Oligosaccharides

Man-9 N-glycan is a glycoprotein that is found on the surface of many viruses. It has an oligosaccharide structure, which consists of a mannose and a glucose molecule linked by an alpha-1,3-glycosidic bond. The Man-9 N-glycan can be found in human serum and is involved in lectin binding to cells. It also has antiviral activity and may be used as a model system for studying glycosidic bonds. This glycan can be broken down into smaller components by methyl glycosides or titration calorimetry, which is a technique for determining the molecular weight of substances. The Man-9 N-Glycan binds to toll-like receptor 2 (TLR2) on the surface of human cells, which activates an antibody response.

Neu5Ac(a2-6)Gal(b1-4)GalNAc is a synthetic, fluorinated monosaccharide. It is an oligosaccharide that has been custom synthesized and glycosylated. It is a complex carbohydrate that has been modified with methylation and click chemistry. Neu5Ac(a2-6)Gal(b1-4)GalNAc has CAS number 383365-43-3. This product is available in high purity and can be used in the synthesis of polysaccharides.

Ex starch-partial hydrolysis,food ingredient, moderatly sweet, easily digested

Man-7D2 N-glycan is a custom synthesis of mannose. It is a modification of the glycan, which is an oligosaccharide that consists of many monosaccharides linked together. The process of glycosylation involves the addition of one or more sugars to an existing carbohydrate molecule. In this case, the sugar is mannose and it has been modified by fluorination, methylation, and click chemistry. This product can be used as a substitute for natural glycans in research applications. The CAS number for this product is 59569-81-1.

The carbohydrate is a saccharide that is a modification of the monosaccharide. It is synthesized from D-mannose and D-glucose and has a fluorination at the C4 position. The carbohydrate has been custom synthesized for high purity, methylation, glycosylation, and click modification.

2-O-a-D-Glucopyranosyl-D-galactopyranose is a synthetic monosaccharide that can be used as a glycosylate building block in the synthesis of oligosaccharides. It has been fluorinated, methylated, and click modified. This high purity material is available for custom synthesis. 2-O-a-D-Glucopyranosyl-D-galactopyranose is also known by its CAS number 7368-73-2.

1,6-Anhydrochitobiose is an anhydosugar that can be used in the synthesis of oligosaccharides and polysaccharides

Produced from high maltose syrup by treatment with transglucosidase

D-Maltose monohydrate is a glycosylation product of maltose. It is a complex carbohydrate that has been methylated, fluorinated, and modified with Click chemistry. D-Maltose monohydrate has the CAS number of 3647-20-3 and can be custom synthesized to meet your specifications. This product is free from endotoxins and can be made in high purity.

8-Methoxycarbonyloctyl-3-O-benzyl-2,2'-dideoxy-2,2'-diphthalimido-3',4',6-tri-O-acetyl-b -cellobiose is a cellobiose with an 8 methoxycarbonyl group at the C8 position. It can be used in the synthesis of oligosaccharides and polysaccharides. The compound has been synthesized by methylation, click modification, and fluorination. The CAS number is 106445-30-1. 8MCOBBIOSE has a purity of > 98% and may have a white to off white powder appearance.

GD1b (shown as sodium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with it’s two sialic acids linked α2,3/α2,8 to the inner galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD1b acts as a receptor for BK virus as well as for heat-labile LTII-a toxin, produced by enteropathogenic E. coli. GD1b ganglioside also interacts with tetanus neurotoxin (TeNT) and is crucial for its entry into cells (Kolter, 2012).

Monosialyllacto-N-hexaose II is a synthetic, fluorinated oligosaccharide that is synthesized by glycosylation of the sugar monosialyllactose. Monosialyllacto-N-hexaose II has a molecular weight of 514.5 Da and is soluble in water. It can be used for applications such as custom synthesis, modification of complex carbohydrates, or click chemistry.

Chitosan is the deacetylated form of chitin. The polysaccharide is deacetylated in order to render it soluble, which is then possible at pH values of less than 7 (normally in dilute acid). This then allows the material to be used in a number of industrial applications as a binder and film former.

3-O-(a-L-fucopyranosyl)-D-galactopyranose is a glycosidic residue that is part of the β-D-Galactoside. It is an amino acid that is used to form carbohydrates. The chemical formula for 3-O-(a-L-fucopyranosyl)-D-galactopyranose is C 12 H 18 O 11 . The molecular weight of 3-O-(a-L-fucopyranosyl)-D-galactopyranose is 308.

