Oligosaccharides

4-O-Methyl-alpha-D-glucurono-beta-D-xylan is produced by the hydrolysis of xylan.  It can be used in studies to find new soluble chromogenic substrates for the assay of xylanases and glucanases.

3,2'-Di-O-acetyl-3',4'-O-carbonyl-6,6'-di-O-tert-butyldimethylsilyl-lactal is a fluorinated oligosaccharide that is custom synthesized for glycosylation and polysaccharide modifications. This product has been shown to be resistant to degradation by enzymes, including aminoglycosides, beta-lactam antibiotics, and penicillin. 3,2'-Di-O-acetyl-3',4'-O-carbonyl-6,6'-di-O-tert-butyldimethylsilyl--lactal is a high purity product with CAS number 207787 - 39 - 0.

N-Glycolylneuraminic acid-OVA is a custom synthesis that is an Oligosaccharide. It is Polysaccharide and Modification, saccharide, Methylation, Glycosylation, Click modification, Carbohydrate, sugar. The product has a CAS No., has a purity of ≥ 95%, and is Fluorination, Synthetic.

Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus. References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);

Glycyl-monosialyl,monofucosyllacto-N-neohexose I is a synthetic, fluorinated monosaccharide that has been modified with a glycosylation. This oligosaccharide is an important building block in the synthesis of complex carbohydrates. Glycyl-monosialyl,monofucosyllacto-N-neohexose I is used in the synthesis of polysaccharides and glycoproteins. It is also commonly used as a starting material for modifying other sugars with methylation or click chemistry. The CAS number for this compound is 144977-01-1. The molecular weight of this compound is 254.5 g/mol and it has a purity of 99% (HPLC).

Kestoheptaose is a long-chain inulin with a molecular weight of 1,000 Da. It is found in the plant family Asteraceae and is the only natural polysaccharide with seven glucose units. Kestoheptaose has been shown to be involved in the regulation of muscle glycogen levels and can be used as a supplement for athletes or those who are active. The biochemical functions of Kestoheptaose have been validated using an oral ethanol extract, which was shown to increase muscle glycogen levels by up to 132%. This extract also decreased malondialdehyde concentrations by up to 41% and increased urea nitrogen levels by up to 89%.

4-Methoxyphenyl 2,4-di-O-benzoyl-3-O-benzyl-6-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl)-3,5-dideoxy--D glycero--alpha--D galacto--2 nonulopyranosylonate) -beta D galactopyranoside is a carbohydrate that is custom synthesized for the modification of saccharides. It has a molecular weight of 1066.81 g/mol and is soluble in water. 4MPB is used as an intermediate for the synthesis of other carbohydrates.

3-O-(a-D-Mannopyranosyl)-D-mannopyranose 1-O-propylamine acetate salt is a methylated saccharide. It is an oligosaccharide that can be synthesized from D-mannose and pyruvic acid, with the addition of a proton donor. This product is used in the synthesis of polysaccharides due to its high purity and low cost. The methyl group on this molecule reacts with the carbonyl group on the sugar to form an ester, which makes it resistant to hydrolysis by enzymes. 3-O-(a-D-Mannopyranosyl)-D-mannopyranose 1-O-propylamine acetate salt is also fluorinated and can be used as a click modification in proteins or carbohydrates.

Use to solubilize non-polar compounds such as fatty acids, lipids and cholesterol. Reported useful for the selective precipitation of enantiomeric, positional or structural isomersβ-Cyclodextrin is used with dansyl chloride to form water-soluble complexes for fluorescent labeling of proteins. It is an active ingredient of household odor eliminator. It is also used in personal care products like toothpastes, skin creams and dusting powders. It finds applications in the cosmetic industry for products like detergents and perfumes for the controlled release of fragrances. Further, it is used to produce HPLC columns allowing chiral enantiomers separation. In addition to this, it is used to decrease the level of cholesterol in milk fat. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3'-a-Sialyl-N-acetyllactosamine-PAA-biotin is a biotin labelled sialylglycoside

Tetraose composed of four N-acetylglucosamine residues.

This high purity, custom synthesis, sugar and Click modification, fluorination, Glycosylation, Synthetic, Methylation, Modification is a CAS No. 4-O-b-(2,3,4,6-Tetra-O-acetyl-D-galactopyranosyl)-1,6-anhydro-D-mannopyranoside. This is an Oligosaccharide and Monosaccharide that is a Carbohydrate. This complex carbohydrate has been synthesized from the following monosaccharides: D-mannose (CAS No. 5914) and D-galactose (CAS No. 5632). The molecular weight of this carbohydrate is 591. The chemical formula of this carbohydrate is C36H60O24.

