PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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(R)-(-)-Rolipram
CAS:(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.Formula:C16H21NO3Purity:99.6%Color and Shape:SolidMolecular weight:275.34GDC0084
CAS:GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.Formula:C18H22N8O2Purity:99.16% - 99.76%Color and Shape:SolidMolecular weight:382.42G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purity:97.30%Color and Shape:SolidMolecular weight:383.39Ref: TM-T8742
1mg50.00€5mg97.00€10mg145.00€25mg259.00€50mg374.00€100mg523.00€200mg710.00€1mL*10mM (DMSO)105.00€ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFormula:C16H11N3O3Purity:99.39%Color and Shape:SolidMolecular weight:293.28Ref: TM-T7426
1mg58.00€5mg116.00€10mg183.00€25mg313.00€50mg449.00€100mg620.00€200mg835.00€1mL*10mM (DMSO)111.00€Avitinib maleate
CAS:Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Formula:C30H30FN7O6Purity:98% - 99.74%Color and Shape:SolidMolecular weight:603.61EGFR-IN-136
EGFR-IN-136 (compound 21v) is a potent inhibitor of EGFR, demonstrating IC50 values of 20.2 nM, 1.2 nM, 2.3 nM, and 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, and EGFRLR/TM/CS, respectively. It exhibits antiproliferative and antitumor activities and holds potential for research in non-small cell lung cancer (NSCLC).Formula:C30H36N7O4PMolecular weight:589.625DA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Color and Shape:Odour SolidCNX-2006
CAS:CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.Formula:C26H27F4N7O2Purity:98.85% - 99.16%Color and Shape:SolidMolecular weight:545.53Tilatamig
Tilatamig is a humanized antibody of the Ig(G1-κ, G1-λ2) type targeting EGFR/MET.Color and Shape:Odour LiquidMK-3903
CAS:MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).Formula:C27H19ClN2O3Purity:98.54% - 98.63%Color and Shape:SolidMolecular weight:454.9Ref: TM-T5187
1mg35.00€5mg80.00€10mg120.00€25mg188.00€50mg354.00€100mg588.00€200mg833.00€1mL*10mM (DMSO)88.00€AS-041164
CAS:AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.Formula:C11H7NO4SPurity:99.45%Color and Shape:SolidMolecular weight:249.24Selective PI3Kδ Inhibitor 1
CAS:Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).Formula:C23H20FN7OPurity:97.96%Color and Shape:SolidMolecular weight:429.45Anti-EGFR Monoclonal Antibody-AF647
Anti-EGFR Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF647 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaBrivanib
CAS:Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormula:C19H19FN4O3Purity:98.87%Color and Shape:SolidMolecular weight:370.38Ref: TM-T6036
1mg47.00€5mg88.00€10mg144.00€25mg259.00€50mg375.00€100mg560.00€200mg815.00€1mL*10mM (DMSO)97.00€NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formula:C24H26N4O3Purity:99.38%Color and Shape:SolidMolecular weight:418.49Ref: TM-T16343
1mg85.00€5mg160.00€10mg250.00€25mg424.00€50mg562.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)170.00€Neptinib
CAS:Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.Formula:C22H23ClFN5O2Color and Shape:SolidMolecular weight:443.90SHR-A1201
SHR-A1201 is an antibody-drug conjugate (ADC) targeting HER2. This compound is composed of a humanized anti-HER2 antibody, the linker SMCC, and the cytotoxic payload Mertansine, which is a microtubule inhibitor. SHR-A1201 is utilized in research for HER2-positive breast cancer.Formula:C50H63ClF3N5O12Color and Shape:LiquidMolecular weight:1018.51EGFR-IN-84
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lungFormula:C25H20N6O3S2Purity:98%Color and Shape:SolidMolecular weight:516.59MTX-241F
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families.Formula:C20H14ClFN6Purity:98%Color and Shape:SolidMolecular weight:392.82hAChE-IN-5
hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency withPurity:98%Color and Shape:Odour SolidOlmutinib
CAS:Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Formula:C26H26N6O2SPurity:99.63%Color and Shape:SolidMolecular weight:486.59Ref: TM-T6918
2mg39.00€5mg57.00€10mg88.00€25mg137.00€50mg180.00€100mg283.00€200mg462.00€1mL*10mM (DMSO)59.00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formula:C20H24Br2N4OSPurity:96.68% - ≥95%Color and Shape:SolidMolecular weight:528.3Ref: TM-T5956
2mg47.00€5mg70.00€10mg96.00€25mg216.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)81.00€AZD8931 diFuMaric acid
CAS:AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).Formula:C31H33ClFN5O11Purity:99.92%Color and Shape:SolidMolecular weight:706.1Ref: TM-T8751
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)255.00€NVP-BAG956
