PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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ES-072
CAS:ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.Formula:C25H27F3N8O2Color and Shape:SolidMolecular weight:528.53ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Formula:C13H13BrN2OSPurity:99.82%Color and Shape:SolidMolecular weight:325.22Ref: TM-T13411
1mg87.00€5mg187.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)188.00€JCN037
CAS:JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formula:C16H11BrFN3O2Purity:99.50%Color and Shape:SolidMolecular weight:376.18Ref: TM-T8431
2mg40.00€5mg74.00€10mg105.00€25mg178.00€50mg273.00€100mg391.00€200mg557.00€1mL*10mM (DMSO)84.00€BQR-695
CAS:BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.Formula:C19H20N4O3Purity:98.91% - 99.69%Color and Shape:SolidMolecular weight:352.39WZ-3146
CAS:WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).Formula:C24H25ClN6O2Purity:97.15%Color and Shape:SolidMolecular weight:464.95Ref: TM-T6733
1mg52.00€2mg74.00€5mg97.00€10mg180.00€25mg319.00€50mg510.00€100mg730.00€1mL*10mM (DMSO)106.00€EGFR-IN-123
CAS:EGFR-IN-123 (compound D06) is an effective EGFR inhibitor. It exhibits inhibitory activity against several cell lines including PC-9G, A549, A431, and HCT116, with IC50 values of 0.74, 1.36, 1.20, and 2.53 μM respectively.Formula:C24H27F3N6OColor and Shape:SolidMolecular weight:472.51WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purity:97.93% - 98.81%Color and Shape:SolidMolecular weight:569.58Pelitinib
CAS:Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).Formula:C24H23ClFN5O2Purity:98.37% - 99.86%Color and Shape:Off-White SolidMolecular weight:467.92Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Formula:C24H25N5OPurity:98% - 99.06%Color and Shape:SolidMolecular weight:399.49740 Y-P
CAS:740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.Formula:C141H222N43O39PS3Purity:98.3% - 99.87%Color and Shape:SolidMolecular weight:3270.7Anticancer agent 137
Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.Formula:C26H27NO6Purity:98%Color and Shape:SolidMolecular weight:449.5VO-Ohpic trihydrate
CAS:VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.Formula:C12H9N2O8V·3H2O·HPurity:100%Color and Shape:SolidMolecular weight:415.2Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Formula:C18H16N2O3Purity:97.18%Color and Shape:SolidMolecular weight:308.33Ref: TM-T22450
1mg51.00€2mg73.00€5mg105.00€10mg164.00€25mg275.00€50mg378.00€100mg543.00€200mg738.00€1mL*10mM (DMSO)117.00€NSC 228155
CAS:NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formula:C11H6N4O4SPurity:99.84%Color and Shape:SolidMolecular weight:290.25Ref: TM-T6908
2mg35.00€5mg50.00€10mg66.00€25mg125.00€50mg205.00€100mg369.00€200mg495.00€1mL*10mM (DMSO)52.00€JBJ-07-149
CAS:JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].Formula:C28H26N6O2SColor and Shape:SolidMolecular weight:510.61MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formula:C22H24F2N6O2Purity:100% - 100%Color and Shape:SolidMolecular weight:442.46PI3Kγ inhibitor 7
CAS:PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].Formula:C31H25N9O2Purity:98%Color and Shape:SolidMolecular weight:555.59STX-478
CAS:STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFormula:C16H12F5N5O2Purity:99.59%Color and Shape:SolidMolecular weight:401.29Ref: TM-T78211
1mg88.00€5mg187.00€10mg303.00€25mg612.00€50mg938.00€100mg1,568.00€1mL*10mM (DMSO)207.00€ON 146040
CAS:ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.Formula:C24H23N7O3SPurity:99.89%Color and Shape:SolidMolecular weight:489.55Ref: TM-T12310
