Stem Cell and Derivatives
Stem cell inhibitors are compounds that specifically target signaling pathways and proteins involved in the maintenance, differentiation, and proliferation of stem cells. These inhibitors are crucial for understanding stem cell biology and for developing strategies to manipulate stem cells for therapeutic purposes, such as regenerative medicine and cancer treatment. By controlling stem cell fate, these inhibitors can help guide stem cell differentiation into specific cell types or prevent unwanted cell growth. At CymitQuimica, we offer a selection of high-quality stem cell inhibitors to support your research in stem cell biology, developmental biology, and regenerative medicine.
Subcategories of "Stem Cell and Derivatives"
- Gamma-secretase
- Hedgehog/Smoothened
- Hippo pathway
- JAK
- Porcupine
- ROCK
- STAT
- Stem Cells
- TGF-beta/Smad
- Wnt/beta-catenin
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Products of "Stem Cell and Derivatives"
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IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formula:C26H20N6OPurity:99.12%Color and Shape:SolidMolecular weight:432.48Ref: TM-T5342
2mg39.00€5mg64.00€10mg101.00€25mg163.00€50mg226.00€100mg320.00€200mg459.00€1mL*10mM (DMSO)70.00€Ac-VDVAD-CHO
CAS:Ac-VDVAD-CHO is an inhibitor of caspase-2 and caspase-3 (IC50: 46 nM for caspase-2 and 15 nM for caspase-3) [1].Formula:C23H37N5O10Purity:98%Color and Shape:SolidMolecular weight:543.57Dynarrestin
CAS:Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Formula:C22H23F2N3O2SPurity:99.49%Color and Shape:SolidMolecular weight:431.5Povorcitinib phosphate
CAS:Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Formula:C23H25F5N7O5PPurity:97.71%Color and Shape:SolidMolecular weight:605.45Ref: TM-T39113L
1mg65.00€2mg95.00€5mg145.00€10mg212.00€25mg359.00€50mg512.00€100mg695.00€200mg937.00€SANT 2
CAS:SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Formula:C26H26ClN3O4Purity:99.23%Color and Shape:SolidMolecular weight:479.96Wnt pathway inhibitor 3
CAS:Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFormula:C21H17BrN2O5Purity:99.69%Color and Shape:SoildMolecular weight:457.27E 2012
CAS:E2012 is a γ-secretase modulator (GSM).Formula:C25H26FN3O2Purity:99.18%Color and Shape:SolidMolecular weight:419.49AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formula:C17H16ClN3OPurity:98.04% - ≥95%Color and Shape:SolidMolecular weight:313.78NRX-103095
CAS:NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Formula:C22H16Cl2F3N3O3SPurity:99.16% - 99.60%Color and Shape:SolidMolecular weight:530.35Ref: TM-T63730
1mg150.00€5mg364.00€10mg588.00€25mg1,169.00€50mg1,882.00€100mg2,822.00€1mL*10mM (DMSO)426.00€IMR-1A
CAS:IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C13H11NO5S2Purity:97.1% - 99.06%Color and Shape:SolidMolecular weight:325.36GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Color and Shape:Odour SolidSTAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formula:C16H15NO3SColor and Shape:SolidMolecular weight:301.36JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Purity:98%Color and Shape:Odour SolidCDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Formula:C21H20ClN3O2Purity:98.97% - 99.83%Color and Shape:SoildMolecular weight:381.86Ref: TM-T72048
1mg52.00€5mg101.00€10mg150.00€25mg250.00€50mg363.00€100mg509.00€200mg695.00€1mL*10mM (DMSO)116.00€KY-05009
CAS:KY-05009 blocks TGF-β1 EMT in lung cancer cells, inhibits TNIK, Wnt genes, induces apoptosis, and is an ATP-competitive TNIK inhibitor (Ki = 100 nM).Formula:C18H16N4O2SPurity:98.06%Color and Shape:SolidMolecular weight:352.41Ref: TM-T11793
5mg50.00€10mg71.00€25mg117.00€50mg170.00€100mg245.00€200mg354.00€1mL*10mM (DMSO)51.00€Neocucurbitacin A
CAS:Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].Formula:C31H42O8Purity:98%Color and Shape:SolidMolecular weight:542.66RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:97.29% - 99.91%Color and Shape:SolidMolecular weight:545.63Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formula:C18H22N4O2Purity:98.67% - 99.4%Color and Shape:SolidMolecular weight:326.39Ref: TM-T6933
2mg40.00€5mg66.00€10mg104.00€25mg182.00€50mg283.00€100mg439.00€200mg645.00€1mL*10mM (DMSO)73.00€LGK974
CAS:LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Formula:C23H20N6OPurity:100% - ≥98%Color and Shape:SolidMolecular weight:396.44Ref: TM-T2618
1mg48.00€2mg65.00€5mg96.00€10mg164.00€25mg304.00€50mg545.00€100mg778.00€1mL*10mM (DMSO)96.00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purity:96.39% - 97.90%Color and Shape:SolidMolecular weight:464.55Ref: TM-T6838
2mg46.00€5mg66.00€10mg93.00€25mg124.00€50mg197.00€100mg350.00€500mg840.00€1mL*10mM (DMSO)72.00€
