Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase
- Cysteine Protease
- DPP-4
- Glutaminase
- HCV Protease
- HIV Protease
- p97
- PAI-1
- Protease-activated Receptor
- Protease Inhibitors
- Proteasome
- Serine Protease
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Products of "Proteases/Proteasome"
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Trelagliptin
CAS:Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.Formula:C18H20FN5O2Purity:98.88%Color and Shape:SolidMolecular weight:357.38ACH-806
CAS:ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.Formula:C19H20F3N3O2SPurity:98%Color and Shape:SolidMolecular weight:411.44Sofosbuvir impurity K
CAS:Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.Formula:C22H29ClN3O9PPurity:98%Color and Shape:SolidMolecular weight:545.91NBD-557
CAS:NBD-557 is a potentially HIV-1 inhibitor.Formula:C17H24BrN3O2Purity:99.52%Color and Shape:SolidMolecular weight:382.3Ref: TM-T7382
1mg48.00€5mg97.00€10mg156.00€25mg301.00€50mg437.00€100mg620.00€200mg843.00€1mL*10mM (DMSO)105.00€Ilomastat
CAS:Formula:C20H28N4O4Purity:>95.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:388.472-Amino-6-bromopyridine
CAS:2-Amino-6-bromopyridine has inhibitory effect on HIV-68 protease.Formula:C5H5BrN2Purity:99.87%Color and Shape:SolidMolecular weight:173.013,3′-Bisdemethylpinoresinol
CAS:3,3′-Bisdemethylpinoresinol, a natural lignin derivative, exhibits MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts and can be isolated fromFormula:C18H18O6Purity:98%Color and Shape:SolidMolecular weight:330.33LY 3000328
CAS:LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.Formula:C25H29FN4O5Purity:97.83% - 99.54%Color and Shape:SolidMolecular weight:484.52Ref: TM-TQ0116
1mg96.00€2mg137.00€5mg210.00€10mg278.00€25mg487.00€50mg708.00€100mg998.00€1mL*10mM (DMSO)220.00€NNRTIs-IN-3
NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor, displaying potent efficacy with an EC50 value of 0.01 µM [1].Formula:C17H20ClN5OPurity:98%Color and Shape:SolidMolecular weight:345.83NP-313
CAS:NP-313 (NSC-4264) is a potent antithrombotic that blocks platelet aggregation via thromboxane A2 synthesis inhibition and targets SOCC-mediated Ca2+ efflux.Formula:C12H8ClNO3Purity:98.97%Color and Shape:SolidMolecular weight:249.65Ac-VRPR-AMC
CAS:Ac-VRPR-AMC is a fluorogenic substrate for metacaspase activity assays, facilitating the detection and measurement of metacaspase activity [1].Formula:C34H51N11O7Purity:98%Color and Shape:SolidMolecular weight:725.842-PMPA
CAS:2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) (IC50=300 pM).Formula:C6H11O7PPurity:98% - 99.50%Color and Shape:SolidMolecular weight:226.12Tyrosinase-IN-32
Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.Formula:C15H19NO3Color and Shape:SolidMolecular weight:261.32ABT530
CAS:ABT530 (Pibrentasvir) is an HCV NS5A inhibitor with EC50s ranging from 1.4-5.0 pM against HCV replicons containing NS5A from genotypes 1-6.Formula:C57H65F5N10O8Purity:99.15% - 99.93%Color and Shape:SolidMolecular weight:1113.18MMP-3 Inhibitor
CAS:MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity.Formula:C27H46N10O9SPurity:98.87%Color and Shape:SolidMolecular weight:686.78Ref: TM-T37048
1mg81.00€5mg208.00€10mg309.00€25mg525.00€50mg757.00€100mg1,035.00€500mg2,110.00€1mL*10mM (DMSO)221.00€Isoangustone A
CAS:Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferationFormula:C25H26O6Purity:98%Color and Shape:SolidMolecular weight:422.47MMP13-IN-3
CAS:MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.Formula:C24H22N4O5Purity:99.05%Color and Shape:SolidMolecular weight:446.46Ref: TM-T16124
1mg87.00€5mg216.00€10mg354.00€25mg620.00€50mg847.00€100mg1,169.00€1mL*10mM (DMSO)240.00€N-α-Tosyl-L-lysine chloromethyl ketone hydrochloride
CAS:N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride inhibits trypsin-like proteases and IFN-γ activities.Formula:C14H22Cl2N2O3SPurity:97.44%Color and Shape:PowderMolecular weight:369.31TNF Protease Inhibitor 2
CAS:TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).Formula:C19H37N5O5Purity:98%Color and Shape:SolidMolecular weight:415.53MG-132
CAS:Formula:C26H41N3O5Purity:>95.0%(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:475.63Z-Leu-Leu-Tyr-COCHO
CAS:Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity, exhibiting a Ki value of 3.0 nM [1].Formula:C30H39N3O7Purity:98%Color and Shape:SolidMolecular weight:553.65Emivirine
CAS:Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.Formula:C17H22N2O3Purity:99.68%Color and Shape:SolidMolecular weight:302.37Benzylsulfonyl Fluoride [for Biochemical Research]
CAS:Formula:C7H7FO2SPurity:>98.0%(GC)Color and Shape:White to Almost white powder to crystalMolecular weight:174.19BI 224436
CAS:BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.Formula:C27H26N2O4Color and Shape:SolidMolecular weight:442.51HIV-1 protease-IN-9
CAS:HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and aFormula:C37H41N7O4SPurity:98%Color and Shape:SolidMolecular weight:679.83CDK9-IN-30