1mg64.00€5mg145.00€10mg226.00€25mg369.00€50mg520.00€100mg695.00€200mg939.00€1mL*10mM (DMSO)158.00€(E)-AG 99
CAS:(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).Formula:C10H8N2O3Purity:99.23%Color and Shape:SolidMolecular weight:204.18TGX-221
CAS:TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.Formula:C21H24N4O2Purity:100% - 99.8%Color and Shape:SolidMolecular weight:364.44Ref: TM-T2661
1mg38.00€2mg49.00€5mg74.00€10mg116.00€25mg217.00€50mg359.00€100mg560.00€500mg1,198.00€1mL*10mM (DMSO)81.00€SST0116CL1
CAS:SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.Formula:C22H31ClN4O6Color and Shape:SolidMolecular weight:482.96Canertinib dihydrochloride
CAS:Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFormula:C24H27Cl3FN5O3Purity:99.13% - 99.23%Color and Shape:SolidMolecular weight:558.86Linperlisib
CAS:Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3KδFormula:C28H37FN6O5SPurity:99.01%Color and Shape:SolidMolecular weight:588.69Ref: TM-T6330
1mg35.00€2mg48.00€5mg70.00€10mg96.00€25mg202.00€50mg311.00€100mg487.00€1mL*10mM (DMSO)92.00€Duvelisib
CAS:Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.Formula:C22H17ClN6OPurity:99.38% - 99.74%Color and Shape:SolidMolecular weight:416.8620(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purity:100% - 99.93%Color and Shape:SolidMolecular weight:785.01SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Formula:C19H21ClF3N5O2Purity:99.42% - 99.79%Color and Shape:SolidMolecular weight:443.85Ref: TM-T12831L
1mg149.00€2mg217.00€5mg368.00€10mg580.00€25mg882.00€50mg1,596.00€1mL*10mM (DMSO)444.00€Insecticidal agent 364
CAS:Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.Formula:C23H18N4O3SPurity:98.24%Color and Shape:SolidMolecular weight:430.48GSK-3β inhibitor 8
CAS:GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidineFormula:C20H20ClN5OSPurity:98%Color and Shape:SolidMolecular weight:413.92PF-06459988
CAS:PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.Formula:C19H22ClN7O3Purity:98%Color and Shape:SolidMolecular weight:431.88Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Formula:C22H18FN7OPurity:98% - 99.39%Color and Shape:SolidMolecular weight:415.42Ref: TM-T1894
5mg35.00€10mg50.00€25mg74.00€50mg93.00€100mg108.00€200mg140.00€500mg225.00€1mL*10mM (DMSO)52.00€Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Formula:C21H24ClN7OPurity:97.04%Color and Shape:SolidMolecular weight:425.91Ref: TM-T7015
1mg46.00€2mg59.00€5mg93.00€10mg131.00€25mg219.00€50mg350.00€100mg505.00€1mL*10mM (DMSO)92.00€CP21R7
CAS:CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.Formula:C19H15N3O2Purity:96.14% - 98.21%Color and Shape:SolidMolecular weight:317.34Ref: TM-T3684
1mg63.00€2mg86.00€5mg97.00€10mg155.00€25mg273.00€50mg462.00€100mg677.00€1mL*10mM (DMSO)81.00€PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain ofFormula:C26H20ClFN8OPurity:98%Color and Shape:SolidMolecular weight:514.94DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Color and Shape:Odour SolidErlotinib hydrochloride
CAS:Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4·HClPurity:99.78% - 99.85%Color and Shape:White Or Off-White PowderMolecular weight:429.9β-Hydroxyisovalerylshikonin
CAS:Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumorFormula:C21H24O7Purity:98.16%Color and Shape:SolidMolecular weight:388.41Cavutilide
CAS:Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Formula:C22H26FN3O3Purity:99.26% - 99.70%Color and Shape:SolidMolecular weight:399.458UCB9608
