PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Formula:C11H5F2NO4SPurity:99.65%Color and Shape:SolidMolecular weight:285.22Osimertinib mesylate
CAS:Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.Formula:C29H37N7O5SPurity:100% - 99.88%Color and Shape:SolidMolecular weight:595.71Anti-EGFR Monoclonal Antibody-Biotin
Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: HumanPurity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaGNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Formula:C21H28N8O3S2Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:504.63MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Formula:C17H12BrN3O2Purity:98.84%Color and Shape:SolidMolecular weight:370.2Ref: TM-T21966
1mg39.00€5mg74.00€10mg117.00€25mg220.00€50mg354.00€100mg520.00€500mg1,130.00€1mL*10mM (DMSO)86.00€(E)-AG 556
CAS:AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.Formula:C20H20N2O3Purity:99.48%Color and Shape:Light Yellow PowderMolecular weight:336.38JNK3 inhibitor-9
JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.Formula:C25H27N7O2Molecular weight:457.528Zorifertinib
CAS:Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.Formula:C22H23ClFN5O3Purity:98.20% - 99.36%Color and Shape:White To Off-White SolidMolecular weight:459.9T-00127_HEV1
CAS:T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).Formula:C22H29N5O3Purity:99.71%Color and Shape:SolidMolecular weight:411.5Ref: TM-T16967
1mg56.00€5mg119.00€10mg187.00€25mg375.00€50mg560.00€100mg800.00€500mg1,644.00€1mL*10mM (DMSO)246.00€Laduviglusib trihydrochloride
CAS:Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.Formula:C22H20Cl5N8Purity:99.03%Color and Shape:SolidMolecular weight:573.71Ref: TM-T22657
1mg43.00€2mg57.00€5mg93.00€10mg136.00€25mg269.00€50mg510.00€100mg682.00€500mg1,415.00€1mL*10mM (DMSO)106.00€(S)-Sunvozertinib
CAS:(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formula:C29H35ClFN7O3Purity:99.64%Color and Shape:SolidMolecular weight:584.08SF2523
CAS:SF2523 is a highly selective and potent inhibitor.Formula:C19H17NO5SPurity:97.78% - 98.06%Color and Shape:SolidMolecular weight:371.41Ref: TM-T3986
1mg37.00€5mg79.00€10mg119.00€25mg274.00€50mg432.00€100mg638.00€500mg1,359.00€1mL*10mM (DMSO)87.00€PI3K-IN-46
CAS:PI3K-IN-46 is a specific inhibitor of PI3Kγ.Formula:C13H9N3OSPurity:97.51%Color and Shape:SoildMolecular weight:255.35-Bromoindole
CAS:5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediateFormula:C8H6BrNPurity:99.99%Color and Shape:White To Beige Crystalline PowderMolecular weight:196.04FD274
CAS:FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,Formula:C22H14ClFN6O2SPurity:98%Color and Shape:SoildMolecular weight:480.9IC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formula:C12H15NO3Purity:99.33%Color and Shape:SolidMolecular weight:221.25GSK3-IN-1
CAS:GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.Formula:C14H10ClN3OSPurity:99.66%Color and Shape:SolidMolecular weight:303.77Ref: TM-T9987
2mg44.00€5mg64.00€10mg105.00€25mg226.00€50mg335.00€100mg480.00€200mg652.00€1mL*10mM (DMSO)77.00€JND3229
CAS:JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.Formula:C33H41ClN8O2Purity:97.35%Color and Shape:SolidMolecular weight:617.18PI3K-IN-10
CAS:PI3K-IN-10 is a potent inhibitor of pan-PI3K .Formula:C23H19ClN6OPurity:98%Color and Shape:SolidMolecular weight:430.89AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Formula:C22H24N4O4Purity:99.79% - 99.95%Color and Shape:SolidMolecular weight:408.45Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.Formula:C9H9BrN2O3Purity:100% - 99.86%Color and Shape:SolidMolecular weight:273.08Ref: TM-T1965
10mg47.00€25mg77.00€50mg119.00€100mg187.00€200mg279.00€500mg472.00€1mL*10mM (DMSO)34.00€Mavelertinib
CAS:Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Formula:C18H22FN9O2Purity:100%Color and Shape:SolidMolecular weight:415.42(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4-Kinase Alpha (PI4KIIIα), pIC50=8.3.Formula:C27H18F5N5O4SPurity:99.35%Color and Shape:SoildMolecular weight:603.52Ref: TM-T67837
1mg73.00€5mg140.00€10mg221.00€25mg393.00€50mg562.00€100mg883.00€1mL*10mM (DMSO)192.00€Isoprenaline hydrochloride
CAS:Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.Formula:C11H18ClNO3Purity:98% - 99.25%Color and Shape:Turn Brownish-Pink Upon Prolonged Exposure To Air (Ntp 1992)Molecular weight:247.719Mutated EGFR-IN-3
CAS:Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formula:C31H29FN4O2Purity:98%Color and Shape:SolidMolecular weight:508.59EGFR-IN-9
