg812.00€25mg1,216.00€50mg1,663.00€100mg2,242.00€500mg4,494.00€1mL*10mM (DMSO)737.00€Efavirenz
CAS:Efavirenz (DMP 266) is an HIV-1 inhibitor, affecting reverse transcriptase and various cytochrome P450 enzymes.Formula:C14H9ClF3NO2Purity:99.2% - 99.83%Color and Shape:White To Slightly Pink Crystalline PowderMolecular weight:315.67Ref: TM-T2393
1g404.00€5mg42.00€10mg52.00€25mg71.00€50mg89.00€100mg116.00€500mg273.00€1mL*10mM (DMSO)49.00€Doxycycline hydrochloride
CAS:Doxycycline hydrochloride (Hyclate) is a synthetic tetracycline derivative with similar antimicrobial activity.Formula:C22H24N2O8·HClPurity:98.77%Color and Shape:Yellow Hygroscopic Crystalline PowderMolecular weight:480.9Atazanavir
CAS:Formula:C38H52N6O7Purity:>95.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:704.87Mk-6186 HCl
MK-6186 HCl, a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity, can be used to study HIV.Formula:C21H13Cl3N6OPurity:98.19%Color and Shape:SoildMolecular weight:471.73