IGF-1R
IGF-1R inhibitors are compounds that specifically target and inhibit the Insulin-like Growth Factor 1 Receptor (IGF-1R), a receptor tyrosine kinase involved in cellular growth, development, and survival. IGF-1R signaling plays a significant role in cancer progression, making these inhibitors valuable in oncology research. At CymitQuimica, we offer IGF-1R inhibitors to support your research in cancer biology, endocrinology, and targeted therapy development.
Products of "IGF-1R"
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GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purity:100% - 99.63%Color and Shape:SolidMolecular weight:532.57MSDC 0160
CAS:MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Formula:C19H18N2O4SPurity:99.45% - 99.53%Color and Shape:SolidMolecular weight:370.42Ref: TM-T2607
1mg35.00€2mg50.00€5mg77.00€10mg99.00€25mg154.00€50mg197.00€100mg350.00€1mL*10mM (DMSO)82.00€Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formula:C42H70O12Purity:98% - 98.07%Color and Shape:SolidMolecular weight:767Ref: TM-T6S1487
1mg113.00€5mg265.00€10mg426.00€25mg702.00€50mg938.00€100mg1,320.00€1mL*10mM (DMSO)360.00€IGF1R/CD221 Protein, Mouse, Recombinant (His)
IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:105.2 kDa (predicted); 172.5 kDa, 117.1 kDa and 49.8 kDa, corresponding to the single chain, α subunit and β subunit respectively (reducing condition, due to glycosylation)Tyrphostin AG 538
CAS:Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.Formula:C16H11NO5Purity:99.73%Color and Shape:SoildMolecular weight:297.26AG1024
CAS:AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Formula:C14H13BrN2OPurity:98% - 99.37%Color and Shape:SolidMolecular weight:305.17AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H31N7O2Purity:97.07%Color and Shape:SolidMolecular weight:485.58WAY-270250
CAS:WAY-270250 is an IGF-1R/SRC inhibitor.Formula:C18H16N2O2Purity:99.77%Color and Shape:SoildMolecular weight:292.33XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg56.00€2mg78.00€5mg99.00€10mg149.00€25mg258.00€50mg393.00€100mg582.00€1mL*10mM (DMSO)110.00€PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purity:99.13%Color and Shape:SolidMolecular weight:341.79PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Formula:C18H17Cl2N3O2Purity:99.9%Color and Shape:SolidMolecular weight:378.25Ref: TM-T4324
2mg35.00€5mg48.00€10mg63.00€25mg99.00€50mg172.00€100mg286.00€200mg418.00€1mL*10mM (DMSO)63.00€BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formula:C23H24FN9OPurity:98.86%Color and Shape:SolidMolecular weight:461.49Ref: TM-T2349
1mg49.00€2mg70.00€5mg96.00€10mg166.00€25mg328.00€50mg537.00€100mg772.00€1mL*10mM (DMSO)116.00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13%Color and Shape:SolidMolecular weight:448.95AZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purity:97.07%Color and Shape:SolidMolecular weight:522.04NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFormula:C27H29N5OPurity:96.03% - 99.55%Color and Shape:SolidMolecular weight:439.55MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurity:98.53%Color and Shape:SolidMolecular weight:314.38IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColor and Shape:Lyophilized PowderMolecular weight:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurity:99.39%Color and Shape:SolidMolecular weight:293.3Ref: TM-T8773
1mg50.00€5mg97.00€10mg145.00€25mg259.00€50mg383.00€100mg545.00€200mg740.00€1mL*10mM (DMSO)109.00€IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColor and Shape:Lyophilized PowderMolecular weight:80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Formula:C20H19N3O4Purity:98.75%Color and Shape:SolidMolecular weight:365.38Ref: TM-T11654
1mg44.00€5mg93.00€10mg131.00€25mg207.00€50mg309.00€100mg459.00€200mg657.00€1mL*10mM (DMSO)93.00€