CAS:EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formula:C29H24N4O3Purity:99.46%Color and Shape:SolidMolecular weight:476.53AZD3458
CAS:AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).Formula:C20H23N3O4S2Color and Shape:SolidMolecular weight:433.54Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51EGFR-IN-126
CAS:EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.Formula:C28H28BrFN4O3Color and Shape:SolidMolecular weight:567.45ZLN 024 hydrochloride
CAS:ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).Formula:C13H14BrClN2OSPurity:99.86%Color and Shape:SolidMolecular weight:361.68Gefitinib-based PROTAC 3
CAS:Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).Formula:C47H57ClFN7O8SPurity:97.29% - 98.25%Color and Shape:SolidMolecular weight:934.51HKI-357
CAS:HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.Formula:C31H29ClFN5O3Purity:95.11%Color and Shape:SolidMolecular weight:574.05Ref: TM-T11569
1mg79.00€5mg153.00€10mg227.00€25mg462.00€50mg662.00€100mg938.00€1mL*10mM (DMSO)187.00€BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Formula:C20H23N3OPurity:99.01%Color and Shape:SolidMolecular weight:321.42Ref: TM-T10606
1mg89.00€5mg183.00€10mg266.00€25mg395.00€50mg553.00€100mg742.00€1mL*10mM (DMSO)200.00€PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purity:96.59% - 99.3%Color and Shape:SolidMolecular weight:348.36PD158780
CAS:PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.Formula:C14H12BrN5Purity:98.81%Color and Shape:SolidMolecular weight:330.18EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formula:C50H49N11O5SColor and Shape:SolidMolecular weight:916.06PIK-inhibitors
CAS:PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.Formula:C19H17N5O2Purity:96.98%Color and Shape:SolidMolecular weight:347.37PI5P4Ks-IN-2
CAS:PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.Formula:C22H23N5Purity:99.09% - 99.21%Color and Shape:SoildMolecular weight:357.45Ref: TM-T72032
1mg160.00€5mg338.00€10mg502.00€25mg848.00€50mg1,111.00€100mg1,454.00€1mL*10mM (DMSO)369.00€RLY-2608
CAS:RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.Formula:C29H14ClF5N6O2Purity:98.7% - 98.96%Color and Shape:SolidMolecular weight:608.91EGFR vIII Protein, Human, Recombinant (His)
EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.Color and Shape:Lyophilized PowderMolecular weight:61-75 Kda (reducing condition)Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Color and Shape:LiquidVS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formula:C17H22N8OPurity:97.82% - 99.54%Color and Shape:SolidMolecular weight:354.41CAL-130
CAS:CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurity:98% - 99.41%Color and Shape:Colourless To Light-Yellow CrystalMolecular weight:943.47AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Formula:C21H16FN7Purity:98.57% - 98.9%Color and Shape:Crystalline SolidMolecular weight:385.4PI3Kγ inhibitor 2
CAS:PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).Formula:C20H18F3N5O3Purity:98%Color and Shape:SolidMolecular weight:433.38WHI-P154
CAS:WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formula:C16H14BrN3O3Purity:98% - 99.6%Color and Shape:SolidMolecular weight:376.2Sapitinib
CAS:Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFormula:C23H25ClFN5O3Purity:98.89% - 99.83%Color and Shape:SolidMolecular weight:473.93EGFR-IN-128
EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.Formula:C27H20N4OColor and Shape:SolidMolecular weight:416.47hSMG-1 inhibitor 11j
CAS:hSMG-1 inhibitor 11j: pyrimidine, IC50=0.11 nM, >455x selective vs. mTOR/PI3Kα/γ/CDK1/CDK2; cancer research use.Formula:C27H28ClN7O3SPurity:99.04% - 99.29%Color and Shape:SolidMolecular weight:566.07BPI-15086
CAS:BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.Formula:C29H33ClN8O4Color and Shape:SolidMolecular weight:593.08FRF-06-057
FRF-06-057 is an allosteric ATP EGFR inhibitor targeting both wild-type and mutant EGFR, with IC50 values of 17 nM (LR/TM), 29 nM (LR/TM/CS), 220 nM (LR), and >1000 nM (WT).Formula:C19H13N3O3SColor and Shape:SolidMolecular weight:363.39NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Formula:C7H13F2NO2Purity:98% - ≥98%Color and Shape:SolidMolecular weight:181.18PI3K/mTOR Inhibitor-1
CAS:PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)Formula:C18H22FN5O3SPurity:98%Color and Shape:SolidMolecular weight:407.46CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Formula:C55H87N15O22Purity:98%Color and Shape:SolidMolecular weight:1310.37Tyrphostin AG30
