Oligosaccharides

Iso-lactosamine HCl is a synthetic monosaccharide, glycosylation product of galactose and lactic acid. It is used in the production of oligosaccharides and complex carbohydrates. Iso-lactosamine HCl is a white powder that can be dissolved in water or ethanol.

Component of human milk; antimicrobial activity against bacterial pathogens

6'-Sulpho Lewisx-BSA is a complex carbohydrate that contains a saccharide moiety with a sulfated Lewisx epitope. It has been synthesized using click chemistry and modified with methylation and fluorination to yield the desired structure. The carbohydrate is of high purity and can be used in research as a model for glycosylation and glycosidic linkage. The carbohydrate also has properties that are analogous to those observed in glycoconjugates, such as antibodies and lectins.

Methyl 2-acetamido-2-deoxy-3-O-(a-L-fucopyranosyl)-b-D-glucopyranoside is a glycosylation product of the natural sugar, galactose. It is a synthetic compound that has been modified with methyl groups and fluorine to form an active pharmaceutical ingredient. Methyl 2-acetamido-2-deoxy-3-O-(a-L-fucopyranosyl)-b-D-glucopyranoside can be used as a monosaccharide or oligosaccharide in the synthesis of complex carbohydrates.

Galactooligosaccharides (GOS) have a sweetness of 30-60 % relative to sucrose. They have applications in a wide range of food products such as sweeteners, bulking agents, and sugar substitutes and are found in a range of product types including bread, ‘sports’ drinks, jams, fermented milk, confectionary and desserts. In Europe they are incorporated into infant formula foods.

2,3,6,2',3',4',6'-Hepta-O-acetyl-b-D-lactosyl isothiocyanate is a fluorinated oligosaccharide that has been custom synthesized with a click modification. This compound is a high purity product and can be used in the synthesis of complex carbohydrates.

A1 Glycan, 2-AB labelled is a custom synthesis of a complex carbohydrate. The carbohydrate is an oligosaccharide that has been modified with methylation and glycosylation. The carbohydrate has a CAS number and is a polysaccharide. It is modified with saccharide, methylation, and glycosylation. The carbohydrate has undergone click modification and fluorination and it is synthetic.

b1-4-Galactosyl-Galactose-BSA is a carbohydrate, modification and saccharide that is an Oligosaccharide and sugar. It is custom synthesized and has high purity. This compound can be fluorinated, complexed, or methylated. It also contains glycosylation or click modification.

Lacto-N-fucopentaose II-GEL is a complex carbohydrate with a molecular weight of 11,000 Da. This product is not for human use and is intended for research purposes only. It should not be used in food or cosmetics.

The hyaluronic acid discaccharide and other enzymatically produced polymer homologs from hyaluronic acid have been of value in the study of hyaluronic acid metabolism in healthy and diseased tissues (Hascall, 2019). Hyaluronic acid is a polysaccharide containing repeating disaccharide units of β-1,3-N-acetyl glucosamine and β-1, 4-glucuronic acid. The unsaturated disaccharide hyalobiuronic acid is released from hyaluronic acid by the action of hyaluronidase on umbilical cord (Weissman, 1954).

Applications 4-Nitrophenyl 2-Acetamido-2-deoxy-4-O-α-L-fucopyranosyl)-β-D-glucopyranoside (cas# 259143-52-7) is a compound useful in organic synthesis.

Applications 2'-Deoxyuridine-1',2',3',4',5'-13C5 is the isotope labelled analogue 2’-Deoxyuridine (D288010), an uridine (U829910) derivative as therapeutic agent for treating allergy, cancer, infection and autoimmune disease. References Fu, M., et al.: J. Biol. Chem., 271, 9982 (1996), Thornalley, P., et al.: Biochem. J., et al.: 344, 109 (1999), Munter, T., et al.: Chem. Res. Toxicol., 15, 1549 (2002)

Globotriaosylsphingosine is dramatically increased in plasma of classically affected male Fabry patients and plasma and tissues of Fabry mice. Globotriaosylsphingosine was shown to be an inhibitor of α-galactosidase A activity. Furthermore, exposure of smooth muscle cells, but not fibroblasts, to globotriaosylsphingosine at concentrations observed in plasma of patients promotes proliferation. It was suggested that measurement of circulating globotriaosylsphingosine would be useful to monitor Fabry disease and may contribute to a better understanding of the disorder.

Man-2b N-glycan is an acidic glycoprotein that is synthesized in the endoplasmic reticulum of mammalian cells. It is a precursor to the oligosaccharide terminal sugar, which connects the glycan to protein. Man-2b N-glycan plays an important role in metabolic disorders such as renal proximal tubule dysfunction and metabolic acidosis by regulating protein synthesis. The Man-2b N-glycan mutation has been shown to lead to changes in cell surface proteins and metabolism, which can be modeled using a glycosylation mutant strain of yeast.

Lacto-N-tetraose-BSA is a carbohydrate that contains four monosaccharides. It has been shown to be an autoantibody in patients with myasthenia gravis and can cause muscle weakness by binding to the muscle protein, actin. Lacto-N-tetraose-BSA has also been found to bind with nerve tissue and may be involved in the development of sclerosis. This carbohydrate is also negatively charged and agglutinates red blood cells. When used for immunofluorescence, it shows a strong reaction against glycoconjugates on the surface of neurons and nerve tissue. Lacto-N-tetraose-BSA binds specifically to bovine serum albumin (BSA) containing antibodies, which are produced by immune cells called B cells. The binding sites are located on the outer part of the molecule, near the sugar residues.