The acetylation of the 2-O-acetamido-1,6-di-O-acetyl-2-deoxy-4-O-(2-acetamido-3,4,6-tri-O-acetyl)-2,3,4,5,6 tetra-, O-(2 acetamido 3,4,6 tri O acetyl) glucopyranoside in the presence of methyl iodide and potassium carbonate yields 2 O -Acetamido 1 6 di O acetyl 2 deoxy 4 0-(2 acetylamino 3 4 6 tri 0 acetyl) glucopyranoside methyl ester. The product is a modification of an oligosaccharide or complex carbohydrate.

Monofucosyl (1-2)-iso-lacto-N-octaose I is an oligosaccharide found in human milk

Asialylated glycosphingolipid and precursor for ganglioside biosynthesis. The compound is a major glycosphingolipid in human neutrophils and is involved in the regulation of superoxides as well as nitric oxide. Moreover, lactosylceramide accumulates in atherosclerotic plaques and is also found elevated in familial hypercholesterolemia and polycystic kidney disease. Animal studies revealed that lactosylceramide induces hypertrophy in cardiomyocytes via signal transduction pathway that is oxygen-sensitive.

4-O-(2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl)-1,2,3,6-tetra-O-acetyl-b-D-thioglucopyranose is a glycosylated saccharide that belongs to the group of complex carbohydrates. The glycosylation of 4-O-(2,3,4,6,-Tetra-O-acetyl b -D -glucopyranosyl)-1,2,3,6,-tetra -O -acetyl b -D -thioglucopyranose is achieved by the enzymatic reaction of an acetate donor and an acceptor molecule in the presence of glucose 1 phosphate (G1P) and UDP sugar pyrophosphorylase. It has been modified by methylation with dimethyl sulphate in the presence of

The blood group B type III/IV tetrasaccharide is a synthetic, fluorinated carbohydrate that has been custom synthesized for glycosylation and methylation. The monosaccharide of the tetrasaccharide is a hexose, which can be modified with fluorine and click chemistry. The product is a complex carbohydrate with high purity and can be used in pharmaceuticals as an antigen for immunoglobulin G (IgG) production.

Monofucosyl (1-2)-iso-lacto-N-octaose II is an oligosaccharide that is found in human milk

Applications A histochemical substrate for a-N-acetyl-galactosaminidase. References Zhu, et al.: Gene, 137, 309 (1994)

Isomaltotriose is used as pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Man-7 Glycan is a synthetic, 2-AB labelled fluorinated monosaccharide. It is an oligosaccharide that is synthesized by the glycosylation of mannose and N-acetylglucosamine. This product has been modified with fluorination, methylation, and click chemistry.

1,5-α-L-Arabinopentaose is a sugar that is found in plants. It inhibits the growth of bacteria by sequencing and binding to the enzyme L-arabinose isomerase, which converts L-arabinose to D-xylulose. 1,5-α-L-Arabinopentaose has been shown to have inhibitory effects on the metabolism of sugars in plants. This sugar binds tightly to immobilized enzymes and can be used for immobilization processes.

Please enquire for more information about Lewis A tetrasaccharide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Stability Hygroscopic Applications α-Glycosidase inhibitor. References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),

3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside is a solubilized form of epidermal growth factor (EGF) that binds to the epidermal growth factor receptor. It has been shown to stimulate epidermal growth and increase the rate of cellular proliferation in human epidermis. 3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside may also have structural roles in mitochondrial matrix, ligand binding, and energy metabolism. Further study is needed to determine the role of this drug in these processes.

