Coumarins

Lactone

4-Hydroxy-6-methylcoumarin (4-HMC), a natural anti-inflammatory and anti-tumor agent, is used in food as a flavor, preservative, and antioxidant.

Lactone

Angelicin is a furocoumarin found in Psoralea corylifolia L. fruit, can block the phosphorylation of IκBα, NFκBp65, p38 MAPK, and JNK in lipopolysaccharide-induced acute lung injury model, suggests that angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways, it might be a potential new agent for prevention of inflammatory reactions and diseases in the clinic.

Angelicin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Murrangetin is a flavonoid compound, which is a natural phytochemical sourced from the peels of various citrus fruits. Its mode of action primarily involves the modulation of inflammatory pathways, potentially through the inhibition of specific enzymes like cyclooxygenases and lipoxygenases. This flavonoid is also known for its antioxidative properties, which contribute to its ability to scavenge free radicals, thereby reducing oxidative stress in biological systems. Murrangetin is currently studied for its potential applications in the development of anti-inflammatory and antioxidant therapies. It shows promise in the treatment of inflammatory diseases and conditions arising from oxidative stress. Moreover, its role in modulating various cellular pathways opens up prospects for research in cancer biology, specifically in investigating its effects on tumor growth and metastasis. Further scientific exploration is warranted to fully understand its therapeutic potential and mechanisms in diverse biological contexts.

Psoralen analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Xanthotoxin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

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Triumbelletin is a tricoumarin rhamnopyranoside obtained from Wikstroemia indica with antitumour activity for the study of tumours.

Lactone

Selinidin is a phytochemical compound, which is derived from the natural source of the Brunsvigia bosmaniae plant. As a bioactive constituent of this plant, it is characterized by its unique structure and chemical properties, enabling it to interact with a variety of cellular targets, primarily through modulation of inflammatory pathways. The mode of action of Selinidin involves the inhibition of pro-inflammatory cytokines and mediators, thereby reducing inflammation and oxidative stress at the cellular level. The applications of Selinidin are primarily within the scientific research domain, where it is utilized to explore novel anti-inflammatory mechanisms and pathways. Researchers focus on its potential to influence molecular signaling pathways, which can offer insights into developing new therapeutic strategies for inflammatory-related conditions. Current studies are investigating its efficacy and molecular interactions, aiming to unlock its potential in pharmacological applications, particularly in conditions where inflammation plays a crucial role. Such research continues to reveal the complexities of its actions and its promise in contributing to the development of innovative treatments.

5-Geranyloxy-7-methoxycoumarin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Bergapten analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Lactone

4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.

Umbelliprenin is a naturally occurring prenylated coumarin, which is primarily isolated from plants in the Apiaceae family. These plants are rich sources of various biologically active compounds. The mode of action of umbelliprenin is attributed to its ability to modulate multiple cellular pathways, including apoptosis and cell cycle arrest. This modulation is largely due to its interaction with reactive oxygen species and various signaling molecules within the cell. Umbelliprenin has garnered significant interest for its potential applications in the biomedical field, particularly in cancer research. Studies have demonstrated its antiproliferative effects in various cancer cell lines, suggesting a potential role in oncological therapeutics. Additionally, its antimicrobial properties have been explored, highlighting its capacity to inhibit the growth of certain pathogenic microorganisms. The compound's natural origin and selective biological activity make it a compelling subject for further investigation in both preclinical and clinical studies aimed at developing novel therapeutic agents.

Glycocoumarin is a phytochemical compound that is primarily categorized as a bioactive flavonoid. It is derived from Glycyrrhiza uralensis, commonly known as liquorice, a plant renowned for its diverse pharmacological properties. The mode of action of glycocoumarin involves the modulation of various biological pathways, including its potential to influence inflammatory responses and antioxidant activity. This compound is known to interact with cellular signaling mechanisms, which could mediate its effects on immune modulation and cellular protection. The applications of glycocoumarin are primarily in the research and development domain, focusing on its therapeutic potential. It has been investigated for its role in managing inflammatory diseases, enhancing immune response, and providing protective effects against oxidative stress-related cellular damage. Its natural origin and bioactive properties make it an intriguing subject for further exploration in pharmacognosy and medicinal chemistry, particularly for its possible incorporation into therapeutic protocols aimed at mitigating chronic health conditions.

M05818 - 7-Methoxycoumarin-3-Carboxylic acid

Cichoriin is a coumarin glycoside, which is a type of phytochemical compound found in certain plants. It is primarily sourced from plants of the Asteraceae family, particularly chicory (Cichorium intybus). The compound exhibits its biochemical effects by interacting with various cellular pathways, including acting as an antioxidant and displaying potential anti-inflammatory and antimicrobial properties. Cichoriin's mode of action involves the inhibition of free radicals and modulation of enzyme activities, which contributes to its protective effects in biological systems. In scientific research, it is explored for its potential therapeutic applications due to its ability to affect oxidative stress and inflammation pathways. The uses and applications of cichoriin are varied, extending into pharmacological studies related to its antioxidative and protective properties. It serves as a subject of interest in studies aiming to develop treatments for conditions linked to oxidative stress and inflammation, highlighting its potential role in advancing our understanding of natural compounds in therapeutic contexts.

Tegerrardin A is an innovative biopesticide derived from microbial fermentation processes, harnessing the potency of naturally occurring microorganisms. It is formulated to exploit the specific biochemical mechanisms within targeted pest populations, effectively disrupting their vital physiological functions. This selective mode of action is achieved through the inhibition of key enzymes essential for pest survival and proliferation, resulting in decreased pest pressure and improved crop health. Tegerrardin A is primarily utilized in agricultural settings, where it plays a crucial role in integrated pest management strategies. Its applications extend to a wide range of crops, providing an eco-friendly alternative to traditional chemical pesticides. The targeted action minimizes collateral damage to non-target organisms, thereby supporting biodiversity and ecological balance. Furthermore, Tegerrardin A's biodegradable nature and reduced risk of resistance development make it a sustainable choice for long-term agricultural productivity.