CAS:Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.Formula:C10H7NO4Purity:99.02%Color and Shape:SolidMolecular weight:205.17Trastuzumab rezetecan
CAS:Trastuzumab rezetecan (SHR-A1811) is an antibody-drug conjugate (ADC) targeting HER2. It is composed of a humanized anti-HER2 antibody, a cleavable linker MC-Gly-Gly-Phe-Gly, and an effective payload of the topoisomerase I inhibitor Rezetecán. Trastuzumab rezetecan is utilized in the research of HER2-positive breast cancer.Color and Shape:LiquidEpertinib hydrochloride
CAS:Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.Formula:C30H28Cl2FN5O3Purity:99.14%Color and Shape:SolidMolecular weight:596.48Ref: TM-T11213
1mg92.00€5mg188.00€10mg311.00€25mg533.00€50mg755.00€100mg1,017.00€500mg2,043.00€1mL*10mM (DMSO)255.00€Labuxtinib
CAS:Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formula:C20H16FN5O2Purity:99.77%Color and Shape:SolidMolecular weight:377.37Ref: TM-T79851
1mg139.00€5mg338.00€10mg540.00€25mg1,074.00€50mg1,549.00€100mg2,080.00€200mg2,802.00€1mL*10mM (DMSO)374.00€PI3K/mTOR Inhibitor-14
CAS:PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, andFormula:C28H30N8O3SPurity:98%Color and Shape:SolidMolecular weight:558.66Dacomitinib
CAS:Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.Formula:C24H25ClFN5O2Purity:100% - 99.72%Color and Shape:SolidMolecular weight:469.94Ref: TM-T2483
1mg38.00€2mg49.00€5mg79.00€10mg127.00€25mg173.00€50mg227.00€100mg354.00€200mg444.00€500mg730.00€1mL*10mM (DMSO)79.00€PI3kδ inhibitor 1
CAS:PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).Formula:C28H33FN6O2Purity:98%Color and Shape:SolidMolecular weight:504.60Rezivertinib
CAS:Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formula:C27H30N6O3Purity:99.43% - 99.89%Color and Shape:SolidMolecular weight:486.57Ref: TM-T36644
1mg99.00€5mg226.00€10mg364.00€25mg702.00€50mg947.00€100mg1,264.00€200mg1,700.00€1mL*10mM (DMSO)47.00€GSK-3β inhibitor 14
CAS:GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.Formula:C17H17NOSPurity:99.88%Color and Shape:SolidMolecular weight:283.39Benidipine hydrochloride
CAS:Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.Formula:C28H32ClN3O6Purity:99.80%Color and Shape:SolidMolecular weight:542.03Nuvenzepine
CAS:Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.Formula:C19H20N4O2Purity:98%Color and Shape:SolidMolecular weight:336.39PI3Kδ-IN-13
CAS:PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, includingFormula:C27H39N7O4S2Color and Shape:SolidMolecular weight:589.77GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Formula:C16H11N5O2SPurity:98.86%Color and Shape:SolidMolecular weight:337.36Ref: TM-T8605
1mg131.00€2mg188.00€5mg283.00€10mg430.00€25mg710.00€50mg998.00€100mg1,349.00€1mL*10mM (DMSO)298.00€Taselisib
CAS:Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.Formula:C24H28N8O2Purity:98.92% - 99.79%Color and Shape:SolidMolecular weight:460.53Ref: TM-T1999
2mg46.00€5mg66.00€10mg92.00€25mg157.00€50mg197.00€100mg350.00€200mg522.00€500mg840.00€1mL*10mM (DMSO)66.00€RG13022
CAS:RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).Formula:C16H14N2O2Purity:98.38%Color and Shape:SolidMolecular weight:266.29KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Formula:C17H11Cl2N3O2Purity:98.06%Color and Shape:SolidMolecular weight:360.19Ref: TM-T9025
1mg99.00€5mg197.00€10mg350.00€25mg590.00€50mg840.00€100mg1,130.00€500mg2,308.00€1mL*10mM (DMSO)243.00€Tideglusib
CAS:Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.Formula:C19H14N2O2SPurity:98.40% - 99.35%Color and Shape:SolidMolecular weight:334.39Ref: TM-T3067
10mg47.00€25mg77.00€50mg113.00€100mg187.00€200mg283.00€500mg490.00€1mL*10mM (DMSO)50.00€EGFR/BRAFV600E-IN-2
E07 Aptamer, targeting the human epidermal growth factor receptor (hEGFR), competes with epidermal growth factor (EGF) for binding to a unique epitope on EGFR.Formula:C25H18N4O2Purity:98%Color and Shape:SolidMolecular weight:406.44BGB-8035
CAS:BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.Formula:C24H31N5O4Purity:96.74%Color and Shape:SolidMolecular weight:453.53Larotinib
CAS:Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.Formula:C24H26ClFN4O4Purity:98.45%Color and Shape:SolidMolecular weight:488.94BEBT-109
CAS:BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.Formula:C27H32N8O3Purity:99.01%Color and Shape:SolidMolecular weight:516.6EGFR-IN-61