Applications D-(+)-Trehalose is a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. D-(+)-Trehalose is also used as a protein stabilize. This is the labeled analog. References Bosquillon, C. et al.: J. Cont. Rel., 99, 357 (2004); Arakawa, T. et al.: Adv. Drug Deliv. Rev., 46, 307 (2001); Singh, S.K. et al.: Pharmac. Res., 28, 873 (2011);

1,5-α-L-Arabinohexaose is a carbohydrate. It is a nonreducing sugar that can be found in plants. 1,5-α-L-Arabinohexaose has an optimum pH of 5 and an ethanol concentration of 0.02%. The enzyme form of 1,5-α-L-Arabinohexaose is α-(1→6)-glycosidase. This enzyme hydrolyzes the α-(1→6) glycosidic bond between two glucose residues in a polysaccharide chain to produce β-(1→4) bonds. It also hydrolyzes the β-(1→4) glycosidic bond between two galactose residues to produce β-(1→2) bonds and oxidizes the terminal carbon atom to produce aldehyde products. A structural analysis of this carbohydrate was conducted using marine microorganisms and it was found that they contain galacturonic acid and sugar residues

GalNAca1-3Galb1-3GalNAc

Benzyl 2-acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-a-D-glucopyranoside is a custom synthesis, complex carbohydrate. It is an Oligosaccharide, Polysaccharide that has been modified and glycosylated. It has a CAS number of 81243-70-1. This product's purity is high and it is fluorinated. The product is synthetic and contains sugar.

Applications N-Acetyllactosamine derivatives were tested as acceptors for α1,3-L-Fucosyltransferase present in human ovarian cancer sera and ovarian tumor. References Lasky, L., et al.: Science, 258, 964 (1992), Hemmerich, S., et al.: Biochemistry, 33, 4830 (1994), Clarke, J., et al.: J. Biol. Chem., 271, 10317 (1996), Komba, S., et al.: Bioorg. Med. Chem., 4, 1833 (1996), Yoshino, K., et al.: J. Med. Chem., 40, 455 (1997),

Used as enzyme substrates, analytical standards and for in vitro diagnostics

Di-N-acetyl-D-lactosamine (DNL) is a sugar that is found in the mammalian tissues and can be used as a lectin to specifically bind to glycoproteins. It has been shown to have specificities for enteritis, and can be used to detect or analyze the sequences of oligosaccharides. DNL has been immobilized on silica gel, which was then reacted with lectins, such as concanavalin A, wheat germ agglutinin, and soybean agglutinin. This process allows for the detection of high-mannose-type oligosaccharides.

ABO trisaccharide conjugated to BSA via Biotin & an aminophenyl ethyl spacer

4-Methoxyphenyl 2,3,6-tri-O-acetyl-4-O-(2,4,6-tri-O-acetyl-3-O-allyl bDgalactopyranosyl)-bDglucopyranoside is a modification of an oligosaccharide. It is a high purity and custom synthesis. This product can be found under CAS No. 807827-28-0.

Applications Gentamicin B1 Acetate Salt is the salt form of Gentamicin B1 (G360575), which is a derivative of Gentamicin (G360605), an aminoglycoside antibiotic. References Jarai, M., et al.: Hung. Teljes, HU 34989 A2 19850528 (1985); Cooper, D., et al.: U.S., US 3915955 A 19751028. (1975)

Cellulose derivative, food thickener and emulsifier, bulk forming laxative

b-Lactopyranosyl phenylisothiocyanate is a synthetic carbohydrate that has been modified with fluorine, methylation, glycosylation, and click chemistry. It is used in the synthesis of saccharides and oligosaccharides. This compound can also be used to modify saccharides or oligosaccharides with fluorine, methylation, glycosylations, or click chemistry.

Zymosan is prepared from the cell walls of baker’s yeast (Saccharomyces cerevisiae) and consists of polysaccharide chains of various molecular weights, containing approximately 73% polysaccharide, 15% protein, 7% lipid and other inorganic components. When injected into animals, it induces inflammation and has been used for many years in inflammation and immunology research. The literature on Zymosan reveals few rigorous analytical studies on the detailed structure of this macromolecule due to the wide variation in extraction procedures reported. A hypothetical structure of the carbohydrate part of the molecule is shown below constructed from the available literature. This shows a β1,3 glucan chain with β1,6 branch points. The image was kindly provided by Dr. Chris Lawson.

1,6-Anhydro-N,N’-diacetylchitobiose is an anhydrosugar that can be used in the synthesis of oligosaccharides

4-O-(2-O-Methyl-b-D-galactopyranosyl)-D-glucopyranose is a disaccharide. The lacto-n-biose unit is a nonreducing sugar that contains an alpha, beta unsaturated 1,6 glycosidic bond and a lactose molecule. 4-O-(2-O-Methyl-b-D-galactopyranosyl)-D-glucopyranose has been found to stimulate the synthesis of galectin in vitro, which may be due to its ability to bind to lectins. This disaccharide can also cause denaturation at high temperatures.