CAS:UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.Formula:C20H26N8O2Purity:98.65% - 99.59%Color and Shape:SolidMolecular weight:410.47Ref: TM-TQ0009
1mg55.00€5mg117.00€10mg170.00€25mg276.00€50mg395.00€100mg562.00€200mg758.00€1mL*10mM (DMSO)128.00€Disitamab vedotin
CAS:Disitamab vedotin (RC-48) is a HER2-targeting ADC with MMAE, effective in HER2-expressing gastric cancer.Purity:95.00% - 98%Color and Shape:LiquidMolecular weight:Approximately 144.15 kDaNeratinib maleate
CAS:Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate cancer studies.Formula:C34H33ClN6O7Purity:99.64%Color and Shape:SolidMolecular weight:673.11Falnidamol
CAS:Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formula:C18H19ClFN7Purity:96.46%Color and Shape:SolidMolecular weight:387.84Ref: TM-TQ0271
2mg42.00€5mg64.00€10mg101.00€25mg192.00€50mg335.00€100mg462.00€200mg645.00€1mL*10mM (DMSO)64.00€PI3Kγ ligand 1
CAS:PI3Kγ ligand 1 serves as a PROTAC target protein ligand (Ligand for Target Protein for PROTAC).Formula:C26H29N5O3SColor and Shape:SolidMolecular weight:491.61ALK-IN-1
CAS:ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.Formula:C26H34ClN6O2PPurity:99.74% - 99.80%Color and Shape:SolidMolecular weight:529.01Canertinib
CAS:Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.Formula:C24H25ClFN5O3Purity:100% - 99.18%Color and Shape:White Or Similar To White Crystalline PowderMolecular weight:485.94AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H31N7O2Purity:97.07%Color and Shape:SolidMolecular weight:485.58JTV-519 hemifumarate
CAS:JTV-519 hemifumarate: Ca2+ blocker, SERCA inhibitor, ryanodine receptor partial agonist; antiarrhythmic, cardioprotective.Formula:C54H68N4O8S2Purity:98%Color and Shape:SolidMolecular weight:965.28Osu03012
CAS:Osu03012 (AR-12): oral celecoxib-derived PDK1 inhibitor with anticancer potential.Formula:C26H19F3N4OPurity:97.95% - 99.22%Color and Shape:SolidMolecular weight:460.45Ref: TM-T2466
2mg37.00€5mg51.00€10mg87.00€25mg143.00€50mg264.00€100mg349.00€200mg454.00€500mg742.00€1mL*10mM (DMSO)51.00€TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formula:C21H32O6Purity:98.08%Color and Shape:SolidMolecular weight:380.48Ref: TM-T13173
1mg80.00€5mg167.00€10mg274.00€25mg465.00€50mg655.00€100mg1,017.00€1mL*10mM (DMSO)170.00€TX2-120-1
CAS:TX2-120-1 possesses the ability to bind with Her3, exhibiting an IC50 of 56 nM for Her3. It can be utilized in the synthesis of TX2-121-1.Formula:C26H27N7O2Color and Shape:SolidMolecular weight:469.54EGFR-IN-73
CAS:EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formula:C19H17ClFN3O4Purity:98%Color and Shape:SolidMolecular weight:405.81WHI-P258
CAS:WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formula:C16H15N3O2Purity:99.64% - 99.95%Color and Shape:SolidMolecular weight:281.31A 1070722
CAS:A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.Formula:C17H13F3N4O2Purity:99.78%Color and Shape:SolidMolecular weight:362.31UCL-TRO-1938
CAS:UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects.Formula:C27H32N6OPurity:99.95%Color and Shape:SolidMolecular weight:456.58Ref: TM-T78092
5mg120.00€10mg187.00€25mg393.00€50mg628.00€100mg1,008.00€200mg1,349.00€1mL*10mM (DMSO)120.00€EGFR-IN-81
EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69Formula:C28H24F3N5O4Purity:98%Color and Shape:SolidMolecular weight:551.52Poziotinib hydrochloride
CAS:Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.Formula:C23H22Cl3FN4O3Purity:97.48% - 99.81%Color and Shape:SolidMolecular weight:527.8Ref: TM-T8758
5mg55.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€200mg409.00€500mg677.00€1mL*10mM (DMSO)88.00€Metformin-d6 hydrochloride
