Coumarins

Xanthotoxol analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Substrate for dealkylase.

7-Methoxy-4-methylcoumarin is a synthetic organic compound, which is a derivative of coumarins-a class of compounds widely found in plants. This compound is primarily synthesized through organic chemical reactions rather than extracted directly from natural sources. Its mode of action involves exhibiting fluorescence, which makes it a valuable probe in various scientific studies. The uses and applications of 7-Methoxy-4-methylcoumarin span across biochemical research fields, particularly in the study of enzyme activity, as this compound can serve as a fluorogenic substrate for certain enzymes. Additionally, its fluorescence properties are harnessed in the development of assays and diagnostic tools. Another notable application is in environmental monitoring, where it can be employed to track and quantify biological activities. Its ability to emit light upon excitation under specific conditions allows it to be a critical tool in spectroscopic studies and molecular investigations. The structural properties and reactivity of 7-Methoxy-4-methylcoumarin continue to support its multifunctional use in advancing scientific knowledge in various biological and chemical domains.

Dalbergin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Chalepensin, a furanocoumarin isolated from Ruta chalepensis L. of the Brassicaceae family, is a selective CYP2A6 inhibitor.

Murrayone from M. paniculata, a bioactive coumarin, prevents cancer metastasis and reduces ADP-induced platelet aggregation.

Fraxetin is a coumarin compound, which is a type of secondary metabolite commonly found in plants. It is principally derived from sources such as Fraxinus rhynchophylla and other related species. Fraxetin functions through various biological mechanisms, including antioxidant, anti-inflammatory, and neuroprotective activities. It accomplishes this by scavenging free radicals, modulating inflammatory pathways, and inhibiting specific enzymes associated with oxidative stress. The uses and applications of Fraxetin are vast within scientific research, particularly in the study of neurodegenerative diseases, where its neuroprotective properties offer potential therapeutic benefits. Additionally, Fraxetin has been investigated for its hepatoprotective effects, cardiac protection, and potential roles in metabolic processes. Researchers are increasingly interested in its ability to interact with cellular pathways, making it a promising candidate for further pharmacological and biomedical studies.

Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS

4-Hydroxy-3-phenylcoumarin is an organic compound, which is a derivative of coumarin. It is synthetically derived through chemical modification processes that introduce a hydroxy group and a phenyl ring to the coumarin core structure. Its mechanism of action involves the inhibition of vitamin K epoxide reductase, an enzyme critical for the cyclic conversion of vitamin K. This inhibition prevents the activation of vitamin K-dependent clotting factors, thereby exerting its anticoagulant effects. In practice, 4-Hydroxy-3-phenylcoumarin and its analogs are primarily used as anticoagulants in medical settings to prevent thrombosis and embolism in patients at risk for stroke, myocardial infarction, or atrial fibrillation. Additionally, they have been employed in research settings to study coagulation pathways and the role of vitamin K in various physiological processes. Researchers continue to investigate analogs of 4-Hydroxy-3-phenylcoumarin for enhanced specificity and reduced side effects in clinical applications.

Applications A labelled metabolite of Coumarin. The aglucon of skimmin. Present in many plants. References Schilling, et al.: Nature, 221, 664 (1969), Indahl, S., et al.: Xenobiotica, 1, 13 (1971), Thompson, S.G., et al.: Antimicrob. Agents Chemother., 18, 264 (1980),

8-Hydroxy-7-methoxycoumarin is a fluorescent compound, which is a derivative of the coumarin family. This compound is typically sourced through synthetic organic chemistry processes involving the modification of natural coumarin compounds. Its mode of action involves the ability to absorb ultraviolet light and re-emit it as visible light, a characteristic feature of fluorescent molecules. This property makes it particularly useful in scientific research. In biochemical applications, 8-Hydroxy-7-methoxycoumarin is widely used as a fluorescent probe, aiding in the study of enzyme activities, protein interactions, and cellular imaging. Because it can provide a distinct fluorescent signal, it is invaluable for tracking molecular and cellular processes, enabling scientists to visualize and quantify various biological interactions and changes. The utility of this compound extends to areas such as environmental monitoring, medical diagnostics, and the development of new materials, where its fluorescent properties can be leveraged to detect the presence of specific molecules or changes in chemical environments. Its robustness in diverse conditions makes it a versatile tool in the arsenal of chemical and biological researchers.

Bergamottin is a furanocoumarin compound, which is primarily found in grapefruit juice and other citrus fruits. It is derived from natural sources, specifically within the fruit and peel of grapefruits. The mode of action of Bergamottin involves the inhibition of the cytochrome P450 enzymes, particularly CYP3A4, which play a significant role in the metabolism of various drugs. This inhibitory effect can alter the pharmacokinetics of certain medications by increasing their bioavailability. Bergamottin is extensively studied for its applications in pharmacokinetics and drug interactions. Its presence can lead to significant clinical implications when patients consume grapefruit juice while on medication metabolized by CYP3A4. This interaction can enhance the therapeutic or adverse effects of drugs, requiring careful monitoring and potential dosage adjustments. Researchers explore Bergamottin’s role to better understand drug metabolism and to refine therapeutic strategies, ensuring safe and effective drug delivery. Understanding these interactions is crucial in the development of new pharmaceuticals and in clinical practice to prevent adverse outcomes associated with drug interactions.

Vinaxanthone (SM-345431), an extract from Penicillium chrysogenum, is a semaphorin3A inhibitor with antimicrobial activity.