CAS:EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Formula:C33H37ClN8O3Purity:98%Color and Shape:SolidMolecular weight:629.15Coprelotamab
CAS:Coprelotamab (GB-221) is an IgG-κ monoclonal antibody that targets EGFR2, frequently produced in CHO DG44 (Chinese Hamster Ovary) cells [1].Purity:98%Color and Shape:LiquidZandelisib
CAS:Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.Formula:C31H38F2N8OPurity:99.15%Color and Shape:SolidMolecular weight:576.68Ref: TM-T13386
1mg87.00€5mg180.00€10mg301.00€25mg487.00€50mg658.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)225.00€BKI-1369
CAS:BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51Anti-EGFR Monoclonal Antibody-PE
Anti-EGFR Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-PE can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaEGFR-IN-90
EGFR-IN-90 (compound 34), an orally active EGFR inhibitor, demonstrates potent activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and effectivelyPurity:98%Color and Shape:Odour Solid6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS:6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to studyFormula:C9H6BrN3OPurity:98.81%Color and Shape:SolidMolecular weight:252.07Vislarafusp alfa
Vislarafusp alfa is a humanized IgG1κ antibody that targets EGFR/CD47, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidPIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Formula:C16H14BrN5O4S·HClPurity:97.82%Color and Shape:SolidMolecular weight:488.74Epertinib
CAS:Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formula:C30H27ClFN5O3Purity:98%Color and Shape:SolidMolecular weight:560.02MBM-55
CAS:MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM.Formula:C28H27FN6O2Purity:99.98%Color and Shape:SolidMolecular weight:498.55Ref: TM-T11960
1mg177.00€5mg298.00€10mg432.00€25mg662.00€50mg868.00€100mg1,169.00€500mg2,365.00€1mL*10mM (DMSO)325.00€mTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to centralFormula:C19H24N6O2SPurity:98%Color and Shape:SolidMolecular weight:400.5Aldometanib
CAS:Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.Formula:C27H43Cl2IN2Purity:100% - 98.8%Color and Shape:SolidMolecular weight:593.46Ref: TM-T60122
1mg46.00€5mg90.00€10mg130.00€25mg274.00€50mg405.00€100mg600.00€200mg837.00€500mg1,283.00€1mL*10mM (DMSO)134.00€WZ4002
CAS:WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.Formula:C25H27ClN6O3Purity:98.12%Color and Shape:SolidMolecular weight:494.97Ref: TM-T6238
2mg35.00€5mg52.00€10mg73.00€25mg117.00€50mg187.00€100mg329.00€200mg490.00€1mL*10mM (DMSO)52.00€PAT-505
CAS:PAT-505 is an autologous epidermal growth factor inhibitor.Formula:C23H18ClF2N3O2SPurity:98.84%Color and Shape:SolidMolecular weight:473.92Tesevatinib
CAS:Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.Formula:C24H25Cl2FN4O2Purity:97.89% - 97.89%Color and Shape:SolidMolecular weight:491.39Ref: TM-TQ0166
1mg107.00€2mg156.00€5mg236.00€10mg457.00€25mg750.00€50mg1,026.00€1mL*10mM (DMSO)255.00€BAY-8400
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy inFormula:C21H17F2N5OPurity:99.32%Color and Shape:SolidMolecular weight:393.39Ref: TM-T9498
1mg85.00€5mg156.00€10mg226.00€25mg464.00€50mg792.00€100mg1,064.00€1mL*10mM (DMSO)170.00€A66
CAS:A66 is a specific and effective p110α inhibitor(IC50=32 nM).Formula:C17H23N5O2S2Purity:99.51% - ≥95%Color and Shape:SolidMolecular weight:393.53Ref: TM-T2418
2mg35.00€5mg50.00€10mg84.00€25mg144.00€50mg246.00€100mg364.00€200mg512.00€1mL*10mM (DMSO)56.00€Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Formula:C16H11N3O2Purity:99.55%Color and Shape:Dark Red SolidMolecular weight:277.28Ref: TM-T5200
2mg38.00€5mg55.00€10mg88.00€25mg165.00€50mg246.00€100mg366.00€200mg538.00€1mL*10mM (DMSO)60.00€ZD-4190
CAS:ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.Formula:C19H16BrFN6O2Purity:99.12%Color and Shape:SolidMolecular weight:459.27Ref: TM-T5475
1mg85.00€5mg183.00€10mg275.00€25mg437.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)185.00€EGFR/CDK2-IN-2
EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively.Formula:C49H32N12O2S2Purity:98%Color and Shape:SolidMolecular weight:884.99PS210
CAS:PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.Formula:C19H15F3O5Purity:99.78%Color and Shape:SolidMolecular weight:380.31Ref: TM-T16670
1mg37.00€2mg52.00€5mg74.00€10mg107.00€25mg197.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)85.00€PQR514
CAS:PQR514: more potent pan-PI3K inhibitor than predecessor PQR309, exhibits strong anticancer activity in vitro and in OVCAR-3 model.Formula:C16H20F2N8O2Purity:98.76% - 99.29%Color and Shape:SolidMolecular weight:394.38EGFR-IN-89