Please enquire for more information about Disialyllacto-N-tetraose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Benzyl 2-acetamido-2-deoxy-4,6-O-benzylidene-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-a-D galactopyranoside is a complex carbohydrate with a CAS number of 8632784. It is an oligosaccharide that is modified with methylation and glycosylation. This molecule has a molecular weight of 907.19 and the purity level is high at 99%. This product can be used for fluoroquinolone resistance research or as an intermediate for other chemical modifications.

Mainly a mixture of Lacto-N-tetraose, Lacto-N-neo-tetraose, Lactodifucotetraose

a-D-Lactose 1-phosphate barium salt is a modification of a D-lactose monosaccharide. It is a complex carbohydrate that has been synthesized using the polyol method. The CAS number for this product is 103404-65-5. This product is available in high purity and the molecular weight of this compound is 576. a-D-Lactose 1-phosphate barium salt can be used as an ingredient in pharmaceuticals, food products, and cosmetics. It has been shown to have anticariogenic activities and may be used as a substitute for sucrose in food products.

CO2-philic compound; used in pharmaceuticals and CO2-based processes

D-Melibiose monohydrate is a type of sugar that can be found in the extracellular space. It is also a component of fatty acids and has been shown to act as a growth factor for some cell types. D-Melibiose monohydrate has been characterized using tissue culture, growth factor profiles, and fluorescence detector. This sugar can be used as an alternative to trehalose in vitro assays, where it has been shown to have similar biological properties. D-Melibiose monohydrate may also be used for the manufacture of solid dispersions due to its solubility in organic solvents.

Bulk sweetener; viscosity/bodying agent; humectant; cryoprotectant

Methyl 2-acetamido-4-O-(2-acetamido-2,3-dideoxy-b-D-glucopyranosyl)-2,6O-(a,L-fucopyranosyl)-b-D-glucopyranoside is a synthetic carbohydrate. It is a high purity and custom synthesis product with CAS No. 97242-84-7. This product has been fluorinated and methylated as well as glycosylated and click modified to increase its stability.

Methyl 3-O-benzyl-6-O-(2,3,4-tri-O-benzyl-a-L-fucopyranosyl)-2,3,4,6-tetra-O-(2,3,4,6,-tetra-O-(2′,3′,4′,-triacetyl)benzoyl) -2′ deoxy -2′ phthalimido -bD glucopyranoside is a synthetic carbohydrate. It is a modification of the natural product Dioscorea polysaccharides that has been modified by an acetylation reaction with 2,3,4 triacetylbenzoic acid and then further modified by a benzoylation reaction with methyl 3 tosylate. Methyl 3 O benzyl 6 O (2 3 4 tri O benzyl a L fucopyranosyl) 2 deoxy 2 phthalimido b

GD1a (shown as sodium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acids linked α2,3/α2,8 to the inner galactose residue, α2,3 to the outer galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. It plays a role in viral infection as it is a receptor for viral glycoproteins in rotavirus and paramyxovirus 1. The hexasaccharide GD1a moiety was also found on a glycoprotein that acts as a receptor for adenovirus type 37. GD1a ganglioside also interacts with botulinum neurotoxin and is crucial for its entry into cells (Kolter, 2012).

Heparin derived dp18 saccharide ammonium salt is a complex carbohydrate that has been modified with methylation, custom synthesis, click modification, and fluorination. It is used as an anticoagulant to prevent the formation of blood clots. Modification of the sugar chain on the heparin molecule can be achieved through either monosaccharide or polysaccharide substitution. The monosaccharides most commonly found in heparin are glucosamine and N-acetylglucosamine. The polysaccharides that can be found in heparin include chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparan sulfate. Heparin derived dp18 saccharide ammonium salt is a high purity product that has been modified to have a higher degree of efficacy for use in clinical applications. This product is available for purchase at a cost-effective price point.

4-Methoxyphenyl 4-O-(3,6-di-O-benzyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-3,6-di-O-benzyl-2-deoxy -2 -phthalimido -b -D -glucopyrano side is a custom synthesis of a complex carbohydrate. It has a CAS number of 140615-82-3 and can be found in glycosylations, carbohydrates, methylation, sugar, fluorination. It is high purity with a lot of modifications.