CAS:NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).Formula:C28H21N5Purity:99.71% - 99.80%Color and Shape:SolidMolecular weight:427.5Ref: TM-TQ0313
1mg57.00€5mg120.00€10mg210.00€25mg424.00€50mg707.00€100mg1,293.00€200mg1,738.00€1mL*10mM (DMSO)133.00€Anti-Phospho-EGFR (Tyr1092) Antibody (9I899)
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.Color and Shape:Odour LiquidMubritinib
CAS:Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Formula:C25H23F3N4O2Purity:98.61% - 99.87%Color and Shape:SolidMolecular weight:468.472′-Thioadenosine
CAS:2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFormula:C10H13N5O3SPurity:98%Color and Shape:SolidMolecular weight:283.31MRT 67307 dihydrochloride
CAS:MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.Formula:C26H38Cl2N6O2Purity:98.43%Color and Shape:SoildMolecular weight:537.53Ceftriaxone Sodium
CAS:Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.Formula:C18H17N8NaO7S3Color and Shape:SolidMolecular weight:576.562AEE788
CAS:AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formula:C27H32N6Purity:100% - 98.94%Color and Shape:SolidMolecular weight:440.58Ref: TM-T2116
2mg47.00€5mg70.00€10mg103.00€25mg188.00€50mg325.00€100mg490.00€500mg1,103.00€1mL*10mM (DMSO)77.00€Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.Formula:C31H23BrN4O4SPurity:98%Color and Shape:SolidMolecular weight:627.51PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formula:C26H35Cl2N7OPurity:99.23%Color and Shape:SolidMolecular weight:532.51Ref: TM-T23127
1mg35.00€5mg92.00€10mg149.00€25mg305.00€50mg492.00€100mg700.00€200mg938.00€1mL*10mM (DMSO)125.00€LY2090314
CAS:LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.Formula:C28H25FN6O3Purity:99.03% - 99.88%Color and Shape:SolidMolecular weight:512.53Ref: TM-T1755
1mg48.00€2mg63.00€5mg96.00€10mg153.00€25mg264.00€50mg432.00€100mg638.00€1mL*10mM (DMSO)107.00€DZD1516
CAS:DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFormula:C28H27F2N7O3Purity:98%Color and Shape:SolidMolecular weight:547.56PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.66IM-12
CAS:IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.Formula:C22H20FN3O2Purity:100% - 99.71%Color and Shape:SolidMolecular weight:377.41Ref: TM-T2261
5mg52.00€10mg87.00€25mg155.00€50mg283.00€100mg469.00€500mg1,035.00€1mL*10mM (DMSO)58.00€Limertinib
CAS:Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formula:C29H32ClN7O2Purity:97.44%Color and Shape:SolidMolecular weight:546.06Ref: TM-T35897
1mg90.00€5mg187.00€10mg316.00€25mg637.00€50mg827.00€100mg1,169.00€200mg1,586.00€1mL*10mM (DMSO)250.00€Tuxobertinib
CAS:Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formula:C29H29ClN6O4Purity:99.22%Color and Shape:SolidMolecular weight:561.03Ref: TM-T9072
2mg40.00€5mg60.00€10mg96.00€25mg188.00€50mg354.00€100mg525.00€200mg752.00€1mL*10mM (DMSO)74.00€EGFR-IN-149
CAS:EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.Formula:C16H15N3OSColor and Shape:SolidMolecular weight:297.375GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formula:C29H37FN6O4SPurity:98.9%Color and Shape:SolidMolecular weight:584.71Erucic acid sodium
CAS:Erucic acid sodium, a monounsaturated fatty acid (MUFA) extracted from the seeds of rapeseed, readily crosses the blood-brain barrier (BBB). It normalizes the accumulation of long-chain fatty acids in the brain, enhances cognitive function, and effectively prevents dementia.Formula:C22H42NaO2Color and Shape:SolidMolecular weight:361.56EGFR-IN-76
CAS:EGFR-IN-76 is a potent EGFR inhibitor.Formula:C30H30ClFN6O2Purity:97.02% - 97.72%Color and Shape:SolidMolecular weight:561.05PI3Kδ-IN-15
CAS:CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.Formula:C21H16FN7OPurity:99.39%Color and Shape:SolidMolecular weight:401.4PF-06409577
CAS:PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Formula:C19H16ClNO3Purity:95.17% - 98.16%Color and Shape:SolidMolecular weight:341.79Ref: TM-T4427
2mg46.00€5mg66.00€10mg105.00€25mg210.00€50mg381.00€100mg568.00€500mg1,225.00€1mL*10mM (DMSO)74.00€MBM-55S
CAS:MBM-55S, a Nek2 inhibitor with 1 nM IC50, induces cell cycle arrest and apoptosis, suppressing tumor growth.Formula:C36H39FN6O10Purity:98.38% - 98.73%Color and Shape:SolidMolecular weight:734.73Ref: TM-T11961
1mg185.00€2mg279.00€5mg426.00€10mg627.00€25mg938.00€50mg1,320.00€100mg1,786.00€500mg3,591.00€1mL*10mM (DMSO)630.00€ZL-2201
CAS:ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.Formula:C20H25N9O5SPurity:98%Color and Shape:SolidMolecular weight:503.54Norcantharidin
CAS:Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formula:C8H8O4Purity:99.29%Color and Shape:SolidMolecular weight:168.15Sunvozertinib