CAS:EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormula:C26H31FN8O2SPurity:98%Color and Shape:SolidMolecular weight:538.64GSK-F1
CAS:GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.Formula:C27H18F5N5O4SPurity:95.5%Color and Shape:SolidMolecular weight:603.52Ref: TM-T19840
1mg110.00€5mg226.00€10mg335.00€25mg538.00€50mg730.00€100mg938.00€200mg1,320.00€1mL*10mM (DMSO)320.00€AZD 3147
CAS:AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).Formula:C24H31N5O4S2Purity:98.34%Color and Shape:SolidMolecular weight:517.66Ref: TM-T36200
1mg97.00€5mg210.00€10mg338.00€25mg582.00€50mg777.00€100mg1,074.00€1mL*10mM (DMSO)273.00€4-FPBUA
CAS:4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.Formula:C31H23FO7Color and Shape:SolidMolecular weight:526.51Depatuxizumab MMAF
Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.Color and Shape:LiquidMolecular weight:148.24 kDaZotarolimus
CAS:Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Formula:C52H79N5O12Purity:95% - ≥98%Color and Shape:SolidMolecular weight:966.21Ref: TM-T6033
1mg66.00€2mg96.00€5mg144.00€10mg225.00€25mg393.00€50mg565.00€100mg818.00€1mL*10mM (DMSO)239.00€GSK3β-IN-2
CAS:GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.Formula:C25H18N4OColor and Shape:SolidMolecular weight:390.437ZSTK474
CAS:PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potentialFormula:C19H21F2N7O2Purity:98.29% - 99.76%Color and Shape:White PowderMolecular weight:417.41Lazertinib
CAS:Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Formula:C30H34N8O3Purity:98.7% - 99.53%Color and Shape:SolidMolecular weight:554.64Chitosan oligosaccharide
CAS:Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine.Formula:C12H24N2O9Purity:98%Color and Shape:SolidMolecular weight:340.327Self-assembling peptide pY1
Self-assembling peptide pY1, which aggregates around cancer cells, specifically targets the EGFR receptor. When co-cultured with Ovalbumin (OVA), pY1 effectively inhibits the endocytosis of OVA.Formula:C104H125N24O29PColor and Shape:SolidMolecular weight:2206.22Anti-EGFR Antibody (9S619)
Anti-EGFR Antibody (9S619) is an antibody targeting EGFR. Anti-EGFR Antibody (9S619) can be used in ELISA, IHC, FCM.Color and Shape:Odour LiquidiMDK
CAS:iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Formula:C21H13FN2O2SPurity:99.77%Color and Shape:SolidMolecular weight:376.4GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Formula:C25H27FN6O4Purity:98.63% - 99.40%Color and Shape:SolidMolecular weight:494.52EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Color and Shape:Lyophilized PowderMolecular weight:69.8 kDa (predicted). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.CHIR-99021 HCl
CAS:CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.Formula:C22H19Cl3N8Purity:98.07% - 98.44%Color and Shape:SolidMolecular weight:501.8Ref: TM-T2310L
1mg35.00€2mg52.00€5mg77.00€10mg96.00€25mg163.00€50mg240.00€100mg465.00€200mg675.00€500mg1,026.00€1mL*10mM (DMSO)86.00€YS-363
CAS:YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (Formula:C30H30N4O3Purity:98%Color and Shape:SolidMolecular weight:494.58Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurity:98.31% - 99.32%Color and Shape:SolidMolecular weight:432.4PIK-293
CAS:PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.Formula:C22H19N7OPurity:99.8%Color and Shape:SolidMolecular weight:397.43Ref: TM-T3348
1mg48.00€2mg65.00€5mg96.00€10mg153.00€25mg274.00€50mg416.00€100mg603.00€1mL*10mM (DMSO)105.00€EGFR-IN-88
CAS:EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosisFormula:C22H18Cl2N4O2SPurity:98%Color and Shape:SolidMolecular weight:473.37BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Formula:C21H13BrN2O3Purity:99.77%Color and Shape:SolidMolecular weight:421.24Ref: TM-T14613
1mg34.00€5mg80.00€10mg116.00€25mg221.00€50mg329.00€100mg472.00€200mg652.00€1mL*10mM (DMSO)86.00€MELK-IN-1
CAS:MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).Formula:C31H33N5O4Purity:99.14%Color and Shape:SolidMolecular weight:539.62BMS-599626
CAS:BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.Formula:C27H27FN8O3Purity:98.73%Color and Shape:SolidMolecular weight:530.55JGK-068S
CAS:Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].Formula:C22H23BrFN5O2Purity:98%Color and Shape:SolidMolecular weight:488.35mTOR inhibitor-11
CAS:mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Formula:C21H26N6O2Purity:98%Color and Shape:SolidMolecular weight:394.47RS1-PDK1 inhibitor
