Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
Products of "Hedgehog/Smoothened"
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SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Formula:C28H29Cl2N3OSPurity:99.19% - 99.77%Color and Shape:SolidMolecular weight:526.52SAG dihydrochloride
CAS:SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.Formula:C28H30Cl3N3OSPurity:100%Color and Shape:SoildMolecular weight:562.98Cyclopamine
CAS:Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.Formula:C27H41NO2Purity:98.31% - 99.66%Color and Shape:White Crystalline SolidMolecular weight:411.62Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Formula:C17H9Cl2N3O2Purity:97.10% - 98.54%Color and Shape:SolidMolecular weight:358.18Ref: TM-T3156
2mg42.00€5mg59.00€10mg85.00€25mg168.00€50mg235.00€100mg331.00€200mg492.00€1mL*10mM (DMSO)69.00€CUR61414 hydrochloride
CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.Formula:C31H43ClN4O5Purity:95.22%Color and Shape:SolidMolecular weight:587.15ALLO-2
CAS:ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.Formula:C18H12F3N5OPurity:99.19%Color and Shape:SolidMolecular weight:371.32Ref: TM-T14188
1mg64.00€5mg140.00€10mg212.00€25mg353.00€50mg500.00€100mg658.00€200mg905.00€1mL*10mM (DMSO)156.00€HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFormula:C24H23ClN4O3Purity:95.73%Color and Shape:SolidMolecular weight:450.92Ref: TM-T3460
1mg52.00€5mg97.00€10mg178.00€25mg379.00€50mg645.00€100mg1,026.00€1mL*10mM (DMSO)110.00€Glasdegib
CAS:Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Formula:C21H22N6OPurity:98.72%Color and Shape:SolidMolecular weight:374.44SMO-IN-2
CAS:SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Formula:C25H25F4N5O2Purity:98.64%Color and Shape:SolidMolecular weight:503.49Dynarrestin
CAS:Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Formula:C22H23F2N3O2SPurity:99.49%Color and Shape:SolidMolecular weight:431.5SANT 2
CAS:SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Formula:C26H26ClN3O4Purity:99.23%Color and Shape:SolidMolecular weight:479.96SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Formula:C16H24BrClN2OPurity:100%Color and Shape:SolidMolecular weight:375.73CUR61414
CAS:CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Formula:C31H42N4O5Purity:97.34% - 98.00%Color and Shape:SolidMolecular weight:550.69Ref: TM-T15019
1mg52.00€5mg111.00€10mg180.00€25mg359.00€50mg550.00€100mg787.00€1mL*10mM (DMSO)123.00€Hh-Ag1.5
CAS:Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Formula:C28H26ClF2N3OSPurity:98.61%Color and Shape:SolidMolecular weight:526.04Ref: TM-T24754
1mg127.00€5mg305.00€10mg472.00€25mg782.00€50mg1,103.00€100mg1,539.00€1mL*10mM (DMSO)354.00€SAG
CAS:SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.Formula:C28H28ClN3OSPurity:98.16% - 98.88%Color and Shape:SolidMolecular weight:490.06Ref: TM-T1779
1mg51.00€2mg71.00€5mg96.00€10mg153.00€25mg274.00€50mg376.00€100mg557.00€200mg797.00€500mg1,188.00€1mL*10mM (DMSO)97.00€RU-SKI 43
CAS:RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits Gli-1, Akt, mTOR pathways.Formula:C22H30N2O2SPurity:99.78%Color and Shape:SolidMolecular weight:386.55Tolnaftate
CAS:Tolnaftate (NP-27) is a synthetic antifungal agent.Formula:C19H17NOSPurity:98.85%Color and Shape:White PowderMolecular weight:307.41SAG 21k
CAS:SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Formula:C29H28ClF2N3O2SPurity:99.51%Color and Shape:SolidMolecular weight:556.07HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Formula:C27H29NO6Purity:94.4%Color and Shape:SolidMolecular weight:463.52Ref: TM-T22089
1mg47.00€2mg60.00€5mg92.00€10mg135.00€25mg217.00€50mg324.00€100mg472.00€500mg1,026.00€1mL*10mM (DMSO)107.00€SANT-1
CAS:SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).Formula:C23H27N5Purity:100% - 99.98%Color and Shape:SolidMolecular weight:373.49