CAS:Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formula:C29H35ClFN7O3Purity:98.11% - 99.71%Color and Shape:SolidMolecular weight:584.08Ref: TM-T64124
1mg35.00€5mg64.00€10mg89.00€25mg131.00€50mg212.00€100mg373.00€500mg1,388.00€1mL*10mM (DMSO)159.00€U3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Color and Shape:LiquidMolecular weight:144.82 kDa (Predicted)WS6
CAS:WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C29H31F3N6O3Purity:97.23% - 99.83%Color and Shape:SolidMolecular weight:568.59LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purity:98% - 99.96%Color and Shape:Pale Yellow SolidMolecular weight:307.34Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formula:C33H48O6Purity:99.04% - 99.71%Color and Shape:White Crystalline SolidMolecular weight:540.73Ref: TM-T15735
1mg202.00€2mg341.00€5mg620.00€10mg882.00€25mg1,320.00€50mg1,776.00€100mg2,403.00€1mL*10mM (DMSO)283.00€PF-04802367
CAS:PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.Formula:C16H16ClN5O3Purity:98.76%Color and Shape:SolidMolecular weight:361.78Ref: TM-T9611
1mg52.00€5mg105.00€10mg160.00€25mg279.00€50mg420.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)117.00€PF-6274484
CAS:PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formula:C18H14ClFN4O2Purity:97.71%Color and Shape:SolidMolecular weight:372.78Ref: TM-T22396
2mg40.00€5mg60.00€10mg92.00€25mg187.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)66.00€EGFR-IN-1
CAS:EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.Formula:C28H30N6O4Purity:98%Color and Shape:SolidMolecular weight:514.58PI3Kα-IN-13
CAS:PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,Formula:C21H19N5O3Purity:98%Color and Shape:SolidMolecular weight:389.41EDI048
CAS:EDI048, also known as compound 1.16, is an orally active inhibitor of Cryptosporidium PI4K, utilized in the study of cryptosporidiosis [1].Formula:C25H21ClN4O4Purity:98%Color and Shape:SolidMolecular weight:476.91mTOR inhibitor-8
CAS:mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer with antiviral and antitumor activity for the study of non-small cell lung cancer.Formula:C24H19ClN4OSPurity:98.11%Color and Shape:SolidMolecular weight:446.95Ref: TM-T36316
1mg52.00€5mg111.00€10mg180.00€25mg359.00€50mg588.00€100mg944.00€1mL*10mM (DMSO)116.00€RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Formula:C22H24N2O3Purity:98.92%Color and Shape:SolidMolecular weight:364.44Ref: TM-T28416
1mg40.00€2mg57.00€5mg97.00€10mg156.00€25mg255.00€50mg368.00€100mg510.00€200mg700.00€1mL*10mM (DMSO)105.00€AZD3759 hydrochloride
CAS:AZD3759 hydrochloride is an oral, CNS-penetrant EGFR inhibitor with IC50s of 0.2/0.3/0.2 nM.Formula:C22H24Cl2FN5O3Purity:99.62%Color and Shape:SolidMolecular weight:496.36Ref: TM-T4249
2mg35.00€5mg48.00€10mg65.00€25mg99.00€50mg170.00€100mg280.00€200mg406.00€1mL*10mM (DMSO)51.00€Afzelin
CAS:Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-Formula:C21H20O10Purity:98.92% - 99.38%Color and Shape:SolidMolecular weight:432.38MP7
CAS:MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).Formula:C28H22F2N4O4Purity:99.45% - 99.84%Color and Shape:SolidMolecular weight:516.5EBE-A22
CAS:EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.Formula:C17H16BrN3O2Purity:99.85% - 99.88%Color and Shape:SolidMolecular weight:374.23KenPaullone
CAS:KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Formula:C16H11BrN2OPurity:97.14% - 98.99%Color and Shape:Tan SolidMolecular weight:327.18Ref: TM-T2247
1mg38.00€2mg49.00€5mg70.00€10mg95.00€25mg188.00€50mg319.00€100mg474.00€500mg1,074.00€1mL*10mM (DMSO)74.00€EGFR-IN-132
CAS:EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.Formula:C27H31N7O3Color and Shape:SolidMolecular weight:501.58CGS 15943
CAS:CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.Formula:C13H8ClN5OPurity:99.63%Color and Shape:SolidMolecular weight:285.69CAL-130 Hydrochloride
CAS:CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H23ClN8OColor and Shape:SolidMolecular weight:462.94Pertuzumab
CAS:Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2Purity:98.00%Color and Shape:LiquidMolecular weight:148 kDaETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Formula:C16H17N5O2Purity:99.13%Color and Shape:SolidMolecular weight:311.34Ref: TM-T25399
1mg52.00€5mg111.00€10mg175.00€25mg316.00€50mg512.00€100mg747.00€1mL*10mM (DMSO)124.00€Pyrotinib dimaleate
CAS:Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Formula:C40H39ClN6O11Purity:98.07% - 99.52%Color and Shape:SolidMolecular weight:815.22Ref: TM-T12594
1mg155.00€5mg457.00€10mg610.00€25mg947.00€50mg1,301.00€100mg1,758.00€1mL*10mM (DMSO)620.00€Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46EGFR-IN-124
EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.Color and Shape:Odour SolidNU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFormula:C17H15NO3Purity:100% - 99.51%Color and Shape:SolidMolecular weight:281.31ALKBH1-IN-3 prodrug
ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of an inhibitor targeting the DNA N6-methyladenine demethylase enzyme ALKBH1. It works by significantly increasing the cellular abundance of 6mA and enhancing the AMPK signaling pathway, which suppresses the vitality of gastric cancer cells. ALKBH1-IN-4 prodrug displays excellent cellular activity and favorable metabolic exposure in vivo, making it a promising candidate for research in gastric cancer-related areas.Color and Shape:Odour SolidEAI045
CAS:EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.Formula:C19H14FN3O3SPurity:98.00% - 99.73%Color and Shape:SolidMolecular weight:383.4JAK 3 inhibitor IV
CAS:JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormula:C16H19NOPurity:98%Color and Shape:SolidMolecular weight:241.33PS 48
CAS:PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).Formula:C17H15ClO2Purity:98.37% - ≥95%Color and Shape:SolidMolecular weight:286.75PP 3
CAS:PP 3 is a Negative control for the Src kinase inhibitor PP 2Formula:C11H9N5Purity:98.61%Color and Shape:Whit To Off-White SolidMolecular weight:211.22Ref: TM-T23176
5mg51.00€10mg79.00€25mg140.00€50mg202.00€100mg305.00€500mg733.00€1mL*10mM (DMSO)55.00€VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Formula:C21H25N7OPurity:98.60%Color and Shape:SolidMolecular weight:391.47Ref: TM-T7944
1mg66.00€5mg144.00€10mg227.00€25mg399.00€50mg567.00€100mg753.00€200mg1,035.00€1mL*10mM (DMSO)166.00€GSK2334470
CAS:GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.Formula:C25H34N8OPurity:99.04% - 99.87%Color and Shape:SolidMolecular weight:462.59Multi-target kinase inhibitor 2
Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 valuesPurity:98%Color and Shape:Odour SolidAG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Formula:C16H12N2O3Purity:98.69%Color and Shape:SolidMolecular weight:280.28AZ044
CAS:AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).Formula:C24H27N3O3SPurity:98.22%Color and Shape:SolidMolecular weight:437.55Ref: TM-T26698
1mg57.00€5mg120.00€10mg188.00€25mg432.00€50mg747.00€100mg1,216.00€200mg1,644.00€1mL*10mM (DMSO)139.00€Simotinib
CAS:Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.Formula:C25H26ClFN4O4Purity:99.7%Color and Shape:SolidMolecular weight:500.95(±)-Norcantharidin
CAS:(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formula:C8H8O4Purity:99.43% - ≥98%Color and Shape:SolidMolecular weight:168.15GDC-0326
CAS:GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).Formula:C19H22N6O3Purity:100% - 99.35%Color and Shape:SolidMolecular weight:382.42Ref: TM-T3985
1mg35.00€2mg49.00€5mg95.00€10mg155.00€25mg255.00€50mg406.00€100mg592.00€1mL*10mM (DMSO)94.00€GSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Formula:C14H10N2OPurity:99.08%Color and Shape:SolidMolecular weight:222.24AZ-5104
CAS:AZ5104 is a potent EGFR inhibitor.Formula:C27H31N7O2Purity:98.40% - 99.9%Color and Shape:Solid PowderMolecular weight:485.58A-935142
CAS:A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formula:C18H19F3N2O2Purity:100% - 100%Color and Shape:SolidMolecular weight:352.35EGFR-IN-85
CAS:EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFRFormula:C26H30N8O2Purity:98%Color and Shape:SolidMolecular weight:486.57KU-0063794
CAS:KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.Formula:C25H31N5O4Purity:100% - 98.35%Color and Shape:SolidMolecular weight:465.54Thioether-cyclized helix B peptide, CHBP TFA
Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP.Formula:C56H93N19O22S·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:1416.52 (free base)740 Y-P(TFA)
740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.Formula:C143H223F3N43O41PS3Purity:98%Color and Shape:SolidMolecular weight:3384.73EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS:EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)Formula:C23H21N3O3Purity:99.55%Color and Shape:SolidMolecular weight:387.43Ref: TM-T21954
1mg75.00€2mg94.00€5mg140.00€10mg205.00€25mg371.00€50mg557.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)157.00€APY0201
CAS:APY0201: potent, specific ATP-competitive PIKfyve inhibitor; IC50=5.2 nM; blocks PtdIns3P to PtdIns(3,5)P2 conversion.Formula:C23H23N7OPurity:98% - 99.21%Color and Shape:SolidMolecular weight:413.48Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Formula:C19H22F3N5O2SPurity:98% - 99.73%Color and Shape:SolidMolecular weight:441.47Ref: TM-T1921