CAS:RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.Formula:C15H9ClN2O2S3Purity:98%Color and Shape:SolidMolecular weight:380.89Chalcone
CAS:Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively asFormula:C15H12OPurity:97.27%Color and Shape:SolidMolecular weight:208.26Afatinib Dimaleate
CAS:Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.Formula:C32H33ClFN5O11Purity:100% - 98.11%Color and Shape:SolidMolecular weight:718.08Ref: TM-T1773
1g467.00€5mg40.00€10mg59.00€25mg87.00€50mg107.00€100mg140.00€200mg188.00€500mg313.00€1mL*10mM (DMSO)66.00€CGP52411
CAS:CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).Formula:C20H15N3O2Purity:99.56%Color and Shape:SolidMolecular weight:329.35ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formula:C23H25NO·HClPurity:98.05%Color and Shape:SolidMolecular weight:367.91AMPK activator 2
CAS:AMPK activator 2, a chloroformin derivative, may boost cancer treatment by enhancing AMPK and inhibiting mTOR pathways, and cancer cell growth.Formula:C13H18F3N5Purity:99.86%Color and Shape:SolidMolecular weight:301.31Tesevatinib tosylate
CAS:Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.Formula:C31H33Cl2FN4O5SColor and Shape:SolidMolecular weight:663.59EGFR-IN-5
CAS:EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.Formula:C31H38FN9OPurity:98.17%Color and Shape:SolidMolecular weight:571.69PI4KIII β inhibitor 3
CAS:PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).Formula:C22H22N8OSPurity:98%Color and Shape:SolidMolecular weight:446.53Intetumumab
CAS:Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Color and Shape:LiquidMolecular weight:145.6 (kDa)PQR620
CAS:PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.Formula:C21H25F2N7O2Purity:97.61%Color and Shape:SolidMolecular weight:445.47Ref: TM-T5472
1mg64.00€5mg150.00€10mg210.00€25mg354.00€50mg505.00€100mg677.00€200mg914.00€1mL*10mM (DMSO)145.00€Dorsomorphin dihydrochloride
CAS:Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity onFormula:C24H25N5O·2HClPurity:97.74% - 99.89%Color and Shape:SolidMolecular weight:472.41Ref: TM-T6146
2mg35.00€5mg51.00€10mg70.00€25mg135.00€50mg235.00€100mg424.00€500mg938.00€1mL*10mM (DMSO)57.00€Desmethyl Erlotinib
CAS:Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).Formula:C21H21N3O4Purity:97.92% - 98.62%Color and Shape:SolidMolecular weight:379.41Ref: TM-T6328
1mg52.00€2mg77.00€5mg115.00€10mg188.00€25mg331.00€50mg497.00€100mg720.00€1mL*10mM (DMSO)127.00€IHMT-PI3Kδ-372 S-isomer
CAS:IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Formula:C26H23F2N7O2Purity:99.68%Color and Shape:SoildMolecular weight:503.5Ref: TM-T60196
1mg115.00€2mg172.00€5mg255.00€10mg374.00€25mg562.00€50mg787.00€100mg1,074.00€1mL*10mM (DMSO)310.00€Tyrphostin AG 528
CAS:Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).Formula:C18H14N2O3Purity:99.74%Color and Shape:SolidMolecular weight:306.32AG1557
CAS:AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formula:C16H14IN3O2Purity:98.61% - 99.23%Color and Shape:SolidMolecular weight:407.21Afatinib
CAS:Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Formula:C24H25ClFN5O3Purity:97.56% - 99.9%Color and Shape:Off-White SolidMolecular weight:485.94Ref: TM-T21312
5mg35.00€10mg51.00€25mg86.00€50mg115.00€100mg144.00€200mg177.00€500mg300.00€1mL*10mM (DMSO)52.00€Dactolisib Tosylate
CAS:Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR.Formula:C37H31N5O4SPurity:99.85%Color and Shape:SolidMolecular weight:641.74Laprituximab
CAS:Laprituximab (J2898A) is a humanized anti-EGFR antibody used for synthesizing ADC compound Laprituximab emtansine.Purity:>95%Color and Shape:LiquidVps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Formula:C17H17N7Purity:98.39% - 98.43%Color and Shape:SolidMolecular weight:319.36Ref: TM-T6945
1mg51.00€2mg71.00€5mg116.00€10mg202.00€25mg454.00€50mg663.00€100mg944.00€500mg1,890.00€1mL*10mM (DMSO)116.00€PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Formula:C17H16ClN3O3Purity:97.02%Color and Shape:SolidMolecular weight:345.78Ref: TM-T24626
1mg48.00€5mg97.00€10mg156.00€25mg250.00€50mg363.00€100mg510.00€200mg700.00€1mL*10mM (DMSO)105.00€7BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.Formula:C16H10BrN3O2Purity:99.77%Color and Shape:SolidMolecular weight:356.17Ref: TM-T22012
5mg46.00€10mg64.00€25mg116.00€50mg178.00€100mg284.00€200mg401.00€1mL*10mM (DMSO)52.00€Endoxifen (Z-isomer)
CAS:Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Formula:C25H27NO2Purity:99.81%Color and Shape:SolidMolecular weight:373.49LY117018