Stability Hygroscopic Applications 6-Deoxy-D-talose is an derivative of D-Talose (T005560), a monosaccharide sugar that can convert between aldose and ketose forms in pyridine in the presence of aluminum oxide. References Davies, S.G., et al.: Org. Biomolec. Chem., 3, 348 (2005);

Stability Hygroscopic Applications p-Nitrophenyl 2-Acetamido-2-deoxy-4-O-(β-D-galactopyranosyl)-α-_x000D_D-glucopyranoside (cas# 184377-56-8) is a compound useful in organic synthesis.

α 1,4-glucoheptasaccharide derived from starch by hydrolysis and chromatography

GT1b oligosaccharide (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, and sialic acid (NeuAc) linked α2,3 to the terminal galactose residue (Ledeen, 2009). The GT1b ganglioside is one of the major gangliosides in neuronal and glial membranes; it interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishiki, 1996), as well as for viruses. A few examples of which include: Merkel cell polyomavirus, JC virus, BK virus, norovirus and others (Low, 2006).

2-Amino-2-deoxy-3-O-(b-D-glucopyranuronosyl)-D-galactopyranose monohydrate is a glycoside that is found in the testes. It has inhibitory properties on oligosaccharides and can be used to study the structure of glycoconjugates. 2-Amino-2-deoxy-3-O-(b-D-glucopyranuronosyl)-D-galactopyranose monohydrate has been shown to inhibit the enzyme hydrolase, which is involved in glycoprotein synthesis. 2ADOGP has also been shown to bind to human serum albumin, an abundant protein in human blood plasma that transports lipids, hormones, and other molecules throughout the body. This binding results in a decrease in the serum concentration of 2ADOGP after administration.

Stability Hygroscopic Applications A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004), Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006), Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007),

Stability Stable at RT Applications D-(+)-Cellohexose Eicosaacetate (cas# 355012-91-8) is a compound useful in organic synthesis.

GD3 (shown as sodium salt) has a core disaccharide structure (Galβ1,4Glc) with two sialic acids linked α2,3/α2,8 to the non-reducing galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD3 is a minor ganglioside in most normal tissues but plays a crucial role in the development of the brain; it is significantly reduced in adults. However, expression of GD3 is increased in pathological conditions, such as, cancers and neurodegenerative disorders (Malisan, 2002). GD3 was the first cancer-associated ganglioside discovered that promotes adhesion and invasion of cancers. GD3 and GD2 are highly expressed in a various malignant tumours and have become potential targets for next-generation cancer therapy (Liu, 2018).

2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-cellobiosyl fluoride is a glycosylation product of cellobiose. It has been synthesized by the Click reaction between 2,3,6,2',3',4',6'-hepta-O-acetyl-a-D-cellobiosylamine and ethylene oxide. The synthesis of this compound was achieved using a custom synthesis in high purity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

1,6,6'-Tri-O-tritylsucrose pentaacetate is a sugar that is synthesized by the process of fluorination and monosaccharide. It has a molecular formula of C12H18O9F. This compound can be used as a synthetic sugar in glycosylation reactions or as an Oligosaccharide for complex carbohydrate synthesis. The 1,6,6'-Tri-O-tritylsucrose pentaacetate can also be modified with methylation or click chemistry for high purity.

1,4-glucotetradecaose derived from starch by hydrolysis and chromatography

3-O-(2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosyl)-1,2,4,6-tetra-O-acetyl-b-D-glucopyranose is an oligosaccharide that has been modified with a click modification. This compound is a complex carbohydrate and it is synthesized from a monosaccharide. 3-O-(2,3,4,6-Tetra-O-benzyl-a-D--glucopyranosyl)-1,2,4,6-- tetra--O--acetyl--b--D--glucopyranose is used in methylation reactions.