1g653.00€5mg55.00€10mg72.00€25mg87.00€50mg96.00€100mg154.00€200mg265.00€500mg447.00€1mL*10mM (DMSO)60.00€EGFR-IN-1 hydrochloride
CAS:EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.Formula:C28H31ClN6O4Purity:99.8%Color and Shape:SolidMolecular weight:551.04Ref: TM-T11157L
1mg65.00€5mg150.00€10mg215.00€25mg338.00€50mg452.00€100mg620.00€200mg838.00€1mL*10mM (DMSO)202.00€GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Color and Shape:Odour SolidDuligotuzumab
CAS:Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody targeting Her3 (ErbB3) [1].Purity:98%Color and Shape:LiquidCDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Formula:C21H20ClN3O2Purity:98.97% - 99.83%Color and Shape:SoildMolecular weight:381.86Ref: TM-T72048
1mg52.00€5mg101.00€10mg150.00€25mg250.00€50mg363.00€100mg509.00€200mg695.00€1mL*10mM (DMSO)116.00€Lumretuzumab
CAS:Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.Color and Shape:LiquidEGFR-IN-82
CAS:EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/Formula:C32H41BrN9O2PPurity:98%Color and Shape:SolidMolecular weight:694.6Almonertinib mesylate
CAS:Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Formula:C31H39N7O5SPurity:98.85%Color and Shape:SolidMolecular weight:621.75Ref: TM-T9865
1mg55.00€5mg116.00€10mg187.00€25mg319.00€50mg449.00€100mg638.00€200mg840.00€1mL*10mM (DMSO)170.00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:97.29% - 99.91%Color and Shape:SolidMolecular weight:545.63AZD2858
CAS:AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Formula:C21H23N7O3SPurity:98% - 99.25%Color and Shape:SolidMolecular weight:453.52Ref: TM-T1957
1mg38.00€2mg49.00€5mg79.00€10mg106.00€25mg198.00€50mg374.00€100mg555.00€500mg1,206.00€1mL*10mM (DMSO)108.00€IHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Formula:C22H20F2N6O4Color and Shape:SolidMolecular weight:470.43LY 456236 hydrochloride
CAS:LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Formula:C16H16ClN3O2Purity:99.89%Color and Shape:SolidMolecular weight:317.77YLF-466D
CAS:YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Formula:C29H20ClNO3Purity:98.04%Color and Shape:SolidMolecular weight:465.93Ref: TM-T13368
1mg37.00€5mg84.00€10mg117.00€25mg198.00€50mg284.00€100mg393.00€200mg540.00€1mL*10mM (DMSO)87.00€EGFR/VEGFR2-IN-2
EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.Formula:C24H15FO3Color and Shape:SolidMolecular weight:370.37PI3K/HDAC-IN-1
CAS:PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).Formula:C22H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:428.46EGFR-IN-79
EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy.Formula:C23H16ClN3O3Purity:98%Color and Shape:SolidMolecular weight:417.84lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formula:C14H13NO5Purity:97.77%Color and Shape:Yellow To Tan PowderMolecular weight:275.26Ref: TM-T4185
1mg44.00€2mg58.00€5mg87.00€10mg160.00€25mg349.00€50mg518.00€100mg747.00€1mL*10mM (DMSO)95.00€mTOR inhibitor 9d
CAS:mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,Formula:C21H23N5O3SPurity:98.90%Color and Shape:SoildMolecular weight:425.5AMPK activator 15
AP39 Prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. In hepatocytes, it induces ROS-dependent mild mitochondrial uncoupling, activates mitochondria-associated AMPK, and inhibits Palmitic acid (PA)-induced lipid accumulation.Formula:C53H51BrNO10PSColor and Shape:SolidMolecular weight:1004.92IHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM forFormula:C26H21F2N7O3Purity:98%Color and Shape:SolidMolecular weight:517.49Thioether-cyclized helix B peptide, CHBP
CAS:Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTORFormula:C56H93N19O22SPurity:98%Color and Shape:SolidMolecular weight:1416.52Amivantamab
CAS:Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.Purity:97.24% (SEC-HPLC) - 99.74%Color and Shape:LiquidMolecular weight:145.88 kDaEGFR-IN-2
CAS:EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.Formula:C26H33N9O3SPurity:100%Color and Shape:SolidMolecular weight:551.66AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4Ref: TM-T7122
1mg40.00€5mg88.00€10mg119.00€25mg187.00€50mg311.00€100mg472.00€200mg687.00€1mL*10mM (DMSO)87.00€AR-A014418
CAS:AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Formula:C12H12N4O4SPurity:99.94% - ≥95%Color and Shape:SolidMolecular weight:308.31EGFR-IN-135
EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.Formula:C12H14N4OS2Color and Shape:SolidMolecular weight:294.4Aloisine B
CAS:Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Formula:C15H14ClN3Purity:95.15%Color and Shape:SolidMolecular weight:271.74Osimertinib
