PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Products of "PI3K"
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UCL-TRO-1938
CAS:UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects.Formula:C27H32N6OPurity:99.95%Color and Shape:SolidMolecular weight:456.58Ref: TM-T78092
5mg120.00€10mg187.00€25mg393.00€50mg628.00€100mg1,008.00€200mg1,349.00€1mL*10mM (DMSO)120.00€CNX-1351
CAS:CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.Formula:C30H35N7O3SPurity:98.83% - 99.69%Color and Shape:SolidMolecular weight:573.71PI3Kδ-IN-1
CAS:PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).Formula:C22H20F3N7O2Purity:99.3%Color and Shape:SolidMolecular weight:471.44BGT226 maleate
CAS:BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .Formula:C28H25F3N6O2·C4H4O4Purity:97.75% - 98.78%Color and Shape:SolidMolecular weight:650.6Ref: TM-T6072
1mg38.00€5mg77.00€10mg114.00€25mg244.00€50mg359.00€100mg512.00€200mg702.00€1mL*10mM (DMSO)99.00€NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Formula:C18H20N8O2Purity:97.79%Color and Shape:SolidMolecular weight:380.4LY-294002 hydrochloride
CAS:LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.Formula:C19H17NO3·HClPurity:99.95%Color and Shape:SolidMolecular weight:343.81GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurity:98.42% - 99.42%Color and Shape:SolidMolecular weight:414.48Ref: TM-T6845
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg210.00€50mg349.00€100mg434.00€200mg635.00€1mL*10mM (DMSO)92.00€Sincalide
CAS:Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.Formula:C49H62N10O16S3Purity:98.32%Color and Shape:SolidMolecular weight:1143.27Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)Formula:C20H22ClFN6O2Purity:98.59%Color and Shape:SolidMolecular weight:432.88Ref: TM-T12367
1mg145.00€5mg305.00€10mg495.00€25mg805.00€50mg1,111.00€100mg1,501.00€1mL*10mM (DMSO)335.00€GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Formula:C21H24ClN5O3S2Purity:97.8%Color and Shape:SolidMolecular weight:494.03Ref: TM-T10804
1mg92.00€5mg216.00€10mg329.00€25mg593.00€50mg893.00€100mg1,216.00€1mL*10mM (DMSO)235.00€PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Formula:C18H13FN6OSPurity:99.85%Color and Shape:SolidMolecular weight:380.4Ref: TM-T6938
2mg39.00€5mg65.00€10mg101.00€25mg187.00€50mg329.00€100mg398.00€200mg565.00€1mL*10mM (DMSO)67.00€Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurity:98.01% - 99.36%Color and Shape:SolidMolecular weight:270.29Ref: TM-T7014
1mg38.00€2mg49.00€5mg79.00€10mg124.00€25mg240.00€50mg384.00€100mg560.00€1mL*10mM (DMSO)79.00€Oroxin B
CAS:Oroxin B (Hypocretin-2) has antioxidant activity.Formula:C27H30O15Purity:98.22% - 98.33%Color and Shape:SolidMolecular weight:594.52Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Formula:C23H27N7O3S2Purity:99% - 99.97%Color and Shape:SolidMolecular weight:513.64Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purity:99.37% - 99.66%Color and Shape:SolidMolecular weight:696.82Ref: TM-T5S1982
1mg35.00€5mg77.00€10mg106.00€25mg170.00€50mg253.00€100mg375.00€500mg892.00€1mL*10mM (DMSO)107.00€IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formula:C25H25N7O2Purity:99.08%Color and Shape:SolidMolecular weight:455.51Ref: TM-T15592
1mg47.00€2mg64.00€5mg104.00€10mg170.00€25mg340.00€50mg472.00€100mg645.00€1mL*10mM (DMSO)113.00€PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formula:C20H15Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:444.27PI3K-IN-38
CAS:PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.Formula:C20H24N6O2Purity:99.74%Color and Shape:SolidMolecular weight:380.44MOMIPP
CAS:MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.Formula:C18H16N2O2Purity:99.66%Color and Shape:SolidMolecular weight:292.33Ref: TM-T33467
1mg114.00€5mg160.00€10mg250.00€25mg455.00€50mg628.00€100mg944.00€1mL*10mM (DMSO)245.00€
