Fibroblast Growth Factor Receptor (FGFR)
FGFR inhibitors are targeted therapies that block the activity of fibroblast growth factor receptors (FGFRs), which are involved in cell proliferation, differentiation, and angiogenesis. FGFR signaling contributes to the formation of new blood vessels in tumors, promoting their growth and survival. Inhibiting FGFR can therefore reduce angiogenesis and tumor progression. At CymitQuimica, we provide a range of high-quality FGFR inhibitors to support your research in cancer, developmental biology, and angiogenesis.
Products of "Fibroblast Growth Factor Receptor (FGFR)"
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Recifercept
CAS:Recifercept (TA-46) is a recombinant human soluble fibroblast growth factor receptor 3, a decoy protein that competes for ligands of mutant FGFR3.Color and Shape:LiquidFGFR-IN-11
CAS:FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (Formula:C28H29ClN4O4Purity:98%Color and Shape:SolidMolecular weight:521.01FGFR1 inhibitor-8
FGFR1 inhibitor-8 (Compound 9), an FGFR1 inhibitor with an IC50 of 0.5 nM, binds to the ATP-binding pocket of FGFR1 and exhibits anticancer activity [1].Formula:C26H18ClNO5Purity:98%Color and Shape:SolidMolecular weight:459.88BLU9931
CAS:BLU9931 is the first selective small molecule inhibitor of FGFR4.Formula:C26H22Cl2N4O3Purity:96.958% - 99.85%Color and Shape:SolidMolecular weight:509.38Regorafenib
CAS:Formula:C21H15ClF4N4O3Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:482.82FGFR4-IN-4
CAS:FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.Formula:C28H32Cl2N6O5Purity:98%Color and Shape:SolidMolecular weight:603.5EOC317
CAS:EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).Formula:C27H26F5N7O3Purity:98.00% - 99.26%Color and Shape:SolidMolecular weight:591.53Ref: TM-T4318
1mg117.00€2mg172.00€5mg248.00€10mg418.00€25mgTo inquire50mgTo inquire100mgTo inquire1mL*10mM (DMSO)324.00€Nintedanib
CAS:Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/Formula:C31H33N5O4Purity:98% - 99.92%Color and Shape:SolidMolecular weight:539.62LY2874455
CAS:LY2874455 has been used in trials studying the treatment of Advanced Cancer.Formula:C21H19Cl2N5O2Purity:97.22% - 99.46%Color and Shape:SolidMolecular weight:444.31Ref: TM-T2361
1mg52.00€5mg97.00€10mg160.00€25mg313.00€50mg494.00€100mg742.00€200mg1,008.00€1mL*10mM (DMSO)111.00€U3-1784
U3-1784 is a humanized monoclonal antibody targeting CD334, with anti-cancer activity, used in liver cancer research.Color and Shape:LiquidMolecular weight:145.5AZ8010
CAS:AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.Formula:C27H34N4O3Color and Shape:SolidMolecular weight:462.58S49076
CAS:S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Formula:C22H22N4O4SPurity:95.35% - 97.4%Color and Shape:SolidMolecular weight:438.5Ref: TM-T3274
1mg47.00€2mg63.00€5mg84.00€10mg96.00€25mg170.00€50mg305.00€100mg558.00€1mL*10mM (DMSO)92.00€Efimosfermin alfa
Efimosfermin alfa is a humanized antibody targeting FGFR1.Color and Shape:Odour LiquidASP5878
CAS:ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.Formula:C18H19F2N5O4Purity:99.8% - 99.86%Color and Shape:SolidMolecular weight:407.37Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formula:C28H30N6OSPurity:100% - 99.55%Color and Shape:SolidMolecular weight:498.64Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormula:C29H27F3N6OPurity:98% - 99.60%Color and Shape:SolidMolecular weight:532.56NSC 12
CAS:NSC 12 is an orally active pan-FGF trap that binds FGF2 and interferes with its interaction with FGFR1 with potential FGF-dependent antitumor activity.Formula:C24H34F6O3Purity:99.51%Color and Shape:SolidMolecular weight:484.52Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
CAS:Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist.Formula:C26H32N4O8Purity:100% - 99.83%Color and Shape:SolidMolecular weight:528.55SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purity:98.43%Color and Shape:SolidMolecular weight:451.6Lenvatinib
CAS:Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Formula:C21H19ClN4O4Purity:98.46% - 99.8000%Color and Shape:SolidMolecular weight:426.85