CAS:LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.Formula:C27H25NO4SPurity:98%Color and Shape:SolidMolecular weight:459.56Oritinib
CAS:Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (Formula:C31H37N7O2Purity:98.4%Color and Shape:SoildMolecular weight:539.67Ref: TM-T60076
1mg134.00€5mg321.00€10mg469.00€25mg777.00€50mg1,035.00€100mg1,415.00€1mL*10mM (DMSO)374.00€Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formula:C6H16ClN5Purity:97.83%Color and Shape:SolidMolecular weight:193.68ETP-46321
CAS:ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).Formula:C20H27N9O3SPurity:99.80%Color and Shape:SolidMolecular weight:473.55Ref: TM-TQ0229
1mg51.00€5mg111.00€10mg170.00€25mg320.00€50mg449.00€100mg615.00€200mg833.00€1mL*10mM (DMSO)117.00€SAR-260301
CAS:SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).Formula:C19H22N4O3Purity:98.65%Color and Shape:SolidMolecular weight:354.4Ref: TM-T16841
2mg46.00€5mg69.00€10mg93.00€25mg183.00€50mg279.00€100mg393.00€200mg552.00€1mL*10mM (DMSO)74.00€SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Formula:C24H33F2N9O4SPurity:98.88%Color and Shape:SolidMolecular weight:581.64Tyrphostin A1
CAS:Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .Formula:C11H8N2OPurity:99.13%Color and Shape:SolidMolecular weight:184.19CH7233163
CH7233163 is a useful organic compound for research related to life sciences and the catalog number is T35334.Purity:98%Color and Shape:SolidEGFR-IN-12
CAS:EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.Formula:C21H18F3N5OPurity:98.30% - 99.19%Color and Shape:SolidMolecular weight:413.4Ref: TM-T5168
1mg82.00€5mg159.00€10mg259.00€25mg520.00€50mg740.00€100mg1,008.00€500mg2,015.00€1mL*10mM (DMSO)168.00€SDZ281-977
CAS:SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formula:C18H20O5Purity:99.64%Color and Shape:SolidMolecular weight:316.35EMI1
CAS:EMI1 targets mutated EGFR in drug-resistant NSCLC research.Formula:C20H18N2O3Purity:100%Color and Shape:SolidMolecular weight:334.37EGFR-TK-IN-5
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.Formula:C26H20ClFN4OSColor and Shape:SolidMolecular weight:490.98PKI-402
CAS:PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.Formula:C29H34N10O3Purity:100%Color and Shape:SolidMolecular weight:570.65CL-387785
CAS:CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Formula:C18H13BrN4OPurity:96.68% - 98.09%Color and Shape:SolidMolecular weight:381.23GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Formula:C12H12N2O3SPurity:98.34%Color and Shape:SolidMolecular weight:264.3Ref: TM-T9725
2mg39.00€5mg64.00€10mg94.00€25mg170.00€50mg261.00€100mg375.00€200mg525.00€1mL*10mM (DMSO)62.00€AG-1478
CAS:AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.Formula:C16H14ClN3O2Purity:99.03% - 99.71%Color and Shape:SolidMolecular weight:315.75EGFR-IN-147
CAS:EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.Formula:C13H13N5OColor and Shape:SolidMolecular weight:255.275TX1-85-1
CAS:TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Formula:C32H36N8O3Purity:98.12% - 98.12%Color and Shape:SolidMolecular weight:580.68CZC24832
CAS:CZC24832 is a selective inhibitor of PI 3-kinase γ.Formula:C15H17FN6O2SPurity:99.08% - 99.12%Color and Shape:SolidMolecular weight:364.4Ref: TM-T1949
1mg50.00€2mg66.00€5mg97.00€10mg145.00€25mg240.00€50mg356.00€100mg525.00€1mL*10mM (DMSO)110.00€MAPK-IN-2
MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cellFormula:C20H11Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:380.23Rilzabrutinib
CAS:Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).Formula:C36H40FN9O3Purity:97.87% - 99.76%Color and Shape:SolidMolecular weight:665.76Ref: TM-T12542
1mg99.00€5mg235.00€10mg376.00€25mg655.00€50mg944.00€100mg1,320.00€500mg2,642.00€1mL*10mM (DMSO)344.00€mTOR inhibitor 9e
CAS:mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.Formula:C22H23N5O2SPurity:98.80%Color and Shape:SoildMolecular weight:421.52Alflutinib
CAS:Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.Formula:C28H31F3N8O2Purity:99.61%Color and Shape:SolidMolecular weight:568.59Ref: TM-T22254
1mg213.00€5mg435.00€10mg620.00€25mg938.00€50mg1,320.00€100mg1,786.00€1mL*10mM (DMSO)560.00€Nezutatug
CAS:Nezutatug, an anti-HER3 antibody, serves as a research tool in cancer studies [1].Purity:98%Color and Shape:LiquidmTOR inhibitor 9c
CAS:mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.Formula:C21H22FN5O2SPurity:98.73%Color and Shape:SoildMolecular weight:427.5COH-SR4
