Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormula:C21H17ClF4N4O4Purity:99.69%Color and Shape:SolidMolecular weight:500.83Ref: TM-T1792L
5mg35.00€10mg48.00€25mg69.00€50mg88.00€100mg140.00€200mg207.00€500mg348.00€1mL*10mM (DMSO)58.00€Thalidomide
CAS:Thalidomide, a glutamic acid derivative, has teratogenic and immunomodulatory effects.Formula:C13H10N2O4Purity:98.88% - 99.88%Color and Shape:White SolidMolecular weight:258.23Taxifolin
CAS:Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.Formula:C15H12O7Purity:94.91% - 98.9%Color and Shape:Yellowish PowderMolecular weight:304.25Beclin1-ATG14L interaction inhibitor 1
CAS:Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.Formula:C23H24N4O5SPurity:98%Color and Shape:SolidMolecular weight:468.53Matrine
CAS:Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.Formula:C15H24N2OPurity:100% - 97.16%Color and Shape:SolidMolecular weight:248.36SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formula:C21H27N5O5SColor and Shape:SolidMolecular weight:461.535Alginic acid
CAS:Alginic acid, a polysaccharide from brown seaweed, has anti-anaphylactic and anti-inflammatory properties and is used in food industry.Formula:C14H22O13Purity:≥98%Color and Shape:SolidMolecular weight:398.317GSK-690693
CAS:GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.Formula:C21H27N7O3Purity:100% - 98.78%Color and Shape:SolidMolecular weight:425.48Brivanib
CAS:Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormula:C19H19FN4O3Purity:98.87%Color and Shape:SolidMolecular weight:370.38Ref: TM-T6036
1mg47.00€5mg88.00€10mg144.00€25mg259.00€50mg375.00€100mg560.00€200mg815.00€1mL*10mM (DMSO)97.00€SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurity:100% - 99.84%Color and Shape:SolidMolecular weight:405.42Carboplatin
CAS:Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.Formula:C6H12N2O4PtPurity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:371.25Licochalcone A
CAS:Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.Formula:C21H22O4Purity:98.11% - 98.96%Color and Shape:White Crystalline PowderMolecular weight:338.4PD 169316
CAS:PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.Formula:C20H13FN4O2Purity:98.65%Color and Shape:SolidMolecular weight:360.34URB-597
CAS:URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.Formula:C20H22N2O3Purity:98.24%Color and Shape:SolidMolecular weight:338.4LRRK2-IN-10
CAS:LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2Formula:C20H15N5OPurity:98%Color and Shape:SolidMolecular weight:341.37LC3-mHTT-IN-AN1
CAS:LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.Formula:C15H9Br2NO3Purity:97.26%Color and Shape:SolidMolecular weight:411.04Spautin-1
CAS:Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.Formula:C15H11F2N3Purity:97.69% - 98.99%Color and Shape:SolidMolecular weight:271.26Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Formula:C18H18N4O4Purity:98.64%Color and Shape:SolidMolecular weight:354.36Ref: TM-T16681
1mg96.00€5mg215.00€10mg378.00€25mg650.00€50mg927.00€100mg1,254.00€1mL*10mM (DMSO)236.00€2-Methoxyestradiol
CAS:2-ME2, an estradiol derivative, hinders angiogenesis and tumor growth, causes cell apoptosis, and stops mitosis.Formula:C19H26O3Purity:98% - 99.95%Color and Shape:Off-White SolidMolecular weight:302.41Schisandrin
CAS:Schisandrin (Wuweizi alcohol-A) is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.Formula:C24H32O7Purity:98.97% - 99.32%Color and Shape:White PowderMolecular weight:432.51
