DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Products of "DUB"
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FT827
CAS:FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Formula:C27H28N6O5SPurity:98.76%Color and Shape:SolidMolecular weight:548.61HBX 41108
CAS:HBX 41108: non-competitive, reversible USP7 inhibitor; IC50: 424nM; blocks USP7-p53 deubiquitination; IC50: 0.8μM.Formula:C13H3ClN4OPurity:95.63%Color and Shape:SolidMolecular weight:266.64ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formula:C23H24N6Purity:99.87% - 99.96%Color and Shape:SolidMolecular weight:384.48Ref: TM-T1757
1mg89.00€5mg207.00€10mg331.00€25mg512.00€50mg775.00€100mg1,140.00€1mL*10mM (DMSO)245.00€USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formula:C29H31F3N6O3Purity:98%Color and Shape:SolidMolecular weight:568.59Vialinin A
CAS:Vialinin A, a p-terphenyl with antioxidant properties, inhibits TNF-α/USP4/5/SENP1, used in autoimmune/cancer research.Formula:C34H26O8Purity:99.89%Color and Shape:SolidMolecular weight:562.57USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formula:C27H28ClN3O3SPurity:96.18%Color and Shape:SolidMolecular weight:510.05USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurity:100% - 96.31%Color and Shape:SolidMolecular weight:368.41USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Formula:C19H20ClF3N4OSPurity:98.83%Color and Shape:SolidMolecular weight:444.9Ref: TM-T67876
1mg88.00€5mg210.00€10mg329.00€25mg548.00€50mg782.00€100mg1,035.00€1mL*10mM (DMSO)245.00€NSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formula:C21H22ClNOPurity:99.74% - 99.87%Color and Shape:SolidMolecular weight:339.86USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Formula:C21H21N3O2Purity:99.31%Color and Shape:SolidMolecular weight:347.41Ref: TM-T9217
1mg48.00€5mg97.00€10mg156.00€25mg284.00€50mg411.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)105.00€TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formula:C9H2Cl4O2Purity:99.34%Color and Shape:SolidMolecular weight:283.92OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFormula:C22H17Cl2FN2O4Purity:99.90%Color and Shape:SolidMolecular weight:463.29DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formula:C16H9N5OPurity:99.34%Color and Shape:SolidMolecular weight:287.28Ref: TM-T11112
1mg137.00€2mg188.00€5mg325.00€10mg465.00€25mg743.00€50mg1,035.00€100mg1,406.00€500mg2,802.00€1mL*10mM (DMSO)341.00€USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formula:C26H28FN3O4SPurity:99.03%Color and Shape:SolidMolecular weight:497.58Ref: TM-T36682
1mg144.00€5mg298.00€10mg472.00€25mg753.00€50mg1,074.00€100mg1,444.00€500mg2,822.00€1mL*10mM (DMSO)325.00€P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formula:C12H7Cl2NO3S2Purity:99.53% - 99.87%Color and Shape:SolidMolecular weight:348.22DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formula:C20H11N5OPurity:98.33% - 98.96%Color and Shape:SolidMolecular weight:337.33Ref: TM-T11110
1mg65.00€5mg116.00€10mg183.00€25mg353.00€50mg495.00€100mg652.00€200mg895.00€1mL*10mM (DMSO)128.00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formula:C30H37N3O4SPurity:98.46%Color and Shape:SolidMolecular weight:535.7Ref: TM-T12024
1mg43.00€5mg87.00€10mg144.00€25mg283.00€50mg454.00€100mg655.00€500mg1,454.00€1mL*10mM (DMSO)120.00€I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formula:C26H23F3N6OPurity:99.41%Color and Shape:SolidMolecular weight:492.5Ref: TM-T73560
1mg188.00€2mg255.00€5mg369.00€10mg597.00€25mg1,121.00€50mg1,700.00€100mg2,205.00€1mL*10mM (DMSO)425.00€EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formula:C25H28Cl2N4O3Purity:98.09%Color and Shape:SolidMolecular weight:503.42Ref: TM-T11209
1mg66.00€5mg144.00€10mg227.00€25mg445.00€50mg717.00€100mg1,064.00€1mL*10mM (DMSO)160.00€STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Formula:C19H19N3O4S2Purity:98.77%Color and Shape:SolidMolecular weight:417.5