CAS:COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.Formula:C13H8Cl4N2OPurity:98.96%Color and Shape:SolidMolecular weight:350.03BGB-102
CAS:BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Formula:C22H25BrN4O2Purity:99.02%Color and Shape:SolidMolecular weight:457.36DBPR112
CAS:DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formula:C32H31N5O3Purity:98.29%Color and Shape:SolidMolecular weight:533.62Kinetin triphosphate tetrasodium
Kinetin triphosphate tetrasodium is salt form of Kinetin triphosphate KTP, an ATP analog that enhances activity of Parkinson's disease-associated mutant PINK1.Formula:C15H16N5Na4O14P3Purity:96.80%Color and Shape:SoildMolecular weight:675.19YKL-06-061
CAS:YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.Formula:C30H37N7O2Purity:99.52% - 99.79%Color and Shape:SolidMolecular weight:527.66SU5214
CAS:SU5214 is a modulator of tyrosine kinase signal transduction.Formula:C16H13NO2Purity:99.45% - 99.55%Color and Shape:SolidMolecular weight:251.28AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
AMPK activator 2 hydrochloride upregulates the AMPK signaling pathway and inhibits the proliferation and migration of human cancer cells.Formula:C13H19ClF3N5Purity:99.68%Color and Shape:SoildMolecular weight:337.77PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .Formula:C18H17N5O3Purity:98.25% - ≥95%Color and Shape:SolidMolecular weight:351.36EGFR/ErbB-2 inhibitor-1
CAS:EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.Formula:C23H15ClFN3OS2Purity:97.55%Color and Shape:SolidMolecular weight:467.97MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Formula:C26H30N6O3Purity:99.76%Color and Shape:SolidMolecular weight:474.55Anti-EGFR Monoclonal Antibody-AF488
Anti-EGFR Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF488 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaOSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Formula:C21H22N6O3Purity:97.42%Color and Shape:SolidMolecular weight:406.44Ref: TM-T6319
1mg42.00€2mg52.00€5mg86.00€10mg138.00€25mg248.00€50mg389.00€100mg567.00€1mL*10mM (DMSO)88.00€mTOR inhibitor 13
CAS:Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).Formula:C24H22N6O2SPurity:99.24%Color and Shape:SolidMolecular weight:458.54JH-XI-10-02
CAS:JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.Formula:C53H69N5O9Purity:98%Color and Shape:SolidMolecular weight:920.161Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14Calotatug
Calotatug is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFormula:C32H26N4O6Purity:98.74%Color and Shape:SolidMolecular weight:562.57THZ-P1-2
CAS:THZ-P1-2 is a PI5P4K inhibitor with anti-leukemic activity and can be used in the study of leukemia.Formula:C31H29N7O2Color and Shape:SolidMolecular weight:531.61Ref: TM-T39459
1mg78.00€5mg169.00€10mg264.00€25mg449.00€50mg660.00€100mg938.00€200mg1,311.00€1mL*10mM (DMSO)187.00€EGFR-IN-16
CAS:EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.Formula:C16H11NO3Purity:98%Color and Shape:SolidMolecular weight:265.26EX229
CAS:EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Formula:C24H18ClN3O3Purity:99.20% - 99.36%Color and Shape:SolidMolecular weight:431.87Ref: TM-TQ0028
1mg37.00€2mg52.00€5mg74.00€10mg111.00€25mg221.00€50mg376.00€100mg565.00€1mL*10mM (DMSO)85.00€GSK3β inhibitor II
CAS:GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).Formula:C14H10IN3OSPurity:99.32%Color and Shape:SolidMolecular weight:395.22PI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Formula:C50H46F4N8O8S2Purity:98%Color and Shape:SolidMolecular weight:1027.07CZC-8004
CAS:CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.Formula:C17H16FN5Purity:99.29%Color and Shape:SolidMolecular weight:309.34MOTS-c(Human) Acetate(1627580-64-6 free)
MOTS-c(Human) Acetate is a mitochondrial-derived peptide.Formula:C103H156N28O24S2Purity:100%Color and Shape:SolidMolecular weight:2234.64PI3K/mTOR Inhibitor-12
CAS:PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.Formula:C27H27F2N9O4SPurity:98%Color and Shape:SolidMolecular weight:611.62GW 583340
CAS:GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Formula:C28H25ClFN5O3S2Purity:98.68%Color and Shape:SoildMolecular weight:598.11Ref: TM-T22827L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€Biochanin A
CAS:Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.Formula:C16H12O5Purity:97.1% - 98.97%Color and Shape:SolidMolecular weight:284.26
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