CAS:Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.Formula:C4H12ClN5Purity:98.1%Color and Shape:SolidMolecular weight:171.66CNX-1351
CAS:CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.Formula:C30H35N7O3SPurity:98.83% - 99.69%Color and Shape:SolidMolecular weight:573.71GSK-3β inhibitor 11
CAS:GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.Formula:C20H15N3O4SPurity:97.33%Color and Shape:SolidMolecular weight:393.42NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Formula:C18H20N8O2Purity:97.79%Color and Shape:SolidMolecular weight:380.4BRD5648
CAS:BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Formula:C20H23N3OPurity:99.37%Color and Shape:SolidMolecular weight:321.42LY-294002 hydrochloride
CAS:LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.Formula:C19H17NO3·HClPurity:99.95%Color and Shape:SolidMolecular weight:343.81MIPS-21335
CAS:MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ withFormula:C24H21N7O5Purity:98%Color and Shape:SolidMolecular weight:487.47GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurity:98.42% - 99.42%Color and Shape:SolidMolecular weight:414.48Ref: TM-T6845
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg210.00€50mg349.00€100mg434.00€200mg635.00€1mL*10mM (DMSO)92.00€GSK-3 inhibitor 4
CAS:Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.Formula:C22H15F2N5OPurity:98.77%Color and Shape:SoildMolecular weight:403.38Ref: TM-T77341
1mg333.00€5mg922.00€10mg1,140.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg3,734.00€Necitumumab
Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Color and Shape:LiquidMolecular weight:145.5 kDaParsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)Formula:C20H22ClFN6O2Purity:98.59%Color and Shape:SolidMolecular weight:432.88Ref: TM-T12367
1mg145.00€5mg305.00€10mg495.00€25mg805.00€50mg1,111.00€100mg1,501.00€1mL*10mM (DMSO)335.00€Desmethyl Erlotinib hydrochloride
CAS:Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.Formula:C21H21N3O4·HClPurity:99.49%Color and Shape:SolidMolecular weight:415.87Ref: TM-T6619
1mg59.00€2mg84.00€5mg115.00€10mg188.00€25mg335.00€50mg505.00€100mg720.00€1mL*10mM (DMSO)127.00€PROTAC EGFR degrader 8
CAS:PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells.Formula:C40H46ClN11O5Purity:98%Color and Shape:SolidMolecular weight:796.32Chrysophanol
CAS:Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.Formula:C15H10O4Purity:97.91% - 99.7%Color and Shape:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMolecular weight:254.24GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44GSK-3β inhibitor 22
CAS:GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.Formula:C18H12F3N3O2S2Color and Shape:SolidMolecular weight:423.43EGFR ligand-11
CAS:EGF Rligand-11, a target protein ligand for EGFR, is utilized in the synthesis of PROTAC MS154.Formula:C25H29ClFN5O4Color and Shape:SolidMolecular weight:517.98GSK-3 Inhibitor XIII
CAS:GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Formula:C18H15N5Purity:100% - 98.57%Color and Shape:SolidMolecular weight:301.35CUDC-101
CAS:CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Formula:C24H26N4O4Purity:95.76% - 99.17%Color and Shape:SolidMolecular weight:434.49mTOR inhibitor-14
mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1Purity:98%Color and Shape:Odour SolidTucatinib
CAS:Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).Formula:C26H24N8O2Purity:99.05% - 99.96%Color and Shape:SolidMolecular weight:480.52Ref: TM-T2364
1g1,130.00€2mg35.00€5mg49.00€10mg79.00€25mg124.00€50mg187.00€100mg350.00€500mg825.00€1mL*10mM (DMSO)87.00€