Byakangelicol methanolate is a bioactive compound, which is a derivative of furanocoumarins, typically found in various plant species. It is naturally sourced from Angelica plants, known for their rich profile of therapeutic compounds. The mode of action of Byakangelicol methanolate involves the inhibition of specific enzymes related to inflammatory pathways, potentially modulating immune responses and reducing inflammation. This compound is of significant interest due to its potential applications in developing treatments for inflammatory-related conditions and possibly other therapeutic areas. Research into Byakangelicol methanolate focuses on understanding its pharmacological properties and exploring its benefits within pharmaceuticals for treating a range of inflammatory disorders. Its ability to act on specific biological pathways might provide insights into new therapeutic mechanisms, making it a subject of interest for scientists investigating novel anti-inflammatory agents.

2-(7-Methoxy-2-oxo-2H-chromen-4-yl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T64951 and the CAS number is 62935-72-2.

7-Methylcoumarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

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Lactone

Praeruptorin E is a natural furanocoumarin, which is derived from the roots of Peucedanum praeruptorum, a plant commonly used in traditional Chinese medicine. As a bioactive compound, Praeruptorin E exhibits significant pharmacological activities, particularly in cardiovascular, anti-inflammatory, and cytoprotective domains. The mode of action of Praeruptorin E involves modulation of calcium channels, which plays a crucial role in its vasorelaxant effects. This compound is also known to inhibit smooth muscle contraction and influence various signaling pathways that contribute to its anti-inflammatory and antioxidative properties. Due to these characteristics, Praeruptorin E has been extensively studied for its potential therapeutic applications in the management of cardiovascular diseases, such as hypertension and atherosclerosis. It also shows promise in reducing inflammation and oxidative stress, making it a candidate for further investigation in the treatment of inflammatory disorders.

(-)-Oxypeucedanin is a natural furanocoumarin, which is a type of organic compound. Furanocoumarins are derived from specific plants and are known for their complex structures and biological activities. (-)-Oxypeucedanin is sourced primarily from plants belonging to the Apiaceae family, such as Peucedanum species. The mode of action of (-)-Oxypeucedanin involves interacting with cellular pathways that may affect processes like phototoxicity and enzyme inhibition. Furanocoumarins, in general, can absorb ultraviolet light, leading to potential photosensitizing effects, which is significant in biological interactions. Uses and applications of (-)-Oxypeucedanin are mainly centered around its potential pharmacological activities. It has been studied for its effects in areas such as antimicrobial activity, cancer research, and photoprotection. However, understanding its full range of activities and therapeutic potential requires further research to delineate mechanisms and efficacy in various biological systems. Scientists are keen to explore its properties to contribute to advancements in biochemical and medical fields.

Scopoletin acetate is a natural product

Lactone

Fraxidin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

7-Amino-4-(methoxymethyl)coumarin is a fluorogenic compound, which is synthesized chemically for bioanalytical applications. This compound serves as a substrate in enzyme assays and is particularly valuable in studying enzymatic activity due to its fluorescent properties. Upon enzymatic cleavage, this coumarin derivative releases a highly fluorescent product, allowing for precise quantification of enzyme activity. This mode of action is particularly useful in the detection and measurement of protease activity, whereby the cleavage of the substrate correlates directly with enzyme function. The use of 7-Amino-4-(methoxymethyl)coumarin spans various research fields, including molecular biology and biochemistry, where it aids in understanding enzyme kinetics and inhibition. Its sensitivity and ability to provide real-time data make it an indispensable tool in high-throughput screening and drug discovery initiatives.

cis-Khellactone is a naturally occurring organic compound, which is a type of coumarin derivative sourced predominantly from the roots of Peucedanum and Angelica species, plants native to various regions. These botanical sources are known for yielding secondary metabolites with diverse biological properties. The mode of action of cis-Khellactone involves interaction with various biological pathways, potentially including modulation of enzyme activity or receptor binding, which may lead to its observed pharmacological effects. This compound has been studied for its potential activities, including anti-inflammatory, antiviral, and antitumor properties, although the exact mechanisms remain under investigation. In scientific research, cis-Khellactone is utilized to explore new therapeutic agents due to its promising bioactive profile. Scientists investigate its effects in vitro and in vivo to unravel its potential benefits and limitations. Its role in traditional medicine in regions where its source plants are native adds an ethnopharmacological dimension to research, providing a basis for further exploration into its utility in modern pharmacology and drug development.

Lactone

6'-Dehydromarmin is a natural product, classified as a coumarin derivative, which is primarily sourced from certain plant species, notably within the Rutaceae family. This compound arises through the biochemical transformation of secondary metabolites in plants, typically involving oxidation processes that occur under specific enzymatic conditions. The mode of action of 6'-Dehydromarmin is rooted in its ability to interact with various biological pathways. It exhibits a range of activities, including antifungal and antimicrobial properties, by disrupting cellular processes within pathogens. This disruption often involves interference with cell wall synthesis and enzyme inhibition, contributing to its efficacy as a bioactive molecule. In terms of uses and applications, 6'-Dehydromarmin is of significant interest in the fields of pharmacology and biochemistry due to its potential therapeutic roles. It is studied for its antimicrobial capabilities, offering a natural alternative for combating resistant microbial strains. Additionally, its role as a model compound in studying plant-derived coumarins underscores its value in scientific research, particularly in understanding plant defense mechanisms and secondary metabolism.

(+)-Columbianetin ((S)-Columbianetin) is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has