Applications 2’-Deoxycytidine-5-carboxylic Acid Sodium Salt, is derivative of 5-Hydroxy-2’-deoxycytidine (H946650), which have been used as a substrate for uracil DNA N-glycosylase and has been used to study the oxidation of DNA due to exposure to reactive oxygen species. References Ganguly, M., et al.: Biochem., 51, 2018 (2012); Foresta, M., et al.: Free. Rad. Biol. Med., 48, 681 (2010); Daviet, S., et al.: DNA Repair., 6, 8 (2007);

2-Acetamido-4-O-(2-acetamido-2-deoxy-a-D-glucopyranosyl)-2-deoxy-D-galactopyranose is a Custom synthesis of an oligosaccharide that is synthesized by the modification of natural sugars. This product has been fluorinated, methylated and modified with click chemistry. It is saccharide consisting of two monosaccharides, which are 2 acetamido 4 O-(2 acetamido 2 deoxy a D glucopyranosyl)-2 deoxy D galactopyranose and 2 deoxy D galactose. The molecular weight of this compound is 528.5 g/mol.

The compound is a custom synthesis of a complex carbohydrate. It is an oligosaccharide with CAS No. and polysaccharide that has been modified by methylation, glycosylation, and click modification. The compound is Methylated, Glycosylated, Click-modified Carbohydrate Sugar with high purity and fluorination.

Galα(1-3) N-glycan is a glycoconjugate that is an oligosaccharide with a galactose residue at the nonreducing end of the glycan. It has been synthesized using Click chemistry to introduce fluorination and methylation. Galα(1-3) N-glycan is an important model for studying the biological function of glycosylations in humans. It has also been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. This product is custom synthesis, high purity, and CAS No. 115973-45-0.

3'-Sialyl Lewis X 1-N-methyl-N-hydroxyethylamine is a custom synthesis of a monosaccharide that contains an N-hydroxymethyl group. The fluorination and methylation reactions are examples of modifications that can be done to this molecule. This monosaccharide can be modified by the click chemistry reaction, which involves the use of azide and alkyne reagents. 3'-Sialyl Lewis X 1-N-methyl-N-hydroxyethylamine is used in glycosylation with complex carbohydrates such as polysaccharides and saccharides, which are large sugars or sugar chains.

NA2F N-Glycan is a custom synthesized, high purity and monosaccharide glycoprotein. NA2F N-Glycan has been fluorinated and methylated to produce NA2F N-Glycan. The product is a complex carbohydrate that is comprised of an oligosaccharide and polysaccharide. NA2F N-Glycan is synthesized from the sugar saccharide, which is a hexose made up of six carbon atoms that are bonded to each other in a ring.

Please enquire for more information about L-Hexaguluronic acid hexasodium including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications p-Nitrophenyl 2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-β-_x000D_D-glucopyranoside (cas# 57467-13-7) is a compound useful in organic synthesis.

Methyl 2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-2-deoxy-4,6-O-(4-methoxybenzylidene)-a-D-galactopyranoside is a custom synthesis of an oligosaccharide with a polysaccharide. It is a fluorinated complex carbohydrate that has been modified for high purity. Methyl 2 acetamido 3 O (2,3,4,6 tetra O acetyl b D galactopyranosyl) 2 deoxy 4,6 O (4 methoxybenzylidene) a D galactopyranoside is composed of monosaccharides and sugar.

Pentagalacturonic acid (α-1,4 galacturonopentaose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate and characterize endo- and exopolygalacturonase(s) and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, tetra-galacturonate, and penta-galacturonate oligosaccharides, restores development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).

N-Acetylneuraminic acid hexamer disodium salt is a custom synthesis of a fluorinated, methylated and acetylated N-acetylneuraminic acid. This molecule is an oligosaccharide with three sugar rings. It has been modified by click chemistry and glycosylation to create a complex carbohydrate. The CAS number for this compound is 156587-48-2.

3-O-(a-L-Fucopyranosyl)-4-O-(3-sialyl-b-D-galactopyranosyl)-D-glucose is a modification of the complex carbohydrate, oligosaccharide, monosaccharide, and polysaccharide. It is synthesized by methylation of glucose and glycosylation with sialic acid. The product has a CAS number and a high purity level. This product is an example of a synthetic oligosaccharide that has been fluorinated. The product can be used as an additive or preservative in food products.