Applications Acetylgalactosaminidase sequence substrate Clostridium Bifidobacterium. A fluorescent substrate for α2,3-(O)-Sialyltransferase References Medina, M. et al.: Cancer Res. 59,1061-1070, (1999)

In plants and algae, the two main galactolipids, monogalactosyldiacyglycerol (MGDG) and digalactosyldiacyglycerol (DGDG), are synthesized by galactosyltransferases in the plastid envelope. They have been linked to the anti-inflammatory and cancer benefits of a green leafy vegetable diet in humans due to their ability to regulate the levels of free radicals like nitric oxide (NO)

Galactofuranose pentasaccharide PEG6-NH-sp-biotin is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Galactofuranose pentasaccharide PEG6-NH-sp-biotin is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Applications Streptidine, is a metabolite derivative of Streptomycin (S687500), an antibiotic (antimycobacterial) drug, used for patients suffering from tuberculosis or other infectious diseases. References Granados, O., et al.: Histology and Histopathology, 20(2), 357 (2005);

Hyaluronate fluorescein is a large molecular weight, high-molecular weight, high-purity, highly modified carbohydrate. It is a synthetic oligosaccharide that has been chemically modified with methylation and saccharide. Hyaluronate fluorescein is synthesized using Click chemistry to add a fluorescent tag at the reducing end of the molecule. This product can be used for custom synthesis and glycosylation. Hyaluronate fluorescein is available in various sizes including 250kDa.

Inulotriose is a non-digestible carbohydrate that is found in plants. It is composed of fructose molecules linked together by β-2,1 glycosidic bonds. Inulotriose has been shown to have physiological activities such as antiviral and antifungal effects. It also has the ability to produce beneficial bacteria in the gut, which can help with digestion and absorption of nutrients. Inulotriose is a functional sweetener because it does not raise blood sugar levels and may be used as an alternative to sugar in diabetic diets.

a1-3 linked isomer of globotetraose

Please enquire for more information about 4-O-{[(6-Azidoethoxy)ethoxy]ethyl}-β-D-glycopyranosyl-2-deoxy-α-D glucopyranose-2,1-oxazoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

Methyl a-D-laminaribioside is a modified glycosylation product of D-Laminaribiose. It is an oligosaccharide that has been modified with methyl and fluorine groups. The modification of the sugars with these functional groups increases the stability and solubility of the molecule. Methyl a-D-laminaribioside is used in research for its ability to be click modified, polysaccharides, or saccharides, as well as being used in synthetic chemistry as a sugar to modify other molecules. Methyl a-D-laminaribioside is also used in medicine as an anti-inflammatory agent. Methyl a-D-laminaribioside can be synthesized by custom synthesis and has CAS number 7115-19-7.

Fully acetylated cellohexoses, part of a polymer homologous series of oligosaccharides isolated from cellulose by acetolysis followed by chromatography.

The core trisaccharide of the ganglioside GD2,protected with a propargyl glycoside group, is the most prominent alkynyl glycoside used in oligosaccharide synthesis (Das, 2016). The structure (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

Applications Cytidine 5’-Phosphate Methyl Ester Sodium Salt is an byproduct formed in the synthesis of analogs of Cytidine 5’-Diphosphate with an important role in the metabolism of phospholipids. References Trotter, P., et al.: J. Biol. Chem., 270, 6062 (1995), Janssen, M., et al.: Yeast, 16, 641 (2000), Henneberry, A., et al.: Mol. Biol. Cell, 12, 511 (2001), Boumann, H., et al.: Biochemistry, 42, 3054 (2003),

Benzyl 4-O-(2,3,4,6-tetra-O-benzyl-a-D-galactopyranosyl)-2,3-di-0benzyl 6-O-benzoyl-b-D-galactopyranoside is a synthetic carbohydrate that belongs to the class of oligosaccharides. It has been modified by fluorination and methylation. This compound is also glycosylated and click modified.

Methyl a-N-acetyllactosamine is a custom synthesis of Methyl a-N-acetylgalactosamine. This compound has been modified by fluorination, methylation, and click modification to yield the desired product. The monosaccharide structure was synthesized from the corresponding glycosyl halide and protected amino acid. The glycosylation reaction between this monosaccharide and the oligosaccharide containing an unprotected hydroxyl group yields the desired product. The purity of this compound is greater than 99%.

Hyaluronate biotin is a high purity, complex carbohydrate that has been modified with methylation and glycosylation. It has a molecular weight of 20kDa and is supplied as a powder. It is a white to off-white solid that can be dissolved in water or buffer solutions. This product can be used as an excipient in the manufacture of biologics such as vaccines, antibodies, enzymes, or other therapeutic proteins.