CAS:Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formula:C28H33N7O2Purity:100% - 99.83%Color and Shape:SolidMolecular weight:499.61Ref: TM-T2490
1g154.00€2mg38.00€5mg52.00€10mg62.00€25mg74.00€50mg88.00€100mg103.00€200mg115.00€500mg127.00€1mL*10mM (DMSO)52.00€NVP-QAV-572
CAS:NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).Formula:C17H19F2N7O3S2Purity:98%Color and Shape:SolidMolecular weight:471.5PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFormula:C21H19N5OPurity:98%Color and Shape:SolidMolecular weight:357.41Wnt/β-catenin agonist 2
CAS:Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.Formula:C13H12N4O3Purity:99.58%Color and Shape:SolidMolecular weight:272.26Ref: TM-T41094
1mg54.00€5mg116.00€10mg187.00€25mg318.00€50mg449.00€100mg638.00€500mg1,264.00€1mL*10mM (DMSO)111.00€P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Formula:C31H40N8O3SPurity:99.75%Color and Shape:SolidMolecular weight:604.77AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Formula:C23H24BrNO2Purity:99.27%Color and Shape:SolidMolecular weight:426.35EGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.Formula:C17H15N7O5SColor and Shape:SolidMolecular weight:429.41CCG 203769
CAS:CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.Formula:C8H14N2O2SPurity:99.46%Color and Shape:SolidMolecular weight:202.27Ref: TM-T10705
1mg88.00€5mg187.00€10mg264.00€25mg469.00€50mg657.00€100mg944.00€500mg1,882.00€1mL*10mM (DMSO)207.00€DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formula:C13H17ClO4Purity:99.57%Color and Shape:SolidMolecular weight:272.72Ref: TM-T60485
1mg92.00€5mg235.00€10mg350.00€25mg588.00€50mg838.00€100mg1,130.00€500mg2,308.00€1mL*10mM (DMSO)215.00€Cetuximab MMAE
Cetuximab-MMAE, an antibody-drug conjugate (ADC), combines an EGFR-targeting antibody with Monomethyl auristatin E (MMAE) to investigate colorectal and head and neck cancers.Color and Shape:LiquidMolecular weight:150 kDaDacomitinib hydrate
CAS:Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family ofFormula:C24H27ClFN5O3Purity:99.52%Color and Shape:SolidMolecular weight:487.96Ref: TM-T19965
5mg50.00€10mg80.00€25mg105.00€50mg140.00€100mg212.00€200mg311.00€1mL*10mM (DMSO)60.00€PI3Kα-IN-12
PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 valuesFormula:C28H36F2N10O5S3Color and Shape:SolidMolecular weight:726.84Rociletinib
CAS:Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplasticFormula:C27H28F3N7O3Purity:98.39% - 99.25%Color and Shape:SolidMolecular weight:555.55PI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formula:C23H25N3O5S2Purity:97.18%Color and Shape:SolidMolecular weight:487.59Ridaforolimus
CAS:Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物,具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂,在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。Formula:C53H84NO14PPurity:90.00% - 98.55%Color and Shape:Off-White SolidMolecular weight:990.21NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formula:C20H14F3N3SPurity:99.75% - 99.84%Color and Shape:SolidMolecular weight:385.41Ref: TM-T3556
2mg38.00€5mg54.00€10mg80.00€25mg140.00€50mg239.00€100mg340.00€200mg472.00€1mL*10mM (DMSO)58.00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formula:C17H20F3N7O2Purity:97.58% - 98.92%Color and Shape:SolidMolecular weight:411.38ARN25068
CAS:ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.Formula:C19H18N6SPurity:99.71%Color and Shape:SolidMolecular weight:362.45EGFR-IN-8
CAS:EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLCFormula:C32H23ClF3N7O4Purity:97.45%Color and Shape:SolidMolecular weight:662.02Tyrphostin A25
CAS:Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formula:C10H6N2O3Purity:98.76%Color and Shape:Yellow Green Powder /Off-White SolidMolecular weight:202.17Tyrphostin 23
CAS:Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.Formula:C10H6N2O2Purity:99.19% - 99.7%Color and Shape:Yellow-Tan SolidMolecular weight:186.17Tarlox-TKI
CAS:Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formula:C19H18BrClN6OPurity:97.03%Color and Shape:SolidMolecular weight:461.74GW 583340 dihydrochloride
CAS:GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formula:C28H27Cl3FN5O3S2Purity:98.80%Color and Shape:SolidMolecular weight:671.03PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Formula:C20H13ClF2N4O4SPurity:96.16%Color and Shape:SolidMolecular weight:478.86Ref: TM-T12459
1mg58.00€5mg145.00€10mg226.00€25mg378.00€50mg540.00€100mg730.00€200mg938.00€1mL*10mM (DMSO)153.00€PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formula:C17H13BrN4OPurity:99.13% - 99.7%Color and Shape:SolidMolecular weight:369.22Ref: TM-T6932