CAS:CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.Formula:C16H20FNO3Purity:99.76%Color and Shape:SolidMolecular weight:293.33Ref: TM-T9632
1mg56.00€5mg119.00€10mg187.00€25mg316.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)114.00€GLPG2451
CAS:GLPG2451 potentiates F508del CFTR at low temp (EC50: 11.1 nM), aiding cystic fibrosis treatment.Formula:C16H16F3N3O5SColor and Shape:SolidMolecular weight:419.38Trisodium Hydrogen Ethylenediaminetetraacetate Hydrate [for Biochemical Research]
CAS:Formula:C10H13N2Na3O8·xH2OPurity:>98.0%(T)Color and Shape:White to Almost white powder to crystalMolecular weight:358.19 (as Anhydrous)Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate
CAS:Formula:C21H25N5O8S2Purity:98%Color and Shape:SolidMolecular weight:539.5819MMP-2 Inhibitor-4
MMP-2Inhibitor-4 (Compound 5g) is an MMP-2 inhibitor with an IC50 of 152.62 nM. It effectively reduces MMP-2 levels in K562 cell lines by stably binding to the active site of MMP-2 and exhibits strong anti-angiogenic effects in ACHN cell lines. MMP-2Inhibitor-4 shows potential for research in chronic myelogenous leukemia (CML).Formula:C19H23N3O5SMolecular weight:405.468Sofosbuvir impurity H
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir.Formula:C29H33FN3O10PPurity:98%Color and Shape:SolidMolecular weight:633.56Licraside
CAS:Licraside is a tyrosinase inhibitor with an IC50 of 0.072 mM for monophenolase and can be used in studies about antibrowning and depigmenting agents.Formula:C26H30O13Purity:99.85%Color and Shape:SolidMolecular weight:550.51Raltegravir potassium
CAS:Raltegravir potassium (MK 0518 potassium salt) salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.Formula:C20H20FN6O5·KPurity:98% - 99.55%Color and Shape:Off-White SolidMolecular weight:482.51Cilastatin
CAS:Cilastatin (MK0791): protects imipenem from renal breakdown; inhibits leukotriene D4 metabolism.Formula:C16H26N2O5SPurity:97.76% - 99.71%Color and Shape:SolidMolecular weight:358.45Ref: TM-T2583
5mg35.00€10mg44.00€25mg63.00€50mg88.00€100mg124.00€200mg188.00€500mg325.00€1mL*10mM (DMSO)55.00€Flovagatran
CAS:Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.Formula:C27H36BN3O7Purity:99.56%Color and Shape:SolidMolecular weight:525.4Ro24-7429
CAS:Ro24-7429: oral HIV-1 Tat antagonist, RUNX1 inhibitor with anti-HIV, antifibrotic, and anti-inflammatory properties.Formula:C14H13ClN4Purity:99.29% - 99.85%Color and Shape:SolidMolecular weight:272.73Ref: TM-T28578
1mg92.00€5mg187.00€10mg298.00€25mg507.00€50mg730.00€100mg1,026.00€500mg2,877.00€1mL*10mM (DMSO)215.00€Caspase-3 activator 3
Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemicPurity:98%Color and Shape:Odour Solid3-Aminobenzene-1,2-diol
CAS:3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.Formula:C6H7NO2Color and Shape:SolidMolecular weight:125.132-Benzylsuccinic acid
CAS:2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is a bacterial xenobiotic metabolite.Formula:C11H12O4Purity:≥95%Color and Shape:SolidMolecular weight:208.21HIV-1 protease-IN-7
CAS:HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1].Formula:C68H104N10O12SPurity:98%Color and Shape:SolidMolecular weight:1285.68Aderamastat
CAS:Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis.Formula:C21H18N2O4SPurity:99.35%Color and Shape:SolidMolecular weight:394.44PF 00356231
CAS:PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).Formula:C25H20N2O3SPurity:99.35%Color and Shape:SolidMolecular weight:428.5R-1479
CAS:R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.Formula:C9H12N6O5Purity:99.68% - 99.95%Color and Shape:SolidMolecular weight:284.23Ref: TM-TQ0162
1mg135.00€2mg187.00€5mg329.00€10mg472.00€25mg753.00€50mg1,074.00€100mg1,444.00€1mL*10mM (DMSO)363.00€Trypsin Inhibitor, soybean
CAS:Trypsin Inhibitor, soybean is a trypsin inhibitor extracted from leguminous plants.Color and Shape:SolidPhepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Formula:C38H60N6O6Color and Shape:SolidMolecular weight:696.92Dolutegravir intermediate-1
CAS:Dolutegravir intermediate-1 is a synthetic precursor for HIV-1 treatment from patent WO 2016125192 A2.Formula:C13H17NO8Purity:99.52%Color and Shape:SolidMolecular weight:315.28Isoderrone
CAS:Isoderrone inhibits α-glucosidase and PTP1B; IC50 = 22.7 uM, potential type 2 diabetes drug.Formula:C20H16O5Purity:98%Color and Shape:SolidMolecular weight:336.34Tenofovir alafenamide hemifumarate
CAS:Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir.Formula:C21H29N6O5PC4H4O4Purity:99.33% - 99.96%Color and Shape:SolidMolecular weight:534.51Glucosamine
CAS:Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids.Formula:C6H13NO5Purity:99.80% - 99.80%Color and Shape:CoaMolecular weight:179.17S-Methylglutathione
CAS:S-Methylglutathione (S-Methyl glutathione) is a 1-chloro-2,4-dinitrobenzene coupling inhibitor, an XOCl scavenger, and inhibitor of glyoxalase 1.Formula:C11H19N3O6SPurity:98%Color and Shape:SolidMolecular weight:321.35
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