Heraclenol is derived from the fruits of Angelica lucida with antibacterial activities. Heraclenol is a germination inhibitor in the parsley and lettuce seeds.

Tomenin is a systemic insecticidal compound, which is synthetically derived with a unique dual mode of action. This product is designed to efficiently target nematodes, plant-parasitic organisms that cause significant agricultural damage. The molecular formulation of Tomenin involves binding to specific nematode receptors, disrupting their neuromuscular functions and metabolic pathways. This dual action results in paralysis and eventual death of the nematodes, ensuring effective control over populations that threaten crop yield and quality. Tomenin is primarily utilized in the agricultural sector, applied as a soil treatment to protect root systems from invasion and damage by nematodes. Its application has shown to significantly enhance crop health and productivity across a variety of plant species. Moreover, its specificity in action minimizes the impact on non-target organisms, making it a valuable tool for integrated pest management strategies. Research continues to explore broader applications and potential resistance management strategies, ensuring Tomenin remains an effective solution for nematode control in sustainable agriculture.

Fraxidin is a naturally occurring compound, specifically an O-methylated coumarin, which is derived from certain plant sources such as the fruits of the ash tree. It is primarily obtained through the processing of various plant materials within the Rutaceae family. The mode of action of Fraxidin involves the inhibition of oxidative damage due to its capacity to scavenge free radicals, thus leading to potential antioxidant properties in biological systems. The possible uses and applications of Fraxidin are of significant interest in scientific research, particularly in the exploration of its antioxidative capabilities. Studies have focused on its role in mitigating oxidative stress, which is implicated in a range of degenerative diseases. Researchers are investigating its efficacy and mechanisms in experimental settings, aiming to understand its potential therapeutic applications in conditions characterized by excessive free radical production. The continued investigation into the pharmacokinetics and bioavailability of Fraxidin is necessary to fully elucidate its role and to fully recognize its applicability in clinical contexts.

Skimmin reduces inflammation, enhances kidney function, and inhibits IgG and glomerular damage in rat kidney disease.

7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist.

Cnidicin: anti-allergic, anti-inflammatory, impedes mast cell degranulation, NO in RAW 264.7 cells (IC50=7.5µM), hinders human tumor cell growth in vitro.

Prenyletin methyl ether is a flavonoid compound, which is a naturally occurring polyphenolic molecule sourced primarily from specific plant species. This compound exerts its effects through a variety of biochemical interactions, notably influencing cellular signaling pathways, including antioxidative and anti-inflammatory processes. As a flavonoid, Prenyletin methyl ether is recognized for its potential therapeutic applications in the modulation of oxidative stress and inflammatory responses. It plays a role in various research areas exploring chronic disease mechanisms, including cardiovascular and neurodegenerative disorders. Its mode of action involves altering the expression of specific enzymes and proteins that mediate oxidative damage and inflammation. Moreover, its pharmacokinetic properties and interaction with biomolecular targets make it a subject of interest for drug development and nutraceutical formulations. Research on Prenyletin methyl ether continues to uncover its diverse pharmacological potentials, contributing insights into its application in developing novel therapeutic strategies.

7-(Diethylamino)-4-methyl-2H-chromen-2-one is a useful organic compound for research related to life sciences.

Calycanthoside is a phenolic glycoside, which is a type of natural compound characterized by a glycosidic bond linking a phenolic moiety. It is derived from the plant Calycanthus chinensis, known for its rich array of bioactive compounds. The extraction and isolation processes of Calycanthoside involve sophisticated chromatographic techniques to ensure its purity and activity. In terms of its mode of action, Calycanthoside exhibits significant biological activity attributed to its anti-inflammatory and antioxidant properties. These effects are achieved through modulation of cellular pathways that reduce oxidative stress and inhibit inflammatory mediators, thereby offering potential therapeutic benefits. Calycanthoside is extensively researched for its applications in pharmacology, especially concerning its protective effects in oxidative stress-related conditions. Its anti-inflammatory properties make it a subject of interest in developing treatments for chronic inflammatory diseases. Additionally, its antioxidant capacity suggests potential uses in skincare formulations, aiming to protect against cellular damage caused by environmental factors. The exploration of Calycanthoside continues to expand, contributing valuable insights into natural product chemistry and pharmacognosy.

Byakangelicin is a furanocoumarin compound, which is derived from the roots of various Angelica plant species. This compound is of particular interest due to its complex chemical structure that allows it to interact with biological systems in distinctive ways. Byakangelicin's mode of action includes the inhibition of specific enzymes, interference with signal transduction pathways, and potential modulation of cellular responses, making it a valuable subject for various pharmacological studies. The primary uses and applications of Byakangelicin are in the domain of biomedical research, where it is explored for its potential therapeutic benefits. Research has indicated its promise in areas such as anti-inflammatory, antimicrobial, and anticancer activities. Scientists continue to investigate its efficacy and mechanisms, exploring its role in modulating immune response and its potential as an adjuvant in drug formulations. Such studies aim to harness Byakangelicin's bioactive properties, fostering a deeper understanding of its effects and paving the way for new therapeutic strategies.

3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.

Lactone

7-Ethoxy-4-Methylcoumarin: fragrant, organic, enzyme inhibitor; used in drug effect studies.

Lactone