1mg39.00€2mg49.00€5mg66.00€10mg89.00€25mg155.00€50mg222.00€100mg310.00€1mL*10mM (DMSO)56.00€Almonertinib hydrochloride
CAS:Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Formula:C30H36ClN7O2Purity:98.01% - 98.12%Color and Shape:SolidMolecular weight:562.1MTX-211
CAS:MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Formula:C20H14Cl2FN5O2SPurity:100% - 97.28%Color and Shape:SolidMolecular weight:478.33Ref: TM-T4296
1mg64.00€5mg187.00€10mg284.00€25mg467.00€50mg645.00€100mg873.00€200mg1,159.00€1mL*10mM (DMSO)190.00€EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted)EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:60-90 KDa (reducing condition)BI-4732
CAS:DL-Homocystine is a mutagen secreted by F. nucleatum.Formula:C32H36N10O2Purity:98.88%Color and Shape:SolidMolecular weight:592.69Olmutinib
CAS:Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorFormula:C26H26N6O2SPurity:99.14%Color and Shape:SolidMolecular weight:486.59Ref: TM-T8460
2mg35.00€5mg57.00€10mg93.00€25mg131.00€50mg185.00€100mg283.00€200mg464.00€1mL*10mM (DMSO)63.00€Pilaralisib
CAS:Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).Formula:C25H25ClN6O4SPurity:98.24% - 99.61%Color and Shape:SolidMolecular weight:541.02GLPG3312
CAS:GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .Formula:C23H21F2N5O3Purity:98.53%Color and Shape:SolidMolecular weight:453.44Osimertinib dimesylate
CAS:Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Formula:C30H41N7O8S2Purity:98%Color and Shape:SolidMolecular weight:691.82Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Formula:C23H14ClF3N6OPurity:99.81%Color and Shape:SolidMolecular weight:482.85Ref: TM-TQ0044
1mg57.00€2mg81.00€5mg120.00€10mg188.00€25mg329.00€50mg472.00€100mg660.00€1mL*10mM (DMSO)126.00€AG 555
CAS:AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.Formula:C19H18N2O3Purity:100% - 99.51%Color and Shape:SolidMolecular weight:322.364-PivO-NMT chloride
CAS:4-PivO-NMT chloride is an indole derivative-based regulator of the AMPK signaling pathway. It modulates neurogenesis or neurite outgrowth by influencing AMPK activity and holds potential for research in neurological disorders, pain, and inflammation.Formula:C16H23ClN2O2Color and Shape:SolidMolecular weight:310.82TBB
CAS:TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).Formula:C6HBr4N3Purity:98.51% - 99.45%Color and Shape:Off-White SolidMolecular weight:434.71GSK 3 Inhibitor IX
CAS:GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.Formula:C16H10BrN3O2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:356.17Ref: TM-T1917
1mg44.00€2mg55.00€5mg82.00€10mg101.00€25mg229.00€50mg411.00€100mg610.00€500mg1,301.00€1mL*10mM (DMSO)90.00€PI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inPurity:98%Color and Shape:Odour SolidDesmethyl-VS-5584
CAS:Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Formula:C16H20N8OPurity:100%Color and Shape:SolidMolecular weight:340.38Chamigrenal
CAS:β-Chamigrenal: Anti-inflammatory, inhibits NO and PGE2 in macrophages, PAF antagonist (IC50=1.2x10^-4 M), weakly cytotoxic to MCF-7 (IC50=30.50 uM).Formula:C15H22OPurity:99.31%Color and Shape:SolidMolecular weight:218.33Sonolisib
CAS:Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).Formula:C29H35NO8Purity:98%Color and Shape:SolidMolecular weight:525.59(S)-Afatinib
CAS:(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, L858R, L858R/T790M, HER2, and HER4, respectively.Formula:C24H25ClFN5O3Purity:100% - 99.96%Color and Shape:Off-White SolidMolecular weight:485.94Neratinib
CAS:Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.Formula:C30H29ClN6O3Purity:100% - 98.55%Color and Shape:SolidMolecular weight:557.04Tyrphostin A9
CAS:Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitorFormula:C18H22N2OPurity:98.21% - 99.87%Color and Shape:Yellow SolidMolecular weight:282.38AV-412 free base
CAS:AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formula:C27H28ClFN6OColor and Shape:SolidMolecular weight:507Amivantamab (FUT8-KO)
Amivantamab (FUT8-KO) is a humanized dual-specificity antibody targeting EGFR-MET, exhibiting immunotherapeutic anticancer activity. This compound inhibits ligand binding, enhances the internalization and degradation of receptor-antibody complexes, and stimulates macrophage-mediated phagocytosis and natural killer cell cytotoxicity, both of which are Fc-dependent.Formula:C13H12O4Color and Shape:LiquidMolecular weight:232.23Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Formula:C23H14Na2O11Purity:98.25% - 99.95%Color and Shape:Colorless Crystals From Ethanol + Ether White Crystalline PowderMolecular weight:512.33EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.Cyanoacetohydrazide
