Coumarins

Fraxin is a naturally occurring anticoagulant, which is derived from the bark of certain species of the Fraxinus tree. It functions by inhibiting thrombin and other key enzymes in the coagulation cascade, thus preventing the formation of blood clots. This mode of action makes it particularly valuable in research settings focused on cardiovascular diseases, as well as in the development of therapeutic agents targeting coagulopathies. Applications of Fraxin extend to experimental investigations involving blood coagulation mechanisms and the testing of novel anticoagulant therapies. It is also utilized within pharmacological studies to assess hemostatic balance and the potential for thrombosis under various pathological conditions. For scientists delving into biochemistry, hematology, or pharmacology, Fraxin offers a unique opportunity to explore the complex interactions within the blood coagulation system.

Lactone

Lactone

Lactone

Imperatorin is a furanocoumarin compound, which is a natural product primarily isolated from plants in the Apiaceae family, such as Angelica dahurica and Citrus species. This compound is characterized by its unique chemical structure that includes a furan ring fused to a coumarin backbone. Imperatorin exerts its biological activities through multiple modes of action, including the modulation of enzymatic activity, interference with cellular signaling pathways, and binding to specific biological targets. The compound is involved in various pharmacological applications due to its anti-inflammatory, antimicrobial, and anticancer properties. It has been studied for its potential in improving cardiovascular health by regulating blood pressure and reducing thrombosis. Moreover, imperatorin has shown promise in neuromodulatory applications, offering potential benefits for neuroprotective interventions. Researchers continue to explore its diverse bioactivities, focusing on its potential in medicinal and therapeutic contexts. Understanding its mechanisms can advance the development of new strategies in drug design and discovery, reinforcing its significance in scientific research and pharmacology.

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M04110 - gamma-L-Glutamic acid 7-amido-4-methylcoumarin

Isobergapten analytical standard provided with w/w absolute assay, to be used for quantitative titration.

5,7-Dihydroxy-4-methylcoumarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Calycanthoside (Isofraxidin 7-O-beta-D-Glucoside) is a natural compound isolated from Angelica tenuissima.

Lactone

Lactone

Fraxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Salvianolic acid A has antioxidant, hepatoprotective, antithrombotic effect, and antiplatelet actions. it also has a significant protective effect against isoproterenol-induced myocardial infarction; it activates the Nrf2/HO-1 axis in RPE cells and protects against oxidative stress via activation of Akt/mTORC1 signaling. Salvianolic acid A (oral) can significantly improve glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats. It is a novel matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats.

Osthol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Daphnetin-8-glucoside is a natural phenolic glucoside compound derived from plants of the Thymelaeaceae family, specifically from the Daphne genus. This compound is produced by the glycosylation of daphnetin, a coumarin derivative found in various botanical sources. The glycoside linkage enhances its solubility and stability, facilitating its bioavailability. Daphnetin-8-glucoside exhibits potent antioxidant and anti-inflammatory activities, mediated through the scavenging of free radicals and inhibition of pro-inflammatory cytokine production. Additionally, it modulates signal transduction pathways involved in cellular oxidative stress responses. In scientific research, Daphnetin-8-glucoside is used for its potential therapeutic effects in managing oxidative stress-related disorders and inflammatory conditions. Its biological activities make it a candidate for investigating new therapeutic avenues in neurodegenerative diseases, cardiovascular health, and skin protection. Researchers explore its efficacy and mechanism of action to understand its role in cellular protection and its potential integration into clinical applications. The study of such natural compounds contributes to the broader understanding of plant-derived bioactives and their impact on human health.

Esculetin is a naturally occurring coumarin compound, which is predominantly derived from various plant sources, such as the bark and leaves of certain trees and shrubs. As a member of the coumarin family, it is characterized by its benzopyrone structure and is often isolated from botanicals through organic solvent extraction methods. Its mode of action primarily involves its ability to scavenge free radicals and chelate metal ions, contributing to its notable antioxidant capacity. Furthermore, Esculetin exerts anti-inflammatory effects by inhibiting the activity of enzymes such as cyclooxygenase and lipoxygenase, which are integral to the inflammatory pathway. Common applications of Esculetin are found in scientific research where it is utilized for its potential therapeutic properties. Studies have investigated its role in modulating oxidative stress, its protective effects in neurodegenerative disorders, and its capability to inhibit the proliferation of certain cancer cell lines. Additionally, it serves as a useful biochemical tool in elucidating the pathways of inflammation and oxidative stress within cellular models. Scientists continue to explore its potential as a lead compound in drug discovery and development.

Coumarin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Lactone

Graveolone is a bioactive compound that functions as a plant defense enhancer, which is derived from certain plant species known for their antimicrobial properties. Its mode of action involves the activation of multiple signaling pathways that bolster the plant's innate immune response. By enhancing the synthesis of defensive proteins and secondary metabolites, Graveolone effectively fortifies plants against pathogenic challenges and abiotic stresses. The uses and applications of Graveolone are particularly relevant in agricultural biotechnology, where it serves as a pivotal component in developing disease-resistant crops. Its integration into crop management practices can reduce dependence on chemical pesticides by naturally augmenting plant resilience. Furthermore, its efficacy in stress modulation opens pathways for improving crop yields in variable environmental conditions. As scientists continue to explore its mechanisms, Graveolone holds potential for broad-spectrum applications in sustainable agriculture.

7,8-Methylenedioxycoumarin is a furanocoumarin compound, which is a type of organic molecule characterized by a coumarin core with an additional methylenedioxy group. It is primarily sourced from various plant species, particularly those in the Rutaceae family, where it is found in essential oils and extracts. The mode of action of 7,8-Methylenedioxycoumarin involves its natural fluorescing properties, making it highly valuable for use in various biochemical assays where visualization is key. Due to its unique chemical structure, it efficiently absorbs ultraviolet light and emits visible fluorescence, which is exploited in photochemistry and as a biological marker. Its applications extend to the fields of pharmaceuticals and environmental sciences, where it serves in drug development studies and as a tool for tracking organic pollutants in ecosystems. Researchers continue to explore its potential uses due to its distinctive chemical behavior and natural origin.

Suberosin is a naturally occurring sesquiterpene lactone, which is isolated from members of the Rutaceae family, such as the plant Feronia limonia. The compound exhibits diverse biological activities, primarily attributed to its complex structure that facilitates interaction with various biological targets. Suberosin's mode of action involves disrupting microbial cell membranes and interfering with critical biochemical pathways, effectively inhibiting microbial growth and propagation. Used extensively in the field of microbiology and pharmacology, suberosin demonstrates promising antifungal and antimicrobial properties. Its ability to impede the growth of pathogens like fungi and bacteria makes it a compound of interest for developing new antimicrobial agents. Moreover, ongoing studies explore its potential in treating infections resistant to conventional therapeutics, thereby addressing a significant medical challenge. As research progresses, suberosin's range of applications might expand further, underlining its importance in developing novel treatments for microbial infections.

6,7-Dihydroxy-4-methylcoumarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Xanthotoxol (Psoralen) is a bioactive furocoumarin with anti-inflammatory, antioxidant, 5-HT antagonist, and neuroprotective properties.

6-Hydroxycoumarin: cytotoxic to HL60, HCT116, COLO205 (35, 42, 37 µM), inhibits CA9, CA12.

Lactone