ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Products of "ALK"
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Alectinib hydrochloride
CAS:Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)Formula:C30H35ClN4O2Purity:99.61% - 99.96%Color and Shape:SolidMolecular weight:519.08LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formula:C25H22N6Purity:98% - 99.86%Color and Shape:SolidMolecular weight:406.48EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Formula:C23H18N8Purity:98.76%Color and Shape:SolidMolecular weight:406.44Ref: TM-T38752
1mg131.00€2mg187.00€5mg311.00€10mg535.00€25mg1,064.00€50mg1,738.00€100mg2,745.00€1mL*10mM (DMSO)344.00€OD36
CAS:OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Formula:C16H15ClN4O2Purity:99.89%Color and Shape:SolidMolecular weight:330.77DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Formula:C24H20N4OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.44CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formula:C28H30N4O2Purity:98.96%Color and Shape:SolidMolecular weight:454.56Ref: TM-T9224
1mg131.00€5mg286.00€10mg430.00€25mg710.00€50mg998.00€100mg1,349.00€1mL*10mM (DMSO)343.00€(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Formula:C10H19ClNO1·5SPurity:98%Color and Shape:SolidMolecular weight:244.78ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formula:C23H28ClN7O3SPurity:98.32%Color and Shape:SolidMolecular weight:518.03Ref: TM-T13416
1mg92.00€5mg230.00€10mg364.00€25mg620.00€50mg848.00€100mg1,121.00€1mL*10mM (DMSO)296.00€CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formula:C29H39ClN6O6SPurity:99.79%Color and Shape:SolidMolecular weight:635.17SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formula:C20H22ClN3O2Purity:98.71%Color and Shape:SolidMolecular weight:371.86KER047
CAS:ALK2-IN-4, a highly effective ALK2 inhibitor.Formula:C26H30FN7OPurity:100% - 98.49%Color and Shape:SolidMolecular weight:475.56Ref: TM-T39764
1mg96.00€5mg227.00€10mg369.00€25mg753.00€50mg1,074.00€100mg1,644.00€1mL*10mM (DMSO)250.00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13%Color and Shape:SolidMolecular weight:448.95ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formula:C13H13NO3Purity:99.54%Color and Shape:SoildMolecular weight:231.25Ref: TM-T203011
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formula:C17H13N5Purity:98.8% - 99.62%Color and Shape:SolidMolecular weight:287.32Ref: TM-T6337
1mg35.00€2mg48.00€5mg66.00€10mg85.00€25mg123.00€50mg172.00€100mg255.00€500mg630.00€1mL*10mM (DMSO)72.00€BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Formula:C31H34N4O2Purity:99.02% - 99.45%Color and Shape:SolidMolecular weight:494.63Ref: TM-T5197
1mg43.00€5mg96.00€10mg135.00€25mg215.00€50mg304.00€100mg437.00€200mg610.00€1mL*10mM (DMSO)96.00€HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Formula:C29H34ClN7OPurity:100% - 99.75%Color and Shape:SolidMolecular weight:532.08A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formula:C18H14N4Purity:98.82% - ≥95%Color and Shape:SolidMolecular weight:286.33INCB-000928
CAS:Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.Formula:C30H38N4O3Purity:98.93%Color and Shape:SolidMolecular weight:502.65SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Formula:C25H26N4O3Purity:99.72%Color and Shape:SolidMolecular weight:430.5AZ12601011
CAS:AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.Formula:C19H15N5Purity:98.81%Color and Shape:SolidMolecular weight:313.36Ref: TM-T10426
1mg99.00€5mg235.00€10mg376.00€25mg728.00€50mg1,093.00€100mg1,510.00€1mL*10mM (DMSO)259.00€