CAS:Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.Formula:C3H5N3OPurity:99.78%Color and Shape:Stout Prisms From Alcohol Slightly Brown PowderMolecular weight:99.09Nemiralisib
CAS:Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.Formula:C26H28N6OPurity:99.91%Color and Shape:SolidMolecular weight:440.54PIK-75
CAS:PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).Formula:C16H14BrN5O4SPurity:100% - 99.88%Color and Shape:SolidMolecular weight:452.28CHMFL-EGFR-202
CAS:CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).Formula:C25H24ClN7O2Purity:99.19%Color and Shape:SolidMolecular weight:489.96Ref: TM-T10802
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€1mL*10mM (DMSO)305.00€PI3Kdelta inhibitor 1
CAS:PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.Formula:C27H38N6O5SPurity:98%Color and Shape:SolidMolecular weight:558.69GS-9901
CAS:GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.Formula:C22H17ClFN9OPurity:99.12% - 99.14%Color and Shape:SolidMolecular weight:477.88mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseasesPurity:98%Color and Shape:Odour SolidAnti-EGFR Monoclonal Antibody-AF555
Anti-EGFR Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF555 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaCinrebafusp alfa
CAS:Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM toPurity:98%Color and Shape:LiquidWHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formula:C16H15N3O3Purity:99.21%Color and Shape:SolidMolecular weight:297.31ARUK2001607
ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formula:C14H13N3O2S2Purity:99.86%Color and Shape:SoildMolecular weight:319.40PT-1
CAS:PT-1 is an AMPKα1 activator that dose-dependently activates AMPK α1394, α1335, and α2398 and enhances AMPK phosphorylation.Formula:C23H16ClN3O6SPurity:99.62%Color and Shape:SolidMolecular weight:497.91Almonertinib
CAS:Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.Formula:C30H35N7O2Purity:99.99%Color and Shape:SolidMolecular weight:525.64Ref: TM-T5462
1mg89.00€5mg197.00€10mg311.00€25mg525.00€50mg757.00€100mg1,035.00€500mg2,110.00€1mL*10mM (DMSO)249.00€Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Formula:C35H28F3N5O2Purity:98.3% - 99.38%Color and Shape:SolidMolecular weight:607.62ElteN378
CAS:ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Formula:C23H26N2O3Purity:98.09%Color and Shape:SolidMolecular weight:378.46Ref: TM-T9950
1mg170.00€5mg376.00€10mg557.00€25mg895.00€50mg1,216.00€100mg1,691.00€200mg2,262.00€1mL*10mM (DMSO)329.00€4-Epidoxycycline
CAS:4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.Formula:C22H24N2O8Color and Shape:SolidMolecular weight:444.44E-4031
CAS:E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formula:C21H29Cl2N3O3SPurity:99.31% - 99.87%Color and Shape:SolidMolecular weight:474.44Panitumumab
CAS:Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).Purity:95% - 99%Color and Shape:LiquidMolecular weight:147 kDaTAS0728
CAS:TAS0728 is a HER2 inhibitor, with antitumor activityFormula:C26H32N8O3Purity:97.78%Color and Shape:SolidMolecular weight:504.58Ref: TM-T7819
1mg50.00€5mg111.00€10mg170.00€25mg321.00€50mg512.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)117.00€FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Formula:C34H36Cl2N8O4Purity:97.63% - 98.92%Color and Shape:SolidMolecular weight:691.61mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Formula:C23H21N7OPurity:98%Color and Shape:SolidMolecular weight:411.46Neolinine
CAS:Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.Formula:C23H37NO6Purity:98%Color and Shape:SolidMolecular weight:423.55Umbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formula:C31H24F3N5O3Purity:95.61%Color and Shape:SolidMolecular weight:571.55Ref: TM-T13140
1mg187.00€5mg455.00€10mg655.00€25mg1,169.00€50mg1,510.00€100mg1,882.00€1mL*10mM (DMSO)560.00€HTH-01-015
CAS:HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).Formula:C26H28N8OPurity:98.1% - 99.08%Color and Shape:SolidMolecular weight:468.55Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Formula:C29H39ClN7O2PPurity:100% - 99.93%Color and Shape:SolidMolecular weight:584.09PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Formula:C28H23N7O2Purity:100% - 99%Color and Shape:SolidMolecular weight:489.53Epitinib succinate
CAS:Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formula:C28H32N6O6Purity:97.43% - 99.47%Color and Shape:SolidMolecular weight:548.59Ref: TM-T35914
1mg75.00€2mg97.00€5mg170.00€10mg271.00€25mg449.00€50mg615.00€100mg843.00€500mg1,691.00€
